Nakao Iwata

Summary

Affiliation: Fujita Health University
Country: Japan

Publications

  1. pmc Study protocol: safety correction of high dose antipsychotic polypharmacy in Japan
    Tsuruhei Sukegawa
    National Hospital Organization, Tottori Medical Center, 876, Mitsu, Tottori shi, Tottori 689 0203, Japan
    BMC Psychiatry 14:103. 2014
  2. pmc Japan useful medication program for schizophrenia (JUMPs)-long-term study on discontinuation rate, resolution and remission, and improvement in social functioning rate associated with atypical antipsychotic medications in patients with schizophrenia
    Jun Ishigooka
    Department of Psychiatry, Tokyo Women s Medical University, School of Medicine, Shinjuku ku, Tokyo, Japan
    BMC Psychiatry 13:243. 2013
  3. pmc Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening
    Branko Aleksic
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 39:720-8. 2013
  4. pmc Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 38:552-60. 2012
  5. pmc Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
    Nobuyuki Yamasaki
    Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
    Mol Brain 1:6. 2008
  6. pmc The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Behav Brain Funct 4:37. 2008
  7. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
  8. pmc Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia
    Xiangdong Deng
    Division of Disease Genes, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    BMC Psychiatry 4:21. 2004
  9. pmc Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia
    Xiangdong Deng
    Division of Human Molecular Genetics, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    BMC Psychiatry 8:58. 2008
  10. ncbi request reprint [Future prospect for identification of schizophrenia susceptive genes]
    Nakao Iwata
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:131-4. 2006

Detail Information

Publications125 found, 100 shown here

  1. pmc Study protocol: safety correction of high dose antipsychotic polypharmacy in Japan
    Tsuruhei Sukegawa
    National Hospital Organization, Tottori Medical Center, 876, Mitsu, Tottori shi, Tottori 689 0203, Japan
    BMC Psychiatry 14:103. 2014
    ..In this study of the SCAP method, we aimed to substantially increase the number of participants...
  2. pmc Japan useful medication program for schizophrenia (JUMPs)-long-term study on discontinuation rate, resolution and remission, and improvement in social functioning rate associated with atypical antipsychotic medications in patients with schizophrenia
    Jun Ishigooka
    Department of Psychiatry, Tokyo Women s Medical University, School of Medicine, Shinjuku ku, Tokyo, Japan
    BMC Psychiatry 13:243. 2013
    ..In Japan, no effectiveness study has been reported: thus, it is desirable to collect data that will serve as evidence for selection of the 3 SGAs approved after olanzapine...
  3. pmc Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening
    Branko Aleksic
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 39:720-8. 2013
    ..02). These findings demonstrate that VAV3 can be seen as novel candidate gene for schizophrenia in which both rare and common variants may be related to increased genetic risk for schizophrenia in Japanese population...
  4. pmc Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 38:552-60. 2012
    ..5) in kalrn or ephb1...
  5. pmc Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
    Nobuyuki Yamasaki
    Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
    Mol Brain 1:6. 2008
    ..Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders...
  6. pmc The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Behav Brain Funct 4:37. 2008
    ..abstract:..
  7. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
    ..We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis...
  8. pmc Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia
    Xiangdong Deng
    Division of Disease Genes, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    BMC Psychiatry 4:21. 2004
    ..In this study we report an association study of the excitatory amino acid transporter 2 gene, SLC1A2 with schizophrenia...
  9. pmc Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia
    Xiangdong Deng
    Division of Human Molecular Genetics, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    BMC Psychiatry 8:58. 2008
    ..We report here association studies of schizophrenia with SLC1A4, SLC1A5 encoding neutral amino acid transporters ASCT1, ASCT2, and SLC6A5, SLC6A9 encoding glycine transporters GLYT2, GLYT1, respectively...
  10. ncbi request reprint [Future prospect for identification of schizophrenia susceptive genes]
    Nakao Iwata
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:131-4. 2006
    ..Recently, it has been reported that more than 70% of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research...
  11. ncbi request reprint Relationship between a GABAA alpha 6 Pro385Ser substitution and benzodiazepine sensitivity
    N Iwata
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Am J Psychiatry 156:1447-9. 1999
    ..In this pilot study, they evaluated the contribution of this polymorphism to benzodiazepine sensitivity...
  12. ncbi request reprint Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Eur Arch Psychiatry Clin Neurosci 259:293-7. 2009
    ..However, it will be important to replicate and confirm these findings in other independent studies using large samples...
  13. ncbi request reprint Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population
    Tomoko Tsunoka
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:639-44. 2010
    ....
  14. ncbi request reprint PROKR2 is associated with methamphetamine dependence in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1033-6. 2010
    ..In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients...
  15. ncbi request reprint Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neuropharmacology 58:452-6. 2010
    ..Furthermore, we conducted an analysis of the association of HTR1A with METH-induced psychosis...
  16. ncbi request reprint Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Ann N Y Acad Sci 1139:70-82. 2008
    ..In conclusion, our results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese METH-use disorder...
  17. ncbi request reprint Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    J Hum Genet 54:629-33. 2009
    ..138). Our results suggest that HTR1A may not have a role in the pathophysiology of Japanese MDD patients. On the other hand, according to the meta-analysis, HTR1A was associated with MDD patients, especially in the Asian population...
  18. ncbi request reprint Meta-analysis of association between genetic variants in COMT and schizophrenia: an update
    Tomo Okochi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Schizophr Res 110:140-8. 2009
    ..This significance did not remain, however, after correcting the P-values using a false discovery rate controlling procedure. Our results suggest that the COMT is unlikely to contribute to susceptibility to schizophrenia...
  19. ncbi request reprint Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis
    Yasuhisa Fukuo
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 67:250-5. 2010
    ....
  20. ncbi request reprint Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population
    Takenori Okumura
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Neuropsychobiology 61:57-63. 2010
    ..Therefore, we studied the association of nNOS gene (NOS1) and mood disorders and the efficacy of fluvoxamine treatment in Japanese MDD patients...
  21. ncbi request reprint Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population
    Yusuke Kajio
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    J Hum Genet 59:54-6. 2014
    ..05). Our findings did not support the shared genetic risk between T2D and psychotic disorders in the Japanese population. However, further replication using a larger sample size is required. ..
  22. ncbi request reprint Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Pharmacogenomics 9:1437-43. 2008
    ....
  23. ncbi request reprint Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Hum Psychopharmacol 25:481-6. 2010
    ..To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample...
  24. ncbi request reprint Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Psychiatry Res 185:20-6. 2011
    ..HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. In the meta-analysis, rs6295 in HTR1A was associated with BP patients...
  25. ncbi request reprint Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    J Neural Transm 115:1457-61. 2008
    ..No significant association was detected in the allele/genotype-wise or haplotype-wise analysis. Our results suggest that CHRNA4 and CHRNB2 do not play a major role in Japanese schizophrenia...
  26. ncbi request reprint Association analysis of SIGMAR1 with major depressive disorder and SSRI response
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neuropharmacology 58:1168-73. 2010
    ....
  27. ncbi request reprint Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population
    Yasuhisa Fukuo
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    J Affect Disord 133:150-7. 2011
    ..We conducted a case control study between seven tagging SNPs (rs10517263, rs17675844, rs6554557, rs12646800, rs2244291, rs10034164, rs346005) in the USP46 gene, MDD, and the SSRI therapeutic response in MDD in the Japanese population...
  28. ncbi request reprint Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population
    Akiko Okuda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 12:78-85. 2010
    ..Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small...
  29. ncbi request reprint No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Schizophr Res 91:22-6. 2007
    ..Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population...
  30. ncbi request reprint Prepulse inhibition of the startle response with chronic schizophrenia: a replication study
    Masatsugu Moriwaki
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 65:259-62. 2009
    ..The gender and smoking state were not correlated with ASR, HAB or any PPI in multiple regression analysis. In conclusion, we were able to replicate the finding of HAB impairment and PPI deficit in chronic Japanese schizophrenic patients...
  31. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  32. ncbi request reprint No association between polymorphisms of neuronal oxide synthase 1 gene (NOS1) and schizophrenia in a Japanese population
    Takenori Okumura
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 11:123-7. 2009
    ..133 and rs3782206: P allele = 0.168). In conclusion, we could not replicate the association between seven SNPs in NOS1 and schizophrenia found in several earlier studies, using larger Japanese schizophrenia and control samples...
  33. ncbi request reprint HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Neuromolecular Med 12:237-42. 2010
    ..However, it will be important to replicate and confirm these findings in other independent studies using large samples...
  34. ncbi request reprint Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 11:114-22. 2009
    ..However, because our samples were small, it will be important to replicate and confirm these findings in other independent studies using larger samples...
  35. ncbi request reprint Orphan nuclear receptor Rev-erb alpha gene (NR1D1) and fluvoxamine response in major depressive disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Neuropsychobiology 59:234-8. 2009
    ..Therefore, we examined the association between the orphan nuclear receptor Rev-erbalpha gene (NR1D1) and the efficacy of fluvoxamine treatment in 118 Japanese patients with major depressive disorder...
  36. ncbi request reprint Genome-wide association study of schizophrenia in a Japanese population
    Masashi Ikeda
    Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Biol Psychiatry 69:472-8. 2011
    ..Moreover, a substantial polygenic component to the disorder consisting of a large number of such alleles has been reported by the International Schizophrenia Consortium...
  37. ncbi request reprint Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Ann N Y Acad Sci 1139:63-9. 2008
    ..No significant association was found with schizophrenia. Our findings suggest that a common genetic variation in the GCLM gene might not contribute to the risk of METH-use disorder and schizophrenia in the Japanese population...
  38. ncbi request reprint A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 55:469-72. 2010
    ..39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects...
  39. ncbi request reprint A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:895-8. 2009
    ..The symptoms of methamphetamine induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an association analysis of rs2234693 with Japanese methamphetamine induced psychosis patients...
  40. ncbi request reprint CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 11:53-7. 2009
    ..Our results indicate that CLOCK genotype may be a predictor of fluvoxamine treatment response in Japanese MDD. However, our sample size was small, and a replication study using larger samples may be required for conclusive results...
  41. ncbi request reprint Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 62:211-5. 2008
    ..No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population...
  42. ncbi request reprint Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Int J Neuropsychopharmacol 9:77-81. 2006
    ..Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition...
  43. ncbi request reprint Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 64:231-4. 2009
    ..In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and mood disorders in the Japanese population, but sample sizes, especially BP, were probably too small to allow a meaningful test...
  44. ncbi request reprint No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:531-4. 2008
    ..158 after SNPSpD correction). Considering the size of our sample and strategy, our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population...
  45. ncbi request reprint Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population
    Tomo Okochi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:903-5. 2009
    ..In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population...
  46. ncbi request reprint Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Ann N Y Acad Sci 1139:83-8. 2008
    ..No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population...
  47. ncbi request reprint Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population
    Tomoko Tsunoka
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:875-9. 2009
    ..Therefore, we studied the association between Group II mGluR genes (GRM2 and GRM3) and mood disorders and the efficacy of fluvoxamine treatment in Japanese MDD patients...
  48. ncbi request reprint No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Schizophr Res 82:185-9. 2006
    ..0424), but this may be a result of type I error due to multiple testing. Our results suggest that complexin genes do not play a major role in schizophrenia in Japanese patients...
  49. ncbi request reprint Association of SOX10 with schizophrenia in the Japanese population
    Nobuhisa Maeno
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Psychiatr Genet 17:227-31. 2007
    ..The SOX10 gene is located on chromosome 22q13.1, a region repeatedly reported to show positive signals in linkage studies on schizophrenia...
  50. ncbi request reprint The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis
    Ayako Nunokawa
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 116:61-7. 2010
    ..Our updated meta-analysis also failed to confirm the existence of a protective haplotype. To draw a definitive conclusion, further studies using larger samples and sufficient markers should be carried out in various ethnic populations...
  51. ncbi request reprint Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population
    Itaru Kushima
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:786-91. 2010
    ..Taken together, we could not strongly show that common SNPs in the BRD1 gene account for a substantial proportion of the genetic risk for schizophrenia in the Japanese population...
  52. ncbi request reprint SIRT1 gene is associated with major depressive disorder in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    J Affect Disord 126:167-73. 2010
    ....
  53. ncbi request reprint The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
    ..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations...
  54. ncbi request reprint Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:62-5. 2009
    ..The results of this study suggest that these polymorphisms in RA susceptibility genes do not contribute to genetic susceptibility to schizophrenia...
  55. ncbi request reprint A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population
    Yoshihito Ito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neurosci Lett 438:70-5. 2008
    ..Our findings suggest that FXYD6 is unlikely to be related to the development of schizophrenia in a Japanese population...
  56. ncbi request reprint BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis
    Kunihiro Kawashima
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Schizophr Res 112:72-9. 2009
    ..Further LD evaluation, as well as an association study in which BDNF-LCPR is genotyped directly, would be required for a more conclusive result...
  57. ncbi request reprint Association analysis of chromosome 5 GABAA receptor cluster in Japanese schizophrenia patients
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Biol Psychiatry 58:440-5. 2005
    ..A GABA(A) receptor gene cluster on 5q31-35 (beta2 [GABRB2], alpha6 [GABRA6], alpha1 [GABRA1], and gamma2 [GABRG2] subunit genes) is one of the most attractive candidate regions for schizophrenia susceptibility...
  58. ncbi request reprint Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
    ..The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population...
  59. ncbi request reprint Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population
    Nobuhisa Kanahara
    Department of Psychiatry, Chiba University Graduate School of Medicine, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:233-8. 2009
    ..The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population...
  60. ncbi request reprint Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD)
    Asuka Katsuki
    Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
    CNS Spectr 17:155-63. 2012
    ..We also examined mirtazapine's effects on the serum BDNF and plasma levels of catecholamine metabolites in these patients...
  61. ncbi request reprint No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population
    Kunihiro Kawashima
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1327-31. 2008
    ..However, these associations could not be confirmed in the second-set analysis. These results suggest that the SNARE complex-related genes do not play a major role in susceptibility to schizophrenia in the Japanese population...
  62. ncbi request reprint Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Schizophr Res 101:1-8. 2008
    ..Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases...
  63. ncbi request reprint Comparison of the efficacy between paroxetine and sertraline augmented with aripiprazole in patients with refractory major depressive disorder
    Reiji Yoshimura
    Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu 8078555, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 39:355-7. 2012
    ..In the present study, we compared the efficacy between paroxetine and sertraline augmented with aripiprazole in patients with refractory major depression...
  64. ncbi request reprint Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:405-13. 2012
    ....
  65. ncbi request reprint Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Drug Alcohol Depend 113:1-7. 2011
    ..The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an analysis of the association of the 5-HT6 gene (HTR6) with METH-induced psychosis...
  66. ncbi request reprint Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Hum Mol Genet 17:3212-22. 2008
    ..Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia...
  67. ncbi request reprint The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population
    Hinako Usui
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, and Ichihara Hospital, Chiba, Japan
    Schizophr Res 88:245-50. 2006
    ..These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population...
  68. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  69. ncbi request reprint Lack of association between MAGEL2 and schizophrenia and mood disorders in the Japanese population
    Yasuhisa Fukuo
    Department of Pychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Neuromolecular Med 12:285-91. 2010
    ..A replication study using larger samples may be required for conclusive results, since our sample size was small and our study analyzed only three SNPs in MAGEL2...
  70. ncbi request reprint Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Neuropsychopharmacology 31:866-71. 2006
    ..Although we failed to find an actual susceptibility variant that could modify the function of HTR7, our results support the supposition that HTR7 is a susceptibility gene for schizophrenia in this ethnic group...
  71. ncbi request reprint Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population
    Branko Aleksic
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Schizophr Res 118:113-7. 2010
    ..However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia...
  72. ncbi request reprint Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 495:216-20. 2011
    ..30). These results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects...
  73. ncbi request reprint Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients
    Shinichi Saito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Aichi, Japan
    Neuropsychobiology 54:226-30. 2006
    ..The purpose of this study was to investigate whether the VAMP2 gene is associated with clinical responses to a specific antidepressant, fluvoxamine...
  74. ncbi request reprint No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Schizophr Res 78:127-30. 2005
    ..Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis...
  75. ncbi request reprint Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Aichi, Japan
    J Hum Genet 55:133-6. 2010
    ..No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46...
  76. ncbi request reprint The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients
    Reiji Yoshimura
    Department of Psychiatry, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 8078555, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1022-5. 2011
    ..In addition, serum BDNF levels in these patients were considered together with the clinical response...
  77. ncbi request reprint Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Genet 120:243-52. 2006
    ..014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis...
  78. ncbi request reprint Association of AKT1 with schizophrenia confirmed in a Japanese population
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Biol Psychiatry 56:698-700. 2004
    ..Recent evidence supporting this hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and significant association of AKT1 haplotypes according to the transmission disequilibrium test...
  79. ncbi request reprint Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 109:80-5. 2009
    ..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population...
  80. ncbi request reprint Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  81. ncbi request reprint Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  82. ncbi request reprint Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population
    Nagahide Takahashi
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Schizophr Res 83:179-83. 2006
    ..007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population...
  83. ncbi request reprint No association between the Bcl2-interacting killer (BIK) gene and schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Lett 463:60-3. 2009
    ..105, rs2235316: corrected p=0.108). We conclude that BIK might not play a major role in the susceptibility of schizophrenia in Japanese population...
  84. ncbi request reprint Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study
    Hideki Amagane
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 118:106-12. 2010
    ..Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia...
  85. ncbi request reprint A two-stage case-control association study of PADI2 with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:430-2. 2009
    ..However, we could not replicate this association in a confirmatory population of 2126 patients and 2228 control individuals. The results of this study suggest that PADI2 does not contribute to genetic susceptibility to schizophrenia...
  86. ncbi request reprint No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population
    Branko Aleksic
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa Ku, Tsurumai cho, 65, Nagoya, Aichi 466 8550, Japan
    J Hum Genet 53:863-6. 2008
    ..We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor...
  87. ncbi request reprint Evaluation of probable or possible dementia with lewy bodies using 123I-IMP brain perfusion SPECT, 123I-MIBG, and 99mTc-MIBI myocardial SPECT
    Yoshitaka Inui
    Department of Radiology, Fujita Health University, Toyoake, Japan
    J Nucl Med 48:1641-50. 2007
    ....
  88. ncbi request reprint Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster
    Marta Radel
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Arch Gen Psychiatry 62:47-55. 2005
    ....
  89. ncbi request reprint No association of GSK3beta gene (GSK3B) with Japanese schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 134:90-2. 2005
    ..Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia...
  90. ncbi request reprint Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder
    Akiko Okuda
    Department of Psychiatry, Okehazama Hospital Fujita Mental Care Center, Aichi, Japan
    Psychiatry Clin Neurosci 64:268-73. 2010
    ..The aim of this study was to analyze the relation between treatment response and the duration of untreated illness (DUI) in 133 outpatients with the first major depressive disorder (MDD) episode...
  91. ncbi request reprint Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Psychopharmacology (Berl) 209:185-90. 2010
    ..We investigated the influence on startle response in chronic schizophrenia in 20 patients with schizophrenia taking risperidone, 21 patients with schizophrenia taking olanzapine, and 20 patients with schizophrenia taking aripiprazole...
  92. ncbi request reprint Investigation of clinical factors influencing cognitive function in Japanese schizophrenia
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 66:340-4. 2010
    ..Because anxiolytics/hypnotics might have a detrimental influence on cognitive function, we strongly suggest that the use of anxiolytics/hypnotics be reduced in schizophrenics as much as possible...
  93. ncbi request reprint No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population
    Shinichi Saito
    Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Neurosci Lett 374:21-4. 2005
    ..Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia. And our results did not support the gender-specific effect of this SNP...
  94. ncbi request reprint Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia
    Hiroki Shibata
    Division of Disease Genes, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Psychiatry Res 141:39-51. 2006
    ..We conclude that SNPs in the gene regions of GRIK3, GRIK4 or GRIK5 do not play a major role in schizophrenia pathogenesis in the Japanese population...
  95. ncbi request reprint Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder
    Nagisa Aoyama
    Department of Medical Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Alcohol Clin Exp Res 30:1644-9. 2006
    ..Moreover, SLC22A3 (which encodes OCT3) is a candidate gene for MAP dependence because it is located within a chromosomal region associated with substance dependence...
  96. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  97. ncbi request reprint Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder
    Takuya Masui
    Psychiatr Genet 16:49-50. 2006
    ..Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder...
  98. ncbi request reprint No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
    ....
  99. ncbi request reprint Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence
    Akira Nomura
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurosci Lett 400:158-62. 2006
    ..83, 95% ci=1.24-2.68)...
  100. ncbi request reprint Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 13:2699-708. 2004
    ..Genetic variants associated with impairments of these functions of dysbindin could play an important role in the pathogenesis of schizophrenia...
  101. ncbi request reprint Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
    Hideaki Kobayashi
    Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:482-6. 2006
    ..These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis...