Research Topics
| Hirofumi FujitaSummaryCountry: Japan Publications
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Detail Information
Publications
Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin BHirofumi Fujita
Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
Biochem Pharmacol 69:1773-84. 2005....- Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathwayHirofumi Fujita
Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522
Brain Res 1113:10-23. 2006..It is likely that pCPT-cAMP prevented the 6-OHDA-induced apoptosis via activation of the PI3-kinase/Akt pathway without any effect on superoxide generation or mitochondrial membrane depolarization... - Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cellsShikibu Muranaka
Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
Free Radic Res 38:613-21. 2004..These results suggested that accumulation of ceramide play an important role in the Cr(VI)-induced apoptosis of CHO cells through activation of mitochondrial membrane permeability transition... - Role of alpha-tocopherol in the regulation of mitochondrial permeability transitionMasae Yorimitsu
Institute of Medical Science, Kurashiki Medical Center, Kurashiki, Japan
Physiol Chem Phys Med NMR 36:95-107. 2004..These results indicate that alpha-tocopherol inhibits ROS generation, ANT oxidation, lipid peroxidation and the opening of MPT, thereby playing important roles in the prevention of oxidative cell death... - Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transitionMakoto Nagano
Institute of Medical Science, Kurashiki Medical Center Kurashiki 710-8522, Japan
Physiol Chem Phys Med NMR 35:131-43. 2003.... - Oxidative stress underlies the mechanism for Ca(2+)-induced permeability transition of mitochondriaTomoko Kanno
Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
Free Radic Res 38:27-35. 2004..These results indicate that Ca2+ increases the generation of ROS which oxidize the free thiol groups in mitochondrial ANT, thereby inducing MPT to release cytochrome c... - Mechanism and characteristics of stimuli-dependent ROS generation in undifferentiated HL-60 cellsShikibu Muranaka
Institute of Medical Science, Kurashiki Medical Center, Kurashiki, Japan
Antioxid Redox Signal 7:1367-76. 2005..These results suggested that the mechanism of ROS generation in undifferentiated HL-60 cells is the same as that in primed neutrophils... - Mitochondrial swelling and cytochrome c release: sensitivity to cyclosporin A and calciumTomoko Kanno
Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
Physiol Chem Phys Med NMR 34:91-102. 2002..c release may occur not only via a CsA-sensitive MPT but also by way of a CsA-insensitive membrane deterioration... - 17beta-estradiol suppresses ROS-induced apoptosis of CHO cells through inhibition of lipid peroxidation-coupled membrane permeability transitionChosei Miyaguchi
Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
Physiol Chem Phys Med NMR 36:21-35. 2004..Furthermore, E2 scavenged the xanthine oxidase generated ROS. These results suggests that Fe2+/H2O2 induced MPT and apoptosis of CHO cells by a mechanism that could be suppressed by antioxidant properties of E2... - Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathwayAkiko Inoue
Department of Pediatrics, Osaka Medical College, Takatsuki 569-8686, Japan
Free Radic Biol Med 37:1290-9. 2004.... - Stimulation of membrane permeability transition by alpha-lipoic acid and its biochemical characteristicsSanae Aoyama
Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Physiol Chem Phys Med NMR 38:1-20. 2006..Since fairly high doses of LA have been used as a dietary supplement, the possible occurrence of such side effects, including mitochondrial dysfunction and induction of apoptosis in normal tissues, should be studied... - Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not on NADPH oxidaseNoriko Kajitani
Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
Biosci Biotechnol Biochem 71:2701-11. 2007..These results indicate that intracellular not extracellular ROS generated by A23187 is associated with the opening of MPT pores that leads to apoptotic cell death... - Alpha-lipoic acid suppresses 6-hydroxydopamine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1Hirofumi Fujita
Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
Brain Res 1206:1-12. 2008..These results suggested that LA suppressed the 6-OHDA induced-apoptosis by the increase in cellular glutathione through stimulation of the GSH synthesis system but not by the expression of HO-1... - Regulation of 5-aminolevulinic acid-dependent protoporphyrin IX accumulations in human histiocytic lymphoma U937 cellsYuya Okimura
Department of Cytology and Histology, Okayama University Graduate School, Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama, Okayama 700 8558, Japan
Physiol Chem Phys Med NMR 39:69-82. 2007..These results suggest that ALA-enhanced accumulation of PpIX in U937 cells was regulated by cellular uptake and conversion of ALA to PpIX and by degradation of Heme...