S Ito

Summary

Affiliation: Fujita Health University
Country: Japan

Publications

  1. ncbi High-performance liquid chromatography estimation of cross-linking of dihydroxyindole moiety in eumelanin
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Anal Biochem 434:221-5. 2013
  2. ncbi Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin
    S Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    J Eur Acad Dermatol Venereol 25:1369-80. 2011
  3. ncbi Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake 470 1192, Japan
    Biochem Pharmacol 84:646-53. 2012
  4. ncbi Cyclic oscillations in melanin composition within hairs of baboons
    S Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 14:180-4. 2001
  5. ncbi Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 16:523-31. 2003
  6. ncbi Chemistry of mixed melanogenesis--pivotal roles of dopaquinone
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Aichi, Japan
    Photochem Photobiol 84:582-92. 2008
  7. ncbi Chemical analysis of melanins and its application to the study of the regulation of melanogenesis
    S Ito
    Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 13:103-9. 2000
  8. ncbi The IFPCS presidential lecture: a chemist's view of melanogenesis
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Pigment Cell Res 16:230-6. 2003
  9. ncbi Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 24:63-74. 2011
  10. ncbi Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice
    S Ito
    School of Hygiene, Fujita Gakuen Health University, Aichi, Japan
    Acta Derm Venereol 69:380-4. 1989

Collaborators

Detail Information

Publications88

  1. ncbi High-performance liquid chromatography estimation of cross-linking of dihydroxyindole moiety in eumelanin
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Anal Biochem 434:221-5. 2013
    ..IsoPTCA also increased gradually at lower levels. Similar changes were observed at 40°C at a much slower rate. These findings suggest that the PTeCA/PTCA ratio may serve as a good indicator of aging (cross-linking) of eumelanin...
  2. ncbi Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin
    S Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    J Eur Acad Dermatol Venereol 25:1369-80. 2011
    ..The chemical phenotype helped evaluate the precise effects of each disease on pigmentation. In studies of human hair, the chemical phenotype will find more and more application as an objective measure of pigmentation...
  3. ncbi Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake 470 1192, Japan
    Biochem Pharmacol 84:646-53. 2012
    ..NPrCAP thus represents a potential new approach to immunotherapy against metastatic melanoma...
  4. ncbi Cyclic oscillations in melanin composition within hairs of baboons
    S Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 14:180-4. 2001
    ....
  5. ncbi Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 16:523-31. 2003
    ..However, eumelanin is always the major constituent of epidermal melanin, and the skin color appears to be determined by the quantity of melanin produced but not by the quality...
  6. ncbi Chemistry of mixed melanogenesis--pivotal roles of dopaquinone
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Aichi, Japan
    Photochem Photobiol 84:582-92. 2008
    ..Based on these data, a casing model of mixed melanogenesis is proposed in which a preformed pheomelanic core is covered by a eumelanic surface...
  7. ncbi Chemical analysis of melanins and its application to the study of the regulation of melanogenesis
    S Ito
    Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 13:103-9. 2000
    ..In conclusion, our HPLC microanalytical method for characterizing eumelanin and pheomelanin has become a useful tool for the study of melanogenesis...
  8. ncbi The IFPCS presidential lecture: a chemist's view of melanogenesis
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Pigment Cell Res 16:230-6. 2003
    ..Finally, it is still unknown how the availability of cysteine is controlled within the melanosome...
  9. ncbi Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 24:63-74. 2011
    ..Based on these data, a hypothesis is proposed to explain the diversity of human hair pigmentation...
  10. ncbi Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice
    S Ito
    School of Hygiene, Fujita Gakuen Health University, Aichi, Japan
    Acta Derm Venereol 69:380-4. 1989
    ..Total indoles had a four-fold greater level of excretion than 5-S-CD, suggesting that the urinary excretion of total indoles is a quantitatively more significant marker of melanoma progression in this melanoma...
  11. ncbi Production, circulation, and excretion of melanin-related metabolites in B16 melanoma-bearing mice
    K Wakamatsu
    School of Hygiene, Fujita Health University, Aichi, Japan
    Acta Derm Venereol 70:367-72. 1990
    ....
  12. ncbi Normal values of urinary excretion and serum concentration of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid, biochemical markers of melanoma progression
    K Wakamatsu
    Fujita Health University School of Health Sciences, Aichi, Japan
    Melanoma Res 1:141-7. 1991
    ..These results suggest that the levels of 5-S-CD and 6H5M12C in serum are more reliable as tumour markers for the estimation of melanoma progression than those in urine...
  13. ncbi Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 22:474-86. 2009
    ..This latter process is consistent with the much higher ratio of benzothiazole-derived units in human red hair than in mouse yellow hair. These findings may be relevant to the (photo)toxic effects of pheomelanin...
  14. ncbi Comparison of phaeomelanin and its precursor 5-S-cysteinyldopa in the serum of melanoma patients
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Melanoma Res 13:357-63. 2003
    ..In the remaining eight patients (54%), serum 4-AHP levels were of less diagnostic value. Thus, the serum phaeomelanin level appears to be less sensitive than the serum 5-S-CD level in detecting distant metastases...
  15. ncbi Chemical characterization of hair melanins in various coat-color mutants of mice
    H Ozeki
    Fujita Health University School of Health Sciences, Aichi, Japan
    J Invest Dermatol 105:361-6. 1995
    ..These results indicate that our methodology, high-performance liquid chromatography and spectrophotometric methods combined, may be useful in chemically characterizing melanin pigments produced in follicular melanocytes...
  16. ncbi Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
    K Ikemoto
    Department of Anatomy, Fujita Health University, School of Medicine, Toyoake, Japan
    Neurosci Lett 253:198-200. 1998
    ..The present results suggest that tyrosinase is not involved in the main pathway of neuromelanin biosynthesis...
  17. ncbi Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets
    H Beppu
    Fujita Memorial Institute of Pharmacognosy, Fujita Health University, 1865 Isshiki cho, Hisai, Mie 514 1296, Japan
    Phytomedicine 13:49-60. 2006
    ....
  18. ncbi Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions
    N Kitaguchi
    Faculty of Clinical Engineering Technology, School of Health Sciences, Fujita Health University, Kutsukake cho, Toyoake, Japan
    Blood Purif 32:57-62. 2011
    ..Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states...
  19. ncbi Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
    S Honda
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Biochem Biophys Res Commun 252:445-9. 1998
    ..These results suggest an important participation of the aromatase gene in the reproductive behaviors...
  20. ncbi Advanced chemical methods in melanin determination
    Kazumasa Wakamatsu
    Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 15:174-83. 2002
    ..Emphasis is given on the usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin...
  21. ncbi Determination of eumelanin in human urine
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 19:163-9. 2006
    ..8-, 22- and 6.2-fold respectively. Thus, although urinary PTCA is of little clinical value in following the progression of melanoma, urinary 4-AHP appears to be of considerable value in this respect...
  22. ncbi Evaluation of melanin-related metabolites as markers of solar ultraviolet-B radiation
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 19:460-4. 2006
    ..483) with solar UVB radiation during the previous month. Levels of 5-S-CD and 6H5MI2C in the serum appear to reflect the degrees of skin injury and pigmentation in the skin, respectively...
  23. ncbi Synthesis and selective in vitro anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol
    Jun Yukitake
    Department of Clinical Immunology and Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan
    Melanoma Res 13:603-9. 2003
    ..These results suggest that the use of enantiomers would increase the efficacy of tyrosinase-dependent cytotoxic phenols...
  24. ncbi The structure of neuromelanin as studied by chemical degradative methods
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    J Neurochem 86:1015-23. 2003
    ..The involvement of DA and CysDA as building blocks of NM demonstrates the detoxifying role of NM synthesis, since it prevents the intraneuronal accumulation of DA and CysDA, which would cause toxic effects...
  25. ncbi The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin
    Kazumasa Wakamatsu
    Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 15:225-32. 2002
    ..Thus, we conclude that 'specific AHP' is a more specific marker of pheomelanin than is 'total AHP'...
  26. ncbi Contribution of a peroxide adduct of copper(II)-peptide complex to modify the secondary structure of albumin
    Y Ishikawa
    Department of Chemistry, Faculty of Science, Yamagata University, Japan
    Z Naturforsch C 53:378-82. 1998
    ..It is implied that conversion of normal cellular prion protein PrPC into a disease-causing isoform, PrPSc is attributed to the activated peroxide ion coordinated to a copper(II) captured in the NH2-terminal domain of the PrPC...
  27. ncbi Seasonal variation in serum concentration of 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid in healthy Japanese
    K Wakamatsu
    Fujita Health University School of Health Sciences, Aichi, Japan
    Pigment Cell Res 8:132-4. 1995
    ..No correlation was observed between 6H5MI2C level and solar radiation. This study showed that serum 5-S-CD and 6H5MI2C in healthy Japanese did not exceed the upper limit of normal values even in sunny season...
  28. ncbi Comparison of in vivo anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol
    Jun Yukitake
    Department of Clinical Immunology, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan
    Melanoma Res 14:115-20. 2004
    ..These results confirm that the use of enantiomers increases the efficacy of tyrosinase-dependent cytotoxic phenolic amines...
  29. ncbi Characterization of melanin in human iridal and choroidal melanocytes from eyes with various colored irides
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 21:97-105. 2008
    ....
  30. ncbi Encapsulation of a reactive core in neuromelanin
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan
    Proc Natl Acad Sci U S A 103:14647-8. 2006
  31. ncbi Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients
    Kazutaka Murakami
    Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan
    Blood Purif 28:209-15. 2009
    ..We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients...
  32. ncbi Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Res 19:154-62. 2006
    ....
  33. ncbi Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis
    Kazutaka Murakami
    Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Blood Purif 25:483-9. 2007
    ..We have examined serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor), pheomelanin, eumelanin, and protein-bound (PB-) 3,4-dihydroxyphenylalanine (DOPA) and PB-5SCD in HD patients...
  34. ncbi Is Borrmann type IV gastric carcinoma a surgical disease? An old problem revisited with reference to the result of peritoneal washing cytology
    Y Kodera
    Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Aichi, Japan
    J Surg Oncol 78:175-81; discussion 181-2. 2001
    ..Cytology examination of the peritoneal washes is an established prognostic factor for gastric carcinoma in general, and may be useful for identifying adequate treatment strategy for B-4...
  35. ncbi Age-dependent changes in eumelanin composition in hairs of various ethnic origins
    S Commo
    Life Sciences Department, L Oreal Research and Innovation, Clichy, France
    Int J Cosmet Sci 34:102-7. 2012
    ..g. decrease in dopachrome tautomerase expression)...
  36. ncbi Evaluation of 5-S-cysteinyldopa as a marker of melanoma progression: 10 years' experience
    K Wakamatsu
    Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Melanoma Res 12:245-53. 2002
    ..These results show that the level of 5-S-CD in the serum is a sensitive and specific marker in predicting distant metastases. Elevated serum levels of 5-S-CD, before or after surgical treatment, is associated with a poor prognosis...
  37. ncbi Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography
    A Goto
    Internal Medicine 1, Nagoya City University Medical School, Nagoya, 467-8601, Aichi, Japan
    Atherosclerosis 159:153-63. 2001
    ..It should also be noted that CETP mass in general correlates to total and LDL cholesterol, so that it would be an indirect atherogenic parameter...
  38. ncbi Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation
    R Zhang
    Department of Immunology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Aichi, Japan
    Clin Exp Immunol 164:417-27. 2011
    ..Further, transplantation of Gr-1(+)CD11b(+) cells greatly suppressed the increase of the same population, especially during the late phase of DSS colitis both in spleen and bone marrow...
  39. ncbi Comparison on reactivity of Fe(III) and Al(III) compounds in the presence of hydrogen peroxide: its relevance to possible origin for central nervous system toxicity by aluminum ion
    Y Nishida
    Department of Chemistry, Faculty of Science, Yamagata University, Japan
    Z Naturforsch C 50:571-7. 1995
    ....
  40. ncbi Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus
    H Yuasa
    First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan
    J Clin Endocrinol Metab 79:361-5. 1994
    ..Each mutation cosegregated with the phenotype of diabetes insipidus and supposed to be a cause for resistance to arginine vasopressin...
  41. ncbi Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells
    Masahiro Endo
    Department of Biology, Faculty of Medical Technology, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Biochim Biophys Acta 1800:669-73. 2010
    ..The active ingredients, polysaccharides and protein-polysaccharide complexes containing beta-glucan, have been isolated and shown to have indirect tumor-suppressing activity via an immunological activation...
  42. ncbi The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Cell Biol 85:537-49. 2006
    ....
  43. ncbi Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Front Biosci 11:2157-73. 2006
    ....
  44. ncbi Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
    Yasuko Kitao
    Department of Neuroanatomy, Kanazawa University Medical School, 13 1, Takara machi, Kanazawa City, 920 8640 Ishikawa, Japan
    Hum Mol Genet 16:50-60. 2007
    ..These data suggest a model in which ER- and dopamine-related stress are major contributors to decreased viability of dopaminergic neurons in a setting relevant to Parkinson's disease...
  45. ncbi Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
    John A D'Orazio
    Melanoma Program, Dana Farber Cancer Institute and Children s Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 443:340-4. 2006
    ..These data emphasize the essential role of intercellular MSH signalling in the tanning response, and suggest a clinical strategy for topical small-molecule manipulation of pigmentation...
  46. ncbi Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:209-17. 2007
    ..Eumelanin and pheomelanin may accumulate with difficulty in slaty melanocytes and be easily released from them during skin development. L-Tyr may stimulate this release...
  47. ncbi The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Dermatol Sci 45:55-62. 2007
    ....
  48. ncbi Regulation of human skin pigmentation and responses to ultraviolet radiation
    Yoshinori Miyamura
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Res 20:2-13. 2007
    ..Further research is needed to characterize the role of skin pigmentation to reduce photocarcinogenesis and to develop effective strategies to minimize such risks...
  49. ncbi High levels of melanin-related metabolites in plasma from pink-eyed dilution mice
    Kazumasa Wakamatsu
    Pigment Cell Res 20:222-4. 2007
  50. ncbi Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Cell Biol 86:315-30. 2007
    ....
  51. ncbi Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor
    Elodie Le Pape
    Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Melanoma Res 21:477-86. 2008
    ....
  52. ncbi Pigmentation effects of solar-simulated radiation as compared with UVA and UVB radiation
    Rainer Wolber
    Beiersdorf AG, R and D, Skin Research Center, Hamburg, Germany
    Pigment Cell Melanoma Res 21:487-91. 2008
    ..These results show that SSR is more effective in promoting delayed tanning than UVB radiation alone, suggesting a synergistic effect of UVA radiation. Furthermore, free 5SCD may serve as a good marker of the effect of SSR and UVB...
  53. ncbi The histological analysis, colorimetric evaluation, and chemical quantification of melanin content in 'suntanned' fish
    Kohsuke Adachi
    Fisheries Laboratory, Kinki University, Shirahama, Wakayama, Japan
    Pigment Cell Res 18:465-8. 2005
    ..These results indicate that eumelanin accumulates in suntanned fish during the increase in skin color, which is induced by sunlight, presumably by ultraviolet radiation...
  54. ncbi Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    J Cell Physiol 191:162-72. 2002
    ..These results suggest that p/p melanocytes in the primary culture are induced to synthesize eumelanin by excess L-Tyr, but difficult to accumulate them in melanosomes...
  55. ncbi Ultrafast absorption and photothermal studies of decarboxytrichochrome C in solution
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol Sci 2:821-3. 2003
    ..The combination of ultrafast absorption and photoacoustic data suggest photoexcitation produces a long-lived intermediate and the energy of this species is at least 133 kJ mol(-1) above the ground state of the dTC molecule...
  56. ncbi Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin
    Seiji Takeuchi
    Departments of Therapeutic Radiology, Genetics, and Dermatology, and Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT 06520 8040, USA
    Proc Natl Acad Sci U S A 101:15076-81. 2004
    ..Melanin-induced apoptosis may contribute to the increased sensitivity of individuals with blonde and red hair to sunburn and skin cancer...
  57. ncbi Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Pigment Cell Res 16:434-47. 2003
    ....
  58. ncbi HPLC analysis of pheomelanin degradation products in human urine
    Akihiko Takasaki
    Department of Biomedicine and Surgery, Division of Clinical Chemistry, Linkoping University, Linkoping, Sweden
    Pigment Cell Res 16:480-6. 2003
    ..The results indicate that 3-AHP in urine is not influenced by excreted 3-nitrotyrosine and the data indicate that pheomelanins are excreted in the urine of melanoma patients...
  59. ncbi Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Pigment Cell Res 17:506-14. 2004
    ..Pheomelanin production in the epidermis from 3.5- and 5.5-d-old A/A mice may be induced by the expression of the agouti gene in the dermis...
  60. ncbi Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Exp Zool 292:351-66. 2002
    ..These results suggest for the first time that p gene exerts its influence on the proliferative activities of mouse epidermal melanoblasts by affecting the regulatory mechanisms dependent on the function of ETs...
  61. ncbi Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells
    Hesamaddin Hejazy Rad
    Department of Dermatology, School of Medicine, Sapporo Medical University, Chuo, Sapporo 060-8543, Japan
    Exp Cell Res 298:317-28. 2004
    ..These biological activities of TYRP1 and DCT may work through the interaction with TYR in melanosomal compartment...
  62. ncbi Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 16:619-28. 2003
    ....
  63. ncbi Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes
    Jennifer E Hauser
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pigment Cell Res 19:303-14. 2006
    ..Therefore, MC, mainly EC, and MC1R function are independent determinants of UVR-induced DNA damage in melanocytes...
  64. ncbi Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708-0346, USA
    Photochem Photobiol 81:510-6. 2005
    ....
  65. ncbi An oxygen transporter hemocyanin can act on the late pathway of melanin synthesis
    Kohsuke Adachi
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Japan
    Pigment Cell Res 18:214-9. 2005
    ....
  66. ncbi Inhibition of transglutaminase by synthetic tyrosine melanin
    Koji Ikura
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Japan
    Biosci Biotechnol Biochem 66:1412-4. 2002
    ..The melanized hemolymph of the silkworm and melanin solutions prepared from melanin precursors inhibited tissue-type transglutaminase. These results suggested that the melanin substances generally inhibit transglutaminases...
  67. ncbi Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase
    Vaishali A Chaubal
    National Centre for Cell Science, NCCS Complex, Pune University Campus, Ganeshkhind, Pune, Maharashtra
    Pigment Cell Res 15:420-5. 2002
    ..Our findings thus introduce a new aspect in the regulation of pigmentation and ascribe a novel role for gamma-GT in pigment cells...
  68. ncbi Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells
    Sreenivasulu Chintala
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 102:10964-9. 2005
    ..Thus, we have found that the Slc7a11 gene controls the production of pheomelanin pigment directly. Cells from sut mice provide a model for oxidative stress-related diseases and their therapies...
  69. ncbi Effects of melanogenesis-inducing nitric oxide and histamine on the production of eumelanin and pheomelanin in cultured human melanocytes
    Michael W Lassalle
    Basic Research Laboratory, Kanebo Ltd, Odawara, Kanagawa, Japan
    Pigment Cell Res 16:81-4. 2003
    ..These results suggest that NO and histamine, as in the case of alpha-MSH, may contribute to UV-induced hyperpigmentation by enhancing eumelanogenesis...
  70. ncbi UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin
    Taketsugu Tadokoro
    Laboratory of Cell Biology, Building 37, Room 1B25, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 17:1177-9. 2003
    ....
  71. ncbi Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati College of Medicine, PO Box 670592, Cincinnati, Ohio 45267 0592, USA
    J Cell Sci 115:2349-55. 2002
    ..We conclude that loss-of-function mutations in the MC1R gene sensitize human melanocytes to the DNA damaging effects of UV radiation, which may increase skin cancer risk...
  72. ncbi Comparison of the structural and physical properties of human hair eumelanin following enzymatic or acid/base extraction
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Pigment Cell Res 16:355-65. 2003
    ..The enzymatically extracted hair melanin, on the contrary, retains the morphology of intact melanosomes and is an excellent source of human melanin...
  73. ncbi Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus
    Rosalynn J Miltenberger
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Genetics 160:659-74. 2002
    ....
  74. ncbi Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status
    Lisa Naysmith
    Systems Group, Dermatology, University of Edinburgh, Edinburgh, UK
    J Invest Dermatol 122:423-8. 2004
    ....
  75. ncbi Ion-exchange and adsorption of Fe(III) by Sepia melanin
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Res 17:262-9. 2004
    ..These observations imply the existence of channels within the melanin granules that can serve to transport metal ions...
  76. ncbi Highly sensitive detection of melanoma at an early stage based on the increased serum secreted protein acidic and rich in cysteine and glypican-3 levels
    Yoshiaki Ikuta
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 11:8079-88. 2005
    ..Thereby, we focused out attention on secreted protein acidic and rich in cysteine (SPARC) overexpressed in melanoma as another candidate for tumor marker...
  77. ncbi Comparison of structural and chemical properties of black and red human hair melanosomes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol 81:135-44. 2005
    ..Excellent agreement is observed between these spectral results and the chemical degradation data...
  78. ncbi Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein
    Gertrude E Costin
    Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Biochem J 391:249-59. 2005
    ..Thus the enzymatic activity of Dct may play a role in determining whether the eumelanin or pheomelanin pathway is preferred for pigment biosynthesis...
  79. ncbi Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells
    Yutaka Machida
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 332:233-40. 2005
    ..Our findings indicate that both parkin and alpha-SN share a common pathway in DA metabolism whose abnormality leads to accumulation of oxidative DA metabolites and subsequent cell death...
  80. ncbi Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation
    Alison Hennessy
    Department of Dermatology, University of Edinburgh, UK
    Pigment Cell Res 18:220-3. 2005
    ..Although our numbers are small, our results extend previous work in man, and lead us to speculate that factors other than the amount of pheomelanin may be important in determining UVR susceptibility in persons with red hair...
  81. ncbi Interaction of Hermansky-Pudlak Syndrome genes in the regulation of lysosome-related organelles
    Rashi Gautam
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Traffic 7:779-92. 2006
    ..Double and triple mutant HPS mice provide unique and practical experimental advantages in the study of LROs...
  82. ncbi The neuromelanin of human substantia nigra: physiological and pathogenic aspects
    Fabio A Zucca
    Institute of Biomedical Technologies-CNR 20090 Segrate (Milano, Italy
    Pigment Cell Res 17:610-7. 2004
    ..On the other hand, experiments in cell culture indicate that NM can activate microglia, eliciting the release of cytotoxic factors that can induce neurodegeneration...
  83. ncbi Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes
    Victoria M Virador
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health (NIH, Bethesda, Maryland, 20892, USA
    FASEB J 16:105-7. 2002
    ....
  84. ncbi Identification of glypican-3 as a novel tumor marker for melanoma
    Tetsuya Nakatsura
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 10:6612-21. 2004
    ..In the present study, we investigated the expression of GPC3 in human melanoma cell lines and tissues and asked whether GPC3 could be a novel tumor marker for melanoma...
  85. ncbi Childhood malnutrition is associated with a reduction in the total melanin content of scalp hair
    Colin A McKenzie
    Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica
    Br J Nutr 98:159-64. 2007
    ..The precise mechanisms by which melanin content is reduced, and the role of aromatic amino acid availability in hair colour change and other features of childhood malnutrition remain to be explored...
  86. ncbi A novel RFP-RET transgenic mouse model with abundant eumelanin in the cochlea
    Hideo Hayashi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hear Res 195:35-40. 2004
    ..In addition, we provide evidence that eumelanin overproduction in the cochlea does not affect normal hearing...
  87. ncbi Pael receptor is involved in dopamine metabolism in the nigrostriatal system
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute BSI, Saitama, Japan
    Neurosci Res 59:413-25. 2007
    ..These results strongly suggest that the Pael-R signal regulates the amount of DA in the dopaminergic neurons and that excessive Pael-R expression renders dopaminergic neurons susceptible to chronic DA toxicity...
  88. ncbi Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:13670-5. 2005
    ..Manipulation of PI3K/Akt signaling may therefore offer therapeutic benefits for the treatment of PD...