Munechika Enjoji

Summary

Affiliation: Fukuoka University
Country: Japan

Publications

  1. ncbi request reprint Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study
    Munechika Enjoji
    Department of Clinical Pharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 22:521-7. 2008
  2. pmc Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease?
    Munechika Enjoji
    World J Gastroenterol 16:800-3. 2010
  3. pmc NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease
    Munechika Enjoji
    Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Lipids Health Dis 9:29. 2010
  4. ncbi request reprint Am80 induces neuronal differentiation via increased tropomyosin-related kinase B expression in a human neuroblastoma SH-SY5Y cell line
    Hideo Shiohira
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biomed Res 33:291-7. 2012
  5. doi request reprint Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury
    Masayuki Miyazaki
    Department of Medicine and Bioregulatory Science, Kyushu University, Japan
    J Gastroenterol Hepatol 26:1749-56. 2011
  6. doi request reprint Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes
    Mako Toyoda
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Int J Mol Med 27:619-24. 2011
  7. pmc Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:264017. 2012
  8. pmc Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:925807. 2012
  9. ncbi request reprint Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line
    Hideo Shiohira
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Jonan ku, Fukuoka, Japan
    Int J Mol Med 26:393-9. 2010
  10. doi request reprint Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis
    Masato Hamabashiri
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Int J Mol Med 28:599-603. 2011

Collaborators

  • Tsukasa Uno
  • Goshi Shiota
  • Ryoichi Takayanagi
  • Hirohisa Yano
  • Tetsuhide Ito
  • Masayuki Miyazaki
  • Naoya Sakamoto
  • Saneyoshi Ueno
  • Yuji Soejima
  • Norihiro Furusyo
  • Hirohiko Tanaka
  • Makoto Nakamuta
  • Kazuhiro Kotoh
  • Motoyuki Kohjima
  • Shusuke Morizono
  • Manabu Nakashima
  • Hajime Nawata
  • Masaki Kato
  • Nobito Higuchi
  • Hideo Shiohira
  • Takuya Nishinakagawa
  • Marie Fukushima
  • Akira Kitaoka
  • Tatsuya Fujino
  • Ryoko Yada
  • Tsuyoshi Yoshimoto
  • Kenichiro Yasutake
  • Hironori Sakai
  • Eiichirou Arimura
  • Masato Hamabashiri
  • Mako Toyoda
  • Kazuyuki Machida
  • Naoki Yamashita
  • Masayoshi Yada
  • Yuki Horikawa
  • Naohiko Harada
  • Sawako Inoue
  • Akinobu Taketomi
  • Shinichi Aishima
  • Yoshihiko Maehara
  • Satoshi Ohta
  • Ken ichi Noguchi
  • Yuko Takami
  • Yoshiyuki Wada
  • Kunitaka Fukuizumi
  • Machiko Bekki
  • Tomoki Ryu
  • Hideki Saitsu
  • Masako Ichinose
  • Michiko Ikemoto
  • Sachiko Ogasawara
  • Kouichi Ohshima
  • Makiko Yasumoto
  • Aya Daichou
  • Sho Fujii
  • Hiromi Shirasawa
  • Tetsuya Nozaki
  • Tatsuhiro Maeda
  • Hirotaka Tajiri
  • Naoko Kinukawa
  • Akihiro Ueda
  • Tomoharu Yoshizumi
  • Yoshinori Fukui
  • Yuzuru Miyagi
  • Tsuyosi Yoshimoto
  • Shinsaku Yamashita
  • Mitsuo Shimada
  • Akihide Masumoto
  • Hideaki Uchiyama
  • Eiji Kajiwara
  • Junya Shimono
  • Koichi Azuma
  • Toshihiro Maruyama
  • Shinji Shimoda
  • Shinji Aishima
  • Kazuhiro Takahashi
  • Hideyuki Nomura
  • Tomoharau Yoshizumi
  • Izuru Miyagi
  • Kengo Yoshimitsu
  • Yuichi Tanabe
  • Jun Hayashi
  • Shin Ichiro Takasugi
  • Marie Fukutomi
  • Rie Sugimoto

Detail Information

Publications30

  1. ncbi request reprint Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study
    Munechika Enjoji
    Department of Clinical Pharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 22:521-7. 2008
    ..The effects tended to be more notable with telmisartan. In conclusion, telmisartan and olmesartan improved insulin sensitivity and may possibly be used as liver protecting agents in CH-C as well as NAFLD patients...
  2. pmc Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease?
    Munechika Enjoji
    World J Gastroenterol 16:800-3. 2010
    ..We review one pathogenic aspect of lipid metabolism dysregulation in NAFLD and survey new strategies for NAFLD treatment based on the modification of cholesterol metabolism...
  3. pmc NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease
    Munechika Enjoji
    Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Lipids Health Dis 9:29. 2010
    ..Therefore, excess cholesterol intake appears to be one of the main factors associated with NAFLD development and liver injury...
  4. ncbi request reprint Am80 induces neuronal differentiation via increased tropomyosin-related kinase B expression in a human neuroblastoma SH-SY5Y cell line
    Hideo Shiohira
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biomed Res 33:291-7. 2012
    ..These results suggest that Am80 induced neuronal differentiation by increasing TrkB expression and BDNF sensitivity...
  5. doi request reprint Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury
    Masayuki Miyazaki
    Department of Medicine and Bioregulatory Science, Kyushu University, Japan
    J Gastroenterol Hepatol 26:1749-56. 2011
    ..Therefore, we investigated whether contrast-enhanced ultrasonography (CEUS) is useful to evaluate the changes in hepatic hemodynamics in patients with ALI...
  6. doi request reprint Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes
    Mako Toyoda
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Int J Mol Med 27:619-24. 2011
    ..The results of this study in cultured cells suggest that HCV infection may activate the cannabinoid system and precede steatosis, but the core protein by itself may not have any effect on the cannabinoid system...
  7. pmc Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:264017. 2012
    ..We also discuss the clinical significance of insulin sensitizers used to improve insulin resistance and lipid modulators used to manage lipid metabolism as potential treatment options for chronic hepatitis C...
  8. pmc Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:925807. 2012
    ..The clinical significance of managing cholesterol metabolism, an option for the treatment of NAFLD, is also discussed...
  9. ncbi request reprint Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line
    Hideo Shiohira
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Jonan ku, Fukuoka, Japan
    Int J Mol Med 26:393-9. 2010
    ..These findings suggest that Am80 induces neuronal differentiation to a greater extent than ATRA and thus may help establishing therapeutic strategies against neuronal degenerative disorders such as Parkinson's disease...
  10. doi request reprint Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis
    Masato Hamabashiri
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Int J Mol Med 28:599-603. 2011
    ..Furthermore, we demonstrated that subtractive immunization is a useful method for producing mAbs specific for the pancreatic juice from PC patients...
  11. ncbi request reprint Assessing current nutritional status of patients with HCV-related liver cirrhosis in the compensated stage
    Kenichiro Yasutake
    Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, Kanzaki, Japan
    Asia Pac J Clin Nutr 21:400-5. 2012
    ..For there to be adequate guidance regarding dietary treatment, it is important that a patient's current nutritional state be clarified...
  12. ncbi request reprint Analysis of cell cycle arrest and apoptosis induced by RCAS1
    Takuya Nishinakagawa
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 25:717-22. 2010
    ..These results suggest that cyclin D3 is one of the key target molecules in the RCAS1-RCAS1-R signaling pathway...
  13. ncbi request reprint Fertile females with nonalcoholic fatty liver disease (NAFLD) have higher levels of ALT than postmenopausal females: implications for the influence of fertility on NAFLD
    Kazuhiro Kotoh
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 54:224-8. 2007
    ..Insulin resistance recently has been reported to play a major role in nonalcoholic fatty liver disease (NAFLD). We evaluated the influence of fertility on fatty liver injury in fertile and postmenopausal women with insulin resistance...
  14. ncbi request reprint SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Mol Med 21:507-11. 2008
    ....
  15. doi request reprint Investigation of hyperuricemia during pegylated-interferon-alpha2b plus ribavirin combination therapy in patients with chronic hepatitis C
    Naoki Yamashita
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Dig Dis 9:27-31. 2008
    ..However, detailed investigation of the elevation of uric acid has not been carried out previously. The incidence and mechanism of hyperuricemia were investigated in this study...
  16. doi request reprint Association between the treatment length and cumulative dose of pegylated interferon alpha-2b plus ribavirin and their effectiveness as a combination treatment for Japanese chronic hepatitis C patients: project of the Kyushu University Liver Disease Study
    Norihiro Furusyo
    Department of General Medicine, Kyushu University Hospital, Higashi ku, Fukuoka, Japan
    J Gastroenterol Hepatol 23:1094-104. 2008
    ....
  17. ncbi request reprint [Cutaneous reactions induced by pegylated-interferon plus ribavirin combination therapy in a patient with chronic hepatitis C]
    Munechika Enjoji
    Department of Hepatology and Pancreatology, Kyushu University Hospital
    Fukuoka Igaku Zasshi 98:353-6. 2007
    ..Specific treatment successfully suppressed the symptom and pegylated-interferon plus ribavirin combination therapy was completely done. Cutaneous reactions induced by pegylated-interferon plus ribavirin combination therapy was reviewed...
  18. ncbi request reprint [Case of NASH exacerbated after testectomy due to seminoma]
    Shusuke Morizono
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 95:146-51. 2004
    ..This case suggests that the altered sex hormone balance might exacerbate NASH because liver dysfunction was particularly worsened after bilateral high orchiectomy...
  19. ncbi request reprint [Evaluation of prognosis and recurrence of hepatocellular carcinoma treated from 1988 to 2002 at Department of Medicine III, Kyushu University Hospital]
    Eiichirou Arimura
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 95:195-200. 2004
    ..In addition, ameliorating hepatitis, by antiviral treatment for example, to maintain hepatic function is also important for improving both the prognosis and the prevention of the recurrence...
  20. ncbi request reprint [A case of valproate-associated hyperammonemia with chronic hepatitis C]
    Marie Fukushima
    Department of Medicine and Bioregulately Science, Graduate School of Medical Sciences, Kyushu University
    Nihon Shokakibyo Gakkai Zasshi 102:42-7. 2005
  21. ncbi request reprint A multi-step, incremental expansion method for radio frequency ablation: optimization of the procedure to prevent increases in intra-tumor pressure and to reduce the ablation time
    Kazuhiro Kotoh
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 25:542-7. 2005
    ..We initially hypothesized that recurrence was attributable to increases in intra-tumor pressure during RFA, and we subsequently measured the pressure and optimized the procedure...
  22. ncbi request reprint Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Mol Med 16:631-5. 2005
    ....
  23. ncbi request reprint Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Kyushu University, Fukuoka, Japan
    Transplantation 80:608-12. 2005
    ..To reduce the risk of liver injury, we applied a short-term combination therapy of diet, exercise and drugs for 11 living-donor liver transplantation (LDLT) candidates with steatosis...
  24. ncbi request reprint Relationship between body surface area and ALT normalization after long-term lamivudine treatment
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 5282, Japan
    World J Gastroenterol 11:6948-53. 2005
    ..To further evaluate the relationship between BSA and the effects of lamivudine in a greater number of cases and over a longer period of observation than in our previous evaluation...
  25. ncbi request reprint [Factors affecting the increase of urinary diacetylspermine levels : a study in patients with liver diseases]
    Munechika Enjoji
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582
    Rinsho Byori 54:126-31. 2006
    ..When we interpret the data of urinary diacetylspermine in patients, it is needed to consider whether these factors exist in the patients...
  26. ncbi request reprint RCAS1-expressing macrophages in inflammatory liver diseases
    Munechika Enjoji
    Liver Int 26:385-7. 2006
  27. ncbi request reprint Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Int J Mol Med 20:351-8. 2007
    ..Further studies will be needed to clarify how fatty acid synthesis is increased by SREBP-1c, which is under the control of insulin and AMP-activated protein kinase...
  28. ncbi request reprint [Estimation of indication for living donor liver transplantation in patients with HCV and/or HBV infection]
    Sawako Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 98:295-300. 2007
    ..Application to liver transplantation should also be considered based on HCC stage such as the UNOS scoring system...
  29. ncbi request reprint Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine
    Nobito Higuchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka, Japan
    Liver Int 27:1342-8. 2007
    ..To analyse the detailed mechanism, steroid injection via the portal vein was performed in an experimental model of liver damage...
  30. ncbi request reprint Various sarcoid lesions in a patient induced by interferon therapy for chronic hepatitis C
    Ken ichi Noguchi
    J Clin Gastroenterol 35:282-4. 2002