Research Topics
Genomes and Genes
| Masashi IkedaSummaryAffiliation: Fujita Health University Country: Japan Publications
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Detail Information
Publications
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disordersNobuyuki Yamasaki
Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
Mol Brain 1:6. 2008..Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders...
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophreniaM Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
Genes Brain Behav 6:107-12. 2007..However, no interaction was seen in our samples. This is the first association analysis of ARRB2, and our results indicate that ARRB2 may play a role in the pathophysiology of METH use disorder...
Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophreniaMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Pharmacogenomics 9:1437-43. 2008....- Failure to replicate the association between NRG1 and schizophrenia using Japanese large sampleMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
Schizophr Res 101:1-8. 2008..Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases... - No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patientsMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Schizophr Res 78:127-30. 2005..Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis... - No association of GSK3beta gene (GSK3B) with Japanese schizophreniaMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Am J Med Genet B Neuropsychiatr Genet 134:90-2. 2005..Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia... - No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese populationMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Schizophr Res 91:22-6. 2007..Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population... - Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Eur Arch Psychiatry Clin Neurosci 259:293-7. 2009..However, it will be important to replicate and confirm these findings in other independent studies using large samples... - Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patientsTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Neuropharmacology 58:452-6. 2010..Furthermore, we conducted an analysis of the association of HTR1A with METH-induced psychosis... - Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese populationTakenori Okumura
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Neuropsychobiology 61:57-63. 2010..Therefore, we studied the association of nNOS gene (NOS1) and mood disorders and the efficacy of fluvoxamine treatment in Japanese MDD patients... - Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysisTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
J Hum Genet 54:629-33. 2009..138). Our results suggest that HTR1A may not have a role in the pathophysiology of Japanese MDD patients. On the other hand, according to the meta-analysis, HTR1A was associated with MDD patients, especially in the Asian population... - Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Ann N Y Acad Sci 1139:70-82. 2008..In conclusion, our results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese METH-use disorder... - Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
J Neural Transm 115:1457-61. 2008..No significant association was detected in the allele/genotype-wise or haplotype-wise analysis. Our results suggest that CHRNA4 and CHRNB2 do not play a major role in Japanese schizophrenia... - Meta-analysis of association between genetic variants in COMT and schizophrenia: an updateTomo Okochi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Schizophr Res 110:140-8. 2009..This significance did not remain, however, after correcting the P-values using a false discovery rate controlling procedure. Our results suggest that the COMT is unlikely to contribute to susceptibility to schizophrenia... - No association between polymorphisms of neuronal oxide synthase 1 gene (NOS1) and schizophrenia in a Japanese populationTakenori Okumura
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
Neuromolecular Med 11:123-7. 2009..133 and rs3782206: P allele = 0.168). In conclusion, we could not replicate the association between seven SNPs in NOS1 and schizophrenia found in several earlier studies, using larger Japanese schizophrenia and control samples... - No association of complexin1 and complexin2 genes with schizophrenia in a Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Schizophr Res 82:185-9. 2006..0424), but this may be a result of type I error due to multiple testing. Our results suggest that complexin genes do not play a major role in schizophrenia in Japanese patients... - Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Ann N Y Acad Sci 1139:63-9. 2008..No significant association was found with schizophrenia. Our findings suggest that a common genetic variation in the GCLM gene might not contribute to the risk of METH-use disorder and schizophrenia in the Japanese population... - Genome-wide association study of schizophrenia in a Japanese populationMasashi Ikeda
Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
Biol Psychiatry 69:472-8. 2011..Moreover, a substantial polygenic component to the disorder consisting of a large number of such alleles has been reported by the International Schizophrenia Consortium... - Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese populationAkiko Okuda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
Neuromolecular Med 12:78-85. 2010..Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small... - Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese populationTomoko Tsunoka
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
Prog Neuropsychopharmacol Biol Psychiatry 33:875-9. 2009..Therefore, we studied the association between Group II mGluR genes (GRM2 and GRM3) and mood disorders and the efficacy of fluvoxamine treatment in Japanese MDD patients... - Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Neurosci Res 62:211-5. 2008..No significant association was found with major depressive disorder. In conclusion, our findings suggest that NR1D1 does not play a major role in the pathophysiology of mood disorders in the Japanese population... - Orphan nuclear receptor Rev-erb alpha gene (NR1D1) and fluvoxamine response in major depressive disorder in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Neuropsychobiology 59:234-8. 2009..Therefore, we examined the association between the orphan nuclear receptor Rev-erbalpha gene (NR1D1) and the efficacy of fluvoxamine treatment in 118 Japanese patients with major depressive disorder... - CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patientsTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
Neuromolecular Med 11:53-7. 2009..Our results indicate that CLOCK genotype may be a predictor of fluvoxamine treatment response in Japanese MDD. However, our sample size was small, and a replication study using larger samples may be required for conclusive results... - Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese populationTomo Okochi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Prog Neuropsychopharmacol Biol Psychiatry 33:903-5. 2009..In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population... - Association of AKT1 with schizophrenia confirmed in a Japanese populationMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Biol Psychiatry 56:698-700. 2004..Recent evidence supporting this hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and significant association of AKT1 haplotypes according to the transmission disequilibrium test... - Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Neurosci Res 64:231-4. 2009..In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and mood disorders in the Japanese population, but sample sizes, especially BP, were probably too small to allow a meaningful test... - Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese populationMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Neuropsychopharmacology 31:866-71. 2006..Although we failed to find an actual susceptibility variant that could modify the function of HTR7, our results support the supposition that HTR7 is a susceptibility gene for schizophrenia in this ethnic group... - Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Ann N Y Acad Sci 1139:83-8. 2008..No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population... - A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosisTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Prog Neuropsychopharmacol Biol Psychiatry 33:895-8. 2009..The symptoms of methamphetamine induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an association analysis of rs2234693 with Japanese methamphetamine induced psychosis patients... - Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
Neuromolecular Med 11:114-22. 2009..However, because our samples were small, it will be important to replicate and confirm these findings in other independent studies using larger samples... - No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Am J Med Genet B Neuropsychiatr Genet 147:531-4. 2008..158 after SNPSpD correction). Considering the size of our sample and strategy, our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population... - The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysisKazutaka Ohi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Schizophr Res 116:126-32. 2010..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations... - No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese populationKunihiro Kawashima
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Am J Med Genet B Neuropsychiatr Genet 147:1327-31. 2008..However, these associations could not be confirmed in the second-set analysis. These results suggest that the SNARE complex-related genes do not play a major role in susceptibility to schizophrenia in the Japanese population... - Association analysis of chromosome 5 GABAA receptor cluster in Japanese schizophrenia patientsMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Biol Psychiatry 58:440-5. 2005..CONCLUSIONS: These results indicate that this gene cluster may not play a major role in Japanese schizophrenia. They also raised an alert with regard to preliminary genetic association analysis using a small sample size... - Positive association of AKT1 haplotype to Japanese methamphetamine use disorderMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Int J Neuropsychopharmacol 9:77-81. 2006..Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition... - BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysisKunihiro Kawashima
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Schizophr Res 112:72-9. 2009..Further LD evaluation, as well as an association study in which BDNF-LCPR is genotyped directly, would be required for a more conclusive result... - Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophreniaMasashi Ikeda
Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
Hum Mol Genet 17:3212-22. 2008..Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia... - The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese populationHinako Usui
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, and Ichihara Hospital, Chiba, Japan
Schizophr Res 88:245-50. 2006..These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population... - Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patientsShinichi Saito
Department of Psychiatry, Nagoya University Graduate School of Medicine, Aichi, Japan
Neuropsychobiology 54:226-30. 2006..The purpose of this study was to investigate whether the VAMP2 gene is associated with clinical responses to a specific antidepressant, fluvoxamine... - Association study of bromodomain-containing 1 gene with schizophrenia in Japanese populationItaru Kushima
Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Am J Med Genet B Neuropsychiatr Genet 153:786-91. 2010..Taken together, we could not strongly show that common SNPs in the BRD1 gene account for a substantial proportion of the genetic risk for schizophrenia in the Japanese population... - Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysisKazutaka Ohi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Am J Med Genet B Neuropsychiatr Genet 159:405-13. 2012.... - Association of SOX10 with schizophrenia in the Japanese populationNobuhisa Maeno
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
Psychiatr Genet 17:227-31. 2007..The SOX10 gene is located on chromosome 22q13.1, a region repeatedly reported to show positive signals in linkage studies on schizophrenia... - Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patientsTakayoshi Koide
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
PLoS ONE 7:e36836. 2012.... - Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibilityItaru Kushima
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
Schizophr Bull 38:552-60. 2012..5) in kalrn or ephb1... - No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese populationBranko Aleksic
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa Ku, Tsurumai cho, 65, Nagoya, Aichi 466 8550, Japan
J Hum Genet 53:863-6. 2008..We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor... - Association between chromogranin A gene polymorphism and schizophrenia in the Japanese populationNagahide Takahashi
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
Schizophr Res 83:179-83. 2006..007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population... - Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among JapaneseTakenori Okumura
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Curr Neuropharmacol 9:155-9. 2011..In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population... - No Association Between GRM3 and Japanese Methamphetamine-Induced PsychosisTomoko Tsunoka
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Curr Neuropharmacol 9:160-2. 2011..To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls)... - No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophreniaMaiko Kitazawa
Juntendo University Schizophrenia Projects, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
Am J Med Genet B Neuropsychiatr Genet 159:456-64. 2012..Taken together these results indicate that the genes HIST1H2BJ, PRSS16, and PGBD1 were not associated with Japanese patients with schizophrenia... - An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disordersShinji Matsunaga
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan Japan Science and Technology Agency, the Core Research for Evolutional Science and Technology, Kawaguchi, Japan
Neurosci Lett 529:66-9. 2012..21) and BD (P=0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population... - Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter studyKazutaka Ohi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Schizophr Res 109:80-5. 2009..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population... - A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese populationMasahiro Banno
Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Aichi Ken, Japan
PLoS ONE 6:e28929. 2011..Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans... - [Molecular genetics of mood disorders]Masashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, 1-98, Dengakugakubo, Kutsukake-cho, Toyoake, 470-1192 Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 22:137-43. 2002..Future molecular genetic studies will find out the mood-disorder susceptible genes and open the gate to true treatment and prevention of this disorder as the Human Genome Project attains its goal... - Association analysis of AKT1 and schizophrenia in a UK case control sampleNadine Norton
Department of Psychological Medicine, Wales School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Schizophr Res 93:58-65. 2007..Examination of our own data and those of other groups leads us to conclude that overall, the evidence for association of AKT1 as a susceptibility gene for schizophrenia is weakly positive, but not yet convincing... - Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactionsYasuyuki Tomita
Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
J Biosci Bioeng 103:303-10. 2007.... - No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control populationShinichi Saito
Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
Neurosci Lett 374:21-4. 2005..Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia. And our results did not support the gender-specific effect of this SNP...