Misao Matsushita

Summary

Affiliation: Fukushima Medical University
Country: Japan

Publications

  1. ncbi Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 164:2281-4. 2000
  2. ncbi The role of ficolins in innate immunity
    Misao Matsushita
    Department of Biochemistry, Fukushima Medical University, Japan
    Immunobiology 205:490-7. 2002
  3. ncbi Activation of the lectin complement pathway by H-ficolin (Hakata antigen)
    Misao Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 168:3502-6. 2002
  4. ncbi Ficolins and the lectin complement pathway
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Japan
    Immunol Rev 180:78-85. 2001
  5. ncbi Activation of the lectin complement pathway by ficolins
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Higariga oka, Fukushima 960 1295, Japan
    Int Immunopharmacol 1:359-63. 2001
  6. ncbi Proteolytic activities of two types of mannose-binding lectin-associated serine protease
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 165:2637-42. 2000
  7. ncbi Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus
    Yuichi Endo
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 170:4701-7. 2003
  8. ncbi Cloning and characterization of mannose-binding lectin from lamprey (Agnathans)
    Momoe Takahashi
    Department of Immunology, Fukushima Medical University, Fukushima, Japan
    J Immunol 176:4861-8. 2006
  9. doi Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    J Immunol 189:5860-6. 2012
  10. ncbi Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway
    Daisuke Iwaki
    Department of Immunology, Fukushima Medical University, 1 Hikariga oka, Fukushima City 960 1295, Japan
    J Immunol 177:8626-32. 2006

Collaborators

Detail Information

Publications47

  1. ncbi Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 164:2281-4. 2000
    ..These findings indicate that ficolin/P35 is a second collagenous lectin capable of activating the lectin pathway and thus plays a role in innate immunity...
  2. ncbi The role of ficolins in innate immunity
    Misao Matsushita
    Department of Biochemistry, Fukushima Medical University, Japan
    Immunobiology 205:490-7. 2002
    ..In addition, L-ficolin/P35 acts as an opsonin. These findings indicate that serum ficolins play an important a role in innate immunity in a similar manner to MBL...
  3. ncbi Activation of the lectin complement pathway by H-ficolin (Hakata antigen)
    Misao Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 168:3502-6. 2002
    ..C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway...
  4. ncbi Ficolins and the lectin complement pathway
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Japan
    Immunol Rev 180:78-85. 2001
    ..These findings indicate that serum ficolins are structurally and functionally similar to MBL and have the capacity to activate the lectin pathway and thus have a role in innate immunity...
  5. ncbi Activation of the lectin complement pathway by ficolins
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Higariga oka, Fukushima 960 1295, Japan
    Int Immunopharmacol 1:359-63. 2001
    ..These findings indicate that, like MBL, serum ficolins are collagenous lectins capable of activating the lectin pathway and thus have a role in innate immunity...
  6. ncbi Proteolytic activities of two types of mannose-binding lectin-associated serine protease
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 165:2637-42. 2000
    ..C2 was activated by both MASPs. C1 inhibitor (C1 INH), an inhibitor for C1r and C1s, formed equimolar complexes with MASP-1 and MASP-2 and inhibited their proteolytic activities...
  7. ncbi Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus
    Yuichi Endo
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Immunol 170:4701-7. 2003
    ..The ancient origin of MASP-1 and MASP-3 suggests that they have crucial functions common to all species which emerged after cephalochordates...
  8. ncbi Cloning and characterization of mannose-binding lectin from lamprey (Agnathans)
    Momoe Takahashi
    Department of Immunology, Fukushima Medical University, Fukushima, Japan
    J Immunol 176:4861-8. 2006
    ....
  9. doi Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    J Immunol 189:5860-6. 2012
    ..pneumoniae. These results suggest that ficolins play a crucial role in innate immunity against pneumococcal infection through the lectin complement pathway...
  10. ncbi Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway
    Daisuke Iwaki
    Department of Immunology, Fukushima Medical University, 1 Hikariga oka, Fukushima City 960 1295, Japan
    J Immunol 177:8626-32. 2006
    ..Therefore, MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway...
  11. doi Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Innate Immun 2:33-42. 2010
    ..Therefore, it is suggested that the lectin pathway collaborates with the coagulation system in the first-line host defense against pathogens under conditions such as injury and inflammation...
  12. pmc Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    J Biomed Biotechnol 2012:105891. 2012
    ..Taken together, these results suggest that like other mammalian homologues, murine ficolin B has an ability to exert its function via the lectin pathway...
  13. doi The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway
    Daisuke Iwaki
    Department of Immunology, Fukushima Medical University, Fukushima 960 1295, Japan
    J Immunol 187:3751-8. 2011
    ..These results suggested that MASP-3 complexed with MBL is converted to an active form by incubation with bacterial targets, and that activated MASP-3 triggered the initial activation step of the alternative complement pathway...
  14. ncbi The lectin-complement pathway--its role in innate immunity and evolution
    Teizo Fujita
    Department of Biochemistry, Fukushima Medical University, Fukushima, Japan
    Immunol Rev 198:185-202. 2004
    ..Based on these findings, it seems likely that the complement system played a pivotal role in innate immunity before the evolution of an acquired immune system in jawed vertebrates...
  15. ncbi Human M-ficolin is a secretory protein that activates the lectin complement pathway
    Yu Liu
    Department of Immunology, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Japan
    J Immunol 175:3150-6. 2005
    ..These results indicate that M-ficolin, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity...
  16. pmc Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin
    Misao Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Fukushima 960 1295, Japan
    Proc Natl Acad Sci U S A 101:10127-31. 2004
    ....
  17. ncbi Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins
    Yuichi Endo
    Departmant of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Genomics 84:737-44. 2004
    ....
  18. ncbi Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway
    Minoru Takahashi
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan
    J Immunol 180:6132-8. 2008
    ..From these results, we propose that MASP-1 contributes to the activation of the lectin pathway, probably through the activation of MASP-2...
  19. ncbi Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G
    Mikio Kuraya
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int Immunol 15:109-17. 2003
    ..Since the glioma cells used are derived from astrocytes, this suggests that human astrocytes may be a source of some components of the LCP in the brain...
  20. ncbi Molecular cloning and characterization of novel ficolins from Xenopus laevis
    Yuji Kakinuma
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, 960 1295, Fukushima, Japan
    Immunogenetics 55:29-37. 2003
    ..The polymeric form of the two types of XeFCN1 specifically recognized GlcNAc and GalNAc residues. These results suggest that like human L-ficolin, XeFCN1 functions in the circulation through its lectin activity...
  21. ncbi Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation
    Mikio Kuraya
    Department of Biochemistry, School of Medicine, Fukushima Medical University, 1 Hikariga oka, Fukushima 960 1295, Japan
    Immunobiology 209:689-97. 2005
    ..Thus, L-ficolin and H-ficolin as well as MBL participate in the clearance of apoptotic cells through complement activation...
  22. ncbi Role of ficolin in innate immunity and its molecular basis
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Immunobiology 212:371-9. 2007
    ..All these observations suggest that ficolins function in clearance of non-self, based on their location sites and their molecular features...
  23. doi The role of ficolins in the lectin pathway of innate immunity
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int J Biochem Cell Biol 43:705-12. 2011
    ..We also discuss their possible physiological roles in innate immunity, especially their defensive role against bacterial infection...
  24. ncbi Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter
    Yuichi Endo
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int Immunol 14:1193-201. 2002
    ....
  25. pmc L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway
    Youko Aoyagi
    Division of Microbiology, Joshi Eiyoh University, Sakado, Saitama 350 0288, Japan
    Infect Immun 76:179-88. 2008
    ..We concluded that L-ficolin/MASP complexes bind to GBS primarily through an interaction with NeuNAc of CPS...
  26. ncbi Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2
    Sandor Cseh
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel Commissariat à l énergie atomique Centre National de La Recherche Scientifique Université Joseph Fourier, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Immunol 169:5735-43. 2002
    ..Preincubation of the MASPs with soluble MBL inhibited subsequent binding to immobilized L-ficolin/P35 and, conversely, suggesting that these lectins compete with each other for binding to the MASPs in vivo...
  27. ncbi LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system
    Lijuan Zhao
    Departments of Oral Microbiology, Graduate School of Dentistry, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Blood 100:3233-9. 2002
    ..These results suggest that the structure of the O-antigen region is important for the platelet response to LPS, and that activation of the lectin pathway of the complement system is involved in this response...
  28. ncbi Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis
    Satoshi Hisano
    Department of Pathology, Faculty of Medicine, Fukuoka University, Nanakuma, Fukuoka, Japan
    Pathol Int 57:351-7. 2007
    ..To the authors' knowledge this is the first report to show that complement activation through both the alternative and lectin pathways is evident in some patients with PSAGN. Complement activation is promoted in situ in the glomerulus...
  29. pmc Structural insights into the innate immune recognition specificities of L- and H-ficolins
    Virginie Garlatti
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Grenoble, France
    EMBO J 26:623-33. 2007
    ....
  30. ncbi Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Mette Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Int Immunol 19:141-9. 2007
    ....
  31. ncbi The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin
    Lynn A Gregory
    Laboratoire de Cristallographie et Cristallogenese des Proteines, France
    J Biol Chem 279:29391-7. 2004
    ..These mutations map a common binding site for these proteins located at the distal end of each CUB1 module and stabilized by the Ca(2+) ion...
  32. ncbi Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Kyushu University, Hakozaki, Fukuoka, Japan
    J Immunol 177:5471-9. 2006
    ..These results imply that bony fish have developed a diverged set of MBL homologs that function in the lectin complement pathway...
  33. ncbi Role of L-ficolin/mannose-binding lectin-associated serine protease complexes in the opsonophagocytosis of type III group B streptococci
    Youko Aoyagi
    Division of Microbiology, Joshi Eiyoh Kagawa Nutrition University, Sakado, Saitama 350 0288, Japan
    J Immunol 174:418-25. 2005
    ..C3b deposited by this lectin pathway forms alternative pathway C3 convertase C3bBb whose activity is enhanced by CPS-specific IgG2, leading to increased opsonophagocytic killing by further deposition of C3b on the GBS...
  34. ncbi Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2
    Stéphanie Zundel
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, France
    J Immunol 172:4342-50. 2004
    ..Based on these observations, it is postulated that MASP-3 activation and control involve mechanisms that are different from those of MASP-1 and -2...
  35. pmc Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin
    Anders Krarup
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Infect Immun 73:1052-60. 2005
    ..The concentrations of the three proteins in 97 plasma samples were estimated. The median concentrations were 0.8 mug per ml for MBL, 3.3 mug per ml for L-ficolin, and 18.4 mug per ml for H-ficolin...
  36. ncbi L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement
    Nicholas J Lynch
    Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, U K
    J Immunol 172:1198-202. 2004
    ..None of the LTA preparations bound MBL, H-ficolin, or the classical pathway recognition molecule, C1q...
  37. ncbi Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2
    Tina Hummelshoj
    Department of Clinical Immunology, Tissue Typing Laboratory 7631, Rigshospitalet, 2100 Copenhagen, Denmark
    Hum Mol Genet 14:1651-8. 2005
    ....
  38. ncbi Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement
    Young Gerl Ma
    College of Pharmacy, Pusan National University, Jangjeon Dong, Kumjeong Ku, Busan 609 735, Korea
    J Biol Chem 279:25307-12. 2004
    ..These results indicate that human PGN and 1,3-beta-D-glucan recognition proteins function as complement-activating lectins...
  39. pmc Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
    Barbro Selander
    Institute of Laboratory Medicine, Section of Microbiology, Immunology, and Glycobiology, Lund University, Lund, Sweden
    J Clin Invest 116:1425-34. 2006
    ..MBL-dependent C2 bypass activation could be particularly important in various inherited and acquired complement deficiency states...
  40. ncbi Significant elevations in serum mannose-binding lectin levels in patients with chronic renal failure
    Atsushi Satomura
    Division of Nephrology, Internal Medicine II, Nihon University School of Medicine, Tokyo, Japan
    Nephron 92:702-4. 2002
    ....
  41. ncbi Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency
    Anja Roos
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Eur J Immunol 34:2589-98. 2004
    ....
  42. ncbi Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
    Anja Roos
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
    J Am Soc Nephrol 17:1724-34. 2006
    ..Together, these findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease...
  43. doi Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy
    Koh Ichi Yuhki
    Department of Pharmacology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    J Pharmacol Exp Ther 325:601-9. 2008
    ..These results clearly indicate that the PGI(2)-IP system together with the complement system plays a key role in exudate formation in zymosan-induced pleurisy...
  44. ncbi Stat3 is involved in control of MASP2 gene expression
    Claudia Unterberger
    Clinical Cooperation Group Inflammatory Lung Diseases GSF National Research Center for Environment and Health, Asklepios Fachkliniken, Gauting, Germany
    Biochem Biophys Res Commun 364:1022-5. 2007
    ..Supershift analysis revealed Stat3 to be the major specific binding protein. We conclude that Stat3 binding is important for MASP2 promoter activity...
  45. ncbi Serum mannose-binding lectin levels in maintenance hemodialysis patients: impact on all-cause mortality
    Atsushi Satomura
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Nephron Clin Pract 102:c93-9. 2006
    ..However, the prognostic value of the serum MBL level has not been examined. The aim of this study was to evaluate whether the serum MBL level can predict all-cause mortality in hemodialysis (HD) patients...
  46. ncbi Activation of the lectin complement pathway in Henoch-Schönlein purpura nephritis
    Satoshi Hisano
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Am J Kidney Dis 45:295-302. 2005
    ..The current study aims to elucidate the correlation between each complement pathway and clinicopathologic findings in patients with Henoch-Schonlein purpura nephritis (HSPN)...
  47. ncbi The phylogeny of the complement system and the origins of the classical pathway
    Alister W Dodds
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Immunobiology 212:233-43. 2007
    ..The classical pathway can, therefore, be regarded as a specialised arm of the lectin pathway in which the specificity of C1q for carbohydrate has been recruited to recognise the Fc region of immunoglobulin...