Hideo Kaneko

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases
    Kaori Yoshikawa
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yoro gun, Gifu 501 1193, Japan
    Int J Mol Med 16:827-31. 2005
  2. ncbi Microsatellite instability in B-cell lymphoma originating from Bloom syndrome
    H Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Tsukasa mati, Japan
    Int J Cancer 69:480-3. 1996
  3. ncbi Relatively common mutations of the Bloom syndrome gene in the Japanese population
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1193, Japan
    Int J Mol Med 14:439-42. 2004
  4. ncbi The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining
    Hideo Kaneko
    Department of Pediatrics, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Adv Biophys 38:45-64. 2004
  5. pmc Leaky phenotype of X-linked agammaglobulinaemia in a Japanese family
    H Kaneko
    Department of Paediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Clin Exp Immunol 140:520-3. 2005
  6. ncbi Effects of dioxins on the quantitative levels of immune components in infants
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    Toxicol Ind Health 22:131-6. 2006
  7. ncbi Detection of the genes induced in activated lymphocytes by modified differential display
    Hideo Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Japan
    J Investig Allergol Clin Immunol 12:86-90. 2002
  8. ncbi Expression of BLM (the causative gene for Bloom syndrome) and screening of Bloom syndrome
    Wataru Morimoto
    Department of Pediatrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Int J Mol Med 10:95-9. 2002
  9. ncbi Autologous peripheral blood stem cell transplantation in a patient with relapsed pleuropulmonary blastoma
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    J Pediatr Hematol Oncol 28:383-5. 2006
  10. ncbi Suppression of IFN-gamma production in atopic group at the acute phase of RSV infection
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido, Gifu, Japan
    Pediatr Allergy Immunol 17:370-5. 2006

Detail Information

Publications65

  1. ncbi A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases
    Kaori Yoshikawa
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yoro gun, Gifu 501 1193, Japan
    Int J Mol Med 16:827-31. 2005
    ..Furthermore, a familial analysis of Glu 4 Lys revealed a link with allergic diseases. Thus, our results suggest that Glu 4 Lys in the LTC4S might be associated with allergic diseases...
  2. ncbi Microsatellite instability in B-cell lymphoma originating from Bloom syndrome
    H Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Tsukasa mati, Japan
    Int J Cancer 69:480-3. 1996
    ..Thus, 2 B-cell lymphomas, despite having the same BLM mutation, showed different phenotypes in terms of p53 mutation and microsatellite instability...
  3. ncbi Relatively common mutations of the Bloom syndrome gene in the Japanese population
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1193, Japan
    Int J Mol Med 14:439-42. 2004
    ..These results suggest that 631delCAA is a relatively common mutation among the Japanese BS patients...
  4. ncbi The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining
    Hideo Kaneko
    Department of Pediatrics, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Adv Biophys 38:45-64. 2004
    ..To elucidate the precise function of RecQ helicase in DNA repair and replication aims not only to improve our understanding of the molecular basis for tumorigenesis, but also to extend the range of potential therapeutic targets...
  5. pmc Leaky phenotype of X-linked agammaglobulinaemia in a Japanese family
    H Kaneko
    Department of Paediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Clin Exp Immunol 140:520-3. 2005
    ..The increased frequency of infection with age expanded the number of B cells with normal BTK gene expression and produced the serum immunoglobulin, including IgE...
  6. ncbi Effects of dioxins on the quantitative levels of immune components in infants
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    Toxicol Ind Health 22:131-6. 2006
    ....
  7. ncbi Detection of the genes induced in activated lymphocytes by modified differential display
    Hideo Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Japan
    J Investig Allergol Clin Immunol 12:86-90. 2002
    ..Differential display is a useful method for detection of inducible genes from a small amount of material and at various time points, although the homology of PCR primer influences the displayed genes...
  8. ncbi Expression of BLM (the causative gene for Bloom syndrome) and screening of Bloom syndrome
    Wataru Morimoto
    Department of Pediatrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Int J Mol Med 10:95-9. 2002
    ..These results indicate that the combinational analysis of immunoblotting and immunohistochemistry is a useful approach to screening of BS, although a mutation analysis is necessary for a definitive diagnosis of BS...
  9. ncbi Autologous peripheral blood stem cell transplantation in a patient with relapsed pleuropulmonary blastoma
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    J Pediatr Hematol Oncol 28:383-5. 2006
    ..Although it might be that the patient could have been cured with second surgery alone or by the surgery and subsequent chemotherapy, high-dose chemotherapy and PBSCT should be considered for the treatment of relapsed PPB...
  10. ncbi Suppression of IFN-gamma production in atopic group at the acute phase of RSV infection
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido, Gifu, Japan
    Pediatr Allergy Immunol 17:370-5. 2006
    ..IFN-gamma suppression in regard to RSV infection might be caused by some genetic factor involved in the development of atopic disease such as IL-18 signal cascade...
  11. ncbi Long-term duration of reduced serum complement level following burn injury
    H Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Japan
    J Investig Allergol Clin Immunol 11:303-4. 2001
    ..In this patient the reduced level of CH50 continued for 4 months. We should consider burn injury one of the causes of complement deficiency even in cases with a duration of more than 1 month...
  12. ncbi Telomerase activity in cell lines and lymphoma originating from Bloom syndrome
    H Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Leuk Lymphoma 42:757-60. 2001
    ..Collectively, the results show that the BLM gene is not a major structural and regulatory factor in maintaining telomere repeat length and telomerase activity...
  13. ncbi Long-term study of a female hyper-IgM immunodeficiency
    H Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan
    Exp Clin Immunogenet 17:173-8. 2000
    ..Non-X-linked HIM has heterogeneous pathogenetic mechanisms, and some groups may show the resistance to infection at the healthy donor level. The underlying defects in non-X-linked HIM might be specifically involved in class switching...
  14. pmc Expression of the BLM gene in human haematopoietic cells
    H Kaneko
    Department of Paediatrics, Gifu University School of Medicine, Gifu, Japan
    Clin Exp Immunol 118:285-9. 1999
    ..Taking into consideration all these results, BLM may not be directly involved in VDJ recombination, but is apparently involved in the maintenance of the stability of DNA...
  15. ncbi Two Japanese siblings with Bloom syndrome gene mutation and B-cell lymphoma
    H Kaneko
    Department of Pediatrics, Gifu University School of Medicine, Tukasa mati, Japan
    Leuk Lymphoma 27:539-42. 1997
    ..These findings indicate the importance of prenatal diagnosis and the detection of BS carriers based on molecular genetic analysis...
  16. ncbi Clinical features of Bloom syndrome and function of the causative gene, BLM helicase
    Hideo Kaneko
    Department of Pediatrics, Gifu University Graduate School of Medicine, 1 1 Yanaido, Gifu 501 1194, Japan
    Expert Rev Mol Diagn 4:393-401. 2004
    ..This review also discusses the nuclear localization signal of BLM, the proteins that interact with BLM and tumors originating from Bloom syndrome...
  17. ncbi A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases
    Minako Aoki
    Department of Pediatrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Int J Mol Med 12:185-91. 2003
    ..Our results suggest that some allergic patients have IFNGR dysfunction, and that L467P in the IFNGR1 gene is one of candidate susceptibility genes for allergic diseases...
  18. doi Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months
    Norio Kawamoto
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Allergy Asthma Proc 34:362-9. 2013
    ..Thus Th2 polarization in the persistent group was confirmed. In clinical use, total IgE at 6 months of age is the most useful predictive marker to know the outcome of infantile AD. The clinical trial registration ID is UMIN000002926. ..
  19. doi Hypothermia augments NF-kappaB activity and the production of IL-12 and IFN-gamma
    Takahiro Arai
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Allergol Int 57:331-8. 2008
    ..It is important to elucidate the effect of environmental factors, such as temperature, on the expression of cytokines of Th1 and Th2...
  20. ncbi A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma
    Chunying Bai
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1193, Japan
    Int J Mol Med 21:139-44. 2008
    ..Thus, our results suggest that E254K in the 5-LO might be associated with BA...
  21. ncbi Various expression patterns of alpha1 and alpha2 genes in IgA deficiency
    Hiroko Suzuki
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Allergol Int 58:111-7. 2009
    ..To investigate the molecular pathogenesis of IgA deficiency, it is important to evaluate each of the expressions of IgA1 and IgA2 separately...
  22. ncbi Age-related changes of transforming growth factor beta1 in Japanese children
    Masahiro Morimoto
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Allergol Int 58:97-102. 2009
    ..We investigated age-related changes of plasma TGF beta 1 levels in a birth-cohort study. In addition, the genotypes of the C-509T polymorphism were investigated in allergic and non-allergic subjects...
  23. ncbi In vitro analysis of the functional effects of an NLRP3 G809S variant with the co-existence of MEFV haplotype variants in atypical autoinflammatory syndrome
    Kazuo Kubota
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Clin Immunol 33:325-34. 2013
    ....
  24. doi The response of bovine beta-lactoglobulin-specific T-cell clones to single amino acid substitution of T-cell core epitope
    Masashi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Pediatr Allergy Immunol 19:592-8. 2008
    ..pY102A and pY102S are partial agonists for the T-cell receptor. These peptides might be considered as candidate peptides for the modification of the T-cell response to BLG in cow's milk allergy...
  25. ncbi Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency
    Rong Jin
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Int J Mol Med 21:233-8. 2008
    ..Elevated BAFF and APRIL expression levels might partially reflect the common immunological feature of primary antibody deficiency...
  26. doi Paclitaxel-based chemotherapy for aggressive kaposiform hemangioendothelioma of the temporomastoid region: Case report and review of the literature
    Michinori Funato
    Department of Pediatrics, Gifu University, Gifu, Japan
    Head Neck 35:E258-61. 2013
    ..Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy and childhood. This tumor results in poor prognosis, and therefore, development of a more effective treatment is needed...
  27. ncbi Predominant expression of 950delCAG of IL-18R alpha chain cDNA is associated with reduced IFN-gamma production and high serum IgE levels in atopic Japanese children
    Mizuho Watanabe
    Department of Pediatrics, Gifu University School of Medicine, Japan
    J Allergy Clin Immunol 109:669-75. 2002
    ....
  28. doi Structural property of soybean protein P34 and specific IgE response to recombinant P34 in patients with soybean allergy
    Hideyuki Morita
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Int J Mol Med 29:153-8. 2012
    ..It may be possible to develop a modified form of recombinant P34 for the diagnosis or treatment of soybean allergy using specific immunotherapy techniques...
  29. pmc Refractory chronic pleurisy caused by Helicobacter equorum-like bacterium in a patient with X-linked agammaglobulinemia
    Michinori Funato
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1Yanagido, Gifu 501 1194, Japan
    J Clin Microbiol 49:3432-5. 2011
    ..Broad-range bacterial PCR targeting the 16S and 23S rRNA genes and in situ hybridization targeting the 16S rRNA gene of H. equorum confirmed the presence of this pathogen in a human for the first time...
  30. pmc Lymphocyte Responses to Chymotrypsin- or Trypsin V-Digested beta-Lactoglobulin in Patients with Cow's Milk Allergy
    Masashi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan T, Nakano Research and Development Department, Bean Stalk Snow Co, Ltd, Kawagoe, Japan
    Allergy Asthma Clin Immunol 3:1-9. 2007
    ..Interferon-c production stimulated by chymotrypsin-digested peptides was still detectable in all five patients tested. Chymotrypsindigested BLG reduced lgE reactivity but still induced some lymphocyte responses...
  31. ncbi Age-related changes in intracellular cytokine profiles and Th2 dominance in allergic children
    Norio Kawamoto
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Pediatr Allergy Immunol 17:125-33. 2006
    ..In allergic diseases, although cord blood showed a Th1-dominant pattern, it changed to Th2 dominance in childhood, and this may reflect on some genetic background...
  32. doi Repeated-dose pharmacokinetics of inhaled ciclesonide (CIC-HFA) in Japanese children with bronchial asthma: a phase I study
    Takahide Teramoto
    Department of Pediatric, Gifu University Graduate School of Medicine, Japan
    Allergol Int 61:619-24. 2012
    ....
  33. doi Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism
    Tomohiro Hori
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Clin Immunol 32:1213-20. 2012
    ....
  34. doi A family having type 2B von Willebrand disease with an R1306W mutation: Severe thrombocytopenia leads to the normalization of high molecular weight multimers
    Michio Ozeki
    Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Thromb Res 125:e17-22. 2010
    ..We must consider 2B VWD in the case of recurrent thrombocytopenia following infection or other stress condition...
  35. doi Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis
    Yang An
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, Japan
    Int J Mol Med 27:795-801. 2011
    ..Furthermore, we propose that loss-of-function variants of Mal could predispose individuals to atopic dermatitis or other immunological disorders...
  36. ncbi [QOL questionnaire for pediatric patients with bronchial asthma and their parents or caregivers. Preparation and evaluation of the short form version 2008 (Gifu)]
    Naomi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University
    Arerugi 57:1022-33. 2008
    ..In this study, we revised the questionnaire for use in routine medical practice...
  37. doi Congenital inner ear malformations without sensorineural hearing loss in children
    Michio Ozeki
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    Int J Pediatr Otorhinolaryngol 73:1484-7. 2009
    ..Isolated vestibular malformation might not be as rare as previously thought, and should be examined by imaging of the temporal bone...
  38. ncbi Refractory osteomyelitis caused by bacille Calmette-Guérin vaccination: a case report
    Michinori Funato
    Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Diagn Microbiol Infect Dis 59:89-91. 2007
    ..The gyrB DNA direct sequencing, followed by restriction fragment length polymorphism of genomic DNA from a biopsy sample of the lesion, made diagnosis rapid...
  39. doi Peripheral blood stem cell transplantation in a significant body weight difference between a smaller donor and a larger recipient: a case report
    Michinori Funato
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan Electronic address
    Transfus Apher Sci 49:504-6. 2013
    ..We report a case of relapsed acute myeloid leukemia (body weight 52 kg and blood type O) who underwent allogeneic PBSCT from his smaller human leukocyte antigen-matched brother (body weight 29.9 kg and blood type A)...
  40. ncbi Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype
    Toshiyuki Fukao
    Department of Pediatrics, Gifu University School of Medicine, Gifu 500 8076, Japan
    Oncogene 23:1498-506. 2004
    ..These results suggest that ATM and BLM have largely distinct roles in recognizing different forms of damage in DNA, but are also compatible with partially overlapping functions in recognizing breaks in radiation-damaged DNA...
  41. doi Characterization of NLRP3 variants in Japanese cryopyrin-associated periodic syndrome patients
    Hidenori Ohnishi
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    J Clin Immunol 32:221-9. 2012
    ..This series of case reports suggests that a combination of in vitro assays could be a useful tool for the diagnosis and characterization of the disease severity of CAPS...
  42. ncbi Hyper-IgM syndrome with putative dominant negative mutation in activation-induced cytidine deaminase
    Yukiko Kasahara
    Department of Pediatrics, Gifu University School of Medicine Gifu, Japan
    J Allergy Clin Immunol 112:755-60. 2003
    ..The gene encoding activation-induced cytidine deaminase (AID) is responsible for the autosomal recessive form of hyper-IgM syndrome...
  43. ncbi Induction of α1 and α2 gene expression in selective immunoglobulin A deficiency
    Hiroko Suzuki
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Mol Med Report 1:395-9. 2008
    ..Based on our results, suppression of α1 gene expression may be related to the pathogenesis of IgAD...
  44. doi Reversible cerebrospinal fluid edema and porencephalic cyst, a rare complication of ventricular catheter
    Michio Ozeki
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu 501 1194, Japan
    J Clin Neurosci 17:658-61. 2010
    ..Advanced MRI techniques, including fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging may be helpful for assessing this pathological condition and its prognosis...
  45. doi Translocation (1;10)(p34;p15) in infant acute myeloid leukemia with extramedullary infiltration in multiple sites
    Michinori Funato
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1 1, Gifu, Japan
    Cancer Genet Cytogenet 192:86-9. 2009
    ..No case of AML with t(1;10)(p34;p15) has been reported in the literature. At the present time, she remains free of disease 12 months after bone marrow transplantation (BMT) in the second complete remission...
  46. doi IL-10 plays an important role as an immune-modulator in the pathogenesis of atopic diseases
    Minako Kawamoto
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Mol Med Report 1:837-42. 2008
    ..Thus, IL-10 modulates other cytokines and plays an important role as an immune-modulator in the pathogenesis of atopic diseases...
  47. doi Augmented cell death with Bloom syndrome helicase deficiency
    Hideo Kaneko
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Mol Med Rep 4:607-9. 2011
    ..Slow cell growth and increased cell death may be one of the causes of the small body size associated with BS patients...
  48. ncbi Progressive multifocal leukoencephalopathy in a patient with X-linked agammaglobulinemia
    Takahide Teramoto
    Department of Pediatrics, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Scand J Infect Dis 35:909-10. 2003
    ..The JC virus was confirmed at autopsy and PML was diagnosed. Humoral immunodeficiency with normal cellular immunity could be infected with JCV...
  49. ncbi Identification of Alu-mediated, large deletion-spanning introns 19-26 in PHKA2 in a patient with X-linked liver glycogenosis (hepatic phosphorylase kinase deficiency)
    Toshiyuki Fukao
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Mol Genet Metab 92:179-82. 2007
    ..An aberrant cDNA with skipping of exons 20-26 was detected. Alu element-mediated unequal homologous recombination between an Alu-Jo in intron 19 and another Alu-Sg in intron 26 appears to be responsible for this deletion...
  50. ncbi A positive Donath-Landsteiner test in paroxysmal cold haemoglobinuria
    Michinori Funato
    Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Eur J Haematol 79:462. 2007
  51. ncbi Clinical improvement of diffuse lymphangiomatosis with pegylated interferon alfa-2b therapy: case report and review of the literature
    Michio Ozeki
    Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Pediatr Hematol Oncol 24:513-24. 2007
    ..The patient was treated with pegylated interferon alfa-2b, and achieved good clinical and radiological improvement...
  52. ncbi A common variable immunodeficient patient who developed acute disseminated encephalomyelitis followed by the Lennox-Gastaut syndrome
    Masashi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Pediatr Allergy Immunol 16:357-60. 2005
    ..We suspect that a genetic defect in the immune system of our patient might also be associated with the neurologic disorders of ADEM and the Lennox-Gastaut syndrome...
  53. ncbi Anaphylactoid transfusion reactions associated with a positively charged white-cell reduction filter: a case report
    Michinori Funato
    Department of Pediatrics, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu, Japan
    Transfus Apher Sci 38:199-201. 2008
    ..However, several complications associated with a white-cell reduction filter have been identified. We report the first case of anaphylactoid reactions caused by a white-cell reduction filter with a positively charged surface...
  54. doi Oral administration of the thyrotropin-releasing hormone (TRH) analogue, taltireline hydrate, in spinal muscular atrophy
    Zenichiro Kato
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    J Child Neurol 24:1010-2. 2009
    ..Oral administration of this thyrotropin-releasing hormone analogue should be noted as a promising therapy for spinal muscular atrophy...
  55. ncbi Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia
    Hiromichi Taneichi
    Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Clin Immunol 126:148-54. 2008
    ..These findings suggest that BTK may thus be required for TLR signaling in DCs. The impaired TLR signaling in DCs may therefore be partly responsible for the occurrence of severe infections with bacteria and some viruses in XLA patients...
  56. ncbi Clinical and bacteriological evaluation of the efficacy of piperacillin in children with pneumonia
    Minako Aoki
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido, Gifu 501 1194, Japan
    J Infect Chemother 13:224-9. 2007
    ..125 microg/ml, respectively. Tazobactam/piperacillin and piperacillin showed the best results, followed by panipenem, ampicillin, and flomoxef. Piperacillin proved to be very useful for the treatment of pneumonia in children...
  57. ncbi [IgA subclass and IgA deficiency]
    Hideo Kaneko
    Division of Pediatrics, Center for Regional Medicine, Gifu University, Gifu, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 32:142-8. 2009
    ..Longitudinal change in the serum IgA of the patient with alpha1 gene deletion showed the pattern of the partial IgAD. Patients with alpha1 gene deletion can be considered as having partial IgAD...
  58. ncbi Acute mumps cerebellitis with abnormal findings in MRI diffusion-weighted images
    Eiji Matsukuma
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Gifu, Japan
    Eur J Pediatr 167:829-30. 2008
    ..High signal intensity in the cerebellum was obvious on diffusion-weighted images, suggesting the importance of diffusion-weighted images in the early stage of cerebellitis...
  59. pmc Pharmacogenetics of asthma in children
    Naomi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Allergy Asthma Immunol Res 2:14-9. 2010
    ..Finally, we show the guideline for personalized medicine for asthma, particularly in childhood, including the pharmacogenetics of anti-asthmatic drugs, preliminarily produced by the authors...
  60. ncbi [Classification of immunodeficiency diseases]
    Naomi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University
    Nihon Rinsho 63:548-58. 2005
  61. ncbi Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
    Heather Beamish
    Queensland Cancer Fund Research Laboratories, The Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Herston, Brisbane, QLD 4029, Australia
    J Biol Chem 277:30515-23. 2002
    ..These data suggest that ATM and BLM function together in recognizing abnormal DNA structures by direct interaction and that these phosphorylation sites in BLM are important for radiosensitivity status but not for SCE frequency...
  62. ncbi Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
    Kiyoshi Higashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Konohana ku, Osaka 554 8558, Japan
    J Biol Chem 278:43470-9. 2003
    ..They also indicate that IFN-gamma/YB-1 inhibits COL1A2 transcription by dual actions: via the IFN-gamma response element and through a cross-talk with the TGF-beta/Smad signaling pathway...
  63. pmc Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression
    Norihisa Ooe
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, Konohana ku, Osaka 554 8558, Japan
    Mol Cell Biol 24:608-16. 2004
    ....
  64. ncbi Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Immunity 25:745-55. 2006
    ..This study identifies human Tyk2 deficiency and demonstrates that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially from Tyk2 function in mice...
  65. ncbi Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma
    Kiyoshi Higashi
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Konohana ku, Osaka 554 8558, Japan
    J Biol Chem 278:5156-62. 2003
    ..Altogether, this study represents the definitive identification of the transcription factor responsible for IFN-gamma-elicited inhibition of COL1A2 expression, namely YB-1...