Akio Kimura

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi request reprint Longitudinal analysis of cytokines and chemokines in the cerebrospinal fluid of a patient with Neuro-Sweet disease presenting with recurrent encephalomeningitis
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan Akio Kimura
    Intern Med 47:135-41. 2008
  2. pmc Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
    Akio Kimura
    Department of Neurology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Neuroinflammation 10:39. 2013
  3. doi request reprint Antibodies against the tom40 subunit of the translocase of the outer mitochondrial membrane complex and cognitive impairment in Alzheimer's disease
    Akio Kimura
    Departments of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu City, Japan
    J Alzheimers Dis 29:373-7. 2012
  4. ncbi request reprint Anti-endothelial cell antibodies in patients with cerebral small vessel disease
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Curr Neurovasc Res 9:296-301. 2012
  5. doi request reprint Elevated anti-heat shock protein 60 antibody titer is related to white matter hyperintensities
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu City, Japan
    J Stroke Cerebrovasc Dis 21:305-9. 2012
  6. doi request reprint Motor-dominant chronic inflammatory demyelinating polyneuropathy
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Neurol 257:621-9. 2010
  7. doi request reprint High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    J Neuroimmunol 219:105-8. 2010
  8. doi request reprint Antibodies in patients with neuropsychiatric systemic lupus erythematosus
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, 1 1 Yanagido, Gifu City, Gifu 501 1194, Japan
    Neurology 74:1372-9. 2010
  9. ncbi request reprint Proteomic analysis of autoantibodies in neuropsychiatric systemic lupus erythematosus patient with white matter hyperintensities on brain MRI
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu City, Gifu, Japan
    Lupus 17:16-20. 2008
  10. ncbi request reprint Late-onset patients with sporadic amyotrophic lateral sclerosis in Japan have a higher progression rate of ALSFRS-R at the time of diagnosis
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
    Intern Med 51:579-84. 2012

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Longitudinal analysis of cytokines and chemokines in the cerebrospinal fluid of a patient with Neuro-Sweet disease presenting with recurrent encephalomeningitis
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan Akio Kimura
    Intern Med 47:135-41. 2008
    ..Neutrophil and other inflammatory cell activities are influenced by many cytokines and chemokines, but to date, no studies have examined the levels of these factors in patients with NSD...
  2. pmc Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
    Akio Kimura
    Department of Neurology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Neuroinflammation 10:39. 2013
    ..In summary, CAA-ri encephalopathy is a relapsing or progressive disorder and may be treatable by adequate immunosuppressive therapy. The anti-Aβ 42 antibody in CSF is a useful biological marker for therapeutic monitoring of CAA-ri...
  3. doi request reprint Antibodies against the tom40 subunit of the translocase of the outer mitochondrial membrane complex and cognitive impairment in Alzheimer's disease
    Akio Kimura
    Departments of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu City, Japan
    J Alzheimers Dis 29:373-7. 2012
    ..In summary, the anti-Tom40 antibody is significantly associated with cognitive impairment in patients with Alzheimer's disease...
  4. ncbi request reprint Anti-endothelial cell antibodies in patients with cerebral small vessel disease
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Curr Neurovasc Res 9:296-301. 2012
    ..The anti-TPM4 antibody level was significantly higher in the subjects with than without CSVD. Therefore, an autoimmune, inflammatory process with high levels of anti-TPM4 antibody may contribute to the development of CSVD in the elderly...
  5. doi request reprint Elevated anti-heat shock protein 60 antibody titer is related to white matter hyperintensities
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu City, Japan
    J Stroke Cerebrovasc Dis 21:305-9. 2012
    ..However, few reports have described the association between anti-Hsp60 antibody and cerebrovascular disease...
  6. doi request reprint Motor-dominant chronic inflammatory demyelinating polyneuropathy
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Neurol 257:621-9. 2010
    ..We consider that treatment for recurrence prevention as an alternative to IVIg therapy is very important for patients with motor-dominant CIDP...
  7. doi request reprint High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    J Neuroimmunol 219:105-8. 2010
    ..Results of our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases...
  8. doi request reprint Antibodies in patients with neuropsychiatric systemic lupus erythematosus
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, 1 1 Yanagido, Gifu City, Gifu 501 1194, Japan
    Neurology 74:1372-9. 2010
    ..To investigate a target for antibodies in patients with neuropsychiatric systemic lupus erythematosus (NPSLE)...
  9. ncbi request reprint Proteomic analysis of autoantibodies in neuropsychiatric systemic lupus erythematosus patient with white matter hyperintensities on brain MRI
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu City, Gifu, Japan
    Lupus 17:16-20. 2008
    ..This proteomic analysis is a useful tool for identifying autoantigens in autoimmune diseases involving autoantibodies...
  10. ncbi request reprint Late-onset patients with sporadic amyotrophic lateral sclerosis in Japan have a higher progression rate of ALSFRS-R at the time of diagnosis
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
    Intern Med 51:579-84. 2012
    ..This study sought to investigate the clinical features of patients with late-onset ALS compared with those with early-onset ALS using the progression rate (ΔFS)...
  11. doi request reprint Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the (13)C-acetate breath test
    Yuji Tanaka
    Department of Neurology and Geriatrics, Gifu University, Gifu Prefecture, Japan
    J Neurol 259:1448-52. 2012
    ..Delayed gastric emptying is one of the autonomic failures and may be a clinical marker of MSA...
  12. doi request reprint Is there a difference in gastric emptying between myotonic dystrophy type 1 patients with and without gastrointestinal symptoms?
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu City, Gifu Prefecture, 501 1194, Japan
    J Neurol 260:1611-6. 2013
    ..These findings suggest that impairment of GE evolves over time and that the progression of delayed GE and skeletal muscle impairment are independent. Smooth muscle impairment may be affected at an earlier stage in MyD1...
  13. doi request reprint Identification of antibodies as biological markers in serum from multiple sclerosis patients by immunoproteomic approach
    Takeo Sakurai
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    J Neuroimmunol 233:175-80. 2011
    ..Results of our study suggest that not only the anti-PGAM1 antibody but also the anti-mtHSP70 antibody is good diagnostic markers of MS and the combination of both these antibodies is useful for a more specific diagnosis of MS...
  14. ncbi request reprint [Case report of a patient with Hashimoto's encephalopathy associated with Basedow's disease mimicking Creutzfeldt-Jakob disease]
    Takeo Sakurai
    Department of Neurology and Geriatrics, Division of Neuroscience, Research Field of Medical Sciences, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Brain Nerve 60:559-65. 2008
    ..The condition in this case clinically mimicked CJD; therefore, the differentiated diagnosis is important because Hashimoto's encephalopathy is treatable disease...
  15. doi request reprint Cardiac sympathetic function in the patients with amyotrophic lateral sclerosis: analysis using cardiac [123I] MIBG scintigraphy
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, Gifu Prefecture 501 1194, Japan
    J Neurol 260:2380-6. 2013
    ..Increased WR in cardiac [(123)I] MIBG scintigraphy may be a predictive factor in ALS patients. ..
  16. ncbi request reprint Neuromyelitis optica in Japanese sisters
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
    Intern Med 50:2829-32. 2011
    ..The final disability status was almost the same in both cases, and both showed a very benign course. These data suggest that genetic factors affect the age at onset and environmental factors may affect the frequency of relapse...
  17. ncbi request reprint [Case of adult influenza type A virus-associated encephalopathy successfully treated with primary multidisciplinary treatments]
    Takeo Sakurai
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
    Rinsho Shinkeigaku 47:639-43. 2007
    ..Adult influenza virus-associated encephalopathy is rare. We were able to successfully treat our patient with primary multidisciplinary treatments without causing sequelae...
  18. ncbi request reprint Diffuse skeletal muscles uptake of [18F] fluorodeoxyglucose on positron emission tomography in primary muscle peripheral T-cell lymphoma
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
    Intern Med 50:2021-4. 2011
    ....
  19. doi request reprint Patterns of levels of biological metals in CSF differ among neurodegenerative diseases
    Isao Hozumi
    Department of Neurology and Geriatrics, Gifu University, Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    J Neurol Sci 303:95-9. 2011
    ..Therefore, Cu-chelating agents and modulators of Cu and Zn such as metallothionein (MT) can be new candidates for the treatment of ALS, AD, and PD...
  20. ncbi request reprint [A case of non-herpetic acute encephalitis with autoantibodies for ionotropic glutamate receptor delta2 and epsilon2]
    Yuichi Hayashi
    Department of Neurology and Geriatrics, Division of Neurosciences, Gifu University Graduate School of Medicine
    Rinsho Shinkeigaku 45:657-62. 2005
    ..This is the first report of MRI-positive non-herpetic acute encephalitis with autoantibodies to GluRdelta2 and epsilon2...
  21. doi request reprint Selective cauda equina hypertrophy with idiopathic inflammation
    Yuichi Hayashi
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Japan
    Muscle Nerve 38:1065-9. 2008
    ..This is the first case of selective cauda equina hypertrophy with idiopathic inflammation. We propose that this is a new disease entity...
  22. ncbi request reprint [Rapidly progressive parkinsonism that developed one year after ventriculoperitoneal shunting for idiopathic aqueductal stenosis: a case report]
    Takeo Sakurai
    Department of Neurology and Geriatrics, Division of Neuroscience, Research Field of Medical Sciences, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Brain Nerve 62:527-31. 2010
    ..If such a patient presents without signs of hydrocephalus or shunt malfunction, dopaminergic medication should be used as the initial treatment...
  23. ncbi request reprint [A case of nonsystemic vasculitic neuropathy with spondylosis deformans in an 84-year-old woman]
    Megumi Yamada
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 50:400-3. 2013
    ..Magnetic resonance imaging revealed that she also had spondylosis deformans and radiculopathy, which was more difficult to differentiate. Neural biopsy was important for diagnosis. ..
  24. doi request reprint Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test
    Yuji Tanaka
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu City, 501 1194 Gifu Prefecture, Japan
    J Neurol 258:421-6. 2011
    ..Gastric emptying of untreated, early-stage PD is already delayed. Delayed gastric emptying may be one of markers of the pre-clinical stage of PD...
  25. ncbi request reprint [Case of varicella myelitis in nursing care worker]
    Mariko Takei-Suzuki
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Yanagido, Japan
    Brain Nerve 60:79-83. 2008
    ..Care persons without anti-IgG antibodies against VZV are at a high risk of contracting varicella infection. Guidelines for infection control in home care, as well as hospitals, are necessary for caregivers...
  26. ncbi request reprint Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population
    Yuichi Hayashi
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Amyotroph Lateral Scler 7:22-6. 2006
    ..We conclude that gene polymorphisms of MT-IIA promoter region and MT-III gene are not associated with SALS phenotypes in a Japanese population...
  27. doi request reprint Progressive multifocal leukoencephalopathy and CD4+ T-lymphocytopenia in a patient with Sjögren syndrome
    Yuichi Hayashi
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Gifu 501 1194, Japan
    J Neurol Sci 268:195-8. 2008
    ..In the present case, CD4+ T-lymphocytopenia was also observed on admission, which is also associated with SjS...
  28. ncbi request reprint Venous congestive myelopathy of the cervical spinal cord: an autopsy case showing a rapidly progressive clinical course
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Neuropathology 27:284-9. 2007
    ..The present autopsy case, with MRI findings, provides further information that might be useful for recognition and diagnosis...
  29. ncbi request reprint Serial monitoring of basal metabolic rate for therapeutic evaluation in an Isaacs' syndrome patient with chronic fluctuating symptoms
    Yuichi Hayashi
    Department of Neurology and Geriatrics, Gifu University, Graduate School of Medicine
    Intern Med 49:475-7. 2010
    ..Serial monitoring of the BMR facilitates therapeutic evaluation in an Isaacs' syndrome patient with chronic fluctuating symptoms...
  30. ncbi request reprint Spinocerebellar degeneration with negative electroretinogram: dysfunction of the bipolar cells
    Akio Kimura
    Department of Neurology and Geriatrics, Gifu University, Gifu 500 8750, Japan
    Doc Ophthalmol 108:241-7. 2004
    ..Further investigation of ERGs in patients with SCD could potentially lead to the identification of an increased number of SCD patients with negative-type ERGs and retinal pathogenesis...
  31. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy in a patient with hyperIgEaemia
    A Kimura
    Department of Neurology and Geriatrics, Hospital of the University of Gifu, 1 1 Yanagido, Gifu City, Gifu 501 1194, Japan
    J Neurol Sci 231:89-93. 2005
    ..Serum IgE levels also fluctuated in parallel with his relapsing-remitting clinical course. We propose that pure motor CIDP may be immune mediated and suggest that IgE-mediated allergy may be one potential cause of this condition...
  32. ncbi request reprint Autoantibodies against glutamate receptor epsilon2-subunit detected in a subgroup of patients with reversible autoimmune limbic encephalitis
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Eur Neurol 58:152-8. 2007
    ..The clinical features and neuroimaging findings of patients with IgM autoantibodies against GluR epsilon2 in CSF resemble those of patients with reversible autoimmune limbic encephalitis...
  33. ncbi request reprint Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study)
    Hiide Yoshino
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry, Chiba, Japan
    Amyotroph Lateral Scler 7:241-5. 2006
    ..Data from the present study suggest that edaravone is safe and may delay the progression of functional motor disturbances by reducing oxidative stress in ALS patients...
  34. ncbi request reprint [Pareneoplastic neurological syndrome --update]
    Takashi Inuzuka
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
    Rinsho Shinkeigaku 51:834-7. 2011
    ....
  35. ncbi request reprint [Diagnosis of adult type of Niemann-Pick disease (type C) in two brothers by filipin staining of bone marrow smears]
    Kenji Wakida
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu shi, Gifu 501 1194, Japan
    No To Shinkei 56:1047-53. 2004
    ..This diagnostic process using a bone marrow smear is more convenient and rapid than previous methods using cultured skin fibroblasts...
  36. doi request reprint Cervical spinal cord injury without bony injury: a multicenter retrospective study of emergency and critical care centers in Japan
    Hiroshi Kato
    Department of Critical Care and Traumatology, National Hospital Organization Disaster Medical Center, Tokyo, Japan
    J Trauma 65:373-9. 2008
    ..To demonstrate the clinical characteristics of patients with cervical cord injury (CCI) without bony injury in Japan...
  37. ncbi request reprint Efficacy of coronary angioplasty following conventional coronary thrombolysis in patients with acute myocardial infarction
    Takahiro Hayashi
    Department of Cardiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Angiology 55:507-15. 2004
    ..From these findings, we conclude that thrombolytic therapy with subsequent angioplasty is an effective strategy for achieving cardiac reperfusion following acute myocardial infarction...
  38. ncbi request reprint Pravastatin reduces the incidence of cardiac events among patients with myocardial infarction
    Hiroki Furuta
    Department of Cardiology, Kinki University School of Medicine, Osaka, Japan
    Jpn Heart J 44:873-87. 2003
    ..These findings are consistent with those previously reported by several large-scale clinical trials carried out in Western countries, and demonstrate that pravastatin is useful for secondary prevention of MI in Japanese patients...
  39. ncbi request reprint Beta-blockers prevent cardiac events in Japanese patients with myocardial infarction
    Kinji Ishikawa
    Department of Cardiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
    Circ J 68:59-67. 2004
    ..Although the favorable effects of beta-blockers in the treatment of myocardial infarction (MI) have been repeatedly demonstrated in Western countries, administration of this drug has been limited in Japan...
  40. ncbi request reprint Modification of treatment strategies over a period of 14 years has markedly reduced cardiac events among post-myocardial infarction patients
    Kinji Ishikawa
    Circ J 66:881-5. 2002
    ..The decline in the incidence of cardiac events among post-MI patients in the 14 years between 1986 and 1999 reflects implementation of new therapeutic modalities proven to be effective in clinical trials and in daily practice...
  41. ncbi request reprint Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells
    Akio Kimura
    Department of Emergency Medicine, Traumatology and Toxicology, International Medical Center of Japan, Tokyo, Japan
    Crit Care Med 30:1499-502. 2002
    ..To clarify the influence of moderate hypothermia on the production of proinflammatory cytokines...