Tetsuo Adachi

Summary

Affiliation: Gifu Pharmaceutical University
Country: Japan

Publications

  1. doi request reprint Contribution of p38 MAPK, NF-κB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Arch Biochem Biophys 520:30-5. 2012
  2. ncbi request reprint Heparin-Affinity of human extracellular-superoxide dismutase in the brain
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 24:191-3. 2001
  3. ncbi request reprint Effects of PPARgamma ligands and C/EBPbeta enhancer on expression of extracellular-superoxide dismutase
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Redox Rep 9:207-12. 2004
  4. ncbi request reprint Effect of hypoxia mimetic cobalt chloride on the expression of extracellular-superoxide dismutase in retinal pericytes
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 34:1297-300. 2011
  5. ncbi request reprint Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Daigaku Nishi, Gifu, Japan
    Free Radic Res 45:1083-92. 2011
  6. ncbi request reprint Heparin-stimulated expression of extracellular-superoxide dismutase in human fibroblasts
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Atherosclerosis 159:307-12. 2001
  7. ncbi request reprint Infliximab neutralizes the suppressive effect of TNF-alpha on expression of extracellular-superoxide dismutase in vitro
    Tetsuo Adachi
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Biol Pharm Bull 29:2095-8. 2006
  8. ncbi request reprint Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu 502 8585, Japan
    J Endocrinol 181:413-7. 2004
  9. doi request reprint Regulation of extracellular-superoxide dismutase in rat retina pericytes
    Tetsuo Adachi
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Redox Rep 15:250-8. 2010
  10. ncbi request reprint Age-related change of plasma extracellular-superoxide dismutase
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Clin Chim Acta 290:169-78. 2000

Collaborators

Detail Information

Publications65

  1. doi request reprint Contribution of p38 MAPK, NF-κB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Arch Biochem Biophys 520:30-5. 2012
    ..The effects of dexamethasone are thought to be due to the transrepression of the above signaling and direct regulation of claudin-5 gene...
  2. ncbi request reprint Heparin-Affinity of human extracellular-superoxide dismutase in the brain
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 24:191-3. 2001
    ..The intracellular localization of EC-SOD could contribute to its slow clearance from the brain and maintenance of its physiological functions in the brain...
  3. ncbi request reprint Effects of PPARgamma ligands and C/EBPbeta enhancer on expression of extracellular-superoxide dismutase
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Redox Rep 9:207-12. 2004
    ..Increasing the EC-SOD expression by treatment with ligands of transcription factors might be one approach to ameliorate the pathological conditions of insulin resistance...
  4. ncbi request reprint Effect of hypoxia mimetic cobalt chloride on the expression of extracellular-superoxide dismutase in retinal pericytes
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 34:1297-300. 2011
    ..The decrease in EC-SOD expression accompanied with elevation of ROS level in pericytes under hypoxia might induce and/or promote the ROS-triggered apoptosis of pericytes and the development of pathogenesis in DR...
  5. ncbi request reprint Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Daigaku Nishi, Gifu, Japan
    Free Radic Res 45:1083-92. 2011
    ..Our observations suggest that ER stress leads to the down-regulation of claudin-5 among tight junction proteins and may induce the elevation of endothelial permeability and leakage of EC-SOD into the vitreous body...
  6. ncbi request reprint Heparin-stimulated expression of extracellular-superoxide dismutase in human fibroblasts
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Atherosclerosis 159:307-12. 2001
    ..The stimulatory effect seemed to increase roughly with the degree of glycosaminoglycan sulfation. The enhanced expression of EC-SOD by heparin must contribute to the antiatherosclerotic effect of heparin...
  7. ncbi request reprint Infliximab neutralizes the suppressive effect of TNF-alpha on expression of extracellular-superoxide dismutase in vitro
    Tetsuo Adachi
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Biol Pharm Bull 29:2095-8. 2006
    ..This reveals a potential usefulness of infliximab on TNF-alpha related pathological conditions such as arthritis and insulin resistance...
  8. ncbi request reprint Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu 502 8585, Japan
    J Endocrinol 181:413-7. 2004
    ..It is possible that the increase in the EC-SOD level by pioglitazone administration in diabetic patients is due to a decline of TNF-alpha, which is known to suppress EC-SOD expression...
  9. doi request reprint Regulation of extracellular-superoxide dismutase in rat retina pericytes
    Tetsuo Adachi
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Redox Rep 15:250-8. 2010
    ....
  10. ncbi request reprint Age-related change of plasma extracellular-superoxide dismutase
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Clin Chim Acta 290:169-78. 2000
    ..However, the results suggest that the changes in EC-SOD levels may be the most sensitive biomarker for age-related changes in the antioxidant capacity...
  11. ncbi request reprint Increase of urinary extracellular-superoxide dismutase level correlated with cyclic adenosine monophosphate
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    FEBS Lett 458:370-4. 1999
    ..Together these observations suggest that factor(s) that stimulate the adenylate cyclase-cAMP system regulate the urinary EC-SOD level...
  12. ncbi request reprint Association of extracellular-superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase polymorphism
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    FEBS Lett 433:166-8. 1998
    ..Whilst the mechanism remains speculative, it is possible that there is a significant interaction between EC-SOD and ecNOS, or that common factor(s), either genetic or environmental, influence both of them...
  13. doi request reprint Expression of extracellular superoxide dismutase during adipose differentiation in 3T3-L1 cells
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Redox Rep 14:34-40. 2009
    ..It is possible that the expression of EC-SOD in adipocytes was stimulated to protect them from oxidative stress in the co-culture system...
  14. ncbi request reprint [Effort to improve advanced problem-based learning tutorial]
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Mitahora Higashi, Gifu, Japan
    Yakugaku Zasshi 129:177-82. 2009
    ..In addition, the usefulness of customer satisfaction (CS) analysis was demonstrated as a result of applying it to the data analysis of evaluation performed on group presentations...
  15. doi request reprint Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Neurochem Int 58:35-43. 2011
    ..Taken together, our data suggest that preconditioning effects induced by Tg mediate an adaptive response to 6-OHDA-induced cytotoxicity via phosphorylation of eIF2α and activation of the ARE...
  16. ncbi request reprint Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Free Radic Res 42:949-56. 2008
    ....
  17. doi request reprint The effect of hypoxia mimetic cobalt chloride on the expression of EC-SOD in 3T3-L1 adipocytes
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Redox Rep 15:131-7. 2010
    ....
  18. doi request reprint Luteolin suppresses the differentiation of THP-1 cells through the Inhibition of NOX2 mRNA expression and the membrane translocation of p47phox
    Junya Makino
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    J Nat Prod 76:1285-90. 2013
    ..Moreover, pretreatment with 1 suppressed TPA-triggered induction of NOX2 and membrane translocation of p47(phox). Overall, it is revealed that 1 suppresses TPA-triggered induction of CD families by the prevention of NOX2 activation. ..
  19. doi request reprint TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS
    Junya Makino
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Free Radic Res 46:637-44. 2012
    ..Moreover, we determined the involvement of NADPH oxidase-derived reactive oxygen species in that induction. Overall, we considered that these results may contribute to clarify the cell-specific expression of EC-SOD...
  20. ncbi request reprint Extracellular-superoxide dismutase expression in COS7 cells exposed to cadmium chloride
    Aya Obara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 34:1443-7. 2011
    ....
  21. ncbi request reprint Increase of antioxidative potential by tert-butylhydroquinone protects against cell death associated with 6-hydroxydopamine-induced oxidative stress in neuroblastoma SH-SY5Y cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res Mol Brain Res 119:125-31. 2003
    ..These results indicate that an increase of intracellular antioxidative potential in SH-SY5Y cells by tBHQ treatment protects cells from 6-OHDA-induced oxidative stress...
  22. ncbi request reprint Propolis suppresses CdCl₂-induced cytotoxicity of COS7 cells through the prevention of intracellular reactive oxygen species accumulation
    Tetsuro Kamiya
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Biol Pharm Bull 35:1126-31. 2012
    ..We demonstrate for the first time the utility of propolis for Cd-related COS7 cytotoxicity, and these novel findings are considered to contribute to the control of ROS-derived disorders...
  23. ncbi request reprint Apomorphine protects against 6-hydroxydopamine-induced neuronal cell death through activation of the Nrf2-ARE pathway
    Hirokazu Hara
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    J Neurosci Res 84:860-6. 2006
    ..Taken together, our findings suggest that not only the function as a radical scavenger but also the function as an Nrf2-ARE pathway activator may be involved in the neuroprotective effects of Apo...
  24. doi request reprint ER stress inducer, thapsigargin, decreases extracellular-superoxide dismutase through MEK/ERK signalling cascades in COS7 cells
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Free Radic Res 45:692-8. 2011
    ....
  25. ncbi request reprint C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression
    Yoko Yasunami
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Drug Metab Dispos 32:685-8. 2004
    ..However, SP600125 did not affect 1,25(OH)(2)D(3)-induced transactivation of the DR3 via VDR. These results indicate that JNK, but not ERK or p38, is required for the optimal activation of the CYP3A4 gene induced by 1,25(OH)(2)D(3)...
  26. ncbi request reprint Protective effects of apomorphine against zinc-induced neurotoxicity in cultured cortical neurons
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Biol Pharm Bull 36:585-91. 2013
    ....
  27. ncbi request reprint Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Biochem Biophys Res Commun 321:909-15. 2004
    ..Taken together, the decrease of VDR binding to the proximal ER6 caused by the mutation results in the loss of CYP3A7 gene activation by 1,25(OH)(2)D(3)...
  28. doi request reprint Ethanol extract of Brazilian red propolis induces apoptosis in human breast cancer MCF-7 cells through endoplasmic reticulum stress
    Tetsuro Kamiya
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    J Agric Food Chem 60:11065-70. 2012
    ..Overall, we revealed that an ethanol extract of BRP induces MCF-7 cell apoptosis through, at least in part, ER stress-related signaling...
  29. pmc Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients
    Hiroshi Izuta
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Mitahora Higashi, Japan
    Mol Vis 15:2663-72. 2009
    ..To investigate the role of EC-SOD in PDR by evaluating its angiostatic effect, using an in vitro angiogenesis model...
  30. ncbi request reprint Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity
    Hirokazu Hara
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neurochem Res 32:489-95. 2007
    ..Therefore, our results suggest the protective effect of PQQ on 6-OHDA-induced neurotoxicity is involved, at least in part, in its function as a scavenger of ROS, especially superoxide...
  31. doi request reprint Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neurochem Res 34:1498-506. 2009
    ..Taken together, these results indicate that Zn2+ regulates the induction of PUMA through p53 and ERK pathways...
  32. doi request reprint Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    J Cell Biochem 112:244-55. 2011
    ..Overall, our results suggest that the expression of EC-SOD is decreased by TPA through intracellular signaling consisting of PKC, NOX-derived ROS and MEK/ERK, but not of NF-κB signaling...
  33. doi request reprint Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    FEBS J 280:3313-27. 2013
    ..Taken together, our findings suggest that Zn(2+) inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS...
  34. ncbi request reprint The expression of extracellular-superoxide dismutase is increased by lysophosphatidylcholine in human monocytic U937 cells
    Masayuki Yamamoto
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1, Mitahora Higashi, Japan
    Atherosclerosis 163:223-8. 2002
    ..Therefore, it is speculated that EC-SOD is induced by lysoPC-stimulated monocytes as a feedback mechanism in vascular homeostasis...
  35. pmc Substitution of glycine for arginine-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface
    T Adachi
    Department of Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biochem J 313:235-9. 1996
    ..This result suggests that the binding of m-EC-SOD to vascular endothelial cells is much decreased in vivo, which causes a high level of serum EC-SOD...
  36. ncbi request reprint Newly synthesized 'hidabeni' chalcone derivatives potently suppress LPS-induced NO production via inhibition of STAT1, but not NF-κB, JNK, and p38, pathways in microglia
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University
    Biol Pharm Bull 37:1042-9. 2014
    ..Our findings indicate that these chalcone derivatives are candidate compounds for preventing microglia-mediated neuroinflammation. ..
  37. doi request reprint Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Bioorg Med Chem 19:5559-68. 2011
    ....
  38. ncbi request reprint Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells
    H Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Free Radic Res 33:279-85. 2000
    ..8-Bromo cGMP had no effect on 1,25(OH)2D3-induced CYP3A4 gene expression. Therefore, the suppression of CYP3A4 mRNA by NO might be mediated through a guanylate cyclase-independent pathway...
  39. ncbi request reprint Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface
    M Yamamoto
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan
    FEBS Lett 505:296-300. 2001
    ....
  40. ncbi request reprint Apomorphine attenuates 6-hydroxydopamine-induced apoptotic cell death in SH-SY5Y cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Redox Rep 8:193-7. 2003
    ..These findings suggested that apomorphine acts principally as a radical scavenger to suppress the level of ROS and ROS-stimulated apoptotic signaling pathway, whereas the other mechanisms might be involved in the protective effects...
  41. pmc Effect of endoplasmic reticulum (ER) stress inducer thapsigargin on the expression of extracellular-superoxide dismutase in mouse 3T3-L1 adipocytes
    Tetsuro Kamiya
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    J Clin Biochem Nutr 52:101-5. 2013
    ..Moreover, eukaryotic translation initiation factor 2α signaling cascade plays a pivotal role in the reduction of extracellular-superoxide dismutase in 3T3-L1 adipocytes during endoplasmic reticulum stress conditions...
  42. ncbi request reprint Contribution of hepatocyte nuclear factor-4 to down-regulation of CYP2D6 gene expression by nitric oxide
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Mol Pharmacol 61:194-200. 2002
    ..These results demonstrated that NO down-regulates CYP2D6 gene expression, at least in part, by directly inhibiting HNF4 binding to the CYP2D6 promoter...
  43. ncbi request reprint The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro
    T Adachi
    Department of Pharmaceutics, Gifu Pharmaceutical University, Japan
    Free Radic Biol Med 13:205-10. 1992
    ..epsilon-Glucitol lysine was identified in both peptides at positions 211 and 212. The primary glycation sites in EC-SOD are thus lysine-211 and lysine-212 in the putative heparin-binding domain in the carboxyterminal end...
  44. ncbi request reprint Quantitative analysis of extracellular-superoxide dismutase in serum and urine by ELISA with monoclonal antibody
    T Adachi
    Department of Pharmaceutics, Gifu Pharmaceutical University, Japan
    Clin Chim Acta 212:89-102. 1992
    ....
  45. ncbi request reprint Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Biochem Biophys Res Commun 296:182-8. 2002
    ..Taken together, these findings suggest that the change in the phosphorylation state via PKC and tyrosine kinase might, at least in part, modulate 1,25(OH)(2)D(3)-induced CYP3A4 mRNA expression via VDR...
  46. ncbi request reprint [Evaluation of the cardio pulmonary resuscitation/automated external defibrillator class and disability experiences class provided as part of the early exposure program]
    Eiji Sakai
    Gifu Pharmaceutical University, Gifu City, Japan
    Yakugaku Zasshi 128:1227-33. 2008
    ..To provide regularly a meaningful early exposure program, the concept of a "model core curriculum" led by learners as well as the age-mixing method with senior students supporting instruction of their juniors should be introduced...
  47. ncbi request reprint Chemical nature of intestinal-type alkaline phosphatase in human kidney
    Y Nishihara
    Department of Pharmaceutics, Gifu Pharmaceutical University, Japan
    Clin Chem 38:2539-42. 1992
    ..The heterogeneity of the intestinal-type alkaline phosphatase can therefore be generated both by partial peptide bond hydrolysis and differences in glycosylation...
  48. doi request reprint Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease
    A Oyagi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1214:169-76. 2008
    ..These findings indicate that SUN N8075 exerts protective effects, at least in part via an anti-oxidation mechanism, in these in vitro and in vivo models of Parkinson's disease...
  49. ncbi request reprint A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis
    Mizuho Kimura
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, Japan
    J Immunol 178:3316-22. 2007
    ..618, p < 0.01). These findings suggest that AIF-1 is closely associated with the pathogenesis of RA and is a novel member of the cytokine network involved in the immunological processes underlying RA...
  50. ncbi request reprint TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes
    Masataka Nishimura
    Department of the Clinical Neuroscience, Tokushima University Hospital, Japan
    Hum Immunol 64:302-9. 2003
    ..These results suggest that the TNFR1 gene region might be a susceptible locus to type 1 diabetes in Japanese...
  51. ncbi request reprint Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications
    Fumiaki Kimura
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Diabetes Care 26:1246-50. 2003
    ....
  52. ncbi request reprint The relationship between exercise-induced oxidative stress and the menstrual cycle
    Mi Hyun Joo
    Tsukuba University Grad, School of Comprehensive Human Sciences, 1 1 1, Tennodai Tsukuba, Ibaraki 305 8574, Japan
    Eur J Appl Physiol 93:82-6. 2004
    ..The results of this study suggest that when the estradiol level is high in a menstrual cycle, free radicals produced as a consequence of exercise may be easily eliminated by sedentary women with normal menstrual cycles...
  53. ncbi request reprint Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes
    Masataka Horiuchi
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 24:106-11. 2004
    ..We examined the vascular expression levels of extracellular superoxide dismutase (EC-SOD), a major antioxidant enzyme in the cardiovascular system, in patients with acute coronary syndromes...
  54. ncbi request reprint Hyperhomocysteinemia is associated with human coronary atherosclerosis through the reduction of the ratio of endothelium-bound to basal extracellular superoxide dismutase
    Shun ichi Nihei
    Second Department of Internal MedicineUniversity of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Circ J 68:822-8. 2004
    ....
  55. ncbi request reprint Blood extracellular superoxide dismutase levels in hemodialysis patients pre- and post-hemodialysis and its association with lipoprotein lipase mass and free fatty acid
    Hiroji Shimomura
    Central Clinical Laboratories, Mitsui Memorial Hospital, 1 Kanda Izumi cho, Chiyoda ku, Tokyo 101 8643, Japan
    Clin Chim Acta 328:113-9. 2003
    ..We have been using extracellular superoxide dismutase (EC-SOD) attached to the heparan sulfate on the endothelial cell surface as a marker of vascular damage...
  56. ncbi request reprint Expression of allograft inflammatory factor-1 in human eutopic endometrium and endometriosis: possible association with progression of endometriosis
    Hisato Koshiba
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Endocrinol Metab 90:529-37. 2005
    ..AIF-1 derived from peritoneal macrophages may also possibly play a significant role in the pathophysiology and progression of endometriosis...
  57. ncbi request reprint [Extracellular-superoxide dismutase production in mesangial cell growing in extracellular matrix]
    Harutaka Yamada
    Nephrology and Rheumatology Division of Internal Medicine, Aichi Medical University, Aichi, Japan
    Nihon Jinzo Gakkai Shi 47:32-7. 2005
    ..MC proliferation with type I collagen and fibronectin might enhance oxygen radical toxity in the glomeruli, and accelerate glomerular sclerosis through the suppression of EC-SOD production...
  58. ncbi request reprint Decreased plasma extracellular superoxide dismutase level in patients with vasospastic angina
    Kazuhito Yamashita
    The Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Atherosclerosis 191:147-52. 2007
    ..Here, we examined whether plasma EC-SOD level was associated with vasospastic angina (VSA), and if it was a risk factor for VSA...
  59. ncbi request reprint Extracellular superoxide dismutase overexpression reduces cuff-induced arterial neointimal formation
    Kiyoshi Ozumi
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu, Japan
    Atherosclerosis 181:55-62. 2005
    ..These results suggest that ROS, especially superoxide anions at an adventitia, are responsible for neointimal formation in a cuff-injury model...
  60. ncbi request reprint Experimental hyperhomocysteinemia impairs coronary flow velocity reserve
    Kazuhito Yamashita
    The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitayushu 807 8555, Japan
    Int J Cardiol 104:163-9. 2005
    ..This study was designed to test the hypothesis that experimental acute hyperhomocysteinemia would impair coronary flow velocity reserve (CFR) by increasing oxidative stress...
  61. ncbi request reprint Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis
    Hiromi Tasaki
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Atherosclerosis 187:131-8. 2006
    ..We studied whether the amount of heparin-released extracellular superoxide dismutase (EC-SOD), which is an antioxidative enzyme, is associated with coronary artery disease (CAD)...
  62. ncbi request reprint Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
    Hyohun Park
    Department of Internal Medicine, Saiseikai Suita Hospital, Osaka 564 0013, Japan
    Clin Chim Acta 374:129-34. 2006
    ..It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance...
  63. ncbi request reprint Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats
    Fumihiko Kamezaki
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku 807 8555, Kitakyushu, Japan
    Am J Respir Crit Care Med 177:219-26. 2008
    ..Objectives: In the present study, we examined whether intratracheal gene transfer of human extracellular superoxide dismutase (EC-SOD) could ameliorate monocrotaline (MCT)-induced PH in rats...
  64. ncbi request reprint Extracellular superoxide dismutase and glomerular mesangial cells: its production and regulation
    Harutaka Yamada
    First Department of Internal Medicine, Aichi Medical University, Yazako Karimata, Nagakute, Aichi, Japan
    FEBS Lett 519:77-81. 2002
    ..The presence of adenylate cyclase inhibitor 2',3'-dideoxyadenosine lost the prednisolone effect. The stimulation of EC-SOD production might be one of the important effects of prednisolone via cAMP pathway in MCs...