B Zhang

Summary

Affiliation: Fukuoka University
Country: Japan

Publications

  1. pmc A human Dravet syndrome model from patient induced pluripotent stem cells
    Norimichi Higurashi
    Department of Pediatrics, School of Medicine, Fukuoka University, 45 1, 7 chome, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Mol Brain 6:19. 2013
  2. ncbi request reprint Reactivity of direct assays for low-density lipoprotein (LDL) cholesterol toward charge-modified LDL in hypercholesterolemia
    Bo Zhang
    Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka, Japan
    Circ J 76:2241-8. 2012
  3. ncbi request reprint Simple and rapid detection of uncoupling protein-2 - 866G/A polymorphism by mutagenically separated polymerase chain reaction
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan, Fukuoka 814 0180, Japan
    Clin Chim Acta 344:205-10. 2004
  4. ncbi request reprint Control of matrix effects in the analysis of urinary F2-isoprostanes using novel multidimensional solid-phase extraction and LC-MS/MS
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    J Lipid Res 48:733-44. 2007
  5. ncbi request reprint Inhibition of cholesteryl ester transfer protein activity by JTT-705 increases apolipoprotein E-containing high-density lipoprotein and favorably affects the function and enzyme composition of high-density lipoprotein in rabbits
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Arterioscler Thromb Vasc Biol 24:1910-5. 2004
  6. ncbi request reprint Paraoxonase (Pon1) Q192R polymorphism and serum Pon1 activity in diabetic patients on maintenance hemodialysis
    B Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka University, Fukuoka, Japan
    Clin Nephrol 60:257-65. 2003
  7. doi request reprint Reduction of charge-modified LDL by statin therapy in patients with CHD or CHD risk factors and elevated LDL-C levels: the SPECIAL Study
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Atherosclerosis 201:353-9. 2008
  8. ncbi request reprint Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    J Am Coll Cardiol 34:1443-51. 1999
  9. ncbi request reprint Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Am J Hypertens 10:1027-33. 1997
  10. ncbi request reprint The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle
    B Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Clin Genet 63:139-44. 2003

Collaborators

Detail Information

Publications95

  1. pmc A human Dravet syndrome model from patient induced pluripotent stem cells
    Norimichi Higurashi
    Department of Pediatrics, School of Medicine, Fukuoka University, 45 1, 7 chome, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Mol Brain 6:19. 2013
    ..However, no such effort has been reported to date. We here report a cellular model for DS that utilizes patient-derived iPSCs...
  2. ncbi request reprint Reactivity of direct assays for low-density lipoprotein (LDL) cholesterol toward charge-modified LDL in hypercholesterolemia
    Bo Zhang
    Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka, Japan
    Circ J 76:2241-8. 2012
    ....
  3. ncbi request reprint Simple and rapid detection of uncoupling protein-2 - 866G/A polymorphism by mutagenically separated polymerase chain reaction
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan, Fukuoka 814 0180, Japan
    Clin Chim Acta 344:205-10. 2004
    ..A common G/A polymorphism in the UCP2 promoter region is associated with enhanced adipose tissue mRNA expression in vivo...
  4. ncbi request reprint Control of matrix effects in the analysis of urinary F2-isoprostanes using novel multidimensional solid-phase extraction and LC-MS/MS
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    J Lipid Res 48:733-44. 2007
    ..These findings should be useful for establishing a routine LC-MS/MS method for the analysis of F(2)-iPs...
  5. ncbi request reprint Inhibition of cholesteryl ester transfer protein activity by JTT-705 increases apolipoprotein E-containing high-density lipoprotein and favorably affects the function and enzyme composition of high-density lipoprotein in rabbits
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Arterioscler Thromb Vasc Biol 24:1910-5. 2004
    ..We investigated the effects of the inhibition of CETP activity by a CETP inhibitor, JTT-705, on the function and composition of HDL particles...
  6. ncbi request reprint Paraoxonase (Pon1) Q192R polymorphism and serum Pon1 activity in diabetic patients on maintenance hemodialysis
    B Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka University, Fukuoka, Japan
    Clin Nephrol 60:257-65. 2003
    ..In conclusion, Pon1 status and HDL levels are independently associated with DM in patients on hemodialysis and may contribute to the increased risk of CHD in diabetic nephropathy...
  7. doi request reprint Reduction of charge-modified LDL by statin therapy in patients with CHD or CHD risk factors and elevated LDL-C levels: the SPECIAL Study
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Atherosclerosis 201:353-9. 2008
    ..Charge-modified LDL subfraction could be a potential marker for atherosclerosis and a target for therapy...
  8. ncbi request reprint Hyperinsulinemic hypoalphalipoproteinemia as a new indicator for coronary heart disease
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    J Am Coll Cardiol 34:1443-51. 1999
    ....
  9. ncbi request reprint Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Am J Hypertens 10:1027-33. 1997
    ..Due to its dual effects on insulin resistance and hypertension, troglitazone offers a new pharmacological approach for the treatment of insulin-resistance syndrome...
  10. ncbi request reprint The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle
    B Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Clin Genet 63:139-44. 2003
    ..In conclusion, the ACE-I allele was associated with increased type I SMF, which may be a mechanism for the association between the ACE genotype and endurance performance...
  11. ncbi request reprint Effects of high-dose troglitaz one on insulin sensitivity and beta-cell function in Watanabe heritable hyperlipidemic rabbits
    B Zhang
    Department of Internal Medicine, Fukuoka University, Japan
    Eur J Drug Metab Pharmacokinet 26:185-92. 2001
    ..CONCLUSION: In WHHL rabbits, troglitazone dose-dependently reduced hyperinsulinemia, improved beta-cell function, and increased insulin sensitivity...
  12. ncbi request reprint Quantity and function of high density lipoprotein as an indicator of coronary atherosclerosis
    K Saku
    Department of Internal Medicine and Pathology, Fukuoka University School of Medicine, Japan
    J Am Coll Cardiol 33:436-43. 1999
    ....
  13. ncbi request reprint Associations among serum lipoprotein(a) levels, apolipoprotein(a) phenotypes, and myocardial infarction in patients with extremely low and high levels of serum lipoprotein(a)
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Jpn Circ J 63:659-65. 1999
    ..A stepwise logistic regression analysis with and without Lp(a) in the model identified Lp(a) and the apo(a) phenotype as significant predictors for MI, respectively...
  14. ncbi request reprint The associations among thoracic aortic atherosclerosis, coronary atherosclerosis and the function of high density lipoprotein
    M Takao
    Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma Jonan-ku, 814-0180, Fukuoka, Japan
    Atherosclerosis 159:407-16. 2001
    ..The function of HDL, as assessed by FER(HDL), enhances the ability of TAA to predict CAD...
  15. ncbi request reprint Angiotensin II type-1 receptor antagonist, CS-866, reduces blood pressure without affecting glucose/insulin metabolism in cholesterol-fed rabbits
    B Zhang
    Department of Internal Medicine, Fukuoka University, Japan
    Br J Biomed Sci 58:217-25. 2001
    ..In conclusion, CS-866 treatment reduced systolic BP without affecting glucose/insulin metabolism under hyperlipidaemic conditions produced by cholesterol feeding...
  16. ncbi request reprint Levels of soluble cell adhesion molecules in patients with angiographically defined coronary atherosclerosis
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Jpn Circ J 63:19-24. 1999
    ..In conclusion, serum levels of soluble VCAM-1, ICAM-1, and P-selectin were not related to CHD or the extent of coronary atherosclerosis, but were inversely related to serum levels of high-density lipoprotein-related lipoproteins...
  17. ncbi request reprint In vivo kinetics of human apolipoprotein A-I variants in rabbits
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Eur J Clin Invest 29:196-203. 1999
    ..In this study, we investigated the in vivo kinetics of several human apo A-I variants, which we had identified previously, in rabbits...
  18. ncbi request reprint Inhibition of cholesteryl ester transfer protein increases serum apolipoprotein (apo) A-I levels by increasing the synthesis of apo A-I in rabbits
    Eiso Shimoji
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Atherosclerosis 172:247-57. 2004
    ..The effects of a CETP inhibitor, JTT-705, on the in vivo kinetics of apolipoprotein (apo) A-I and apo A-I gene expression in the liver and intestine were investigated...
  19. ncbi request reprint Hybrid therapy with pilsicainide and pulmonary vein isolation for atrial fibrillation
    Hideaki Tojo
    Department of Cardiology, Fukuoka University Hospital, Japan
    Circ J 69:1503-7. 2005
    ..Therefore, the effects and mechanisms of hybrid therapy with pilsicainide and PV isolation for AF were assessed in the present study...
  20. ncbi request reprint Association of angiotensin-converting-enzyme gene polymorphism with the depressor response to mild exercise therapy in patients with mild to moderate essential hypertension
    B Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Clin Genet 62:328-33. 2002
    ....
  21. ncbi request reprint Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with angina pectoris
    T Takezako
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Am J Hypertens 12:291-7. 1999
    ....
  22. ncbi request reprint Relation between charge-based apolipoprotein B-containing lipoprotein subfractions and remnant-like particle cholesterol levels
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Atherosclerosis 191:153-61. 2007
    ..We examined the relation between the RLP-cholesterol (C) level and charge-based apolipoprotein (apo) B-containing lipoprotein subfractions as determined by capillary isotachophoresis (cITP) in patients with hypercholesterolemia...
  23. pmc Effects of rosuvastatin on electronegative LDL as characterized by capillary isotachophoresis: the ROSARY Study
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    J Lipid Res 50:1832-41. 2009
    ..In conclusion, rosuvastatin effectively reduced both the vfLDL subfraction and sd-cm-LDL subfractions as analyzed by cITP...
  24. ncbi request reprint The D allele of the angiotensin-converting enzyme gene and reperfusion-induced ventricular arrhythmias in patients with acute myocardial infarction
    T Takezako
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Jpn Circ J 65:603-9. 2001
    ..The ACE-D allele may play a pivotal role in sudden cardiac death in patients with AMI...
  25. ncbi request reprint Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Atherosclerosis 178:199-205. 2005
    ..We examined the relationship of lipoprotein-associated S1P concentrations with cholesterol (C) and apolipoprotein (apo) contents of lipoprotein and lipoprotein subfractions characterized by capillary isotachophoresis (cITP)...
  26. ncbi request reprint Effects of atorvastatin and apoA-I/phosphatidylcholine discs on triglyceride-rich lipoprotein subfractions as characterized by capillary isotachophoresis
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Clin Chim Acta 373:55-61. 2006
    ....
  27. ncbi request reprint Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Atherosclerosis 186:291-301. 2006
    ..However, it has been reported to be a risk factor for coronary heart disease. The present study examined the effects of cholesterol feeding and simvastatin treatment on plasma PAF-AH activity...
  28. ncbi request reprint New approach to pulmonary vein isolation for atrial fibrillation using a multielectrode basket catheter
    Koichiro Kumagai
    Department of Cardiology, Fukuoka University Hospital, Japan
    Circ J 70:88-93. 2006
    ..A new approach to PV isolation during distal PV pacing is to use a basket catheter...
  29. ncbi request reprint Comparison of 2 mapping strategies for pulmonary vein isolation
    Koichiro Kumagai
    Department of Cardiology, Fukuoka University Hospital, Japan
    Circ J 69:1496-502. 2005
    ..We describe a new approach for PV isolation during distal PV pacing using a basket catheter (BC). The purpose of the present study was to compare 2 mapping strategies for PV isolation...
  30. ncbi request reprint Effects of the NA+ channel blocker pilsicainide on the electrophysiologic properties of pulmonary veins in patients with atrial fibrillation
    Koichiro Kumagai
    Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    J Cardiovasc Electrophysiol 15:1396-401. 2004
    ..The aim of the present study was to evaluate the effect of the pure Na+ channel blocker pilsicainide on the PVs...
  31. ncbi request reprint Effects of reconstituted HDL on charge-based LDL subfractions as characterized by capillary isotachophoresis
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    J Lipid Res 48:1175-89. 2007
    ..040-1.063 g/ml) and increased the size of LDL. ApoA-I/POPC discs reduced charge-modified LDL in human plasma by remodeling cITP fLDL into sLDL subfractions...
  32. doi request reprint Impact of angulated lesions on angiographic late loss in patients with drug-eluting stent implantation
    Yusuke Fukuda
    Department of Cardiology, Fukuoka University Hospital, Jonan ku, Fukuoka, Japan
    J Cardiol 53:396-401. 2009
    ..6% in bending lesions and 17.8% in non-bending lesions (p=NS). Lesion bending is not associated with long-term angiographic late loss after DES implantation. DES may reduce clinical events in patients with bending lesion...
  33. ncbi request reprint Pravastatin promotes coronary collateral circulation in patients with coronary artery disease
    Hiroaki Nishikawa
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Coron Artery Dis 13:377-81. 2002
    ....
  34. ncbi request reprint POPC/apoA-I discs as a potent lipoprotein modulator in Tangier disease
    Yoshinari Uehara
    Department of Neurology and Healthcare, Fukuoka University Hospital, 7 45 1 Nanakuma, Jonan ku, 814 0180 Fukuoka, Japan
    Atherosclerosis 197:283-9. 2008
    ..In conclusion, POPC/apoA-I discs not only have beneficial effects on cholesterol efflux, but also have potential as a lipoprotein modulator in patients with TD...
  35. ncbi request reprint Changes in lipid metabolism in postmenopausal Japanese women using hormone therapy evaluated by capillary isotachophoresis: a pilot study
    Yoshihito Inoue
    Department of Obstetrics and Gynecology, Fukuoka University School of Medicine, Fukuoka, Japan
    Menopause 15:157-63. 2008
    ..The aim of this study was to clarify the changes in lipid metabolism in postmenopausal Japanese women during continuous combined hormone therapy (HT) in detail by using capillary isotachophoresis (cITP)...
  36. ncbi request reprint Statins induce the regression of left ventricular mass in patients with angina
    Hiroaki Nishikawa
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 68:121-5. 2004
    ..Conclusions Treatment with statins was associated with a lower cardiac mass in patients with angina, suggesting that this is one of the drugs' pleiotropic effects...
  37. ncbi request reprint Strong linkage disequilibrium and association of -1131T>C and c.553G>T polymorphisms of the apolipoprotein A5 gene with hypertriglyceridemia in a Japanese population
    Akira Matsunaga
    Department of Cardiology, Fukuoka University School of Medicine, Johnan ku, Fukuoka, Japan
    Circ J 71:746-52. 2007
    ..In the present study the relationships of 5 single nucleotide polymorphisms, including the -1131T>C, c.56C>G, IVS3+476G>A, c.553G>T, and c.1259T>C polymorphisms of ApoA5, with HTG were investigated...
  38. ncbi request reprint Angiotensin-converting enzyme inhibitor promotes coronary collateral circulation in patients with coronary artery disease
    Shin Ichiro Miura
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 67:535-8. 2003
    ..Therefore, treatment with ACEI was associated with the development of collateral circulation in patients with CAD, suggesting that such an action is associated with bradykinin production by ACEI...
  39. ncbi request reprint Possible induction of renal dysfunction in patients with lecithin:cholesterol acyltransferase deficiency by oxidized phosphatidylcholine in glomeruli
    S Jimi
    Departments of Pathology and Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 19:794-801. 1999
    ..In conclusion, these results indicate that oxPC in plasma and glomeruli is distinctive for patients with LCAT deficiency. Therefore, oxPC may be a factor in the deterioration of kidneys in patients with familial LCAT deficiency...
  40. ncbi request reprint ApoA-I/phosphatidylcholine discs remodels fast-migrating HDL into slow-migrating HDL as characterized by capillary isotachophoresis
    Bo Zhang
    Departments of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Atherosclerosis 188:95-101. 2006
    ..We used this technique to examine the mechanism by which apoA-I/phosphatidylcholine (POPC) discs increase pre-beta HDL...
  41. doi request reprint Pharmacological intervention using reconstituted high-density lipoprotein changes in the lipid profile in spontaneously hypersensitive rats
    Satoshi Imaizumi
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    Clin Exp Hypertens 32:202-8. 2010
    ..In conclusion, chronic administration of rHDL decreased iHDL. Further investigations are needed to understand the mechanisms by which rHDL affects lipid profiles and its relation to clinical outcomes...
  42. ncbi request reprint Angiotensin II type 1 receptor blockers do not promote coronary collateral circulation in patients with coronary artery disease
    Satoshi Imaizumi
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Hypertens Res 29:135-41. 2006
    ..These results suggest that treatment with an ACE-I, but not treatment with an ARB, was associated with the enhancement of collateral circulation in patients with CAD...
  43. ncbi request reprint Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men
    Shoudai Furuyama
    Department of Cardiology, Fukuoka University Faculty of Medicine, Fukuoka 814 0180, Japan
    J Atheroscler Thromb 16:194-200. 2009
    ..Moreover, HDL-mediated cholesterol efflux is increased in cultured ABCG1 overexpressed cells; however, the physiological roles of ABCG1 and its contribution to atherosclerosis in humans remain unclear...
  44. ncbi request reprint Ratio of LDL- to HDL-associated platelet-activating factor acetylhydrolase may be a marker of inflammation in patients with paroxysmal atrial fibrillation
    Keisuke Okamura
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 71:214-9. 2007
    ..In addition, low-density lipoprotein (LDL)-associated platelet-activating factor acetylhydrolase (L-PAF-AH) is associated with inflammation. Therefore, the association between AF and PAF-AH was examined...
  45. ncbi request reprint Clinical significance of the coronary calcification score by multidetector row computed tomography for the evaluation of coronary stenosis in Japanese patients
    Ryoko Mitsutake
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 70:1122-7. 2006
    ..To evaluate the clinical significance of the CAC score, coronary artery stenosis as assessed by coronary angiography (CAG) was compared with the CAC score determined by MDCT, risk factors and medications...
  46. ncbi request reprint Relation between insulin resistance and fast-migrating LDL subfraction as characterized by capillary isotachophoresis
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan bozhang fukuoka u ac jp
    J Lipid Res 46:2265-77. 2005
    ..cITP lipoprotein analysis is an accurate and sensitive method for quantifying charge-based LDL subfractions in human plasma, and insulin resistance is related to cITP fLDL independent of LDL size...
  47. ncbi request reprint Effect of levothyroxine on total lipid profiles as assessed by analytical capillary isotachophoresis in a patient with hypothyroidism
    Yoshihiro Kiya
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Endocr J 53:865-8. 2006
    ..The cITP analysis was able to obtain more information about coronary risk factors and may be clinically useful for evaluating the effect of treatment with levothyroxine in patients with hypothyroidism and secondary hyperlipidemia...
  48. doi request reprint Association between the angiotensin I-converting enzyme gene insertion/deletion polymorphism and endurance running speed in Japanese runners
    Takuro Tobina
    Graduate School of Sports and Health Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 810 0180, Japan
    J Physiol Sci 60:325-30. 2010
    ..There were no I/I genotypes among the five fastest marathon runners. These results suggest that the D allele of the ACE gene I/D polymorphism is associated with a high level of human endurance...
  49. ncbi request reprint Influence of age and hypertension on the association between small artery compliance and coronary artery disease
    Kazuma Takeuchi
    Departments of Cardiology, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    Am J Hypertens 17:1188-91. 2004
    ..05) after considering conventional risk factors of CAD. In conclusion, age and HT should be considered when using SAEI in the early diagnosis of CAD, and lower SAEI could be of greatest diagnostic value in male patients with HT...
  50. ncbi request reprint Combined treatment with statin and angiotensin-receptor blocker after stenting as a useful strategy for prevention of coronary restenosis
    Hiroaki Nishikawa
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka
    J Cardiol 45:107-13. 2005
    ..The present case-control study investigated the efficacy of combined treatment with statin and ARB for preventing restenosis in patients with coronary artery disease...
  51. ncbi request reprint Evaluation of apolipoprotein A-I kinetics in rabbits in vivo using in situ and exogenous radioiodination methods
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    Lipids 38:209-18. 2003
    ....
  52. ncbi request reprint Serum high-density lipoprotein-cholesterol levels modify the association between plasma levels of oxidatively modified low-density lipoprotein and coronary artery disease in men
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Metabolism 53:423-9. 2004
    ..HDL-C levels interact with the association between plasma Ox-LDL levels and CAD in men, and increased Ox-LDL levels are an indicator of CAD in male subjects with high HDL-C levels...
  53. ncbi request reprint Significance of urinary liver-fatty acid-binding protein in cardiac catheterization in patients with coronary artery disease
    Yusuke Fukuda
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka
    Intern Med 48:1731-7. 2009
    ..Urinary and serum parameters were measured immediately before and after and 1 day after PCI...
  54. ncbi request reprint Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells
    Ping Fan
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Circ J 68:1061-6. 2004
    ....
  55. ncbi request reprint Do valsartan and losartan have the same effects in the treatment of coronary artery disease?
    Atsushi Iwata
    Department of Cardiology, Fukuoka University School of Medicine
    Circ J 71:32-8. 2007
    ..Many angiotensin II type 1 receptor blockers (ARBs) are available for clinical use, but because they do not all have the same effects, the present study investigated whether all benefits conferred by ARBs are class effects...
  56. ncbi request reprint A comparative crossover study of the effects of fluvastatin and pravastatin (FP-COS) on circulating autoantibodies to oxidized LDL in patients with hypercholesterolemia
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    J Atheroscler Thromb 12:41-7. 2005
    ..Fluvastatin lowered circulating levels of OxLDL-Ab, and these effects continued after switching to pravastatin...
  57. doi request reprint HDL-associated factors provide additional prognostic information for coronary artery disease as determined by multi-detector row computed tomography
    Ryoko Mitsutake
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Int J Cardiol 143:72-8. 2010
    ..We tested the hypothesis that the severity of CAD as determined by a non-invasive method, multi-detector row computed tomography (MDCT), is also associated with lipidemic factors...
  58. ncbi request reprint Association between fast-migrating low-density lipoprotein subfraction as characterized by capillary isotachophoresis and intima-media thickness of carotid artery
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Atherosclerosis 187:205-12. 2006
    ..The present study examined the association between the level of fast (f)-migrating LDL subfraction characterized by capillary isotachophoresis (cITP) and carotid-artery intima-media thickness (CA-IMT)...
  59. ncbi request reprint Potent capillary isotachophoresis (cITP) for analyzing a marker of coronary heart disease risk and electronegative low-density lipoprotein (LDL) in small dense LDL fraction
    Keita Noda
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 69:1568-70. 2005
    ..The potency and usefulness of capillary isotachophoresis (cITP) for assessing whole-serum lipoprotein profiles and quantifying electronegative low-density lipoprotein (LDL) has been previously reported...
  60. doi request reprint Results of provisional stenting with a Sirolimus-eluting stent for bifurcation lesion: multicenter study in Japan
    Daizaburo Yanagi
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    J Cardiol 51:89-94. 2008
    ..Treatment of bifurcation lesion with a drug-eluting stent (DES) remains problematic. The purpose of this study was to investigate an appropriate treatment strategy for bifurcation lesion with a Sirolimus-eluting stent (SES)...
  61. ncbi request reprint Cardiovascular risk factor profiles and endothelial function in coronary artery disease patients treated with statins
    Yoshifumi Okura
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Hypertens Res 27:723-9. 2004
    ..In conclusion, even after cholesterol-lowering treatment, male patients with myocardial infarction still had endothelial dysfunction, and higher levels of lipoprotein (a) may be associated with endothelial dysfunction in such patients...
  62. doi request reprint Positive association between benign familial infantile convulsions and LGI4
    Atsushi Ishii
    Department of Pediatrics, School of Medicine, Fukuoka University, Jonanku, Fukuoka, Japan
    Brain Dev 32:538-43. 2010
    ..LGI4 belongs to a family of proteins with the epilepsy-associated repeat (EAR) domain and is associated with various epilepsies. We investigated whether LGI4 is a candidate gene for BFIC...
  63. ncbi request reprint Measurement of atherosclerotic plaque volume in hyperlipidemic rabbit aorta by intravascular ultrasound
    Atsushi Iwata
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka
    J Cardiol 50:229-34. 2007
    ....
  64. ncbi request reprint Multivariate analysis of the prognostic determinants of the depressor response to exercise therapy in patients with essential hypertension
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 67:579-84. 2003
    ....
  65. ncbi request reprint Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis
    Akira Kawamura
    Department of Cardiology, Fukuoka University School of Medicine, Japan
    Circ J 68:6-10. 2004
    ..The levels of expression of leukocyte adhesion molecules were evaluated in patients with CAD or HD...
  66. doi request reprint Intensive LOwering of BlOod pressure and low-density lipoprotein ChOlesterol with statin theraPy (LOBOCOP) may improve neointimal formation after coronary stenting in patients with coronary artery disease
    Yosuke Takamiya
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Coron Artery Dis 20:288-94. 2009
    ....
  67. ncbi request reprint Histochemical characteristics of soleus muscle in angiotensin-converting enzyme gene knockout mice
    Bo Zhang
    Department of Cardiology, School of Medicine, Faculty of Science, Fukuoka University, Fukuoka, Japan
    Hypertens Res 28:681-8. 2005
    ..This finding suggests a possible mechanism for the cardioprotective effects of ACE inhibitors...
  68. doi request reprint Antiarrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats
    Satoshi Imaizumi
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    J Am Coll Cardiol 51:1604-12. 2008
    ..This study analyzed the antiarrhythmogenic effect of reconstituted high-density lipoprotein (rHDL) against ischemia/reperfusion in vivo...
  69. ncbi request reprint Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1
    Hiroyuki Tanigawa
    Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    Atherosclerosis 188:245-50. 2006
    ..Since most previous reports have provided data only using extensively Ox-LDL, a re-evaluation is needed to analyze several signals that use LDL which has been oxidized to various degrees...
  70. ncbi request reprint Clinicopathological and genetic characteristics in Chinese patients with lipoprotein glomerulopathy
    Bo Zhang
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002 corrected China corrected
    J Nephrol 21:110-7. 2008
    ..In this study, we report on 16 Chinese patients with biopsy-proven lipoprotein glomerulopathy (LPG) investigated for clinical manifestations, pathological characteristics and apolipoprotein E (apoE) genetic analysis...
  71. ncbi request reprint Plasma level and genetic variation of apolipoprotein E in patients with lipoprotein glomerulopathy
    Bo Zhang
    Research Institute of Nephrology, Jingling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Chin Med J (Engl) 118:555-60. 2005
    ..In this study, 15 Chinese patients with LPG were involed in exploring the association of the genetic variation and its plasma level in the pathogenesis of LPG...
  72. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  73. ncbi request reprint [Effects of Smac gene overexpression on chemotherapeutic sensitivity of gastric cancer cell line MKN-45]
    Li Duan Zheng
    Department of Pathology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, PR China
    Ai Zheng 23:361-6. 2004
    ..This study was designed to explore the effects of overexpressed Smac gene on chemotherapeutic sensitivity of gastric cancer cell line...
  74. ncbi request reprint A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy
    Masahiro Hagiwara
    Department of Nephrology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    Nephrol Dial Transplant 23:381-4. 2008
  75. pmc A second generation human haplotype map of over 3.1 million SNPs
    Kelly A Frazer
    The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
    Nature 449:851-61. 2007
    ..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
  76. ncbi request reprint Associations among plasma lipoprotein subfractions as characterized by analytical capillary isotachophoresis, apolipoprotein E phenotype, Alzheimer disease, and mild cognitive impairment
    Bo Zhang
    Arterioscler Thromb Vasc Biol 24:e144-6. 2004
  77. ncbi request reprint [Typing for HLA-DR DNA by polymerase chain reaction with sequence-specific primers]
    Guo jun Wu
    Department of Urology Surgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 19:560-2. 2003
    ..To type the HLA-DR DNA for renal transplantation by PCR with sequence specific primers (PCR-SSP)...
  78. pmc Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis
    Dieter Egli
    Institut für Molekularbiologie and Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    EMBO J 22:100-8. 2003
    ..These findings expand the roles of MTF-1 in the control of heavy metal homeostasis...
  79. ncbi request reprint Effect of atorvastatin on total lipid profiles assessed by analytical capillary isotachophoresis
    Bo Zhang
    Cardiology 99:211-3. 2003
  80. ncbi request reprint Immunohistochemical and genetic analysis of Chinese nasal natural killer/T-cell lymphomas
    Ting Li
    Department of Pathology, The First Hospital of Peking University, Beijing 100034, China
    Hum Pathol 37:54-60. 2006
    ....
  81. ncbi request reprint Promoter usage and estrogen regulation of prolactin receptor gene in the brain of the female rat
    Xiujun Pi
    Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, Kansas 66160 7401, USA
    Neuroendocrinology 77:187-97. 2003
    ..Estrogen differentially regulates expression of the PRL-R mRNA in the different brain regions by increasing the utilization of PRL-R gene promoters 1A and 1C in the female rat...
  82. doi request reprint Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China
    Xing Zheng Zheng
    Laboratory for Xinjiang Endemic and Ethnic Diseases, Department of Pathology, Shihezi University Medical School, Xinjiang, China
    Eur J Cancer Prev 17:460-6. 2008
    ..231, P<0.05). These observations suggest that individuals with different genetic backgrounds carry different susceptibilities to CC, at least in the Uigur and Han ethnic women studied in China...
  83. doi request reprint Chemoenzymatic synthesis of 7-deaza cyclic adenosine 5'-diphosphate ribose analogues, membrane-permeant modulators of intracellular calcium release
    Bo Zhang
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
    J Org Chem 73:1693-703. 2008
    ..3 was also found to be stable to enzyme-mediated hydrolysis using CD38 ectoenzyme...
  84. ncbi request reprint Selective separations of peptides with sequence deletions, single amino acid polymorphisms, and/or epimeric centers using macrocyclic glycopeptide liquid chromatography stationary phases
    Bo Zhang
    Department of Chemistry, Iowa State University, Ames, IA 50011 3111, USA
    J Chromatogr A 1053:89-99. 2004
    ..Mobile phase optimization, its effect on peptide elution behavior, and chromatographic efficiency is also discussed. Using LC-ESI-MS, a 2 ng limit of detection was obtained, two orders of magnitude lower than the UV detection limit...
  85. ncbi request reprint The spleen as a target in severe acute respiratory syndrome
    Jun Zhan
    Department of Histology and Embryology, Peking University Health Science Center, Beijing, China
    FASEB J 20:2321-8. 2006
    ..On average, CD68+ macrophages were increased in size by 2.21-fold. We hypothesize that the collapse of the splenic immune system plays a key role in the clinical outcome of these patients...
  86. ncbi request reprint T13M mutation of lecithin-cholesterol acyltransferase gene causes fish-eye disease
    Takashi Miida
    Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata, Niigata 951 8510, Japan
    Clin Chim Acta 343:201-8. 2004
    ..We investigated the first homozygous case with a substitution of threonine to methionine at codon 13 (T13M) of LCAT gene...
  87. pmc Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 90:159-65. 2007
    ....
  88. ncbi request reprint Salt tolerance conferred by overexpression of Arabidopsis vacuolar Na(+)/H (+) antiporter gene AtNHX1 in common buckwheat (Fagopyrum esculentum)
    Li hong Chen
    Shaanxi Provincial Key Laboratory of Biotechnology, Northwest University, Xi an, 710069, P R China
    Transgenic Res 17:121-32. 2008
    ..Moreover, the content of important nutrients in buckwheat was not affected by the high salinity of the soil. These results demonstrated the potential value of these transgenic plants for agriculture use in saline soil...
  89. ncbi request reprint Intravenous infusion of dihydroginsenoside Rb1 prevents compressive spinal cord injury and ischemic brain damage through upregulation of VEGF and Bcl-XL
    Masahiro Sakanaka
    Department of Functional Histology, Ehime University Graduate School of Medicine, Shitukawa, Toon, Ehime, Japan
    J Neurotrauma 24:1037-54. 2007
    ..We also showed that dgRb1-induced expression of bcl-x(L) and VEGF mRNA was HRE (hypoxia response element) and STRE (signal transducers and activators of transcription 5 (Stat5) response element) dependent, respectively...
  90. ncbi request reprint Establishment and biological characteristics of human multiple myeloma cell line CZ-1
    Jian Hou
    Department of Hematology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 117:115-9. 2004
    ..There were only 3 multiple myeloma (MM) cell lines established in China. In this study, we succeeded in establishing a novel MM cell line and analyzed its biological characteristics...
  91. ncbi request reprint Construction of the subtractive cDNA library of injured adult and fetal rabbit skins
    Bo Zhang
    Research Institute of Surgery, Daping Hospital, Chongqing 400042, China
    Chin J Traumatol 7:13-7. 2004
    ..In this sense, it is reasonable to construct subtractive cDNA library for future research...
  92. ncbi request reprint Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer
    Bo Zhang
    Department of Medical Genetics, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China
    Biochem Pharmacol 75:660-7. 2008
    ..Our results suggest that pretreatment with recombinant adenovirus to inhibit Prx-I expression can enhance the radiosensitivity of cancer cells, and thus might be a potential application in clinical therapy...
  93. ncbi request reprint Greater habitual soyfood consumption is associated with decreased carotid intima-media thickness and better plasma lipids in Chinese middle-aged adults
    Bo Zhang
    Faulty of Nutrition, School of Public Health, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou 510080, People s Republic of China
    Atherosclerosis 198:403-11. 2008
    ..008). In conclusion, higher habitual soyfood consumption is associated with decreased bifurcation IMT, plasma TC and LDL-c in middle-aged Chinese adults. The association is more apparent in men than in women...
  94. ncbi request reprint Limonoids and sesquiterpenoids from Amoora tsangii
    Hua Dong Chen
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People s Republic of China
    J Nat Prod 71:93-7. 2008
    ..Seven new limonoids, amotsangins A-G (1-7), two known limonoids, and four known sesquiterpenoids were isolated from the twigs and leaves of Amoora tsangii. Their structures were elucidated primarily on the basis of spectroscopic data...
  95. ncbi request reprint Changes in total lipid profiles assessed by analytical capillary isotachophoresis throughout the acute phase of myocardial infarction
    Keisuke Okamura
    Int J Cardiol 108:264-6. 2006