Yutaka Tsutsumi

Summary

Affiliation: Fujita Health University
Country: Japan

Publications

  1. ncbi request reprint Molecular analysis of T-cell repertoire in patients with graft-versus-host disease after allogeneic stem cell transplantation
    Yutaka Tsutsumi
    Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Leuk Lymphoma 45:481-8. 2004
  2. doi request reprint Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Jpn J Clin Oncol 42:375-86. 2012
  3. ncbi request reprint Deposition of IgD, alpha-1-antitrypsin and alpha-1-antichymotrypsin on Demodex folliculorum and D. brevis infesting the pilosebaceous unit
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan
    Pathol Int 54:32-4. 2004
  4. ncbi request reprint [Roles of pathological autopsy for analyzing causes of death]
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine
    Rinsho Byori . 2008
  5. ncbi request reprint Histopathological diagnosis of infectious diseases using patients' sera
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Semin Diagn Pathol 24:243-52. 2007
  6. ncbi request reprint Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues
    Yoichi Sakurai
    Department of Surgery, Fujita Health University School of Medicine, 1 98 Dengakugakubo Kutsukake cho, Toyoake, 470 1192, Japan
    Gastric Cancer 10:234-40. 2007
  7. ncbi request reprint Histochemical identification of methicillin-resistant Staphylococcus aureus: contribution to preventing nosocomial infection
    Ryoichi Shimomura
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Semin Diagn Pathol 24:217-26. 2007
  8. ncbi request reprint Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Oncol Rep 14:1223-30. 2005
  9. ncbi request reprint The etiological role of allogeneic fetal rejection in pre-eclampsia
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Am J Reprod Immunol 58:11-20. 2007
  10. ncbi request reprint Expression of cancer cachexia-related factors in human cancer xenografts: an immunohistochemical analysis
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Biomed Res 27:275-81. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Molecular analysis of T-cell repertoire in patients with graft-versus-host disease after allogeneic stem cell transplantation
    Yutaka Tsutsumi
    Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Leuk Lymphoma 45:481-8. 2004
    ..0055). These results suggest that we might be able to consider a possible development of cGVHD by analyzing TCR-VB spectratyping after allo-SCT...
  2. doi request reprint Apocrine carcinoma as triple-negative breast cancer: novel definition of apocrine-type carcinoma as estrogen/progesterone receptor-negative and androgen receptor-positive invasive ductal carcinoma
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Jpn J Clin Oncol 42:375-86. 2012
    ..In the present study, the author immunohistochemically defined apocrine-type carcinoma as ER-/PgR-/AR+ invasive ductal carcinoma and analyzed the significance of apocrine-type carcinoma as triple-negative breast cancer...
  3. ncbi request reprint Deposition of IgD, alpha-1-antitrypsin and alpha-1-antichymotrypsin on Demodex folliculorum and D. brevis infesting the pilosebaceous unit
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan
    Pathol Int 54:32-4. 2004
    ..These findings suggest a novel function of IgD and serum protease inhibitors as a protective host response to the mite...
  4. ncbi request reprint [Roles of pathological autopsy for analyzing causes of death]
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine
    Rinsho Byori . 2008
    ..In order to overcome the present insufficiency, Japan needs not only to establish new laws for death certification, but also to revise the present medical residency system for the training of autopsy-performing medical doctors...
  5. ncbi request reprint Histopathological diagnosis of infectious diseases using patients' sera
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Semin Diagn Pathol 24:243-52. 2007
    ..Endogenous human immunoglobulins in paraffin sections were scarcely detected by the peroxidase-labeled secondary antibody. The method is simple, economic, useful, and beautiful for the histopathologic diagnosis of infectious diseases...
  6. ncbi request reprint Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues
    Yoichi Sakurai
    Department of Surgery, Fujita Health University School of Medicine, 1 98 Dengakugakubo Kutsukake cho, Toyoake, 470 1192, Japan
    Gastric Cancer 10:234-40. 2007
    ....
  7. ncbi request reprint Histochemical identification of methicillin-resistant Staphylococcus aureus: contribution to preventing nosocomial infection
    Ryoichi Shimomura
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Semin Diagn Pathol 24:217-26. 2007
    ..This review focuses on such histopathological approaches, which should have profound potential for contributing to decreasing and preventing nosocomial infection of MRSA...
  8. ncbi request reprint Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Oncol Rep 14:1223-30. 2005
    ..Fluoropyrimidine treatment may be selected, based on the simultaneous immunohistochemical evaluation of the fluoropyrimidine metabolic enzymes...
  9. ncbi request reprint The etiological role of allogeneic fetal rejection in pre-eclampsia
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Am J Reprod Immunol 58:11-20. 2007
    ..It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia...
  10. ncbi request reprint Expression of cancer cachexia-related factors in human cancer xenografts: an immunohistochemical analysis
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Biomed Res 27:275-81. 2006
    ..Any of five factors examined were not conclusive for causing cancer cachexia in the murine xenograft model. Further analysis is needed in order to elucidate the mechanisms responsible for cancer cachexia...
  11. doi request reprint Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts
    Yoichi Sakurai
    Department of Surgery, Fujita Health University School of Medicine, 1 98 Dengakugakubo Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Ann Surg Oncol 15:2301-9. 2008
    ....
  12. ncbi request reprint Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts
    Yoichi Sakurai
    Department of Surgery, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Anticancer Res 28:1593-602. 2008
    ..Although a variety of combination chemotherapies has been tested in gastric carcinoma, the most effective chemotherapeutic regimen and the precise mechanisms underlying anticancer agent combination have not yet been sufficiently elucidated...
  13. ncbi request reprint Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Aichi 470 1192, Japan
    Oncol Rep 16:721-7. 2006
    ..S-1, a fluoropyrimidine containing a strong DPD inhibitor, may be effective for AFP-positive gastric cancers with poorly differentiated medullary growth pattern...
  14. ncbi request reprint Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan
    Pathol Int 54:564-75. 2004
    ..In conclusion, the combination of low expression of TS and induction of p16(INK4a) after chemotherapy can be important indicators of the sensitivity to 5-FU-based chemotherapy in colorectal cancers...
  15. ncbi request reprint Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Jpn J Clin Oncol 34:594-601. 2004
    ..The present study aimed to assess the relationship between the biological behavior of advanced colorectal cancer treated post-operatively by 5-FU-based chemotherapy and the expression of TS and p16(INK4a) in primary tumors...
  16. pmc Enzyme-labeled antigen method: histochemical detection of antigen-specific antibody-producing cells in tissue sections of rats immunized with horseradish peroxidase, ovalbumin, or keyhole limpet hemocyanin
    Yasuyoshi Mizutani
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan
    J Histochem Cytochem 57:101-11. 2009
    ..Expectedly, this method allows us to observe antigen-specific antibody-producing cells under varied pathological conditions...
  17. doi request reprint Hepatitis C virus infection in a Japanese leprosy sanatorium for the past 67 years
    Kazuya Shiogama
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan
    J Med Virol 82:556-61. 2010
    ..HCV genotypes 1b and 2a were found by RT-PCR at 85.7% and 14.3%, respectively, in patients with leprosy...
  18. ncbi request reprint [Histopathological diagnosis of opportunistic infection]
    Yutaka Tsutsumi
    Department of Pathology, Fujita Health University School of Medicine, Toyoake 470 1192
    Rinsho Byori 50:649-57. 2002
    ..Pathologists must realize the importance of correct and prompt histopathological diagnosis of a wide variety of infectious diseases in both immunocompetent and immunocompromised patients...
  19. ncbi request reprint [Predictive value of orotate phosphoribosyltransferase in chemoresistant patients with gastric carcinoma who underwent S-1-based neoadjuvant/adjuvant chemotherapy]
    Yoichi Sakurai
    Dept of Surgery, Fujita Health University School of Medicine
    Gan To Kagaku Ryoho 35:1147-55. 2008
    ..0 ng/mg protein)are non-responders to S-1- based adjuvant/neoadjuvant chemotherapy. The determination of OPRT levels in gastric carcinoma tissue enables to predict the response to S-1-based neoadjuvant/adjuvant chemotherapy...
  20. ncbi request reprint [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]
    Yoichi Sakurai
    Dept of Surgery, Fujita Health University School of Medicine
    Gan To Kagaku Ryoho 34:1581-7. 2007
    ..These results suggest that activation of fluoropyrimidine mainly occurs in carcinoma tissues and the OPRT levels in carcinoma tissues were not influenced by neoadjuvant chemotherapy with fluoropyrimidine...
  21. ncbi request reprint Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state
    Nobutake Yamamichi
    Division of Host Parasite Interaction, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Cancer Res 67:10727-35. 2007
    ..Via regulating such genes important for gut differentiation, Brm should play significant roles in determining the histologic features of gastric malignancy...
  22. ncbi request reprint [Clinical and prognostic significance of protein and gene expression of orotate phosphoribosyltransferase in gastric carcinoma]
    Yoichi Sakurai
    Dept of Surgery, Fujita Health University School of Medicine
    Gan To Kagaku Ryoho 33:1111-8. 2006
    ....
  23. ncbi request reprint [Clinicopathological significance of orotate phosphoribosyltransferase in gastric carcinoma]
    Yoichi Sakurai
    Dept of Surgery, Fujita Health University School of Medicine
    Gan To Kagaku Ryoho 33:487-92. 2006
    ..These results suggest that OPRT levels were related to the histopathological characteristics of gastric carcinoma, and may be related to the response to fluoropyrimidine-based anticancer chemotherapy...
  24. ncbi request reprint Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells
    Junji Tanaka
    Department of Hematology and Oncology, Institute for Genetic Medicine, Hokkaido University Graduate School of Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan
    Blood 104:768-74. 2004
    ..Therefore, CD94-expressing cells with cytolytic activity against the recipient's leukemic and tumor cells without enhancement of alloresponse might be able to be expanded from donor G-PBMCs...
  25. ncbi request reprint Hepatitis B virus reactivation in a case of non-Hodgkin's lymphoma treated with chemotherapy and rituximab: necessity of prophylaxis for hepatitis B virus reactivation in rituximab therapy
    Yutaka Tsutsumi
    Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan
    Leuk Lymphoma 45:627-9. 2004
    ..After administration of lamivudine, however, she gradually recovered from liver failure...
  26. ncbi request reprint Bronchial carcinoid tumor with gangliocytic- and paraganglionlike differentiation
    Masato Nakamura
    Virchows Arch 442:183-5. 2003
  27. ncbi request reprint Monitoring of plasma imatinib concentration for the effective treatment of CML patients
    Yutaka Tsutsumi
    Leuk Res 28:1117-8. 2004
  28. ncbi request reprint Successful treatment of lymphoma with fludarabine combined with rituximab after immune thrombocytopenia induced by fludarabine
    Yutaka Tsutsumi
    Ann Hematol 84:269-71. 2005
    ..In the discussion, we analyze the characteristics and the treatment outcome of the thrombocytopenia induced by fludarabine reviewed in the literature...
  29. ncbi request reprint Reduced-intensity allogeneic hematopoietic stem-cell transplantation as an immunotherapy for metastatic colorectal cancer
    Rie Kojima
    Hematopoietic Stem Cell Transplant Unit, The National Cancer Center Hospital, Tokyo, Japan
    Transplantation 78:1740-6. 2004
    ..Because the gastrointestinal tract is a target of graft-versus-host disease (GvHD), colorectal cancer might be a candidate for allo-SCT...
  30. doi request reprint Long-term administration of a low-molecular-weight heparin contributed to successful treatment in a patient with primary mediastinal large B-cell lymphoma and venous thromboembolism
    Akio Mori
    Department of Internal Medicine Hakodate Municipal Hospital, Hakodate, Japan
    Clin Appl Thromb Hemost 14:468-71. 2008
    ..This case suggests that long-term administration of an LMWH contributes to the primary improvement and secondary prevention of VTE even in patients who are at high risk for thrombosis...
  31. ncbi request reprint Reactivation of hepatitis B virus with rituximab
    Yutaka Tsutsumi
    Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate 041 8680, Japan
    Expert Opin Drug Saf 4:599-608. 2005
    ..The authors reviewed their cases and the previous literature to clarify the characteristics of HBV-reactivated patients who were administered rituximab...
  32. ncbi request reprint Inhibitory effect of etodolac, a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils
    Hirohito Magari
    Second Department of Internal Medicine, Wakayama Medical University, Wakayama 641 0012, Japan
    Biochem Biophys Res Commun 334:606-12. 2005
    ..These results suggest that COX-2 is a key molecule in inflammation-mediated stomach carcinogenesis and that chemoprevention of stomach cancer should be possible by controlling COX-2 expression or activity...
  33. ncbi request reprint Randomized study of Helicobacter pylori eradication therapy and proton pump inhibitor monotherapy for idiopathic thrombocytopenic purpura
    Yutaka Tsutsumi
    Department of Internal Medicine, Hakodate Municipal Hospital, 1 10 1 Minato cho, Hakodate, 041 8680, Japan
    Ann Hematol 84:807-11. 2005
    ..No significant differences were observed in the CR + PR of these patients between HP eradication therapy and PPI monotherapy. As for cost comparisons, HP eradication therapy is cheaper than PPI monotherapy, but it is less effective...
  34. ncbi request reprint Delayed reduction in left ventricular function following treatment of non-Hodgkin's lymphoma with chemotherapy and rituximab, unrelated to acute infusion reaction
    Hiroe Kanamori
    Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan
    Cardiology 105:184-7. 2006
    ..Reduction in cardiac functions is a severe complication that must be considered when rituximab is administered...
  35. ncbi request reprint Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils
    Koichi Takeda
    Second Department of Pathology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Oleo Sci 56:253-60. 2007
    ..We conclude that dietary supplementation with 500 ppm of AUR suppresses Hp colonization, but does not reduce gastric inflammation...
  36. ncbi request reprint A case of non-Hodgkin's lymphoma and invasive thymoma treated with R-CHOP therapy
    Hiroaki Yamato
    Int J Hematol 83:464-6. 2006
  37. ncbi request reprint Establishment and characterization of amylase-producing lung adenocarcinoma cell line, IMEC-2
    Hiroshi Yokouchi
    First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo, Japan
    Anticancer Res 26:2821-7. 2006
    ..Few studies have successfully established an amylase-producing lung cancer cell line or have examined its cytological, biochemical and biological features...
  38. ncbi request reprint Syndrome of inappropriate secretion of ADH after administration of intrathecal chemotherapy in acute promyelocytic leukemia with empty sella of pituitary gland
    Yutaka Tsutsumi
    Ann Hematol 86:149-50. 2007
  39. ncbi request reprint Analysis of T-cell repertoire and mixed chimaerism in a patient with aplastic anaemia after allogeneic bone marrow transplantation
    Yutaka Tsutsumi
    Department ofHaematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Br J Haematol 118:136-9. 2002
    ..Therefore, some immune responses induced by the recipient CD8-positive T cells had an important role in pancytopenia in AA patients after allo-BMT...