Munechika Enjoji

Summary

Affiliation: Fukuoka University
Country: Japan

Publications

  1. pmc Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:925807. 2012
  2. pmc Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:264017. 2012
  3. pmc Nutrition therapy for liver diseases based on the status of nutritional intake
    Kenichiro Yasutake
    Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, Kanzaki 842 8585, Japan Clinical Research Center, Kyushu Medical Center, National Hospital Organization, Fukuoka 810 0065, Japan
    Gastroenterol Res Pract 2012:859697. 2012
  4. pmc Early dynamics of viremia in patients with genotype 1b chronic hepatitis C: Peg-IFNalpha2a shows earlier viral decline than peg-IFNalpha2b in combination therapy with ribavirin
    Tatsuya Fujino
    Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan
    Med Sci Monit 17:CR687-91. 2011
  5. ncbi request reprint Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study
    Munechika Enjoji
    Department of Clinical Pharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 22:521-7. 2008
  6. pmc NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease
    Munechika Enjoji
    Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Lipids Health Dis 9:29. 2010
  7. pmc Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease?
    Munechika Enjoji
    World J Gastroenterol 16:800-3. 2010
  8. ncbi request reprint Early decline of the HCV core antigen can predict SVR in patients with HCV treated by Pegylated interferon plus ribavirin combination therapy
    Tatsuya Fujino
    Clinical Research Center, National Hospital Organization, Fukuoka, Japan
    J Dig Dis 10:21-5. 2009
  9. ncbi request reprint Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy?
    Makoto Nakamuta
    Clinical Research Center, National Hospital Organization, Fukuoka, Japan
    Int J Mol Med 24:825-8. 2009
  10. ncbi request reprint The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease
    Makoto Nakamuta
    Department of Gastroenterology, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
    Int J Mol Med 22:663-7. 2008

Collaborators

  • Akinobu Taketomi
  • Naoya Sakamoto
  • Yoshiyuki Wada
  • Yasuhito Tanaka
  • Hiromi Ishibashi
  • Tsukasa Uno
  • Goshi Shiota
  • Hirohisa Yano
  • Tetsuhide Ito
  • Masaki Kato
  • Ryoichi Takayanagi
  • Masayuki Miyazaki
  • Saneyoshi Ueno
  • Yuji Soejima
  • Norihiro Furusyo
  • Hirohiko Tanaka
  • Makoto Nakamuta
  • Kazuhiro Kotoh
  • Motoyuki Kohjima
  • Manabu Nakashima
  • Tatsuya Fujino
  • Kenichiro Yasutake
  • Tsuyoshi Yoshimoto
  • Naohiko Harada
  • Ryoko Yada
  • Nobito Higuchi
  • Kunitaka Fukuizumi
  • Shusuke Morizono
  • Masayoshi Yada
  • Yoko Aoyagi
  • Yoshihiko Maehara
  • Hajime Nawata
  • Takuya Nishinakagawa
  • Ryosuke Takemoto
  • Hideo Shiohira
  • Marie Fukushima
  • Akira Kitaoka
  • Hironori Sakai
  • Toshihiko Miyahara
  • Eiichirou Arimura
  • Masato Hamabashiri
  • Mako Toyoda
  • Yuko Takami
  • Kazuyuki Machida
  • Hideki Saitsu
  • Naoki Yamashita
  • Yuki Horikawa
  • Sawako Inoue
  • Shinichi Aishima
  • Satoshi Ohta
  • Ken ichi Noguchi
  • Nobuyoshi Fukushima
  • Machiko Bekki
  • Tomoki Ryu
  • Masako Ichinose
  • Michiko Ikemoto
  • Sachiko Ogasawara
  • Mika Fukuda
  • Kouichi Ohshima
  • Makiko Yasumoto
  • Hiroshi Yatsuhashi
  • Takeaki Satoh
  • Aya Daichou
  • Sho Fujii
  • Hiromi Shirasawa
  • Tetsuya Nozaki
  • Tatsuhiro Maeda
  • Kotaro Koga
  • Kaori Masuda
  • Noriko Haruta
  • Masatake Tanaka
  • Yuki Shima
  • Momoko Koga
  • Fukuko Hayata
  • Akiko Ohyama
  • Hirotaka Tajiri
  • Naoko Kinukawa
  • Akihiro Ueda
  • Tomoharu Yoshizumi
  • Yoshinori Fukui
  • Yuzuru Miyagi
  • Tsuyosi Yoshimoto
  • Shinsaku Yamashita
  • Mitsuo Shimada
  • Akihide Masumoto
  • Hideaki Uchiyama
  • Eiji Kajiwara
  • Junya Shimono
  • Koichi Azuma
  • Toshihiro Maruyama

Detail Information

Publications41

  1. pmc Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:925807. 2012
    ..The clinical significance of managing cholesterol metabolism, an option for the treatment of NAFLD, is also discussed...
  2. pmc Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments
    Munechika Enjoji
    Health Care Center, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hepatol 2012:264017. 2012
    ..We also discuss the clinical significance of insulin sensitizers used to improve insulin resistance and lipid modulators used to manage lipid metabolism as potential treatment options for chronic hepatitis C...
  3. pmc Nutrition therapy for liver diseases based on the status of nutritional intake
    Kenichiro Yasutake
    Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, Kanzaki 842 8585, Japan Clinical Research Center, Kyushu Medical Center, National Hospital Organization, Fukuoka 810 0065, Japan
    Gastroenterol Res Pract 2012:859697. 2012
    ..Late evening snacks, branched-chain amino acids, zinc, and probiotics are considered for effective nutritional utilization...
  4. pmc Early dynamics of viremia in patients with genotype 1b chronic hepatitis C: Peg-IFNalpha2a shows earlier viral decline than peg-IFNalpha2b in combination therapy with ribavirin
    Tatsuya Fujino
    Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan
    Med Sci Monit 17:CR687-91. 2011
    ..We aimed to assess differences in early viral dynamics following treatment with either peg-IFNalpha2a or peg-IFNalpha2b in combination with ribavirin in patients with chronic genotype 1b HCV infection...
  5. ncbi request reprint Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study
    Munechika Enjoji
    Department of Clinical Pharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 22:521-7. 2008
    ..The effects tended to be more notable with telmisartan. In conclusion, telmisartan and olmesartan improved insulin sensitivity and may possibly be used as liver protecting agents in CH-C as well as NAFLD patients...
  6. pmc NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease
    Munechika Enjoji
    Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Lipids Health Dis 9:29. 2010
    ..Therefore, excess cholesterol intake appears to be one of the main factors associated with NAFLD development and liver injury...
  7. pmc Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease?
    Munechika Enjoji
    World J Gastroenterol 16:800-3. 2010
    ..We review one pathogenic aspect of lipid metabolism dysregulation in NAFLD and survey new strategies for NAFLD treatment based on the modification of cholesterol metabolism...
  8. ncbi request reprint Early decline of the HCV core antigen can predict SVR in patients with HCV treated by Pegylated interferon plus ribavirin combination therapy
    Tatsuya Fujino
    Clinical Research Center, National Hospital Organization, Fukuoka, Japan
    J Dig Dis 10:21-5. 2009
    ..We estimated the predictive serum HCV core antigen levels for SVR in the early therapeutic stage of combination therapy...
  9. ncbi request reprint Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy?
    Makoto Nakamuta
    Clinical Research Center, National Hospital Organization, Fukuoka, Japan
    Int J Mol Med 24:825-8. 2009
    ..In summary, the regulation of lipid metabolism was impaired and cholesterol and fatty acid synthesis continued to increase without negative feedback in HCV-infected liver. These changes may be beneficial for HCV replication...
  10. ncbi request reprint The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease
    Makoto Nakamuta
    Department of Gastroenterology, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
    Int J Mol Med 22:663-7. 2008
    ....
  11. doi request reprint Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C
    Motoyuki Kohjima
    Department of Gastroenterology, Kyushu Medical Center, Fukuoka, Japan
    J Med Virol 85:250-60. 2013
    ..Addition of pitavastatin and EPA to peg-IFN/ribavirin treatment improved sustained virological response in patients infected with HCV-1b. Genotype variation of IL-28B is a strong predictive factor in add-on therapy...
  12. doi request reprint Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes
    Mako Toyoda
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Int J Mol Med 27:619-24. 2011
    ..The results of this study in cultured cells suggest that HCV infection may activate the cannabinoid system and precede steatosis, but the core protein by itself may not have any effect on the cannabinoid system...
  13. ncbi request reprint Expression profile of lipid metabolism-associated genes in hepatitis C virus-infected human liver
    Tatsuya Fujino
    Clinical Research Center, Kyushu Medical Center, National Hospital Organization, Japan
    Hepatol Res 40:923-9. 2010
    ..The positive correlations in the expression levels of some cholesterol metabolism-associated genes indicate that not all of the metabolic pathways are dysregulated in HCV-infected liver...
  14. doi request reprint Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol
    Kenichiro Yasutake
    Dietetic Laboratory, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
    Scand J Gastroenterol 44:471-7. 2009
    ..The purpose of this study was to identify potential nutritive factors that affect NAFLD and its related nutritional problems...
  15. ncbi request reprint Assessing current nutritional status of patients with HCV-related liver cirrhosis in the compensated stage
    Kenichiro Yasutake
    Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, Kanzaki, Japan
    Asia Pac J Clin Nutr 21:400-5. 2012
    ..For there to be adequate guidance regarding dietary treatment, it is important that a patient's current nutritional state be clarified...
  16. ncbi request reprint Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease
    Makoto Nakamuta
    Department of Gastroenterology, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
    Int J Mol Med 23:603-8. 2009
    ..Overproduction of cholesterol may lead to an increased level of oxysterols, activation of LXRalpha and SREBP-1c, and enhanced fatty acid synthesis...
  17. ncbi request reprint Am80 induces neuronal differentiation via increased tropomyosin-related kinase B expression in a human neuroblastoma SH-SY5Y cell line
    Hideo Shiohira
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biomed Res 33:291-7. 2012
    ..These results suggest that Am80 induced neuronal differentiation by increasing TrkB expression and BDNF sensitivity...
  18. pmc Dietary habits and behaviors associated with nonalcoholic fatty liver disease
    Kenichiro Yasutake
    Kenichiro Yasutake, Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, Kanzaki 842 8585, Japan
    World J Gastroenterol 20:1756-67. 2014
    ..In this article, we update knowledge about NAFLD, review the important aspects of nutritional assessment targeting treatment success, and present some concrete nutritional care plans which can be applied generally. ..
  19. doi request reprint Validity of FibroScan values for predicting hepatic fibrosis stage in patients with chronic HCV infection
    Ryosuke Takemoto
    Department of Gastroenterology, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
    J Dig Dis 10:145-8. 2009
    ..We also tried to determine the cut-off levels and assess the feasibility of using FibroScan values to predict the fibrosis stage...
  20. doi request reprint Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury
    Masayuki Miyazaki
    Department of Medicine and Bioregulatory Science, Kyushu University, Japan
    J Gastroenterol Hepatol 26:1749-56. 2011
    ..Therefore, we investigated whether contrast-enhanced ultrasonography (CEUS) is useful to evaluate the changes in hepatic hemodynamics in patients with ALI...
  21. doi request reprint Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis
    Masato Hamabashiri
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    Int J Mol Med 28:599-603. 2011
    ..Furthermore, we demonstrated that subtractive immunization is a useful method for producing mAbs specific for the pancreatic juice from PC patients...
  22. ncbi request reprint Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line
    Hideo Shiohira
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Jonan ku, Fukuoka, Japan
    Int J Mol Med 26:393-9. 2010
    ..These findings suggest that Am80 induces neuronal differentiation to a greater extent than ATRA and thus may help establishing therapeutic strategies against neuronal degenerative disorders such as Parkinson's disease...
  23. ncbi request reprint Analysis of cell cycle arrest and apoptosis induced by RCAS1
    Takuya Nishinakagawa
    Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Mol Med 25:717-22. 2010
    ..These results suggest that cyclin D3 is one of the key target molecules in the RCAS1-RCAS1-R signaling pathway...
  24. ncbi request reprint Fertile females with nonalcoholic fatty liver disease (NAFLD) have higher levels of ALT than postmenopausal females: implications for the influence of fertility on NAFLD
    Kazuhiro Kotoh
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 54:224-8. 2007
    ..Insulin resistance recently has been reported to play a major role in nonalcoholic fatty liver disease (NAFLD). We evaluated the influence of fertility on fatty liver injury in fertile and postmenopausal women with insulin resistance...
  25. ncbi request reprint RCAS1-expressing macrophages in inflammatory liver diseases
    Munechika Enjoji
    Liver Int 26:385-7. 2006
  26. ncbi request reprint [Case of NASH exacerbated after testectomy due to seminoma]
    Shusuke Morizono
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 95:146-51. 2004
    ..This case suggests that the altered sex hormone balance might exacerbate NASH because liver dysfunction was particularly worsened after bilateral high orchiectomy...
  27. ncbi request reprint Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine
    Nobito Higuchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka, Japan
    Liver Int 27:1342-8. 2007
    ..To analyse the detailed mechanism, steroid injection via the portal vein was performed in an experimental model of liver damage...
  28. doi request reprint Investigation of hyperuricemia during pegylated-interferon-alpha2b plus ribavirin combination therapy in patients with chronic hepatitis C
    Naoki Yamashita
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Dig Dis 9:27-31. 2008
    ..However, detailed investigation of the elevation of uric acid has not been carried out previously. The incidence and mechanism of hyperuricemia were investigated in this study...
  29. ncbi request reprint Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Mol Med 16:631-5. 2005
    ....
  30. ncbi request reprint [Evaluation of prognosis and recurrence of hepatocellular carcinoma treated from 1988 to 2002 at Department of Medicine III, Kyushu University Hospital]
    Eiichirou Arimura
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 95:195-200. 2004
    ..In addition, ameliorating hepatitis, by antiviral treatment for example, to maintain hepatic function is also important for improving both the prognosis and the prevention of the recurrence...
  31. ncbi request reprint [A case of valproate-associated hyperammonemia with chronic hepatitis C]
    Marie Fukushima
    Department of Medicine and Bioregulately Science, Graduate School of Medical Sciences, Kyushu University
    Nihon Shokakibyo Gakkai Zasshi 102:42-7. 2005
  32. ncbi request reprint SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Mol Med 21:507-11. 2008
    ....
  33. ncbi request reprint [Estimation of indication for living donor liver transplantation in patients with HCV and/or HBV infection]
    Sawako Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 98:295-300. 2007
    ..Application to liver transplantation should also be considered based on HCC stage such as the UNOS scoring system...
  34. ncbi request reprint A multi-step, incremental expansion method for radio frequency ablation: optimization of the procedure to prevent increases in intra-tumor pressure and to reduce the ablation time
    Kazuhiro Kotoh
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 25:542-7. 2005
    ..We initially hypothesized that recurrence was attributable to increases in intra-tumor pressure during RFA, and we subsequently measured the pressure and optimized the procedure...
  35. ncbi request reprint Short-term intensive treatment for donors with hepatic steatosis in living-donor liver transplantation
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Kyushu University, Fukuoka, Japan
    Transplantation 80:608-12. 2005
    ..To reduce the risk of liver injury, we applied a short-term combination therapy of diet, exercise and drugs for 11 living-donor liver transplantation (LDLT) candidates with steatosis...
  36. ncbi request reprint Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Int J Mol Med 20:351-8. 2007
    ..Further studies will be needed to clarify how fatty acid synthesis is increased by SREBP-1c, which is under the control of insulin and AMP-activated protein kinase...
  37. ncbi request reprint Various sarcoid lesions in a patient induced by interferon therapy for chronic hepatitis C
    Ken ichi Noguchi
    J Clin Gastroenterol 35:282-4. 2002
  38. ncbi request reprint Relationship between body surface area and ALT normalization after long-term lamivudine treatment
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 5282, Japan
    World J Gastroenterol 11:6948-53. 2005
    ..To further evaluate the relationship between BSA and the effects of lamivudine in a greater number of cases and over a longer period of observation than in our previous evaluation...
  39. ncbi request reprint Association between the treatment length and cumulative dose of pegylated interferon alpha-2b plus ribavirin and their effectiveness as a combination treatment for Japanese chronic hepatitis C patients: project of the Kyushu University Liver Disease Study
    Norihiro Furusyo
    Department of General Medicine, Kyushu University Hospital, Higashi ku, Fukuoka, Japan
    J Gastroenterol Hepatol 23:1094-104. 2008
    ....
  40. ncbi request reprint [Factors affecting the increase of urinary diacetylspermine levels : a study in patients with liver diseases]
    Munechika Enjoji
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582
    Rinsho Byori 54:126-31. 2006
    ..When we interpret the data of urinary diacetylspermine in patients, it is needed to consider whether these factors exist in the patients...
  41. ncbi request reprint [Cutaneous reactions induced by pegylated-interferon plus ribavirin combination therapy in a patient with chronic hepatitis C]
    Munechika Enjoji
    Department of Hepatology and Pancreatology, Kyushu University Hospital
    Fukuoka Igaku Zasshi 98:353-6. 2007
    ..Specific treatment successfully suppressed the symptom and pegylated-interferon plus ribavirin combination therapy was completely done. Cutaneous reactions induced by pegylated-interferon plus ribavirin combination therapy was reviewed...