Hirofumi Fujita

Summary

Country: Japan

Publications

  1. ncbi request reprint Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B
    Hirofumi Fujita
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Biochem Pharmacol 69:1773-84. 2005
  2. ncbi request reprint Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway
    Hirofumi Fujita
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522
    Brain Res 1113:10-23. 2006
  3. ncbi request reprint Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells
    Shikibu Muranaka
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Free Radic Res 38:613-21. 2004
  4. ncbi request reprint Role of alpha-tocopherol in the regulation of mitochondrial permeability transition
    Masae Yorimitsu
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki, Japan
    Physiol Chem Phys Med NMR 36:95-107. 2004
  5. ncbi request reprint Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition
    Makoto Nagano
    Institute of Medical Science, Kurashiki Medical Center Kurashiki 710 8522, Japan
    Physiol Chem Phys Med NMR 35:131-43. 2003
  6. ncbi request reprint Oxidative stress underlies the mechanism for Ca(2+)-induced permeability transition of mitochondria
    Tomoko Kanno
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Free Radic Res 38:27-35. 2004
  7. ncbi request reprint Mechanism and characteristics of stimuli-dependent ROS generation in undifferentiated HL-60 cells
    Shikibu Muranaka
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki, Japan
    Antioxid Redox Signal 7:1367-76. 2005
  8. ncbi request reprint Mitochondrial swelling and cytochrome c release: sensitivity to cyclosporin A and calcium
    Tomoko Kanno
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Physiol Chem Phys Med NMR 34:91-102. 2002
  9. ncbi request reprint 17beta-estradiol suppresses ROS-induced apoptosis of CHO cells through inhibition of lipid peroxidation-coupled membrane permeability transition
    Chosei Miyaguchi
    Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Physiol Chem Phys Med NMR 36:21-35. 2004
  10. ncbi request reprint Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway
    Akiko Inoue
    Department of Pediatrics, Osaka Medical College, Takatsuki 569 8686, Japan
    Free Radic Biol Med 37:1290-9. 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B
    Hirofumi Fujita
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Biochem Pharmacol 69:1773-84. 2005
    ....
  2. ncbi request reprint Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway
    Hirofumi Fujita
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522
    Brain Res 1113:10-23. 2006
    ..It is likely that pCPT-cAMP prevented the 6-OHDA-induced apoptosis via activation of the PI3-kinase/Akt pathway without any effect on superoxide generation or mitochondrial membrane depolarization...
  3. ncbi request reprint Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells
    Shikibu Muranaka
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Free Radic Res 38:613-21. 2004
    ..These results suggested that accumulation of ceramide play an important role in the Cr(VI)-induced apoptosis of CHO cells through activation of mitochondrial membrane permeability transition...
  4. ncbi request reprint Role of alpha-tocopherol in the regulation of mitochondrial permeability transition
    Masae Yorimitsu
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki, Japan
    Physiol Chem Phys Med NMR 36:95-107. 2004
    ..These results indicate that alpha-tocopherol inhibits ROS generation, ANT oxidation, lipid peroxidation and the opening of MPT, thereby playing important roles in the prevention of oxidative cell death...
  5. ncbi request reprint Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition
    Makoto Nagano
    Institute of Medical Science, Kurashiki Medical Center Kurashiki 710 8522, Japan
    Physiol Chem Phys Med NMR 35:131-43. 2003
    ....
  6. ncbi request reprint Oxidative stress underlies the mechanism for Ca(2+)-induced permeability transition of mitochondria
    Tomoko Kanno
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Free Radic Res 38:27-35. 2004
    ..These results indicate that Ca2+ increases the generation of ROS which oxidize the free thiol groups in mitochondrial ANT, thereby inducing MPT to release cytochrome c...
  7. ncbi request reprint Mechanism and characteristics of stimuli-dependent ROS generation in undifferentiated HL-60 cells
    Shikibu Muranaka
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki, Japan
    Antioxid Redox Signal 7:1367-76. 2005
    ..These results suggested that the mechanism of ROS generation in undifferentiated HL-60 cells is the same as that in primed neutrophils...
  8. ncbi request reprint Mitochondrial swelling and cytochrome c release: sensitivity to cyclosporin A and calcium
    Tomoko Kanno
    Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710 8522, Japan
    Physiol Chem Phys Med NMR 34:91-102. 2002
    ..c release may occur not only via a CsA-sensitive MPT but also by way of a CsA-insensitive membrane deterioration...
  9. ncbi request reprint 17beta-estradiol suppresses ROS-induced apoptosis of CHO cells through inhibition of lipid peroxidation-coupled membrane permeability transition
    Chosei Miyaguchi
    Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Physiol Chem Phys Med NMR 36:21-35. 2004
    ..Furthermore, E2 scavenged the xanthine oxidase generated ROS. These results suggests that Fe2+/H2O2 induced MPT and apoptosis of CHO cells by a mechanism that could be suppressed by antioxidant properties of E2...
  10. ncbi request reprint Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway
    Akiko Inoue
    Department of Pediatrics, Osaka Medical College, Takatsuki 569 8686, Japan
    Free Radic Biol Med 37:1290-9. 2004
    ....
  11. ncbi request reprint Stimulation of membrane permeability transition by alpha-lipoic acid and its biochemical characteristics
    Sanae Aoyama
    Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Physiol Chem Phys Med NMR 38:1-20. 2006
    ..Since fairly high doses of LA have been used as a dietary supplement, the possible occurrence of such side effects, including mitochondrial dysfunction and induction of apoptosis in normal tissues, should be studied...
  12. ncbi request reprint Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not on NADPH oxidase
    Noriko Kajitani
    Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Biosci Biotechnol Biochem 71:2701-11. 2007
    ..These results indicate that intracellular not extracellular ROS generated by A23187 is associated with the opening of MPT pores that leads to apoptotic cell death...
  13. doi request reprint Alpha-lipoic acid suppresses 6-hydroxydopamine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1
    Hirofumi Fujita
    Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1206:1-12. 2008
    ..These results suggested that LA suppressed the 6-OHDA induced-apoptosis by the increase in cellular glutathione through stimulation of the GSH synthesis system but not by the expression of HO-1...
  14. ncbi request reprint Regulation of 5-aminolevulinic acid-dependent protoporphyrin IX accumulations in human histiocytic lymphoma U937 cells
    Yuya Okimura
    Department of Cytology and Histology, Okayama University Graduate School, Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama, Okayama 700 8558, Japan
    Physiol Chem Phys Med NMR 39:69-82. 2007
    ..These results suggest that ALA-enhanced accumulation of PpIX in U937 cells was regulated by cellular uptake and conversion of ALA to PpIX and by degradation of Heme...