H Ichinose

Summary

Affiliation: Fujita Health University
Country: Japan

Publications

  1. ncbi request reprint Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Gene 230:233-9. 1999
  2. ncbi request reprint Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, 470 1192, Aichi, Japan
    Brain Dev 22:S107-10. 2000
  3. ncbi request reprint Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Nat Genet 8:236-42. 1994
  4. ncbi request reprint Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma
    T Nomura
    Department of Pharmacology, Fujita Health University School of Medicine, Aichi, Japan
    J Neural Transm Gen Sect 101:237-42. 1995
  5. ncbi request reprint Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I
    T Nomura
    Department of Pharmacology, Fujita Health University School of Medicine, Aichi, Japan
    Biochem Biophys Res Commun 191:523-7. 1993
  6. ncbi request reprint Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: relationship to etiology of dopa-responsive dystonia
    T Suzuki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    J Neurochem 73:2510-6. 1999
  7. ncbi request reprint Genomic organization and chromosomal localization of the human sepiapterin reductase gene
    T Ohye
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Toyoake, 470 1192, Japan
    Biochem Biophys Res Commun 251:597-602. 1998
  8. ncbi request reprint Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    J Biol Chem 270:10062-71. 1995
  9. ncbi request reprint A new splicing variant for human tyrosine hydroxylase in the adrenal medulla
    T Ohye
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan
    Neurosci Lett 312:157-60. 2001
  10. ncbi request reprint [Autosomal-dominant DOPA-responsive dystonia, caused by mutations in the GTP-cyclohydrolase I gene]
    T Nagatsu
    Institute for Comprehensive Medical Science, Fujita Health University Toyoake, Aichi, Japan
    Vopr Med Khim 44:225-8. 1998

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Gene 230:233-9. 1999
    ..Potential regulatory regions included consensus binding sites for NF-kappaB, CREB, and Sp1. Isolation of human Nurr1 cDNAs from fetal brain suggested the presence of a new splicing variant of Nurr1 in the human brain...
  2. ncbi request reprint Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, 470 1192, Aichi, Japan
    Brain Dev 22:S107-10. 2000
    ..We review herein the recent progress in the molecular genetics of HPD/DRD and clarify the points to be answered...
  3. ncbi request reprint Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Nat Genet 8:236-42. 1994
    ..This is the first report of a causative gene for the inherited dystonias...
  4. ncbi request reprint Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma
    T Nomura
    Department of Pharmacology, Fujita Health University School of Medicine, Aichi, Japan
    J Neural Transm Gen Sect 101:237-42. 1995
    ..The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single mRNA species of 4.0 kb in human pheochromocytoma tissue...
  5. ncbi request reprint Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I
    T Nomura
    Department of Pharmacology, Fujita Health University School of Medicine, Aichi, Japan
    Biochem Biophys Res Commun 191:523-7. 1993
    ..The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1 (89%) enzymes...
  6. ncbi request reprint Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: relationship to etiology of dopa-responsive dystonia
    T Suzuki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    J Neurochem 73:2510-6. 1999
    ..We suggest that reduction of the amount of the enzyme protein, which is independent of the mutation type, could be a reason for the dominant inheritance in HPD/DRD...
  7. ncbi request reprint Genomic organization and chromosomal localization of the human sepiapterin reductase gene
    T Ohye
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Toyoake, 470 1192, Japan
    Biochem Biophys Res Commun 251:597-602. 1998
    ..We found the Sp1-binding consensus sequence in the 5'-flanking region. The human SPR gene was mapped to chromosome band 2p13 by fluorescence in situ hybridization...
  8. ncbi request reprint Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
    H Ichinose
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    J Biol Chem 270:10062-71. 1995
    ..We identified missense mutations in patients with GTP cyclohydrolase I deficiency and expressed mutated enzymes in Escherichia coli to confirm alterations in the enzyme activity...
  9. ncbi request reprint A new splicing variant for human tyrosine hydroxylase in the adrenal medulla
    T Ohye
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan
    Neurosci Lett 312:157-60. 2001
    ..The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity...
  10. ncbi request reprint [Autosomal-dominant DOPA-responsive dystonia, caused by mutations in the GTP-cyclohydrolase I gene]
    T Nagatsu
    Institute for Comprehensive Medical Science, Fujita Health University Toyoake, Aichi, Japan
    Vopr Med Khim 44:225-8. 1998
    ..However, administration of low doses of dopamine can control the development of AD-DRD. Determination of GTP-cyclohydrolase I activity in mononuclear blood cells is convenient diagnostic method...
  11. ncbi request reprint [Molecular biology of hereditary dystonia]
    T Nagatsu
    Division of Molecular Genetics II Neurochemistry, School of Medicine, Fujita Health University, Aichi
    No To Hattatsu 30:93-100. 1998
    ..Measurement of the activity of GTP cyclohydrolase I in mononuclear blood cells is useful for the diagnosis of Segawa's disease...
  12. ncbi request reprint Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice
    C Sumi-Ichinose
    Department of Pharmacology, School of Medicine, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Biol Chem 276:41150-60. 2001
    ....
  13. ncbi request reprint Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain
    I Nagatsu
    Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    J Neural Transm 106:607-17. 1999
    ..The present observation suggests that L-dopa is not produced in the cells immunoreactive for TH but not for GCH, and that TH in these cells which lack GCH may have an unidentified role other than dopa synthesis...
  14. ncbi request reprint Mouse sepiapterin reductase: an enzyme involved in the final step of tetrahydrobiopterin biosynthesis. Primary structure deduced from the cDNA sequence
    A Ota
    Joint Research Division for Therapies against Intractable Diseases, School of Medicine, Fujita Health University, Aichi, Japan
    Biochim Biophys Acta 1260:320-2. 1995
    ..The amino acid sequence of mouse sepiapterin reductase revealed the identity of 88% with rat and 74% with human sequence...
  15. ncbi request reprint GTP cyclohydrolase I gene in hereditary progressive dystonia with marked diurnal fluctuation
    H Ichinose
    Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Aichi, Japan
    Neurosci Lett 196:5-8. 1995
    ..We found two independent new mutations (leucine 79 proline and a deletion in exon 4) in patients with HPD. We also found four families of HPD without any mutations in the coding region of GCH-I gene...
  16. ncbi request reprint Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2
    H Ichinose
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch
    Gene 188:95-100. 1997
    ....
  17. pmc SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells
    C Sumi-Ichinose
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, CU de Strasbourg
    Mol Cell Biol 17:5976-86. 1997
    ..Thus, in F9 EC cells, SNF2beta-BRG1 appears to play an essential role in basal processes involved in cell proliferation, in addition to its putative role in the activation of transcription mediated by nuclear receptors...
  18. pmc A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors
    B Le Douarin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, France
    EMBO J 15:6701-15. 1996
    ..Here we discuss how the function of members of the TIF1 family in the control of transcription could be exerted at the level of the structure of the chromatin template...
  19. ncbi request reprint Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase
    H Ichinose
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 164:1024-30. 1989
    ..9 kDa. The amino acid sequence Asn-Phe-Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes...
  20. ncbi request reprint Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease
    L Wang
    Department of Neurology, Jichi Medical School, Japan
    Gene Ther 9:381-9. 2002
    ..These data indicate that a delayed delivery of GDNF gene using AAV vector is efficacious even 4 weeks after the onset of progressive degeneration in a rat model of PD...
  21. ncbi request reprint Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains
    M Mogi
    Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, 464-8650, Nagoya, Japan
    Neurosci Lett 300:179-81. 2001
    ..05). However, the content of GDNF in the dopaminergic regions showed no significant difference between parkinsonian and control patients...
  22. ncbi request reprint Multiple mRNA forms of human GTP cyclohydrolase I
    A Togari
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    Biochem Biophys Res Commun 187:359-65. 1992
    ..These results indicate that, in humans, GTP cyclohydrolase I molecules are encoded by at least three distinct mRNAs...
  23. ncbi request reprint Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis
    N Kaneda
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    J Biol Chem 263:7672-7. 1988
    ..Chromosomal assignment of the gene for human PNMT was carried out using mouse-human somatic cell hybrids. The PNMT gene was assigned to chromosome 17...
  24. ncbi request reprint Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types
    K Kobayashi
    Department of Biochemistry, Nagoya University School of Medicine, Aichi
    J Biochem 103:907-12. 1988
    ..We propose a possible secondary structure for the latter alternative splicing pathway...
  25. ncbi request reprint Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene
    N Kaneda
    Biochem Biophys Res Commun 146:971-5. 1987
    ..Southern blot analysis of human genomic DNA indicated that TH is encoded by a single gene. This suggests that the four different forms of TH mRNA are produced by alternative RNA splicing from a single primary transcript...
  26. ncbi request reprint Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis
    H Ichinose
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 179:183-9. 1991
    ..We further found a striking homology between human SPR and carbonyl reductase, estradiol 17 beta-dehydrogenase, and 3 beta-hydroxy-5-ene steroid dehydrogenase, especially in their N-terminal region...
  27. ncbi request reprint Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis
    C Sumi-Ichinose
    Department of Pharmacology, Nagoya University School of Medicine, Japan
    Biochemistry 31:2229-38. 1992
    ..The human AADC gene was mapped to chromosome band 7p12.1-p12.3 by fluorescence in situ hybridization. This is the first report on the genomic structure and chromosomal localization of the AADC gene in mammals...
  28. ncbi request reprint Identification and heterologous expression of the cytochrome P450 oxidoreductase from the white-rot basidiomycete Coriolus versicolor
    H Ichinose
    Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Appl Microbiol Biotechnol 59:658-64. 2002
    ..A recombinant CPR protein was expressed using a pET/ Escherichia coli system. The recombinant CPR protein migrated at 81 kDa on SDS polyacrylamide gel electrophoresis. It exhibited an NADPH-dependent cytochrome c reducing activity...