Antonio del Sol

Summary

Affiliation: Fujirebio Inc
Country: Japan

Publications

  1. pmc The origin of allosteric functional modulation: multiple pre-existing pathways
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Hachioji shi, Tokyo, Japan
    Structure 17:1042-50. 2009
  2. pmc Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Genome Biol 8:R92. 2007
  3. ncbi request reprint Small-world network approach to identify key residues in protein-protein interaction
    Antonio del Sol
    Bioinformatics Research Project, Frontier Research Division, Fujirebio Inc, 51 Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Proteins 58:672-82. 2005
  4. ncbi request reprint Topology of small-world networks of protein-protein complex structures
    Antonio del Sol
    Bioinformatics Research Project, Research and Development Division, Fujirebio Inc, 51 Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Bioinformatics 21:1311-5. 2005
  5. pmc The modular organization of domain structures: insights into protein-protein binding
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio, Tokyo, Japan
    PLoS Comput Biol 3:e239. 2007
  6. pmc Residues crucial for maintaining short paths in network communication mediate signaling in proteins
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Hachioji shi, Tokyo, Japan
    Mol Syst Biol 2:2006.0019. 2006
  7. pmc Residue centrality, functionally important residues, and active site shape: analysis of enzyme and non-enzyme families
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Tokyo, Japan
    Protein Sci 15:2120-8. 2006
  8. doi request reprint Energetic determinants of protein binding specificity: insights into protein interaction networks
    Pablo Carbonell
    Bioinformatics Research Unit, Research and Development Division, Fujirebio, Inc, Komiya cho, Hachioji shi, Tokyo, Japan
    Proteomics 9:1744-53. 2009
  9. doi request reprint Methyl side-chain dynamics prediction based on protein structure
    Pablo Carbonell
    Fujirebio Inc, Bioinformatics Research Unit, Research and Development Division, Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Bioinformatics 25:2552-8. 2009
  10. pmc TreeDet: a web server to explore sequence space
    Angel Carro
    Protein Design Group, CNB CSIC C Darwin n 3, 28049, Madrid, Spain
    Nucleic Acids Res 34:W110-5. 2006

Collaborators

Detail Information

Publications14

  1. pmc The origin of allosteric functional modulation: multiple pre-existing pathways
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Hachioji shi, Tokyo, Japan
    Structure 17:1042-50. 2009
    ....
  2. pmc Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Genome Biol 8:R92. 2007
    ..Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways...
  3. ncbi request reprint Small-world network approach to identify key residues in protein-protein interaction
    Antonio del Sol
    Bioinformatics Research Project, Frontier Research Division, Fujirebio Inc, 51 Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Proteins 58:672-82. 2005
    ....
  4. ncbi request reprint Topology of small-world networks of protein-protein complex structures
    Antonio del Sol
    Bioinformatics Research Project, Research and Development Division, Fujirebio Inc, 51 Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Bioinformatics 21:1311-5. 2005
    ..We show that these highly central residues are strongly correlated with the presence of hot spots of binding free energy...
  5. pmc The modular organization of domain structures: insights into protein-protein binding
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio, Tokyo, Japan
    PLoS Comput Biol 3:e239. 2007
    ..A modular organization of binding sites confers robustness and flexibility to the performance of the functional activity, and facilitates the evolution of protein interactions...
  6. pmc Residues crucial for maintaining short paths in network communication mediate signaling in proteins
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Hachioji shi, Tokyo, Japan
    Mol Syst Biol 2:2006.0019. 2006
    ..Thus, here we propose that centrally conserved residues, whose removal increases the characteristic path length in protein networks, may relate to the system fragility...
  7. pmc Residue centrality, functionally important residues, and active site shape: analysis of enzyme and non-enzyme families
    Antonio del Sol
    Bioinformatics Research Unit, Research and Development Division, Tokyo, Japan
    Protein Sci 15:2120-8. 2006
    ..Residue centrality is more conserved than the protein sequence, emphasizing the robustness of protein structures...
  8. doi request reprint Energetic determinants of protein binding specificity: insights into protein interaction networks
    Pablo Carbonell
    Bioinformatics Research Unit, Research and Development Division, Fujirebio, Inc, Komiya cho, Hachioji shi, Tokyo, Japan
    Proteomics 9:1744-53. 2009
    ..Knowledge of those factors playing a role in protein specificity is important for understanding how proteins acquire additional partners during evolution. It should also be useful in drug design...
  9. doi request reprint Methyl side-chain dynamics prediction based on protein structure
    Pablo Carbonell
    Fujirebio Inc, Bioinformatics Research Unit, Research and Development Division, Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
    Bioinformatics 25:2552-8. 2009
    ..In particular, quantitative description of side-chain dynamics would allow us to understand the role of side-chain flexibility in different functional processes, such as protein-ligand and protein-protein interactions...
  10. pmc TreeDet: a web server to explore sequence space
    Angel Carro
    Protein Design Group, CNB CSIC C Darwin n 3, 28049, Madrid, Spain
    Nucleic Acids Res 34:W110-5. 2006
    ..An additional method is provided to highlight the reliability of the position in the alignments. The server is available at http://www.pdg.cnb.uam.es/servers/treedet...
  11. pmc Ligand binding and circular permutation modify residue interaction network in DHFR
    Zengjian Hu
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia, United States of America
    PLoS Comput Biol 3:e117. 2007
    ..Ligand binding at the active site has profound effects on the network centrality, especially the closeness...
  12. ncbi request reprint A framework for computational and experimental methods: identifying dimerization residues in CCR chemokine receptors
    David de Juan
    Protein Design Group, National Center of Biotechnology CNB CSIC Cantoblanco, Madrid, Spain
    Bioinformatics 21:ii13-8. 2005
    ..The experimental validation of computational procedures demonstrated here provides a wealth of valuable information not obtainable by any of the individual approaches alone...
  13. pmc Allostery: absence of a change in shape does not imply that allostery is not at play
    Chung Jung Tsai
    Basic Research Program, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI Frederick, Frederick, MD 21702, USA
    J Mol Biol 378:1-11. 2008
    ..Assuming that the enthalpy change does not reverse the free-energy change due to the change in entropy, entropy is mainly responsible for binding...
  14. ncbi request reprint Identification of amino acid residues crucial for chemokine receptor dimerization
    Patricia Hernanz-Falcón
    Department of Immunology and Oncology, National Center of Biotechnology, Campus Universitario de Cantoblanco, E 28049 Madrid, Spain
    Nat Immunol 5:216-23. 2004
    ..This is the first description of the residues involved in chemokine receptor dimerization, and indicates a potential target for the modification of chemokine responses...