Shinya Minatoguchi

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi request reprint Vasospastic angina and Ca channel blockers
    Shinya Minatoguchi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1 1, Gifu, Gifu 501 1194, Japan
    Curr Hypertens Rev 9:219-23. 2013
  2. doi request reprint Comparative effect of candesartan and amlodipine, and effect of switching from valsartan, losartan, telmisartan and olmesartan to candesartan, on early morning hypertension and heart rate
    Shinya Minatoguchi
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 5011194, Japan
    Blood Press 22:29-37. 2013
  3. pmc Motion of left atrial appendage as a determinant of thrombus formation in patients with a low CHADS2 score receiving warfarin for persistent nonvalvular atrial fibrillation
    Koji Ono
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Cardiovasc Ultrasound 10:50. 2012
  4. pmc Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
    Takahiko Yamaki
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Japan
    Cardiovasc Ultrasound 10:33. 2012
  5. pmc Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound
    Yoshiyuki Ishihara
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Cardiovasc Ultrasound 10:32. 2012
  6. pmc Left atrial pathological degeneration assessed by integrated backscatter transesophageal echocardiography as a predictor of progression to persistent atrial fibrillation: results from a prospective study of three-years follow-up
    Tomoki Kubota
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Cardiovasc Ultrasound 10:28. 2012
  7. doi request reprint Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits
    Shinya Minatoguchi
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Gifu 500, Japan
    J Cardiovasc Pharmacol 54:25-30. 2009
  8. ncbi request reprint Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure
    Hideshi Okada
    Division of Cardiology, Gifu Univ Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 296:H616-26. 2009
  9. doi request reprint Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction
    Shinji Yasuda
    Dept of Cardiology, Gifu Univ Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 296:H1558-65. 2009
  10. doi request reprint Postinfarct treatment with oxytocin improves cardiac function and remodeling via activating cell-survival signals and angiogenesis
    Hiroyuki Kobayashi
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 54:510-9. 2009

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Vasospastic angina and Ca channel blockers
    Shinya Minatoguchi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1 1, Gifu, Gifu 501 1194, Japan
    Curr Hypertens Rev 9:219-23. 2013
    ....
  2. doi request reprint Comparative effect of candesartan and amlodipine, and effect of switching from valsartan, losartan, telmisartan and olmesartan to candesartan, on early morning hypertension and heart rate
    Shinya Minatoguchi
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 5011194, Japan
    Blood Press 22:29-37. 2013
    ..In conclusion, candesartan significantly decreased early morning hypertension more than amlodipine or other ARBs except olmesartan in early morning hypertensives...
  3. pmc Motion of left atrial appendage as a determinant of thrombus formation in patients with a low CHADS2 score receiving warfarin for persistent nonvalvular atrial fibrillation
    Koji Ono
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Cardiovasc Ultrasound 10:50. 2012
    ....
  4. pmc Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
    Takahiko Yamaki
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Japan
    Cardiovasc Ultrasound 10:33. 2012
    ....
  5. pmc Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound
    Yoshiyuki Ishihara
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Cardiovasc Ultrasound 10:32. 2012
    ....
  6. pmc Left atrial pathological degeneration assessed by integrated backscatter transesophageal echocardiography as a predictor of progression to persistent atrial fibrillation: results from a prospective study of three-years follow-up
    Tomoki Kubota
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Cardiovasc Ultrasound 10:28. 2012
    ..The purpose of this study was to elucidate the usefulness of integrated backscatter (IBS) values for the prediction of progression from paroxysmal AF (PAF) to persistent AF...
  7. doi request reprint Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits
    Shinya Minatoguchi
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Gifu 500, Japan
    J Cardiovasc Pharmacol 54:25-30. 2009
    ..A recent large-scale clinical trial, STOP-NIDDM, showed that acarbose reduces the risk of myocardial infarction. We examined whether acarbose reduces myocardial infarct size and investigated its mechanisms...
  8. ncbi request reprint Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure
    Hideshi Okada
    Division of Cardiology, Gifu Univ Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 296:H616-26. 2009
    ..The results suggest that combined use of G-CSF administration and sFas gene therapy is a potentially powerful tool against post-MI heart failure...
  9. doi request reprint Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction
    Shinji Yasuda
    Dept of Cardiology, Gifu Univ Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 296:H1558-65. 2009
    ..Pioglitazone may be a novel strategy for the treatment of diabetes mellitus with coronary artery disease...
  10. doi request reprint Postinfarct treatment with oxytocin improves cardiac function and remodeling via activating cell-survival signals and angiogenesis
    Hiroyuki Kobayashi
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 54:510-9. 2009
    ..We investigated whether postinfarct treatment with oxytocin (OT) improves left ventricular (LV) function and remodeling via cardiac repair of myocardial ischemia-reperfusion injury...
  11. ncbi request reprint Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling
    Atsushi Ogino
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Am J Physiol Heart Circ Physiol 293:H2271-80. 2007
    ..These findings may provide new insight into the mechanism by which calcium channel blockers attenuate postinfarction cardiac remodeling and dysfunction...
  12. ncbi request reprint Molecular signaling mediated by angiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart failure
    Yiwen Li
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    J Card Fail 13:155-62. 2007
    ..In patients with end-stage renal disease, angiotensin II type 1A receptor (AT1) blockade attenuates the associated cardiac dysfunction. We investigated the molecular signaling mediating that effect...
  13. doi request reprint Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction
    Longhu Li
    Division of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Physiol Heart Circ Physiol 297:H1504-13. 2009
    ..In summary, postinfarction decorin gene therapy mitigated cardiac remodeling and dysfunction by altering infarct tissue noncardiomyocyte dynamics and preventing cardiac fibrosis, accompanying inhibition of Smad2/3 activation...
  14. ncbi request reprint Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy
    Masayasu Esaki
    Division of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 294:H1048-57. 2008
    ..These beneficial effects appear to be related to HGF-induced ERK activation and upregulation of c-Met, GATA-4, and sarcomeric proteins...
  15. ncbi request reprint Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs
    Itta Kawamura
    Dept of Cardiology, Gifu Univ Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 299:H372-8. 2010
    ..An adequately controlled phlebotomy might be one method by which to induce therapeutic angiogenesis...
  16. ncbi request reprint Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair
    Hiroyuki Kobayashi
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 5011194, Japan
    Cardiovasc Res 79:611-20. 2008
    ..We investigated the effect of an erythropoietin (EPO)-gelatin hydrogel drug delivery system (DDS) applied to the heart on myocardial infarct (MI) size, left ventricular (LV) remodelling and function...
  17. ncbi request reprint Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure
    Yiwen Li
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 71:684-94. 2006
    ..We investigated the mechanisms, including the downstream signaling pathways, for the beneficial effect of late treatment with EPO on chronic post-MI heart failure...
  18. ncbi request reprint Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy
    Longhu Li
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Lab Invest 87:440-55. 2007
    ..In conclusion, these findings imply the therapeutic usefulness of G-CSF mainly through restoring ERK activation against DOX-induced nonischemic cardiomyopathy...
  19. ncbi request reprint ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart
    Yiwen Li
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagito, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 292:H946-53. 2007
    ..In conclusion, altered structural dynamics of infarct scar and increasing myocardial fibrosis may be responsible for the deleterious effects of AT(1A) signaling following MI...
  20. ncbi request reprint Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy
    Longhu Li
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Circulation 113:535-43. 2006
    ..Doxorubicin is a highly effective antineoplastic drug, but its clinical use is limited by its adverse side effects on the heart. We investigated possible protective effects of erythropoietin against doxorubicin-induced cardiomyopathy...
  21. pmc Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis
    Shusaku Miyata
    Division of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Pathol 176:687-98. 2010
    ..Therefore, sFas gene therapy prevents the progression of doxorubicin-induced acute cardiotoxicity, with accompanying attenuation of the cardiomyocyte degeneration, inflammation, fibrosis, and oxidative damage caused by Fas signaling...
  22. ncbi request reprint Modification of post-myocardial infarction granulocyte-colony stimulating factor therapy with myelo-suppressives
    Yu Misao
    Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
    Circ J 71:580-90. 2007
    ..The purpose of the present study was to investigate the effect of granulocyte colony-stimulating factor (G-CSF) in combination with myelo-suppressives on post-myocardial infarction (MI) myocardial repair...
  23. ncbi request reprint Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits
    Narentuoya Bao
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Circ J 71:1622-8. 2007
    ..Statins reportedly protect against myocardial infarction, but the precise mechanism is unclear...
  24. pmc Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart
    Ningyuan Wang
    Second Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500, Japan
    Br J Pharmacol 142:983-90. 2004
    ..4 These data suggest that miglitol reduces myocardial apoptosis by attenuating production of hydroxyl radicals and suppressing the upregulation of the expression of Bax protein...
  25. doi request reprint Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels
    Yushan Bai
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu Pharmaceutical University, Gifu, Japan
    Clin Exp Pharmacol Physiol 38:658-65. 2011
    ..Cilostazol might provide a new strategy for the treatment of coronary heart disease...
  26. ncbi request reprint Conservative medication follow-up for over 20 years of a patient with ischemic heart disease after diagnosis of chronic total occlusion of the 3 main coronary arteries
    Shinichiro Tanaka
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Circ J 72:1205-9. 2008
    ..The left ventricular ejection fraction has been maintained at >60%. During the 20-year follow-up, he has had refractory angina, but has not suffered from acute coronary syndrome, congestive heart failure, or critical arrhythmia...
  27. doi request reprint Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits
    Masamitsu Iwasa
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Gifu, Japan
    J Cardiovasc Pharmacol 55:625-34. 2010
    ..These findings may provide new insight into therapeutic strategies for the treatment of patients with coronary artery disease...
  28. pmc Functional significance and morphological characterization of starvation-induced autophagy in the adult heart
    Hiromitsu Kanamori
    Department of Laboratory Medicine, Division of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Pathol 174:1705-14. 2009
    ..The present findings suggest a critical role of autophagy in the maintenance of cardiac function during starvation in the adult...
  29. doi request reprint Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels
    Shohei Sumi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Physiol Heart Circ Physiol 299:H1174-82. 2010
    ....
  30. doi request reprint Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia
    Longhu Li
    Division of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    J Am Coll Cardiol 53:2378-88. 2009
    ..We hypothesized that erythropoietin (EPO)-immersed gelatin hydrogel microspheres (GHM) injected into ischemic legs might continuously release a small amount of EPO to locally stimulate angiogenesis without unfavorable systemic effects...
  31. ncbi request reprint The Fas/Fas-ligand pathway does not mediate the apoptosis in elastase-induced emphysema in mice
    Masahiro Sawada
    Second Department of Internal Medicine, Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu, Japan
    Exp Lung Res 33:277-88. 2007
    ..These findings suggest that apoptosis associated with PPE-induced emphysema is not mediated via the Fas/Fas-ligand pathway...
  32. ncbi request reprint Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits
    Hirohito Onogi
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Clin Exp Pharmacol Physiol 33:1035-41. 2006
    ..In conclusion, edaravone significantly reduces MI size and improves cardiac function and LV remodelling by decreasing hydroxyl radicals and superoxide in the myocardium and increasing the production of NO during reperfusion in rabbits...
  33. ncbi request reprint Lindera strychnifolia is protective against post-ischemic myocardial dysfunction through scavenging hydroxyl radicals and opening the mitochondrial KATP channels in isolated rat hearts
    Ningyuan Wang
    Second Department of Internal Medicine, Gifu University School of Medicine 40 Tsukasa Machi, Gifu, 500 8705, Japan
    Am J Chin Med 32:587-98. 2004
    ..In conclusion, L. strychnifolia is protective against post-ischemic left ventricular dysfunction through scavenging hydroxyl radicals and opening the KATP channels in the isolated rat heart...
  34. ncbi request reprint Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes
    Hiroaki Ushikoshi
    Department of Gene Therapy and Regenerative Medicine, Gifu University School of Medicine, Gifu, Japan
    Lab Invest 85:862-73. 2005
    ..These results imply that regulation of HB-EGF may be a therapeutic target for treating cardiac hypertrophy and fibrosis...
  35. ncbi request reprint Autologous bone marrow cell transplantation improves left ventricular function in rabbit hearts with cardiomyopathy via myocardial regeneration-unrelated mechanisms
    ChuanJiang Lu
    Second Department of Medicine, Gifu University, 1 1 Yanagido, Gifu, 501 1194, Japan
    Heart Vessels 21:180-7. 2006
    ..In conclusion, autologous BMC transplantation into cardiomyopathic rabbit hearts ameliorates the decline in ventricular function without regenerating cardiomyocytes, most likely by altering expression of various cytokines...
  36. doi request reprint The role of autophagy emerging in postinfarction cardiac remodelling
    Hiromitsu Kanamori
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 91:330-9. 2011
    ..We observed the dynamics of cardiomyocyte autophagy and examined its role during postinfarction cardiac remodelling...
  37. doi request reprint Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart
    Hideshi Okada
    Division of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    J Cell Mol Med 12:1272-83. 2008
    ..The findings may also imply a more feasible way of G-CSF administration in the clinical settings...
  38. pmc Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits
    Masamitsu Iwasa
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Br J Pharmacol 164:119-31. 2011
    ..We hypothesized that p.o. administration of miglitol, an absorbable antidiabetic drug, reduces myocardial infarct size by stimulating GLP-1 receptors and inhibiting glycogenolysis in the myocardium...
  39. ncbi request reprint Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction
    Xuehai Chen
    Second Department of Internal Medicine, Gifu University School of Medicine
    Circ J 71:574-9. 2007
    ..This study will examine whether celiprolol reduces myocardial infarct size, as well as investigate the mechanisms for its infarct size-reducing effect in rabbits...
  40. doi request reprint Application of an adenoviral vector encoding soluble transforming growth factor-beta type II receptor to the treatment of diabetic nephropathy in mice
    Takehito Kondo
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Clin Exp Pharmacol Physiol 35:1288-93. 2008
    ..This problem will have to be overcome if gene therapies for slowly progressing diseases, like diabetic nephropathy, are to be realised...
  41. ncbi request reprint Effects of pitavastatin on cardiac structure and function and on prevention of atrial fibrillation in elderly hypertensive patients: a prospective study of 2-years' follow-up
    Shunichiro Warita
    Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan
    Circ J 76:2755-62. 2012
    ....
  42. ncbi request reprint Cilnidipine, an N+L-type dihydropyridine Ca channel blocker, suppresses the occurrence of ischemia/reperfusion arrhythmia in a rabbit model of myocardial infarction
    Hiroshi Nagai
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Hypertens Res 28:361-8. 2005
    ..The antiarrhythmic effect of cilnidipine may be related to the attenuation of cardiac sympathetic nerve activity. This finding may provide new insight into therapeutic strategies for hypertensive patients with ventricular arrhythmias...
  43. ncbi request reprint Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure
    Yiwen Li
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Circ Res 95:627-36. 2004
    ..Blockade of this apoptosis by interfering with the Fas/Fas ligand interaction may become one of the therapeutic strategies against chronic heart failure after large MI...
  44. ncbi request reprint Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway
    Hiromitsu Kanamori
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Pathol 182:701-13. 2013
    ..In conclusion, resveratrol is a beneficial pharmacological tool that augments autophagy to bring about reverse remodeling in the postinfarction heart...
  45. ncbi request reprint Tissue characterization of coronary plaques: comparison of integrated backscatter intravascular ultrasound with virtual histology intravascular ultrasound
    Munenori Okubo
    Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
    Circ J 72:1631-9. 2008
    ..The purpose of this study was to compare the overall agreement between IB-IVUS and IVUS-VH in the tissue characterization of plaques from the same coronary arterial cross-section...
  46. ncbi request reprint Nicorandil improves post-ischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts
    ChuanJiang Lu
    Second Department of Internal Medicine, Gifu University School of Medicine
    Circ J 70:1650-4. 2006
    ..Nicorandil has been reported to induce cardioprotection by opening the mitochondrial K(ATP) channels. However, whether nicorandil affects reactive oxygen species is unclear...
  47. ncbi request reprint Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan
    Hiromitsu Kanamori
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagito, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 292:H2184-94. 2007
    ....
  48. doi request reprint Evaluation of left atrial degeneration for the prediction of atrial fibrillation: usefulness of integrated backscatter transesophageal echocardiography
    Tomoki Kubota
    Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    JACC Cardiovasc Imaging 2:1039-47. 2009
    ....
  49. doi request reprint Mechanisms by which late coronary reperfusion mitigates postinfarction cardiac remodeling
    Munehiro Nakagawa
    Division of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Circ Res 103:98-106. 2008
    ..Along with various mechanisms proposed earlier, the present findings appear to provide an additional pathophysiological basis for the benefits of late reperfusion...
  50. ncbi request reprint Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation
    Yu Misao
    Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 69:476-90. 2006
    ..Whether bone marrow cells injected following acute myocardial infarction (MI) transdifferentiate into cardiomyocytes remains controversial, and how these cells affect repair-related cytokines is not known...
  51. ncbi request reprint Reduction of QTc dispersion by the angiotensin II receptor blocker valsartan may be related to its anti-oxidative stress effect in patients with essential hypertension
    Katsuaki Miyajima
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Hypertens Res 30:307-13. 2007
    ..In conclusion, antihypertensive therapy with valsartan reduces QTc dispersion and this may be related to the ability of valsartan to reduce oxidative stress in patients with essential hypertension...
  52. ncbi request reprint Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure
    Hideshi Okada
    Second Department of Internal Medicine, Gifu University School of Medicine, Japan
    Circulation 111:2430-7. 2005
    ..We examined the effects of inhibiting transforming growth factor-beta (TGF-beta) signaling on post-MI cardiac fibrosis and ventricular remodeling and function...
  53. doi request reprint Simvastatin reduces myocardial infarct size via increased nitric oxide production in normocholesterolemic rabbits
    Narentuoya Bao
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    J Cardiol 53:102-7. 2009
    ..However their precise mechanism for MI-protection is unclear. We investigated the effect of lipophilic statin administration in a normocholesterolemic rabbit MI model...
  54. ncbi request reprint The anti-diabetic drug miglitol is protective against anginal ischaemia through a mechanism independent of regional myocardial blood flow in the dog
    Yoshihiro Uno
    Department of General Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Clin Exp Pharmacol Physiol 32:805-10. 2005
    ..Miglitol has an anti-anginal ischaemia effect via a mechanism that is independent of regional myocardial blood flow...
  55. ncbi request reprint Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF
    Yu Misao
    Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 71:455-65. 2006
    ..Our aim was to test the hypothesis that bone marrow-derived cells recruited into the infarcted myocardium are the primary mediators of the beneficial effects by G-CSF...
  56. ncbi request reprint Association among blood pressure control in elderly patients with hypertension, left atrial structure and function and new-onset atrial fibrillation: a prospective 2-year study in 234 patients
    Takatomo Watanabe
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Hypertens Res 36:799-806. 2013
    ..The incidence of new-onset AF depended on the long-term level of BP control rather than short-term changes in LA structure and function. Poor BP control increased the risk of new-onset AF in elderly patients with HTN...
  57. doi request reprint Effects of atorvastatin on carotid atherosclerotic plaques: a randomized trial for quantitative tissue characterization of carotid atherosclerotic plaques with integrated backscatter ultrasound
    Kiyofumi Yamada
    Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
    Cerebrovasc Dis 28:417-24. 2009
    ..The purpose of this study was to examine whether cholesterol-lowering therapy with atorvastatin in nonhypercholesterolemic patients reduces carotid plaque instability as assessed by ultrasound integrated backscatter (IBS) analysis...
  58. doi request reprint Long-term changes in neointimal hyperplasia following implantation of bare metal stents assessed by integrated backscatter intravascular ultrasound
    Shinichiro Tanaka
    Department of Cardiology, Gifu Prefectural General Medical Center, 4 6 1 Noisshiki, Gifu, 500 8717, Japan
    Heart Vessels 28:415-23. 2013
    ....
  59. ncbi request reprint Renoprotective effect of the addition of losartan to ongoing treatment with an angiotensin converting enzyme inhibitor in type-2 diabetic patients with nephropathy
    Hirohiko Abe
    Second Department of Internal Medicine, Gifu University School of Medicine, Japan
    Hypertens Res 30:929-35. 2007
    ....
  60. ncbi request reprint Effect of granulocyte colony-stimulating factor treatment at a low dose but for a long duration in patients with coronary heart disease
    Koji Suzuki
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Japan
    Circ J 70:430-7. 2006
    ..We hypothesized that a low dose but long duration of G-CSF will have a beneficial effect without serious complications to patients with coronary heart disease...
  61. doi request reprint Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes
    Tomonori Kawaguchi
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 96:456-65. 2012
    ..Active autophagy has recently been reported in doxorubicin-induced cardiotoxicity; here we investigated its pathophysiological role...
  62. doi request reprint Treatment of leg ischemia with biodegradable gelatin hydrogel microspheres incorporating granulocyte colony-stimulating factor
    Itta Kawamura
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 57:416-23. 2011
    ..In conclusion, G-CSF-GHM administration is suggested to be a promising and readily usable approach to treating peripheral artery disease, applicable even during the chronic stage...
  63. doi request reprint Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits
    Yoshihisa Yamada
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Physiol Heart Circ Physiol 304:H1124-33. 2013
    ..EPO-encapsulated liposomes with SLX may be a promising strategy for active targeting treatment of acute MI...
  64. ncbi request reprint In vivo hepatocyte growth factor gene transfer reduces myocardial ischemia-reperfusion injury through its multiple actions
    Xue Hai Chen
    Department of Cardiology, Regeneration and Advanced Medical Science, Gifu University, Gifu, Japan
    J Card Fail 13:874-83. 2007
    ..However, whether in vivo adenovirus-mediated HGF gene transfer before ischemia is protective against ischemia-reperfusion and its precise mechanisms are still unknown...
  65. ncbi request reprint Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice
    Takamasa Ohno
    Department of Oriental Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Life Sci 77:1391-403. 2005
    ..Furthermore, renal TGF-beta(1) expression was decreased in the LR extract-treated group. These findings suggest that the LR therapy can be a novel therapeutic approach against diabetic nephropathy...
  66. ncbi request reprint Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage
    Kenji Hayakawa
    Second Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Circulation 108:104-9. 2003
    ..We hypothesized that postinfarct inhibition of apoptosis might preserve myofibroblasts and endothelial cells in granulation and modulate chronic left ventricular (LV) remodeling and heart failure...
  67. ncbi request reprint Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment
    Shinya Minatoguchi
    Second Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu, Japan
    Circulation 109:2572-80. 2004
    ....
  68. doi request reprint Unique mode of cell death in freshly isolated adult rat ventricular cardiomyocytes exposed to hydrogen peroxide
    Kazuko Goto
    Division of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Med Mol Morphol 42:92-101. 2009
    ..These findings caution against the use of oxidant stress, H2O2 in particular, as an inducer of apoptosis in ARVCs...
  69. pmc Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor
    Shusaku Miyata
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Pathol 168:386-97. 2006
    ....
  70. ncbi request reprint Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits
    Ningyuan Wang
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 43:747-57. 2004
    ..Benidipine reduces the infarct size through PKC-dependent production of nitric oxide and decreasing hydroxyl radicals but not through involving protein tyrosine kinase or mitochondrial KATP channels in rabbits...
  71. ncbi request reprint Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits
    Xuehai Chen
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 41:938-45. 2003
    ..Quinaprilat reduces myocardial infarct size involving NO production and mitochondrial KATP channels in rabbits without collateral circulation...
  72. ncbi request reprint The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits
    Toshihiro Asai
    Second Department of Internal Medicine, Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu, Japan
    Clin Exp Pharmacol Physiol 34:22-6. 2007
    ..4. The findings of the present study suggest that edaravone may be useful in the prevention of acute lung injury resulting from the production of reactive oxygen species...
  73. ncbi request reprint Alpha1-receptor or adenosine A1-receptor dependent pathway alone is not sufficient but summation of these pathways is required to achieve an ischaemic preconditioning effect in rabbits
    Kaori Baba
    Second Department of Internal Medicine, Gifu University School of Medicine, Tsukasa machi, Gifu, Japan
    Clin Exp Pharmacol Physiol 32:263-8. 2005
    ....
  74. ncbi request reprint Treatment with granulocyte colony-stimulating factor ameliorates chronic heart failure
    Yiwen Li
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Lab Invest 86:32-44. 2006
    ..Collectively, these findings suggest G-CSF administration could be an effective approach to treating chronic heart failure following a large MI...
  75. doi request reprint Can negative cardiac effect of proton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stable angina?
    Shinichiro Tanaka
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    J Cardiol 52:39-48. 2008
    ..Additionally, a recent in vitro study showed that PPI reduced cardiac contractility. In this study, we evaluated whether chronic administration of PPI and high-dose H2-blocker affects left ventricular function...
  76. ncbi request reprint Nuclear hypertrophy reflects increased biosynthetic activities in myocytes of human hypertrophic hearts
    Masahiko Koda
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Circ J 70:710-8. 2006
    ..The nucleus of the myocytes in human hypertrophic hearts is characterized by its bizarre shape and widespread clumping of chromatin. The functional significance has not been determined...
  77. ncbi request reprint In-hospital monitoring of T-wave alternans in a case of amiodarone-induced torsade de pointes: clinical and methodologic insights
    Tomonori Kawaguchi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Europace 14:1372-4. 2012
    ..We report a case of macroscopic T-wave alternans occurring 30 min before the onset of amiodarone-induced torsade de pointes, illustrating a means to monitor for proarrhythmia...
  78. ncbi request reprint The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts
    Yasuko Shimizu
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    J Am Coll Cardiol 40:1347-55. 2002
    ..We aimed to clarify the relation between sarpogrelate (SG), a 5-hydroxytryptamine (5-HT)-2 receptor blocker, and myocardial interstitial serotonin or infarct size during ischemia and reperfusion...
  79. ncbi request reprint Narirutin inhibits airway inflammation in an allergic mouse model
    Norihiko Funaguchi
    Second Department of Internal Medicine, Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu, Japan
    Clin Exp Pharmacol Physiol 34:766-70. 2007
    ..These findings suggest that narirutin may be an effective new tool in the treatment of bronchial asthma...
  80. ncbi request reprint Cardiomyopathy with prominent autophagic degeneration, accompanied by an elevated plasma brain natriuretic peptide level despite the lack of overt heart failure
    Mieko Saijo
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194
    Intern Med 43:700-3. 2004
    ..This case may belong to one of the unclassified cardiomyopathies characterized by prominent autophagic vacuoles...
  81. ncbi request reprint Long-term and strict blood pressure lowering by imidapril reverses left ventricular hypertrophy in patients with essential hypertension: an evaluation using a novel indicator of burden on the left ventricle
    Masahiko Takahashi
    Second Department of Internal Medicine, Gifu University School of Medicine, Yanagido 1 1, Gifu 501 1911, Japan
    Hypertens Res 29:89-94. 2006
    ....
  82. doi request reprint Sudden reversible pacemaker failure in a patient with cardiac sarcoidosis: an unfortunate case of ventricular septal pacing
    Nobuhiro Takasugi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Europace 14:1061-2. 2012
    ..Echocardiography revealed septal wall thinning at the electrode-tissue interface, which was not detected pre-operatively. Endomyocardial biopsy confirmed cardiac sarcoidosis. The increased threshold was reversible with prednisolone...
  83. ncbi request reprint Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits
    Bulin Baila
    Second Department of Internal Medicine, Graduate School of Medicine, Gifu University, Japan
    Biol Pharm Bull 35:494-502. 2012
    ..Tetomilast may inhibit the development of emphysema by attenuating pulmonary inflammation and apoptosis caused by PPE-induced oxidative stress...
  84. doi request reprint Asialoerythropoietin, a nonerythropoietic derivative of erythropoietin, displays broad anti-heart failure activity
    Toshiaki Takeyama
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Circ Heart Fail 5:274-85. 2012
    ..We investigated the effects of asialoerythropoietin (asialoEPO), a nonerythrogenic erythropoietin derivative, on 3 murine models of heart failure with different etiologies...
  85. ncbi request reprint Cross-talk among noradrenaline, adenosine and protein kinase C in the mechanisms of ischemic preconditioning in rabbits
    Shinya Minatoguchi
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 41:S39-47. 2003
    ..Thus, pathway II plays an important role in the pathogenesis of the infarct size-reducing effect in ischemic preconditioning...
  86. ncbi request reprint Myocardial apoptotic index based on in situ DNA nick end-labeling of endomyocardial biopsies does not predict prognosis of dilated cardiomyopathy
    Hideshi Okada
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Chest 128:1060-2. 2005
    ..DNA breaks detected largely by terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate in situ nick end-labeling (TUNEL) are observed in the hearts of patients with diseases such as dilated cardiomyopathy (DCM)...
  87. doi request reprint Transcatheter embolization by autologous blood clot is useful management for small side branch perforation due to percutaneous coronary intervention guide wire
    Shinichiro Tanaka
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu City, Gifu 501 1194, Japan
    J Cardiol 52:285-9. 2008
    ..Autologous blood clot is useful to occlude and repair perforations in small side branches of the coronary artery without myocardial damage...
  88. ncbi request reprint Sarpogrelate, a 5-HT2 receptor blocker, may have a preconditioning-like effect in patients with coronary artery disease
    Eishun Horibe
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Japan
    Circ J 68:68-72. 2004
    ..The present study used a percutaneous coronary intervention (PCI) model to define the protective effect of sarpogrelate against ischemic injury and its mechanism in human coronary artery disease...
  89. doi request reprint Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion
    Hiromitsu Kanamori
    Dept of Cardiology, Gifu Univ Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 300:H2261-71. 2011
    ..The present findings suggest that autophagy is an innate and potent process that protects cardiomyocytes from ischemic death during acute myocardial infarction...
  90. doi request reprint Effects of candesartan versus amlodipine on home-measured blood pressure, QT dispersion and left ventricular hypertrophy in high-risk hypertensive patients
    Yasunari Matsuno
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Blood Press Suppl 1:12-9. 2011
    ..Larger studies in patients treated for longer periods are needed to determine whether this candesartan effect will translate into improved prognosis in terms of cardiovascular mortality and morbidity...
  91. doi request reprint Polymerase chain reaction positivity of Pneumocystis jirovecii during primary lung cancer treatment
    Hidenori Mori
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Jpn J Clin Oncol 40:658-62. 2010
    ..The purpose of this study was to assess the frequency of pneumocystic pneumonia during cancer treatment...
  92. doi request reprint Over 10 years clinical outcomes in patients with mitral stenosis with unilateral commissural calcification treated with catheter balloon commissurotomy: single-center experience
    Shinichiro Tanaka
    Second Department of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    J Cardiol 51:33-41. 2008
    ..Treatment of mitral valve stenosis with catheter balloon commissurotomy (CBC) yields acceptable immediate results even when one commissure shows calcification. However, the long-term outcomes in such cases remain unclear...
  93. ncbi request reprint Sesquiterpene lactone suppresses vascular smooth muscle cell proliferation and migration via inhibition of cell cycle progression
    Munehiro Nakagawa
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Biol Pharm Bull 30:1754-7. 2007
    ....
  94. doi request reprint Dual blockade of the rennin-angiotensin system versus maximal recommended dose of angiotensin II receptor blockade in chronic glomerulonephritis
    Urara Mori-Takeyama
    Second Department of Internal Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    Clin Exp Nephrol 12:33-40. 2008
    ....
  95. ncbi request reprint Extracts from the roots of Lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumor-bearing mice
    Yun Mo Li
    Second Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Am J Chin Med 31:857-69. 2003
    ..0 mg/ml concentration. These findings suggested that the components of L. strychifolia have anticancer activity and may contribute to clinical applications in the prevention and treatment of lung cancer...
  96. ncbi request reprint Benefits of reperfusion beyond infarct size limitation
    Genzou Takemura
    Division of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 83:269-76. 2009
    ..This review focuses on the effects of late reperfusion on the pathophysiology of MI in the context of the infarct tissue dynamics and clinical outcomes. We also discuss the issues that need to be resolved to improve clinical application...
  97. ncbi request reprint J-SAP study 1-2: outcomes of patients with stable high-risk coronary artery disease receiving medical-preceding therapy in Japan
    Masanori Fukunishi
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Japan
    Circ J 70:1012-6. 2006
    ..In addition, a randomized study has not been performed in Japan...
  98. ncbi request reprint Use of multidetector row CT to evaluate the need for bronchial arterial embolization in hemoptysis patients
    Hidenori Mori
    Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Respiration 80:24-31. 2010
    ..Bronchial artery (BA) embolization (BAE) is recommended as a minimally invasive therapy for hemoptysis, though some patients recover after only conservative treatment...
  99. ncbi request reprint A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells
    Akiko Tsujimoto
    From the Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    J Cardiovasc Pharmacol 48:160-5. 2006
    ....
  100. ncbi request reprint Synchronous progression of calcium transient-dependent beating and sarcomere destruction in apoptotic adult cardiomyocytes
    Rumi Maruyama
    Second Dept of Internal Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Am J Physiol Heart Circ Physiol 290:H1493-502. 2006
    ..It thus appears that, in adult cardiomyocyte apoptosis, Ca(2+) transients mediate apoptotic beating and efficient sarcomere destruction initiated by Z disk breakdown...