Senji Shirasawa

Summary

Affiliation: Fukuoka University
Country: Japan

Publications

  1. pmc Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Mol Cancer 11:46. 2012
  2. pmc BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
    Eleni Makrodouli
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, VAS, Constantinou Ave 48, 11635, Athens, Greece
    Mol Cancer 10:118. 2011
  3. ncbi request reprint ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model
    Yasuhiro Yoshida
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Anticancer Res 32:2301-8. 2012
  4. ncbi request reprint KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells
    Takeharu Ota
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Anticancer Res 32:2271-5. 2012
  5. ncbi request reprint KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines
    Yasuhiro Yoshida
    Department of Cell Biology, Faculty of Medicine, Fukuoka University 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2535-9. 2011
  6. doi request reprint ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts
    Keiko Doi
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Cell Mol Biol Lett 16:89-100. 2011
  7. pmc Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Neoplasia 12:397-404. 2010
  8. pmc Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMC Neurol 11:89. 2011
  9. doi request reprint APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neural Transm 118:1335-44. 2011
  10. ncbi request reprint Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2453-9. 2011

Collaborators

Detail Information

Publications34

  1. pmc Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Mol Cancer 11:46. 2012
    ....
  2. pmc BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
    Eleni Makrodouli
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, VAS, Constantinou Ave 48, 11635, Athens, Greece
    Mol Cancer 10:118. 2011
    ..In particular, the role of RhoA (Ras homolog gene family, member A), Rac1 (Ras-related C3 botulinum toxin substrate 1) and Cdc42 (cell division cycle 42) in cancer progression induced by each of the three oncogenes is described...
  3. ncbi request reprint ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model
    Yasuhiro Yoshida
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Anticancer Res 32:2301-8. 2012
    ..However, the identity of the crucial genes which are down-regulated through oncogenic KRAS in 3D cultures remains unclear...
  4. ncbi request reprint KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells
    Takeharu Ota
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Anticancer Res 32:2271-5. 2012
    ....
  5. ncbi request reprint KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines
    Yasuhiro Yoshida
    Department of Cell Biology, Faculty of Medicine, Fukuoka University 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2535-9. 2011
    ..Of these genes, we focused on ribonucleotide reductase M2 (RRM2), which was reported to be associated with DNA synthesis...
  6. doi request reprint ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts
    Keiko Doi
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Cell Mol Biol Lett 16:89-100. 2011
    ..Further elucidation of the molecular functions for ZFAT might shed light on the cellular programs in the mesoderm-derived cells...
  7. pmc Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Neoplasia 12:397-404. 2010
    ....
  8. pmc Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMC Neurol 11:89. 2011
    ..Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD...
  9. doi request reprint APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neural Transm 118:1335-44. 2011
    ....
  10. ncbi request reprint Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2453-9. 2011
    ..Oncogenic KRAS plays several key roles in a three-dimensional (3D) colonic-crypt model. However, miRNA expression regulated by oncogenic KRAS in this model is still elusive...
  11. doi request reprint Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biochem Biophys Res Commun 408:282-6. 2011
    ..All these results provide insight into the understandings for the molecular mechanisms underlying the regulation of IP(3)R, and would reveal a potent strategy for the drug development targeting on IP(3)R...
  12. doi request reprint ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response
    Keiko Doi
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Biochem Biophys Res Commun 425:107-12. 2012
    ..Thus, our findings reveal that Zfat is a critical regulator in peripheral T cell homeostasis and its TCR-mediated response...
  13. doi request reprint ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Jonan ku, Fukuoka, Japan
    FEBS Lett 583:568-72. 2009
    ..Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells...
  14. doi request reprint KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, and Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biochem Biophys Res Commun 408:214-7. 2011
    ..Thus, KRAP is involved in the proper regulation of IP(3)R-mediated Ca(2+) release...
  15. doi request reprint KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biochem Biophys Res Commun 407:438-43. 2011
    ....
  16. pmc Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, and Center for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Proc Natl Acad Sci U S A 107:14199-204. 2010
    ....
  17. doi request reprint Tespa1 protein is phosphorylated in response to store-operated calcium entry
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Fukuoka 814 0180, Japan
    Biochem Biophys Res Commun 434:162-5. 2013
    ..All these results suggested a novel molecular modification of Tespa1 and the existence of the regulatory pathway that SOCE affects the Tespa1-IP3R molecular complex...
  18. doi request reprint ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model
    Yasuhiro Yoshida
    Department of Cell Biology, Fukuoka University, Japan
    Cell Mol Biol Lett 15:541-50. 2010
    ..Elucidating the ZFAT-mediated transcriptional network will lead to a better understanding of the molecular mechanisms of angiogenesis...
  19. ncbi request reprint KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2413-7. 2011
    ..In this review, we summarize the current understanding of KRAP and the roles that it plays in a variety of diseases...
  20. pmc Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes
    Hiroshi Matsuzaki
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    FEBS Open Bio 2:255-9. 2012
    ..These findings suggest that Tespa1 plays critical roles in the immune system through the regulation of the IP3R...
  21. doi request reprint Case-control study of eczema associated with IL13 genetic polymorphisms in Japanese children
    Yoshihiro Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Jonan ku, Fukuoka, Japan
    Int Arch Allergy Immunol 154:328-35. 2011
    ..We conducted a case-control study of the relationship between the polymorphisms of rs1800925 and rs20541 and the risk of eczema in Japanese children aged 3 years...
  22. doi request reprint Identification of independent risk loci for Graves' disease within the MHC in the Japanese population
    Kazuhiko Nakabayashi
    Department of Cell Biology, Fukuoka University, Fukuoka, Japan
    J Hum Genet 56:772-8. 2011
    ..Although causal variants remain to be identified, our results demonstrate the existence of multiple GD susceptibility loci within the MHC region...
  23. pmc Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    PLoS ONE 4:e4240. 2009
    ..Thus, KRAP is a novel regulator in whole-body energy homeostasis and may be a therapeutic target in obesity and related diseases...
  24. doi request reprint Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux
    Hiroshi Matsuzaki
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biochem Biophys Res Commun 433:322-6. 2013
    ..All these results suggested that Tespa1 will participate in the molecular link between IP3R-mediated Ca(2+) release and mitochondrial Ca(2+) uptake in the MAM compartment...
  25. doi request reprint Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney
    Takahiro Fujimoto
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 30:1287-93. 2012
    ..These findings demonstrate that KRAP physically associates with IP(3)Rs and regulates the proper localization of IP(3)Rs in the mucous cells and the chief cells of the stomach and in the proximal tubular cells of the kidneys...
  26. ncbi request reprint Roles of ZFAT in haematopoiesis, angiogenesis and cancer development
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Anticancer Res 33:2833-7. 2013
    ..In this article, we have reviewed investigations on the roles of ZFAT in haematopoietic and angiogenesis, and discussed the possible involvement of ZFAT in haematopoietic malignancies...
  27. doi request reprint LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan
    Yoshihiro Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Neurol Sci 297:15-8. 2010
    ..In addition, we provide new evidence for the biological interaction between the polymorphism and smoking with regard to the risk of sporadic PD...
  28. ncbi request reprint Recent advances in the association studies of autoimmune thyroid disease and the functional characterization of AITD-related transcription factor ZFAT
    Kazuhiko Nakabayashi
    Department of Cell Biology, Faculty of Medicine, Fukuoka University
    Nihon Rinsho Meneki Gakkai Kaishi 33:66-72. 2010
    ....
  29. doi request reprint High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells
    Tomohiro Kozako
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Int J Cancer 131:2044-55. 2012
    ..These results suggest that SIRT1 is a crucial antiapoptotic molecule in ATL cells and that SIRT1 inhibitors may be useful therapeutic agents for leukemia, especially in patients with ATL...
  30. doi request reprint The increased expression of periostin during early stages of prostate cancer and advanced stages of cancer stroma
    Toshiyuki Tsunoda
    Faculty of Medicine, Department of Cell Biology, Fukuoka University, Nanakuma, Jonan ku, Fukuoka, Japan
    Prostate 69:1398-403. 2009
    ..Recent studies have indicated that 3DC-associated genes would be more sensitive as prognostic markers for cancer; however, no 3DC-associated genes in prostate cancer (CaP) have thus far been elucidated...
  31. doi request reprint Molecular hierarchy of heparin-binding EGF-like growth factor-regulated angiogenesis in triple-negative breast cancer
    Fusanori Yotsumoto
    Department of Biochemistry, Faculty of Medicine, Fukuoka University, Jonan ku, Fukuoka, Japan
    Mol Cancer Res 11:506-17. 2013
    ..Taken together, these results suggest that HB-EGF plays a pivotal role in the acquisition of tumor aggressiveness in TNBC by orchestrating a molecular hierarchy regulating tumor angiogenesis...
  32. doi request reprint ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes
    Midori Koyanagi
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Fukuoka 814 0180, Japan
    Genomics 91:451-7. 2008
    ..These results suggest that ZFAT functions as a critical transcriptional regulator in B and T lymphocytes...
  33. ncbi request reprint [Susceptibility genes for the development of autoimmune thyroid disease]
    Senji Shirasawa
    Department of Cell Biology, School of Medicine, Fukuoka University
    Nihon Rinsho 64:2208-14. 2006
    ..The associated SNP in ZFAT affected the antisense transcript of ZFAT, which in turn affected the ZFAT expression...
  34. ncbi request reprint Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese
    Hajime Nawata
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hum Genet 49:629-34. 2004
    ..These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12...