Research Topics
Species | Kenji MatsumotoSummaryAffiliation: Gifu International Institute of Biotechnology Country: Japan Publications
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Detail Information
Publications
Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritisKenji Matsumoto
Experimental Animal Division, Bio Resource Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
Exp Mol Pathol 72:186-95. 2002....- Induction of apoptosis by xanthones from mangosteen in human leukemia cell linesKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
J Nat Prod 66:1124-7. 2003..All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis... - Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activityKenji Ohguchi
Gifu International Institute of Biotechnology, Kakamigahara, Japan
Biosci Biotechnol Biochem 67:1587-9. 2003..The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency... - Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cellsKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Bioorg Med Chem 12:5799-806. 2004..It was also shown that the cytotoxicity substantially correlated with deltapsim decrease. These results indicate that alpha-mangostin and its analogs would be candidates for preventive and therapeutic application for cancer treatment... - Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cellsKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Bioorg Med Chem 13:6064-9. 2005..These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs... - Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell lineKenji Ohguchi
Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
Biosci Biotechnol Biochem 69:353-6. 2005..These results suggest that vaticanol C might induce apoptosis via a mechanism involving activation of Bad through disruption of pro-survival signaling pathways... - Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol CTetsuro Ito
Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan
Carcinogenesis 24:1489-97. 2003..Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential... - Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell linesKenji Matsumoto
Gifu International Institute of Biotechnology, Kani-gun, Gifu, Japan
Biol Pharm Bull 26:569-71. 2003..The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative... - Human DEAD-box/RNA unwindase rck/p54 contributes to maintenance of cell growth by affecting cell cycle in cultured cellsYukihiro Akao
Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
Int J Oncol 29:41-8. 2006..These data suggest that rck/p54 contributes to cell growth possibly by modulating translation-initiation control of the genes involved in the cell proliferation, which is a newly defined mechanism leading to carcinogenesis... - Gnetol as a potent tyrosinase inhibitor from genus GnetumKenji Ohguchi
Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu 505 0116, Japan
Biosci Biotechnol Biochem 67:663-5. 2003..Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells... - Effects of hydroxystilbene derivatives on tyrosinase activityKenji Ohguchi
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Biochem Biophys Res Commun 307:861-3. 2003.... - Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell linesYukihiro Akao
Gifu International Institute of Biotechnology, Kakamigahara, Japan
Biol Pharm Bull 26:1057-9. 2003..Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin... - A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cellsYukihiro Akao
Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
Bioorg Med Chem 12:4791-801. 2004..These data suggest that lig-8 is a promising neuroprotector, which affects the signaling pathway of neuronal cell death and that it would be of benefit to delay the progress of neurodegenerative diseases... - Expression of rck/p54, a DEAD-box RNA helicase, in gametogenesis and early embryogenesis of miceKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
Dev Dyn 233:1149-56. 2005..These findings indicate that rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals... - Localization of sphingosine kinase-1 in mouse sperm acrosomesKenji Matsumoto
Gifu International Institute of Biotechnology, Gifu, Japan
J Histochem Cytochem 53:243-7. 2005..Furthermore, we identified the presence of the S1P receptors S1P1, S1P2, S1P3, and S1P5, in mouse spermatozoa by RT-PCR. These results suggest that S1P produced by SPHK-1 would play a role in the acrosomal reaction through S1P receptors... - A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitroYukihiro Akao
Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
Genes Cells 8:671-6. 2003..Our previous data suggested that rck/p54 positively affected the translation initiation of c-myc mRNA... 
Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potentialTaisuke Mori
Department of Reproductive Biology and Pathology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
Mol Cell Biol 25:5183-95. 2005..Thus, the results of this study support the possible use of autologous-cell graft systems to treat central nervous system diseases in geriatric patients...- NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitroShinji Kagaya
Genox Research Inc, Bunkyo, Japan
Int Arch Allergy Immunol 137:35-44. 2005..These results suggest that the expression of the NR4A receptor family genes through CD30 signaling may regulate eosinophil apoptosis in allergic conditions such as AD... - Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal modelSatoshi Mishima
API Company Research Institute, Gifu, Japan
J Exp Ther Oncol 3:283-88. 2003..These results demonstrated that the ethanol extract containing various stilbenoids from the stem bark of V. indica has the potent antitumor activity... - Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cellsIbrahim Iliya
Gifu Pharmaceutical University, Japan
Biol Pharm Bull 29:1490-2. 2006.... - Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patientsYukiho Imai
Genox Research, Inc, Teikyo University Biotech Center, 907 Nogawa, Miyamae, Kawasaki, 216 0001, Kanagawa, Japan
Biochem Biophys Res Commun 297:1282-90. 2002..The enhanced expression of ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients... - PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout miceKenji Matsumoto
Experimental Animal Division, Bio Resource Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki, 305 0074, Japan
Biochem Biophys Res Commun 290:1220-7. 2002..These results suggest that failures of both TNC and PDGFR-alpha are a candidate for abnormal restoration of TNKO mice... - Gremlin enhances the determined path to cardiomyogenesisDaisuke Kami
Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan
PLoS ONE 3:e2407. 2008.... - Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeabilityXuejun Chen
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
Eur J Immunol 37:434-44. 2007..Together, these findings suggest the key role of hBD in inflammatory responses by recruiting and activating mast cells, and increasing vascular permeability... - Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity modelKenji Matsumoto
Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Japan
Biol Pharm Bull 29:2532-5. 2006..The results indicate that young persimmon fruits are beneficial in the development of preventive and therapeutic agents against dyslipidemia... - Gene expression profiling of human mast cell subtypes: an in silico studyHirohisa Saito
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Allergol Int 55:173-9. 2006..e., tryptase- and chymase-positive MCs (MC(TC)) and tryptase-only-positive MCs (MC(T)). However, differences in global molecular expression between these subtypes are unknown... - B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in miceYoshinobu Akiyama
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Transplantation 74:732-8. 2002..The mechanism of hyporesponsiveness induced by intratracheal (IT) delivery of alloantigen was examined and its effect on cardiac graft survival was assessed in studies in mice... - CpG oligodeoxynucleotide prolongs eosinophil survival through activation of contaminating B cells and plasmacytoid dendritic cells in vitroKenji Matsumoto
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Int Arch Allergy Immunol 140:42-50. 2006.... - The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathyNaoko Okada
Department of Ophthalmology, Keio University, Shinanomachi, Tokyo, Japan
Invest Ophthalmol Vis Sci 46:4512-8. 2005..The present study investigated the expression of ICAM-1 and VCAM-1 on fibroblasts with interleukin (IL)-4 and/or tumor necrosis factor (TNF)-alpha stimulation and assessed the effect of eosinophil adhesion on fibroblast viability... - Okara, soybean residue, prevents obesity in a diet-induced murine obesity modelKenji Matsumoto
Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology, Minokamo, Gifu, Japan
Biosci Biotechnol Biochem 71:720-7. 2007..We also found that the okara intake caused a marked reduction in the expression of leptin and TNF-alpha genes in EWAT. Our results suggest that okara is beneficial in preventing obesity... - Synthesis of multisubstituted furans, pyrroles, and thiophenes via ynolatesMitsuru Shindo
Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan
Org Lett 9:1963-6. 2007..This novel formal [4 + 1] annulation by C2-C3 and C3-C4 bond formations includes cycloaddition, cyclization, decarboxylation, and dehydration as key steps... - Rapid and strong induction of apoptosis in human eosinophils by anti-CD30 mAb-coated microspheres and phagocytosis by macrophagesKenji Matsumoto
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Int Arch Allergy Immunol 143:60-7. 2007.... 
Induction of apoptosis in human basophils by anti-Fas antibody treatment in vitroKenji Matsumoto
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Int Arch Allergy Immunol 146:40-6. 2008..In the present study, the expression and function of Fas in human basophils were investigated in vitro...- Interleukin-3 does not affect the differentiation of mast cells derived from human bone marrow progenitorsYuji Shimizu
Department of Respiratory Medicine, National Hospital Organization, Takasaki Hospital, Takasaki, Japan
Immunol Invest 37:1-17. 2008..These findings indicate that initial incubation of human bone marrow CD34+ progenitors with IL-3 does not affect the differentiation of mast cells... - Prolongation of survival of fully allogeneic cardiac grafts and generation of regulatory cells by a histamine receptor 2 antagonistFumihiko Inoue
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Japan
Transplantation 84:1288-97. 2007..We examined whether the HR2 antagonist ranitidine affects the alloimmune response in a murine model of cardiac transplantation... - Effects of tumor necrosis factor-alpha on cell proliferation, prostaglandins and matrix-metalloproteinases production in rat endometrial stromal cells cultured in vitroToru Gamo
Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School, Kyushu University, Fukuoka, Japan
J Exp Zool A Ecol Genet Physiol 307:699-707. 2007..We believe that these results demonstrate part of the functions of TNF-alpha in endometrium and contribute to the better understanding of endometrial functions... - Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virusMasashi Shingai
Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
J Immunol 179:6123-33. 2007..Thus, the stem-loop structure, rather than full genome replication or specific internal sequences of the MV genome, is required for an early phase of type I IFN induction by MV in host cells... - Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesisAkio Matsuda
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, 157 8535, Japan
Am J Respir Cell Mol Biol 38:168-75. 2008..Of note, the CXCR2 chemokine-induced tube formation was independent of VEGF. Therefore, CXCR2 chemokines may represent potential therapeutic targets for bronchial asthma... - Haplotypes and a novel defective allele of CES2 found in a Japanese populationSu Ryang Kim
Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
Drug Metab Dispos 35:1865-72. 2007..These findings are useful for further pharmacogenetic studies on CES2-activated prodrugs... - 'Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cellsKazuma Okamoto
Department of Reproductive Biology and Pathology, National Research Institute for Child Health and Development, Tokyo, Japan
Exp Cell Res 313:2550-62. 2007..Placenta-derived human fetal cells may be useful for patients who cannot supply bone marrow cells but want to receive stem cell-based cardiac therapy... - Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cellsKoji Hase
Laboratory of Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN Yokohama, Kanagawa, Japan
DNA Res 12:127-37. 2005..Such a unique pattern of gene expression distinguishes FAE and M cells from IECs, and may reflect their cellular phenotype(s) associated with specific functional features... - Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamilyShinji Kagaya
Genox Research Inc, Tokyo, Japan
Biol Pharm Bull 28:1603-7. 2005..These observations suggest that PGA2 can serve as a transactivator of NOR1, and thus suggest a possibility of pharmacological modulation of the NOR1 pathways by PGA2-related compounds... - Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cellsToshiki Homma
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8567, Japan
Am J Respir Cell Mol Biol 31:463-9. 2004..These results provide evidence for a novel function of corticosteroids in airway inflammatory disorders, and indicate that the use of inhaled corticosteroids in such disorders may have a beneficial role in host defense mechanisms... - Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitisKaoru Ogawa
Genox Research Inc, Kawasaki, Kanagawa, Japan
Int Arch Allergy Immunol 134:2-6. 2004..It is a protein that also interacts with the cyclin-dependent kinase inhibitor p16(INK4), suggesting that HSOCP-1 is involved in cell cycle control and apoptosis... - Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytesAtsushi Kato
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
J Immunol 172:6185-94. 2004..This critical role for LBP implies the presence of possible mechanisms linking LBP to the intracellular signaling between Toll-like receptor 4 and IRF-3, leading to the induction of IFN-beta by LPS... - TNF-alpha and IL-4 regulate expression of fractalkine (CX3CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblastsMamoru Yoshikawa
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishidou, Setagaya Ku, Tokyo 154 8567, Japan
FEBS Lett 561:105-10. 2004..These results suggest that TNF-alpha- and IL-4-stimulated fibroblasts may play an important role in accumulation of monocytes at inflammatory sites... - Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitroKenji Matsumoto
National Research Institute for Child Health and Development, Tokyo, Japan
J Immunol 172:2186-93. 2004..These data demonstrate that CD30 can modify eosinophil survival by causing an extremely rapid and intense induction of apoptosis through a tightly regulated intracellular signaling pathway... - Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006Atsushi Kato
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
BMC Immunol 4:8. 2003..Although several genes have been reported, no comprehensive study of the gene expression profiles in human cells after stimulation with CpG ODN has been reported... - TNF-alpha and IL-4 regulate expression of IL-13 receptor alpha2 on human fibroblastsMamoru Yoshikawa
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishidou, Setagaya Ku, 154 8567, Tokyo, Japan
Biochem Biophys Res Commun 312:1248-55. 2003.... - Antitumor effect of arsenic trioxide in murine xenograft modelMariko Kito
Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Kani-gun, Gifu 505-0116
Cancer Sci 94:1010-4. 2003..Thus, ATO appears to have potential for the treatment of solid tumors, as well as hematopoietic malignancies... - Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FcepsilonRIShigeru Okumura
Laboratory of Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan
Blood 102:2547-54. 2003..These results reveal that human MCs express tailored pathogen- and antigen-specific immune responses and that human MCs may play important roles in innate and adaptive immunity... - Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigenNozomu Shirasugi
First Department of Surgery, Teikyo University, Tokyo, Japan
Transplantation 75:1636-9. 2003..In this study, the authors used a CD28-deficient model to evaluate which signal, either through CD28 or cytotoxic T-lymphocyte-associated antigen (CTLA4), is involved in the induction of hyporesponsiveness... - Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2)Takashi Kubo
Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Drug Metab Dispos 33:1482-7. 2005..These results suggested that 100C>T (R34W), 424G>A (V142M), and IVS8-2A>G are functionally deficient SNPs... - Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer regionSatoru Koyano
Project Team for Pharmacogenetics, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Drug Metab Dispos 32:149-54. 2004..These data suggest that the R98C, R381W, and I403V hPXR variants, especially R98C, may influence the expression of drug-metabolizing enzymes and transporters, which are transactivated by PXR... - High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cellsOsamu Aramaki
Department of Surgery, Nihon University, Tokyo, Japan
Transplantation 75:217-20. 2003..In vitro, AT-III suppressed proliferation of mixed leukocyte responses and generation of interleukin-2. CONCLUSION: AT-III can be not only an antithrombotic agent but also a strong immunomodulating agent when used at high dose... - The role of nitric oxide after a short period of liver ischemia-reperfusionAtsushi Morisue
Department of Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
J Surg Res 109:101-9. 2003..CONCLUSIONS: A reduction of the ischemia-reperfusion injury is important in inhibiting the production of high-output NO and peroxynitrite, and in maintaining NO levels necessary for maintenance of microcirculation... - Induction of indefinite survival of fully allogeneic cardiac grafts and generation of regulatory cells by intratracheal delivery of alloantigens under blockade of the CD40 pathwayNorio Uchida
Department of Surgery, Keio University, Tokyo, Japan
Transplantation 75:878-84. 2003..CONCLUSIONS: ITD of donor splenocytes or Kb peptide under blockade of the CD40 pathway induced operational tolerance and generated regulatory cells... - Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis by differential displayRyoichi Hashida
Genox Research Inc, Teikyo University Biotechnology Center, 907 Nogawa, Kawasaki, Japan
Int Arch Allergy Immunol 131:26-33. 2003..The mouse counterpart of one of these genes, intersectin 2, was expressed dramatically, as measured by ear edema, in 1-fluoro-2,4-dinitrobenzene-induced mouse contact dermatitis and in NC/Nga mouse dermatitis... - Synthesis, solution behavior, thermal stability, and biological activity of an Fe(III) complex of an artificial siderophore with intramolecular hydrogen bonding networksKenji Matsumoto
Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan
Inorg Chem 43:8538-46. 2004..These results indicate that the artificial siderophore with intramolecular hydrogen bonding networks, TAGE, is a good structural and functional model for a natural ferrichrome... - Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the ratViengvansay Nabandith
Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
Asian Pac J Cancer Prev 5:433-8. 2004..This finding that crude alpha-mangostin has potent chemopreventive effects in our short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development... - Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activityHaruhito Azuma
Department of Urology, Osaka Medical College, Takatsuki, Osaka, 569-8686, Japan
Anticancer Res 23:3183-93. 2003..CONCLUSION: FTY720 may be a promising candidate for a new anticancer therapy, which potentially induces selective apoptosis in cancer cells...