Research Topics
Genomes and Genes | Shin ichi KonnoSummaryAffiliation: Fukushima Medical University Country: Japan Publications
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Publications
Development of a clinical diagnosis support tool to identify patients with lumbar spinal stenosisShinichi Konno
Department of Orthopaedic Surgery, Fukuhsima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan
Eur Spine J 16:1951-7. 2007..0% in the top quartile (12 to 16). We developed a simple clinical diagnostic support tool to identify patients with LSS. Further studies are needed to validate this tool in primary care settings...- A diagnostic support tool for lumbar spinal stenosis: a self-administered, self-reported history questionnaireShin ichi Konno
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
BMC Musculoskelet Disord 8:102. 2007..The aim of the present study was to use this tool to assess the diagnostic value of the history of the patient for categorization of LSS... - Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compressionMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295, Japan
Eur Spine J 18:1978-85. 2009..Thus, differences in the time course of mechanical allodynia might be associated with an imbalance in DRG apoptosis... - Vasodilative effects of prostaglandin E1 derivate on arteries of nerve roots in a canine model of a chronically compressed cauda equinaMasayoshi Shirasaka
Department of Pharmacy, Fukushima Medical University Hospital, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
BMC Musculoskelet Disord 9:41. 2008..The aim of this study was to assess whether PGE1 derivate has vasodilatory effects on both arteries and veins in a canine model of chronic cauda equina compression... 
The reactions of glial cells and endoneurial macrophages in the dorsal root ganglion and their contribution to pain-related behavior after application of nucleus pulposus onto the nerve root in ratsKen ichi Otoshi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 35:10-7. 2010..Controlled, interventional, animal study...- Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in ratsSatoshi Hatashita
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 33:1344-51. 2008..The contralateral pain-related behavioral and immunohistochemical changes after hemilateral spinal nerve injury in rats were investigated... - The effects of a 5-HT2A receptor antagonist on blood flow in lumbar disc herniation: application of nucleus pulposus in a canine modelMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295, Japan
Eur Spine J 17:307-13. 2008..5-HTRA might be a potential agent to improve blood flow in the nerve roots of patients with lumbar disc herniation... - Participation of 5-hydroxytryptamine in pain-related behavior induced by nucleus pulposus applied on the nerve root in ratsKinshi Kato
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Japan
Spine (Phila Pa 1976) 33:1330-6. 2008..The role of 5-hydroxytryptamine (5-HT) in sciatica in lumbar disc herniation (LDH) in rats was investigated... - Augmented cerebral activation by lumbar mechanical stimulus in chronic low back pain patients: an FMRI studyYoshitaka Kobayashi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 34:2431-6. 2009..Cerebral activation by lumbar mechanical stimulus was investigated by functional magnetic resonance imaging in healthy subjects and patients with chronic low back pain (LBP)... - An immunohistochemical study of the antinociceptive effect of calcitonin in ovariectomized ratsBunji Takayama
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295, Japan
BMC Musculoskelet Disord 9:164. 2008..The aim of this study to investigate antinociceptive effect of calcitonin in OVX rats using the immunohistochemical study... - The reactions of glial cells and endoneurial macrophages in the dorsal root ganglion and their contribution to pain-related behavior after application of nucleus pulposus onto the nerve root in ratsKen ichi Otoshi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 35:264-71. 2010..Controlled, interventional, animal study... - Interaction of 5-hydroxytryptamine and tumor necrosis factor-α to pain-related behavior by nucleus pulposus applied on the nerve root in ratsHiroshi Kobayashi
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 36:210-8. 2011..The effects of exogenous 5-hydroxytryptamine (5-HT), tumor necrosis factor(TNF)-α, 5-HT + TNF in combination, and autologous nucleus pulposus (NP) at dorsal root ganglion (DRG) were examined using rat models... - Analgesic effects of prostaglandin E2 receptor subtype EP1 receptor antagonist: experimental study of application of nucleus pulposusMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 36:1829-34. 2011..The effect of an EP1 receptor antagonist on pain-related behavior induced by nucleus pulposus (NP) applied to the dorsal root ganglion (DRG) in rats was investigated... - Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation modelMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
BMC Musculoskelet Disord 9:15. 2008..This experimental study was conducted to control for the placebo effect and to study the efficacy of the plaster method in relieving pain by using a rat model of inflammation... - Spinal stenosis: assessment of motor function, VEGF expression and angiogenesis in an experimental model in the ratKazuyuki Watanabe
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, 960 1295, Japan
Eur Spine J 16:1913-8. 2007..05). Vascular density in the cauda equina was not increased at any of the time points examined. Cauda equina compression decreased walking duration, and induced VEGF expression in nerve roots and DRG... 
Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation modelNobuhisa Sasaki
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 35:1663-7. 2010..An experimental animal study...- Correlation between inflammatory cytokines released from the lumbar facet joint tissue and symptoms in degenerative lumbar spinal disordersAkira Igarashi
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
J Orthop Sci 12:154-60. 2007..The purpose of this study was to seek involvement of inflammatory facet joint for radiculopathy in lumbar spinal canal stenosis with clinical and anatomical studies... - Increased intramuscular pressure in lumbar paraspinal muscles and low back pain: model development and expression of substance P in the dorsal root ganglionYoshitaka Kobayashi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 35:1423-8. 2010..The association between intramuscular pressure and low back pain was investigated by measuring intramuscular pressure and blood flow, assessing histologic appearance, and performing immunohistochemical testing in rats... - Complications of endoscopic spinal surgery: a retrospective study of thoracoscopy and retroperitoneoscopyKazuyuki Watanabe
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960 1295, Japan
J Orthop Sci 12:42-8. 2007..Since 1996, we have applied endoscopic techniques to the treatment of various spinal disorders. The purpose of this study was to clarify the complications of endoscopic spinal surgery using thoracoscopy and retroperitoneoscopy... - Etanercept attenuates pain-related behavior following compression of the dorsal root ganglion in the ratKazuyuki Watanabe
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
Eur Spine J 20:1877-84. 2011..Much basic research suggests that anti-TNFα therapy may be useful for the treatment of sciatica. The purpose of this study was to clarify the effects of etanercept in a dorsal root ganglion (DRG) compression model... - Anti-HMGB1 neutralization antibody improves pain-related behavior induced by application of autologous nucleus pulposus onto nerve roots in ratsKen ichi Otoshi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 36:E692-8. 2011..Controlled, interventional, animal study... - A validation study of the Brief Scale for Psychiatric problems in Orthopaedic Patients (BS-POP) for patients with chronic low back pain (verification of reliability, validity, and reproducibility)Katshuhiro Yoshida
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960 1295, Japan
J Orthop Sci 16:7-13. 2011..The present study aimed to proactively verify the factorial validity, internal consistency, criterion-related validity and reproducibility of the BS-POP with regard to chronic low back pain patients... - Sympathectomy reduces mechanical allodynia, tumor necrosis factor-alpha expression, and dorsal root ganglion apoptosis following nerve root crush injuryMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Japan
Spine (Phila Pa 1976) 33:1163-9. 2008..An analysis of pain behavior and neuronal apoptosis in the dorsal root ganglion (DRG) following crush injury to the L5 nerve root, with or without surgical sympathectomy... - Localization and function of insulin-like growth factor 1 in dorsal root ganglia in a rat disc herniation modelBunji Takayama
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 36:E75-9. 2011..we investigated the localization of insulin-like growth factor 1 (IGF-1) using immunohistochemistry and the effects of small interfering RNA (siRNA) on IGF-1 in dorsal root ganglions (DRG) in a rat lumbar disc herniation (LDH) model... - The effect of repeated restraint stress in pain-related behavior induced by nucleus pulposus applied on the nerve root in ratsKazuhide Uesugi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
Eur Spine J 20:1885-91. 2011..The aim of this study was to investigate the effect of the restraint stress (RS) on pain-related behavior induced by application of nucleus pulposus (NP) in rats... - A comparison of pain-related behavior following local application of nucleus pulposus and/or mechanical compression on the dorsal root ganglionNobuhisa Sasaki
Department of Orthopedic Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan
Fukushima J Med Sci 57:46-53. 2011..In the antibody group, the threshold was significantly higher than that of the untreated group. An anti-TNF-α antibody reduced allodynia caused by DRG compression... - Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administrationNobuhisa Sasaki
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 32:413-6. 2007..An experimental animal study... - Increase of 200-kDa neurofilament-immunoreactive afferents in the substantia gelatinosa in allodynic rats induced by compression of the dorsal root ganglionKazuyuki Watanabe
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 32:1265-71. 2007..An experimental study on mechanical allodynia, c-Fos expression, and 200-kDa-neurofilament immunoreactive (IR) afferent expression in the substantia gelatinosa related to compression of dorsal root ganglion (DRG)... - Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation?Hisayoshi Tachihara
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 33:743-7. 2008..Experimental animal study... - Effects of asialo-erythropoietin on pain-related behavior and expression of phosphorylated-p38 map kinase and tumor necrosis factor-alpha induced by application of autologous nucleus pulposus on nerve root in ratNobuyuki Sasaki
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Japan
Spine (Phila Pa 1976) 36:E86-94. 2011..this study was designed to examine the neuroprotective effects of asialo-erythropoietin (A-EPO) in a rat model of lumbar disc herniation... - The effects of cilostazol on nerve conduction velocity and blood flow: acute and chronic cauda equina compression in a canine modelMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 33:2605-11. 2008..Analyses of improvements in nerve conduction velocity (NCV) and blood flow after administering cilostazol in a dog model of experimental acute and chronic cauda equina compression... - Development of a self-administered questionnaire to screen patients for cervical myelopathyHiroshi Kobayashi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
BMC Musculoskelet Disord 11:268. 2010..As there is presently no screening tool for cervical myelopathy, the aim of this study was to develop a self-administered questionnaire for the screening of cervical myelopathy... - Does facet joint inflammation induce radiculopathy?: an investigation using a rat model of lumbar facet joint inflammationHisayoshi Tachihara
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 32:406-12. 2007..The association between lumbar facet joint inflammation and radiculopathy was investigated using behavioral, histologic, and immunohistochemical testing in rats... - Involvement of EphB1 receptor/EphrinB2 ligand in neuropathic painHideo Kobayashi
Department of Orthopaedic Surgery and Biomolecular Science, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 32:1592-8. 2007..We investigated involvement of EphB/ephrinB system in neuropathic pain... - Locomotor dysfunction and risk of cardiovascular disease, quality of life, and medical costs: design of the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) and baseline characteristics of the study populationKoji Otani
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
J Orthop Sci 17:261-71. 2012..The present study determined baseline characteristics of participants in the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS)... - Surgical treatment assessment using the Japanese orthopedic association cervical myelopathy evaluation questionnaire in patients with cervical myelopathy: a new outcome measure for cervical myelopathyTakuya Nikaido
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Spine (Phila Pa 1976) 34:2568-72. 2009..Prospective study of assessment of surgical results using a new outcome measure for cervical myelopathy, the Japanese Orthopedic Association cervical myelopathy evaluation questionnaire (JOACMEQ)... - Local application of nucleus pulposus induces expression OF P2X3 in rat dorsal root ganglion cellsKaoru Takahashi Sato
Department of Anesthesiology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, Japan
Fukushima J Med Sci 58:17-21. 2012..This may increase our understanding of the pathophysiologic mechanisms related to disc herniation and sciatica... - Necessity of rib head resection for anterior discectomy in the thoracic spineTakatomo Moro
Department of Orthopaedic Surgery, Fukushima Medical University, School of Medicine, Fukushima City, Japan
Spine (Phila Pa 1976) 29:1703-5. 2004..The relation between the rib head and the thoracic disc was investigated anatomically... - Correlation of low back pain with functional status, general health perception, social participation, subjective happiness, and patient satisfactionYoshiaki Takeyachi
Department of Orthopaedic Surgery, Fukushima Medical University, School of Medicine, Fukushima City, Japan
Spine (Phila Pa 1976) 28:1461-6; discussion 1467. 2003..A cross-sectional and epidemiologic study investigated low back pain... - Lumbar spinal stenosis associated with peripheral arterial disease: a prospective multicenter observational studyKazuhide Uesugi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
J Orthop Sci 17:673-81. 2012..The aim of this study was to investigate the prevalence and clinical characteristics of LSS associated with PAD... - The process of tendon regeneration in an achilles tendon resection rat model as a model for hamstring regeneration after harvesting for anterior cruciate ligament reconstructionKen ichi Otoshi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Japan
Arthroscopy 27:218-27. 2011..The purpose of this study was to clarify the mechanism of tendon regeneration by investigating macroscopically, histologically, and biomechanically... - Effects on improvement of blood flow in the chronically compressed cauda equina: comparison between a selective prostaglandin E receptor (EP4) agonist and a prostaglandin E1 derivateMiho Sekiguchi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Spine (Phila Pa 1976) 31:869-72. 2006..Vasodilatation was studied in a model of experimental chronic cauda equina compression using measurements of vessel diameter on video recordings... - Insertion of lateral mass screw of the atlas via the posterior arch: anatomical study of screw insertion using dry bone samples of the atlas from Japanese cadaversYoshitaka Kobayashi
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, 960 1295, Japan
J Orthop Sci 13:452-5. 2008..Because the posterior arch is thin, lateral mass screws risk penetrating the upper part of the posterior arch and damaging the vertebral artery running along the upper part of the posterior arch... - Short-term results of endoscopic (Okutsu method) versus palmar incision open carpal tunnel release: a prospective randomized controlled trialSoichi Ejiri
Department of Orthopedic Surgery, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, Japan
Fukushima J Med Sci 58:49-59. 2012..However, no prospective randomized controlled trials (RCTs) have compared treatment outcomes between these two procedures. This RCT compared short-term outcomes between ECTR and OCTR for CTS... - An anatomic study of the lumbar plexus with respect to retroperitoneal endoscopic surgeryTakatomo Moro
Department of Orthopaedic Surgery, Fukushima Medical University, School of Medicine, Fukushima City, Japan
Spine (Phila Pa 1976) 28:423-8; discussion 427-8. 2003..The distribution of the lumbar plexus was analyzed using cadavers... - Ifosfamide encephalopathy associated with chemotherapy for musculoskeletal sarcomas: incidence, severity, and risk factorsTakahiro Tajino
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
J Orthop Sci 15:104-11. 2010..Although it has been reported in European and American patients with various carcinomas, there have been no published reports regarding ifosfamide encephalopathy in Asian patients with bone and soft tissue sarcomas... - Effect of methotrexate on fracture healingKoichiro Satoh
Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
Fukushima J Med Sci 57:11-8. 2011..Although more macrophages were found in the groups treated with MTX, their impact on surrounding inflammatory processes remains unclear...