Yoshihiro Miyake

..20-12.36), respectively]. The authors found that, overall, neither exclusive nor partial breastfeeding had a strong impact on the risk of atopic eczema. However, a parental allergic history may affect the risk...

..Intake levels of fish, EPA, and DHA may be inversely associated with depressive symptoms during pregnancy while intake levels of total fat and saturated fatty acids may be positively related to depressive symptoms during pregnancy...

..We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan...

..The current cross-sectional study examined the association between employment, job type, household income, and educational level and the prevalence of depressive symptoms during pregnancy...

..We do not find evidence for interactions between smoking or caffeine intake and SNP rs11724635 affecting sporadic PD...

..11). This is the first study to demonstrate a significant relationship between IL4 SNP rs2227284 and rhinoconjunctivitis. Smoking may modify the relationship between SNP rs2227284 and rhinoconjunctivitis...

..Multiple A disintegrin and metalloprotease 33 (ADAM33) single nucleotide polymorphisms (SNPs) have been shown to be associated with asthma, but results have been inconsistent...

..The aim of this study was to investigate the association between smoking status and environmental tobacco smoke (ETS) exposure and the prevalence of allergic diseases...

..Epidemiological evidence on the relationship between socio-economic status and allergic disorders has been inconsistent...

..The current study provides no evidence that hair mercury levels in either mothers or children are positively associated with the risk of wheeze or eczema in children aged 29-39 months in Japan, where fish intake is high...

..We also present new evidence for biological interactions between SNPs rs356219 and rs356220 and smoking that affect sporadic PD...

..The current cross-sectional study investigated such relationships in Japan...

..Our results suggest that SNPs and haplotypes in the ADAM33 gene are associated with rhinoconjunctivitis. This study is the first to demonstrate an interaction between rs628977 and smoking that affects rhinoconjunctivitis...

..Epidemiological evidence for the associations between intake of dairy products, calcium and vitamin D and allergic disorders has been inconsistent...

..The present cross-sectional study examined the potential association between SHSe at home and the prevalence of dental caries in children...

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..This prospective study investigated the association between employment, type of job, household income, and educational level and the risk of postpartum depression...

..This prospective study examined the association between maternal intake of specific types of fatty acids, cholesterol, fish and meat during pregnancy and the risk of wheeze and eczema in the offspring...

..Bacillus Calmette-Guérin (BCG) vaccination triggers a T-helper type 1 response. Whether BCG vaccination and positive tuberculin reactivity are preventive against allergic disorders remains controversial...

..We conducted a case-control study of the relationship between the polymorphisms of rs1800925 and rs20541 and the risk of eczema in Japanese children aged 3 years...

..In addition, we provide new evidence for the biological interaction between the polymorphism and smoking with regard to the risk of sporadic PD...

..Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD...

..We investigated the relationship between dietary intake of selected antioxidant vitamins, vegetables and fruit and the risk of PD in Japan using data from a multicenter hospital-based case-control study...

..The present prospective study showed no statistically significant relationship between breastfeeding duration and the risk of wheeze or asthma in Japanese infants...

..It has been hypothesized that increased consumption of n-6 polyunsaturated fatty acids and decreased consumption of n-3 polyunsaturated fatty acids have contributed to the recent increased prevalence of asthma...

..Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia...

..98), respectively). Higher consumption of calcium and dairy foods other than yoghurt during pregnancy may reduce the risk of infantile wheeze. Higher vitamin D intake during pregnancy may be protective against childhood wheeze and eczema...

..Docosahexaenoic acid intake may be associated with a reduced prevalence of atopic eczema in pregnant Japanese females...

..Our results are likely to support the hypothesis that intrauterine exposure to traffic-related air pollutants and/or such exposure after birth may increase the risk of more extreme manifestations of allergic disorders in infants...

..This prospective study investigated the relationship of consumption of selected high-fat foods and specific types of fatty acids with the risk of postpartum depression...

..This prospective study examined the relationship of dietary consumption of folate and B vitamins during pregnancy with the risk of postpartum depression...

..The current cross-sectional study examined the relationship between number of siblings and prevalence of allergic disorders among adult women in Japan...

..Our results suggest that intake of dairy products, calcium, and vitamin D was not related to PD, regardless of sex. However, such null relationships might be a consequence of PD...

..The findings suggest that proximity of schools to municipal waste incineration plants may be associated with an increased prevalence of wheeze, headache, stomach ache, and fatigue in Japanese children...

..The current cross-sectional study examined the association between intake levels and the prevalence of eczema and rhinoconjunctivitis in Japanese children...

..We investigated the associations between IL13 SNPs rs1800925 and rs20541 and the risk of rhinoconjunctivitis in Japanese women...

..Aims:  This prospective study examined the relationship between maternal dietary patterns during pregnancy and the risk of wheeze and eczema in the offspring aged 16-24 months...

..There is sparse epidemiologic information regarding the role of dietary factors in the development of idiopathic pulmonary fibrosis (IPF)...

..50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD...

..We investigated the relationship between the IL13 SNPs rs1800925 and rs20541 and the risk of eczema in Japanese young adult women...

..Our results suggest that concentrations of β-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk are not evidently associated with the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis in young female Japanese adults...

..Prolonged breastfeeding may be associated with a higher prevalence of atopic eczema in Japanese children...

..This cross-sectional study investigated the association of intake of selected high-fat foods and specific types of fatty acids with the prevalence of allergic rhinitis in Japan where intake of fish is high...

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..These findings suggested that consumption of vegetables other than green and yellow vegetables and insoluble fiber may be related to a decreased prevalence of tooth loss among young Japanese women...

..We investigated the independent and joint effects of in utero exposure to maternal smoking and postnatal ETS exposure at home on allergic disorders among Japanese children...

..We examined the associations between lifestyle factors and the risk of amyotrophic lateral sclerosis (ALS) using a case-control study in Aichi Prefecture, Japan...

..The purpose of this cross-sectional study was to examine the association between intake of dairy products and the prevalence of dental caries in young children...

..A relationship between a history of selected disorders and the risk of IPF was assessed in a multicentre hospital-based case-control study in Japan...

..58 (95%CI 0.40-0.96) for polyunsaturated fatty acids (PUFAs). Our findings suggest that high intakes of carbohydrate and low intakes of fat and some kinds of fatty acids may, when combined, increased the risk of ALS...

..We confirmed that the intake of coffee and caffeine reduced the risk of PD. Furthermore, this is the first study to show a significant inverse relationship between the intake of Japanese and Chinese teas and the risk of PD...

..Few studies, however, have focused on the relationship between passive smoking exposure and oral health in adults. We investigated the association of active and passive smoking exposure with tooth loss in Japan...

..Our findings suggest that dietary habits may constitute independent risk factors for OPLL. Further studies will be needed to prospectively determine the relationship between dietary habits and OPLL risk...

..23; 95% CI = 1.01-10.84). Our results appear to confirm data from previous epidemiologic studies. Metal dust exposure may be a particularly important risk factor for IPF...

..The findings suggest that coffee consumption might be associated with an increased prevalence of tooth loss among young adult women...

..Poor physical condition may lead to the development of psychological distress...

..It has been hypothesized that isoflavones reduce the risk of many chronic diseases, but there are no data on the effects of dietary soy and isoflavone consumption on allergic disorders...

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..Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD...

..We examined the relationship between alcohol intake and PD among Japanese subjects using data from a case-control study...

..To assess the association between active and passive smoking and the risk of Parkinson's disease (PD), a case-control study with 249 PD patients and 369 controls was carried out in Japan...

..The present large-scale cross-sectional study examined the relationship between passive smoking at home and the prevalence of allergic disorders in Japanese schoolchildren...

..The relationship between single nucleotide polymorphisms (SNPs) in ADAM33 and atopic dermatitis (AD) in Japanese children was examined using case-control design...

..Evidence remains inconclusive as to whether smoking is a risk factor for allergic disorders in adults...

..This cross-sectional study investigated the relationship between dietary intake of seaweed, vegetables, fruit, antioxidants, fiber, and minerals and the prevalence of allergic rhinitis...

..The effects of formaldehyde (FA) exposure on allergic disorders are not clearly understood. This cross-sectional study examined the relationship between FA exposure and the prevalence of allergic disorders in Japan...

..The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan...

..The aim of this study was to investigate whether soy and isoflavone intake is associated with the prevalence of periodontal disease...

..We investigated the relationship between dietary intake of vegetables, fruit, cereals, antioxidants, and fiber and the risk of IPF in Japan...

....

..The aim of this cross-sectional study was to investigate the association between dental caries and the prevalence of allergic disorders...

..We examined the association between body mass index (BMI) and the prevalence of wheeze, asthma, eczema, and rhinoconjunctivitis in Japanese schoolchildren...

..These results are likely to support the in utero programming hypothesis because it is probable that the in utero environment would change with parity, although our observations could not refute the hygiene hypothesis...

..Consortia and international collaborative studies, which may maximize study efficacy and overcome the limitations of individual studies, are needed to help further illuminate the complex landscape of AD risk and genetic variations...

..We investigated the effect of maternal smoking during pregnancy and postnatal household smoking on the prevalence of dental caries...

..These three genes are involved in the generation of reactive oxygen species (ROS), which play a critical role for autoimmune diseases...

..Water hardness may increase the risk of atopic dermatitis among elementary-school children in Japan, as well as in the United Kingdom...

..CONCLUSIONS: The results of the study failed to substantiate a positive association between passive smoking and caries experience in Japanese children...

..Further investigations with more precise and detailed exposure and health outcome measurements are needed to corroborate the relationship between traffic related factors and allergic disorders and general symptoms...

..There has been little interest in the role of nutrition in the prevention of amyotrophic lateral sclerosis (ALS). We investigated the relationship between dietary intake of vegetables, fruit, and antioxidants and the risk of ALS in Japan...

..90 (95% confidence interval = 0.79, 1.02) in females. In addition, the difference between the sexes was not significant. In summary, the authors found no evidence that water hardness protected against cerebrovascular mortality...

..Further investigations with more precise and detailed measurements are needed to corroborate the relationship between inhabitants' experience with MD and mental health...

..To investigate the relationship between a history of hypertension, cigarette smoking and alcohol intake and the lifetime prevalence of stroke in the oldest-old population...

..This ecologic study assessed whether water hardness is related to lower mortality from CHD in Osaka Prefecture, with 44 municipalities, Japan...

..To elucidate the clinical significance of progressive cervical length (CL) shortening before 31 weeks' gestation...

....

..50, 95% CI = 0.12-0.88), compared with the NAT2 rapid acetylator genotype and no history of smoking. This study suggests that, in this Japanese population, the NAT2 slow acetylator status may be a determinant in susceptibility to SLE...

..This cross-sectional study investigated the association of active and passive smoking exposure with levels of total serum IgE in Japan...

..This study examined the relationship between selected familial factors and the prevalence of symptoms of wheeze, atopic eczema and rhinoconjunctivitis in Japanese adolescents...

..Environmental factors acting early in life are key determinants of the incidence of allergic disease. Whether breastfeeding is protective against allergic disorders remains controversial...

..We investigated the association between maternal intake of vegetables, fruit, and selected antioxidants during pregnancy and the risk of wheeze and eczema in the offspring aged 16-24 months...

..Data on the association between breastfeeding and allergies are conflicting...

..This cross-sectional study investigated the relationship between fat and fish intake and the prevalence of asthma using baseline data from a prospective study...

..The present findings suggest that intake of magnesium is related to reduced prevalence of tooth loss among young Japanese women...

..67, 2.97), drinking (OR=1.08, 95% CI=0.53, 2.20) and hangover (OR=1.12, 95% CI=0.43, 2.94) in the prime of life showed no correlation with risk of OPLL. CONCLUSION: Good sleeping habits in the prime of life may decrease the risk of OPLL...

..The findings suggest that risk factors for AMI in the elderly are generally similar to those of middle-aged persons, but provide no evidence that hypercholesterolemia in the elderly is an important risk factor...

..Future studies involving larger control and case populations and better pesticide exposure histories will undoubtedly lead to a more thorough understanding of the role of the GST polymorphisms in PD development...

..To examine the obstetrical risk factors for death and brain injury among extremely-low-birth-weight (ELBW) infants (birth weight <1000 g)...

..These findings suggest that danaparoid may be useful for the prevention of DIC and has less tendency to cause bleeding than dalteparin or heparin, probably as a result of its weaker ability to inhibit platelet aggregation...

..An educational program for non-medical students should be recommended to help them to understand our rapidly aging society and to take an interest in public policies and social services for the elderly in Japan...

..These mutations were found in more than 30% of unrelated Japanese FH patients. By using the detection methods developed in this study, the diagnosis of more than 30% of the genetic bases of Japanese FH heterozygotes is expected...