Yoshio Tsuboi

..The prognosis and rate of the disease's progression vary considerably among individual patients and genetic kindreds, ranging from life expectancies of several months to several years, and, in exceptional cases, as long as two decades...

..We examined the relationship between alcohol intake and PD among Japanese subjects using data from a case-control study...

..DWI abnormalities may be characteristic features that should be considered in the diagnosis of familial as well as of sporadic CJD...

....

..Correlations between genetic mutations and the heterogeneity of clinical and neuropathologic features remain unclear...

..To estimate the prevalence of restless leg syndrome (RLS) in elderly Japanese people by means of a population-based survey of subjects aged > or = 65 years...

....

..We also present new evidence for biological interactions between SNPs rs356219 and rs356220 and smoking that affect sporadic PD...

..Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD...

..Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia...

..50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD...

....

..We confirmed that the intake of coffee and caffeine reduced the risk of PD. Furthermore, this is the first study to show a significant inverse relationship between the intake of Japanese and Chinese teas and the risk of PD...

..The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan...

..In addition, we provide new evidence for the biological interaction between the polymorphism and smoking with regard to the risk of sporadic PD...

..We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan...

..It is suggested that mucormycosis should be considered in case of Garcin syndrome without osteolysis in the skull base...

..Intravenous steroid administration seems safe and effective against relapse of NMO during pregnancy...

..It is suggested that the clivus tumor affected the petroclival segment of abducent nerve in our case...

..Accumulation of information as to phenotype-genotype association will settle this hypothesis...

..The present case is the first report in Japan of HSP associated clinically and electrophysiologically with confirmed acute motor sensory axonal neuropathy. Common pathogenesis might have a role for development for two distinct disorders...

..However, it is less well known that aseptic meningitis may be an initial manifestation of ADEM...

..There have been a few reports of IVL presenting with lower lumbar spinal cord and conus medullaris. It should be noted that IVL can cause unidentified progressive ascending myelopathy without positive MRI findings...

..Mutations in exons 1, 10 and intron following exon 10 are associated with neuronal and glial tau deposition. Mutations in exons 9, 11, 12 and 13 lead to deposits of tau filaments predominantly in neurons...

..There are few pathologic differences between PDD and DLB, despite differences in their clinical course...

..VATS thymectomy should be considered a valid alternative to the established approaches aimed at achieving a "curative thymectomy" in patients with MG...

..It is possible that RPLS in our patient might be a manifestation related to Wegener's granulomatosis-mediated vascular endothelial injury...

..Indeed, some authors have described NMS as a variant of malignant catatonia. If treatment is refractory in cases of NMS, malignant catatonia may be suspected, and changing treatment to diazepam administration may be useful...

..Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD...

..To prevent fatal complication of arrhythmia, appropriate examination and therapy against cardiomyopathy associated with myasthenia gravis should be considered...

..This case indicate that cortical infarction in the primary motor cortex may produce isolated hypoglossal nerve paresis and dysarthria due to disruption of the corticolingual tract...

..This case was thought to be a thyrotoxic encephalopathy with beneficial response to corticosteroid therapy. Abnormalities seen in DWI and EEG were normalized ten days later...

....

..It is suggested that cheiromegaly/podomegaly in present case may be caused by chronic cervical cord injury affecting descending central sympathetic tract associated with primary progressive multiple sclerosis...

..In conclusion, POPC/apoA-I discs not only have beneficial effects on cholesterol efflux, but also have potential as a lipoprotein modulator in patients with TD...

..Further clinicopathologic studies are needed to define other pathologic differences between DLB and PDD and to explore the role of neuritic, basal forebrain and striatal pathology in these clinical syndromes...

..It is speculated that bacterial infection might cause clinical features mimicking Tolosa-Hunt syndrome in our case...

....

..The present study aimed to examine the composition of erythrocyte phospholipids including pl-PE in patients with AD...

..527). Prolonged mealtimes and the ejection of insufficiently masticated food from the oral cavity into oropharynx were associated with PD progression. These results indicate the importance of the oral phase of swallowing in PD patients...

....

..Because of central hypoventilation, all affected members need ventilation assistance, which is thought beneficial for prolongation of survival time as well as improving quality of life in this syndrome...

..The degree of autonomic dysfunction correlated significantly with disease duration and with indices of disease severity. In conclusion, there is evidence in PPND of a disturbance in the central autonomic network...

....

..7; 95% confidence interval, 1.4-98.7; P=0.008). Our results suggest that tau genotype does not influence the disease course. However, it may predispose to a specific clinical sign in the early stage of FTDP-17...

..These results support the assertion that the H1/H1 genotype may contribute to the earlier occurrence of clinical symptoms...

..Results of genealogical and molecular genetic studies determined that the families were not related. The N279K mutations found in both families have independent origins...

..To assess demographic and genetic determinants of Alzheimer type pathology in progressive supranuclear palsy (PSP)...

..Electrophysiology yielded remarkable findings in those asymptomatic at-risk individuals that carried the N279K tau mutation...

..This knowledge will help to better our understanding of the basic mechanisms leading to the degeneration of vulnerable substantia nigra neurons and other susceptible brain structures...

..It is hoped that future studies of these families will also lead to finding the curative treatments for the tauopathies...

..Hsp70/CHIP may therefore play an important role in the pathogenesis of tauopathies and also represents a potential therapeutic target...

..This review emphasizes the importance of testing for SCA2 in patients with parkinsonism and a family history of neurodegenerative disorders. Testing for SCA2 is also important in studies of inherited parkinsonism...

..Autopsy of six affected subjects showed frontotemporal degeneration with extensive tauopathy. Further studies of FTDP-17 patients are needed to replicate these findings...

..The present study shows that in AD/ALB, the olfactory bulb is nearly equally vulnerable to tau and alpha-synuclein pathology as the amygdala and suggests that neurodegeneration in these two anatomical regions is linked...