S Misaka

Summary

Affiliation: Fukushima Medical University
Country: Japan

Publications

  1. doi request reprint Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Biomed Chromatogr 27:1-6. 2013
  2. ncbi request reprint Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 28:244-9. 2013
  3. doi request reprint Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers
    Shingen Misaka
    Department of Pharmacology, School of Medicine, Fukushima Medical University, Fukushima, Japan
    J Clin Pharmacol 53:738-45. 2013
  4. ncbi request reprint Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats
    S Misaka
    Department of Pharmacology, School of Medicine, Fukushima Medical University, Fukushima, Japan Electronic address
    Phytomedicine 20:1247-50. 2013
  5. ncbi request reprint Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects
    S Misaka
    1 Department of Pharmacology, School of Medicine, Fukushima Medical University, Fukushima, Japan 2 Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Clin Pharmacol Ther 95:432-8. 2014

Detail Information

Publications5

  1. doi request reprint Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Biomed Chromatogr 27:1-6. 2013
    ..From these findings, taken together with the high productivity and precision, the developed method could be a reliable and reproducible tool for the evaluation of pharmacokinetic properties of catechins...
  2. ncbi request reprint Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 28:244-9. 2013
    ..1 ┬ÁM, respectively. EGCG moderately inhibited CYP3A activity in a noncompetitive manner. These results suggest that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP2C8 in addition to CYP3A...
  3. doi request reprint Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers
    Shingen Misaka
    Department of Pharmacology, School of Medicine, Fukushima Medical University, Fukushima, Japan
    J Clin Pharmacol 53:738-45. 2013
    ..These results suggest that itraconazole substantially increases the oral availability of nadolol possibly by the inhibition of intestinal P-glycoprotein, whereas grapefruit juice has little effect on nadolol pharmacokinetics. ..
  4. ncbi request reprint Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats
    S Misaka
    Department of Pharmacology, School of Medicine, Fukushima Medical University, Fukushima, Japan Electronic address
    Phytomedicine 20:1247-50. 2013
    ....
  5. ncbi request reprint Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects
    S Misaka
    1 Department of Pharmacology, School of Medicine, Fukushima Medical University, Fukushima, Japan 2 Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Clin Pharmacol Ther 95:432-8. 2014
    ..36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine...