Katsunori Iwasaki

Summary

Affiliation: Fukuoka University
Country: Japan

Publications

  1. ncbi request reprint Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Biol Pharm Bull 30:698-701. 2007
  2. ncbi request reprint Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 995:131-9. 2004
  3. ncbi request reprint Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Brain Res 1097:216-23. 2006
  4. ncbi request reprint Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 93:188-96. 2003
  5. ncbi request reprint Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurotox Res 6:299-309. 2004
  6. doi request reprint Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Eur J Pharmacol 589:117-21. 2008
  7. ncbi request reprint Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Eur J Pharmacol 592:103-8. 2008
  8. doi request reprint Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Neuropharmacology 55:1280-6. 2008
  9. ncbi request reprint Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180, Japan
    Neuropharmacology 52:1079-87. 2007
  10. ncbi request reprint Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neurochem 102:1488-96. 2007

Detail Information

Publications98

  1. ncbi request reprint Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Biol Pharm Bull 30:698-701. 2007
    ..These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD)...
  2. ncbi request reprint Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 995:131-9. 2004
    ..YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia...
  3. ncbi request reprint Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Brain Res 1097:216-23. 2006
    ..These findings suggest that ischemia is an important factor facilitating the symptoms of Alzheimer's disease, and this model may be useful for developing new drugs for the treatment of Alzheimer's disease...
  4. ncbi request reprint Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 93:188-96. 2003
    ..Nilvadipine may have a neuroprotective effect and could be a useful pharmacotherapeutic agent for cerebrovascular dementia...
  5. ncbi request reprint Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurotox Res 6:299-309. 2004
    ....
  6. doi request reprint Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Eur J Pharmacol 589:117-21. 2008
    ..WAY100635 (1 mg/kg) also reversed the reduction effect of citalopram (10 mg/kg). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced enhancement of immobility...
  7. ncbi request reprint Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Eur J Pharmacol 592:103-8. 2008
    ..These findings suggest that aripiprazole may be a useful drug for the treatment of obsessive-compulsive disorder, and that aripiprazole inhibits the marble-burying behavior via 5-HT1A receptor-independent mechanisms...
  8. doi request reprint Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Neuropharmacology 55:1280-6. 2008
    ..Cannabidiol will open new therapeutic possibilities for post-ischemic injury via HMGB1-inhibiting mechanism...
  9. ncbi request reprint Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180, Japan
    Neuropharmacology 52:1079-87. 2007
    ..It is to be hoped that cannabidiol will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders...
  10. ncbi request reprint Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neurochem 102:1488-96. 2007
    ....
  11. doi request reprint Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 1249:222-8. 2009
    ..Measuring ACh release in this model might be a useful index for the screening of new drugs to treat the early-phase of Alzheimer's disease...
  12. ncbi request reprint Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors
    Taro Shindo
    Department of Psychiatry, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biol Pharm Bull 35:2141-7. 2012
    ..These results suggest that telmisartan has ameliorative effects on the impairment of spatial memory in a rat model of AD incorporating additional cerebrovascular disease factors via its anti-inflammatory effect...
  13. ncbi request reprint Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka, Japan
    J Pharmacol Sci 106:84-91. 2008
    ..This model may be useful for developing new drugs for the treatment of early-phase Alzheimer's disease...
  14. doi request reprint Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Eur J Pharmacol 586:164-70. 2008
    ..By contrast, amantadine (30 mg/kg, i.p.) did not affect prepulse inhibition. These findings suggest that amantadine could be a useful drug for the treatment of OCD...
  15. pmc Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences
    Sei Higuchi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    PLoS ONE 7:e38609. 2012
    ..Here, we hypothesized that increased 2-AG influences the hypothalamic reward system...
  16. doi request reprint Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, and Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1516-20. 2008
    ....
  17. ncbi request reprint Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 104:329-34. 2007
    ..These results suggest that in this repeated cerebral ischemia model, the 4-oxo group and the 2,3-double bond in the C ring of rutin and quercetin are related to their neuroprotective action...
  18. ncbi request reprint Antipsychotics improve Delta9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice
    Hiroshi Nagai
    Department of Psychiatry, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 84:330-6. 2006
    ..These results suggest that dopaminergic hyperfunction in the nucleus accumbens may be involved in THC-induced PPI deficits...
  19. ncbi request reprint Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 1069:54-62. 2006
    ..These findings suggest that 5-HT1A receptors in the DH play an important role in the mechanisms underlying the 8-OH-DPAT-induced impairment of spatial memory in rats...
  20. ncbi request reprint Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Fukuoka, Japan
    Brain Res 1188:157-64. 2008
    ..These findings may contribute in setting the basis for interaction of cannabinoids and to find a cannabinoid mechanism in central nervous system...
  21. doi request reprint Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse
    Nobuaki Egashira
    Department of Neuropharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Behav Brain Res 209:142-7. 2010
    ..The results of the present study indicate that testosterone may play an important role in the depression-like behavior in SAMP10...
  22. doi request reprint Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors
    Sei Higuchi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Behav Brain Res 216:477-80. 2011
    ..Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus...
  23. ncbi request reprint Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 109:424-30. 2009
    ..These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area...
  24. ncbi request reprint Delta9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Fukuoka 814 0180, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:499-506. 2008
    ..Therefore, olanzapine could attenuate the acute short-term and working memory deficits induced by cannabis...
  25. doi request reprint Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia
    Tamami Haraguchi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 1353:125-32. 2010
    ..Telmisartan, which has the unique character of having both ARB and PPARgamma agonistic effect, will be useful for preventing memory impairment after cerebrovascular disease...
  26. ncbi request reprint Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Neuropsychopharmacology 30:1996-2005. 2005
    ..The results of the present study indicate that V1bR may be involved in the regulation of PPI of the startle reflex. The V1bR has been considered an important molecular target for the development of antipsychotic drugs...
  27. doi request reprint Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neurosci Res 88:1908-17. 2010
    ..These results suggest that Abeta oligomers induce memory impairment via dynamin 1 degradation, which may imply that dynamin 1 degradation is one of the causes of synaptic dysfunction in AD...
  28. ncbi request reprint Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia
    Keiichi Irie
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814 0180, Fukuoka, Japan
    Life Sci 72:621-9. 2002
    ..These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells...
  29. ncbi request reprint Cholinergic involvement and synaptic dynamin 1 expression in Yokukansan-mediated improvement of spatial memory in a rat model of early Alzheimer's disease
    Naoki Uchida
    Department of Psychiatry, Faculty of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Phytother Res 27:966-72. 2013
    ..Future studies will determine whether YKS is similarly useful in the treatment of memory defects in patients diagnosed with early-stage AD...
  30. ncbi request reprint Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress
    Shinji Soeda
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurochem Int 45:619-26. 2004
    ....
  31. ncbi request reprint Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 94:393-402. 2004
    ..These results suggested that BWP might ameliorate spatial memory impairment by inhibiting glutamate release and the delayed generation of NO(x)(-) in rats subjected to repeated cerebral ischemia...
  32. ncbi request reprint Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo
    Takashi Ochiai
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biochim Biophys Acta 1770:578-84. 2007
    ....
  33. ncbi request reprint Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka, 814 0180, Japan
    Neuroreport 15:2381-5. 2004
    ....
  34. ncbi request reprint Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 83:161-7. 2006
    ..Taken together these findings suggest that low dose citalopram is useful for the treatment of memory deficits and consciousness disturbance...
  35. ncbi request reprint Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma Jonan ku, Fukuoka University, Fukuoka 814 0180, Japan
    Behav Brain Res 178:123-7. 2007
    ....
  36. ncbi request reprint Calcium-channel antagonists inhibit marble-burying behavior in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 108:140-3. 2008
    ..p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior...
  37. doi request reprint Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka, 814 0180 Japan
    Stroke 39:951-8. 2008
    ..However, the cerebroprotective mechanism of minocycline remains unclear. In the present study, we investigated that mechanism of minocycline in a murine model of 4-hour middle cerebral artery (MCA) occlusion...
  38. ncbi request reprint Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka and Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Eur J Pharmacol 563:149-54. 2007
    ....
  39. ncbi request reprint Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University Fukuoka 814 0180, Japan
    Am J Chin Med 33:475-89. 2005
    ..These results suggested that the TSS has neuroprotective action which may be indirectly mediated by the AMPA receptor, and TSS may be beneficial for the treatment of cerebrovascular dementia...
  40. ncbi request reprint Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Phytother Res 21:126-9. 2007
    ..Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits...
  41. pmc Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice
    Kazuhide Hayakawa
    Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan
    J Cereb Blood Flow Metab 30:871-82. 2010
    ..Our results suggest that reactive astrocytes in peri-infarct cortex may promote neurovascular remodeling, and these glial responses may aid functional recovery after stroke...
  42. ncbi request reprint Characteristics of behavioral abnormalities in alpha1d-adrenoceptors deficient mice
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka 814 0180, Japan
    Behav Brain Res 152:365-73. 2004
    ....
  43. ncbi request reprint Protective effect of Toki-shakuyaku-san on amyloid beta25-35-induced neuronal damage in cultured rat cortical neurons
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Phytother Res 19:450-3. 2005
    ..These results suggest that TSS has a protective effect against Abeta25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD...
  44. doi request reprint Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Nat Med 64:167-74. 2010
    ..These data suggest neuroprotection with KGKR requires continuous pre-ischemic treatment, and that the mechanisms of protection may be involved in inhibiting the glutamatergic receptors of the post-synaptic neurons...
  45. ncbi request reprint Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka, University, 8 19 1, Nanakuma, Fukuoka 814 0180, Japan
    Eur J Pharmacol 550:117-22. 2006
    ..On the other hand, WAY100635 (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced catalepsy-like immobilization...
  46. ncbi request reprint The serotonin1A receptor agonist 8-OHDPAT reverses delta 9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats
    Keiichrio Inui
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Neurotox Res 6:153-8. 2004
    ..These findings suggest that low doses of 8-OHDPAT may improve delta9-tetrahydrocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus...
  47. ncbi request reprint Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Psychopharmacology (Berl) 226:295-305. 2013
    ..Marble-burying behavior is a pharmacological model for study of OCD...
  48. ncbi request reprint Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Fukuoka 814 0180, Japan
    Brain Res 1059:7-12. 2005
    ..These results suggest that R406W Tg mice exhibit changes in depression-related behavior involving serotonergic neurons and provide an animal model for investigating AD with depression...
  49. ncbi request reprint Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Fukuoka, Japan
    Stroke 36:1077-82. 2005
    ..Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice...
  50. ncbi request reprint Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder
    Michihiko Matsushita
    Department of Psychiatry, Fukuoka University School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Pharmacol Sci 99:154-9. 2005
    ..These findings suggest that perospirone may exhibit anti-OCD activity in clinical use and that 5-HT(1A)-receptor agonistic activity may be involved in the inhibition of marble-burying behavior by perospirone...
  51. ncbi request reprint Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Biol Pharm Bull 35:376-9. 2012
    ..Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice...
  52. ncbi request reprint 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 105:361-6. 2007
    ..p.). Thus, on the basis of these results, it appears that 5-HT(2A)-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization...
  53. ncbi request reprint Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat
    Eun hee Chung
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814 0180, Japan
    Life Sci 72:609-19. 2002
    ..The repeated cerebral ischemia model which produces cell death and ACh dysfunction in the hippocampus is thought to be useful for evaluating new drugs for the treatment of cerebrovascular dementia...
  54. ncbi request reprint Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory impairment
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180 Japan
    Neurosci Lett 376:194-9. 2005
    ....
  55. ncbi request reprint Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814 0180, Fukuoka, Japan
    Life Sci 72:397-407. 2002
    ..These findings suggest that inhibition of the cholinergic pathway by reduced acetylcholine release is one of the means by which Delta9-tetrahydrocannabinol impairs spatial memory in the 8-arm radial maze...
  56. ncbi request reprint Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 105:211-4. 2007
    ..These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA(A) receptors...
  57. ncbi request reprint Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats
    Kenichi Mishima
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka 814 0180, Japan
    Behav Brain Res 151:209-17. 2004
    ..These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats...
  58. ncbi request reprint Hypoxia enhances beta-amyloid-induced apoptosis in rat cultured hippocampal neurons
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Jpn J Pharmacol 90:321-7. 2002
    ....
  59. ncbi request reprint Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress
    Kazunori Sano
    Advanced Materials Institute, Fukuoka University, 8 19 1 Nanakuma, Fukuoka, 814 0180, Japan
    Biol Pharm Bull 32:2065-7. 2009
    ..This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB(1) receptor, thereby increasing the risk of depression...
  60. ncbi request reprint Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurosci Lett 536:74-9. 2013
    ..These results suggest that the memory of Tg mice is affected by 2VO, and the memory impairment may be due to cholinergic dysfunction induced by Aβ. Our findings support the idea that cerebral hypoperfusion could be a risk factor for AD...
  61. doi request reprint Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 99:52-8. 2011
    ..o.) reversed inhibition of head-twitch response by NBQX and URB597. These findings indicated that endocannabinoid and glutamatergic systems participate in the mechanism of action of DOI to induce head-twitch response...
  62. doi request reprint Involvement of opioid system in cognitive deficits induced by ∆⁹-tetrahydrocannabinol in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Psychopharmacology (Berl) 219:1111-8. 2012
    ..1 mg/kg), suggesting that the effect of THC is mediated through cannabinoid CB(1) receptors...
  63. doi request reprint Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia
    Ai Nogami
    Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Nat Med 65:275-81. 2011
    ..This study revealed that yokukansan shows anxiolytic effects not only in normal animals but also in cerebrovascular model rats...
  64. doi request reprint Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism
    Tamami Haraguchi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Neurosci Lett 464:151-5. 2009
    ..These data suggest that telmisartan may be a potential treatment for post-ischemic injury by partially inhibiting the inflammatory reaction after cerebral ischemia via a PPARgamma-dependent HMGB1 inhibiting mechanism...
  65. ncbi request reprint Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: possible involvement of GABA(A)-benzodiazepine receptor complex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    J Pharmacol Sci 116:316-20. 2011
    ..p.), but not WAY100635. These findings suggest that the GABA(A)-benzodiazepine receptor complex, but not 5-HT(1A) receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation...
  66. ncbi request reprint New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 109:44-9. 2009
    ..Moreover, V1aR KO mice exhibited reduced anxiety-like behavior and impairment of spatial learning. These results suggest that V1aR and V1bR play an important role in psychological and cognitive functions...
  67. ncbi request reprint A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain gangliosides in rats with cerebral ischemia
    Kiwamu Yamagishi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan, Fukuoka 814 80, Japan
    Eur J Pharmacol 462:53-60. 2003
    ..These results are an indication that L-PDMP may ameliorate spatial cognition deficit by upregulating ganglioside biosynthesis in ischemic brain...
  68. ncbi request reprint Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents
    Takashi Egawa
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, Japan
    Behav Brain Res 129:31-9. 2002
    ..These results suggest that the impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with dysfunction of the hippocampal cholinergic and noradrenergic systems...
  69. ncbi request reprint Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABA(A) - Benzodiazepine Receptor Complex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 116:316-20. 2011
    ..p.), but not WAY100635. These findings suggest that the GABA(A) - benzodiazepine receptor complex, but not 5-HT(1A) receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation...
  70. ncbi request reprint Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia
    Kotaro Takasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Japan
    J Pharmacol Sci 116:232-7. 2011
    ..These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia...
  71. ncbi request reprint Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory
    Nobuaki Egashira
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Eur J Pharmacol 445:221-9. 2002
    ..These results suggest that the 5-HT neuronal system may be involved in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory...
  72. ncbi request reprint Intracerebral microinjections of delta 9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats
    Nobuaki Egashira
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 952:239-45. 2002
    ..These results suggest that DH and VH may be important brain sites for the delta(9)-THC-induced impairment of spatial memory...
  73. ncbi request reprint Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Fukuoka University, Japan
    Biol Pharm Bull 32:1538-44. 2009
    ..Cannabidiol may provide therapeutic possibilities for the progressing brain injury via HMGB1-inhibiting mechanism...
  74. ncbi request reprint [Synthesis of sphingomyelin analogues as a sphingomyelinase inhibitor and the application as a blocking agent of extracellular stress signaling]
    Yoshiaki Tsuji
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Nihon Yakurigaku Zasshi 120:67P-69P. 2002
    ..These results suggest a possibility that the prevention of various extracellular stress-induced cell death signalings is accomplished by inhibiting the cell membrane SMase...
  75. ncbi request reprint Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice
    Kenta Umeda
    Department of Neuropharmacology Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Eur J Pharmacol 553:157-62. 2006
    ..3 mg/kg, s.c.), lithium carbonate exacerbated the dizocilpine-induced disruption. These results suggest that valproate, carbamazepine and lithium carbonate reverse the disruption of prepulse inhibition through the dopaminergic system...
  76. ncbi request reprint Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurosci Lett 363:58-61. 2004
    ..These results suggest that theanine directly provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction...
  77. ncbi request reprint V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurosci Lett 356:195-8. 2004
    ..Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-arm radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice...
  78. ncbi request reprint The pharmacological characterization of attentional processes using a two-lever choice reaction time task in rats
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Biol Pharm Bull 25:1570-6. 2002
    ....
  79. pmc Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation
    Tetsuro Murakami
    Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Am J Pathol 169:1365-75. 2006
    ..These transgenic mice may aid therapeutic development for FTDP-17 and other diseases featuring accumulations of four-repeat tau, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy...
  80. ncbi request reprint Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Turkey
    J Pharmacol Sci 103:83-91. 2007
    ..These results reveal the differential effects of the SI and RI on memory and expression of the AMPARs subunits GluR1 and GluR2 and their flip and flop variants in the CA1...
  81. ncbi request reprint Schizandrin reverses memory impairment in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:49-52. 2008
    ..Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits...
  82. ncbi request reprint Local administration of glial cell line-derived neurotrophic factor improves behavioral and histological deficit of neonatal Erb's palsy in rats
    Hidenobu Ochiai
    Department of Neurosurgery, Miyazaki Medical College, Miyazaki, Japan
    Neurosurgery 53:973-7; discussion 977-8. 2003
    ..We sought to evaluate from a behavioral and histological viewpoint the effect of local administration of glial cell line-derived neurotrophic factor (GDNF) on neonatal preganglionic Erb's palsy in rats...
  83. ncbi request reprint Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats
    Izzettin Hatip-Al-Khatib
    Division of Internal Medicine, Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli 20070, Turkey
    Brain Res 1012:169-76. 2004
    ..On the other hand, the fast and specific effect of TAK-147 may be useful for cure of early stages of Alzheimer's disease (AD)...
  84. ncbi request reprint Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale, University, Denizli, Turkey
    Life Sci 75:1967-78. 2004
    ..These results suggest that direct inhibition of PARP and caspase-3, but not of caspase-1, prevents apoptosis and improves spatial memory impaired by repeated ischemia...
  85. ncbi request reprint Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli, Denizli 20070, Turkey
    Phytother Res 21:291-4. 2007
    ..TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS...
  86. ncbi request reprint Theanine prevents memory impairment induced by repeated cerebral ischemia in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:65-8. 2008
    ..These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease...
  87. ncbi request reprint Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy
    Jesmin I Noor
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Stroke 36:2468-74. 2005
    ..We examined the effect of edaravone on the optimal duration of treatment, the long-term effect on the brain, and the effect on learning and memory disability in a rat model of neonatal hypoxic-ischemic encephalopathy...
  88. pmc Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli, Denizli 20070, Turkey
    Br J Pharmacol 145:1035-44. 2005
    ....
  89. ncbi request reprint Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats
    Shinji Katsuragi
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake cho, Miyazaki, Japan
    Am J Obstet Gynecol 192:1028-37. 2005
    ..We examined the effect of glial cell line-derived neurotrophic factors on long-term learning and memory impairment and morphological changes up to 18 weeks after hypoxic-ischemic stress in neonatal rats...
  90. ncbi request reprint Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Obstet Gynecol 192:719-26. 2005
    ....
  91. ncbi request reprint Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 16, Japan
    Am J Obstet Gynecol 191:2132-41. 2004
    ..We assessed the long-term effects of perinatal hypoxia-ischemia and endotoxin on attention and short- and long-term memory in neonatal rats with the use of behavioral tasks and brain histologic results...
  92. ncbi request reprint Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    J Pharmacol Sci 96:33-41. 2004
    ..The improving effect of TSS is produced greatly by the Toki component, the activity of which was greatly produced by the fraction extracted by butanol...
  93. ncbi request reprint Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kihara, Japan
    Pediatr Res 59:61-5. 2006
    ..Rehabilitative training tasks prevented the neonatal HI-induced late-onset slowly progressive learning and memory disability...
  94. ncbi request reprint [Vasopressin receptor knockout mice as an animal model of psychiatric disorders]
    Nobuaki Egashira
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:101-5. 2006
    ..These results suggest that V1aR and V1bR may be involved in psychiatric disorders associated with impairments of sensorimotor gating and social behavior such as schizophrenia and autism...
  95. ncbi request reprint Dexamethasone prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Japan
    Behav Brain Res 136:161-70. 2002
    ....
  96. ncbi request reprint Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice
    Fujio Umehara
    Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8 35 1, Kagoshima, Japan
    Behav Brain Res 174:167-73. 2006
    ..These behavioral abnormalities of Dhh KO male mice may be due to lower testosterone levels with abnormal development of the testes caused by Dhh-null mutation...
  97. pmc Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
    Yoshitaka Tatebayashi
    Laboratory for Alzheimer s Disease and Neural Architecture, Brain Science Institute, Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:13896-901. 2002
    ....
  98. pmc Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
    Tomonori Kaifu
    Department of Experimental Immunology and Core Research for Evolutional Science and Technology CREST Program of the Japan Science and Technology Corporation JST, Tohoku University, Sendai, Japan
    J Clin Invest 111:323-32. 2003
    ..These results provide a molecular basis for a unique combination of skeletal and psychotic characteristics of Nasu-Hakola disease as well as for schizophrenia and presenile dementia...