T Yamada

Summary

Affiliation: Environmental Health Science Laboratory
Country: Japan

Publications

  1. ncbi request reprint Production of human metabolites of cyclosporin A, AM1, AM 4 N and AM 9, by microbial conversion
    Kazuo Ohta
    Bioresource Laboratories, Mercian Corp, 1808 Nakaizumi, Iwata shi, Shizuoka 438 0078, Japan
    J Biosci Bioeng 99:390-5. 2005
  2. doi request reprint Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicol Sci 142:137-57. 2014
  3. ncbi request reprint Functional genomics may allow accurate categorization of the benzimidazole fungicide benomyl: lack of ability to act via steroid-receptor-mediated mechanisms
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Osaka, Japan
    Toxicol Appl Pharmacol 205:11-30. 2005
  4. ncbi request reprint Reliable safety assessment depends on species differences in epigenetic mechanisms of gene regulation
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd, Osaka, Japan
    Yakugaku Zasshi 127:481-90. 2007
  5. ncbi request reprint Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicology 186:227-39. 2003
  6. ncbi request reprint Comparative evaluation of a 5-day Hershberger assay utilizing mature male rats and a pubertal male assay for detection of flutamide's antiandrogenic activity
    T Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Osaka, Japan
    Toxicol Sci 53:289-96. 2000
  7. doi request reprint Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, 1 98, 3 Chome, Kasugade Naka, Konohana ku, Osaka, Japan
    Toxicol Sci 108:59-68. 2009
  8. ncbi request reprint Dissection and weighing of accessory sex glands after formalin fixation, and a 5-day assay using young mature rats are reliable and feasible in the Hershberger assay
    T Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98, Kasugade Naka, Konohana ku, Osaka, Japan
    Toxicology 162:103-19. 2001
  9. ncbi request reprint Development of a novel CHL/IU cell line with an incorporated gpt shuttle vector for concurrent analysis of gene mutations and chromosome aberrations
    T Yamada
    Environmental and Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Mutat Res 393:295-306. 1997
  10. ncbi request reprint In vitro and in vivo electrocardiographic evaluation of the novel calcium antagonist monatepil on cardiac conduction system
    I Nose
    Department of Pharmacology, Dainippon Pharmaceutical Co, Ltd, Suita, Osaka, Japan
    Arzneimittelforschung 43:722-8. 1993

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Production of human metabolites of cyclosporin A, AM1, AM 4 N and AM 9, by microbial conversion
    Kazuo Ohta
    Bioresource Laboratories, Mercian Corp, 1808 Nakaizumi, Iwata shi, Shizuoka 438 0078, Japan
    J Biosci Bioeng 99:390-5. 2005
    ..Large-scale microbial conversion of CyA (1.5 g) using a 30-l jar fermentor yielded 288 mg of AM1 (19.2%), 147 mg of AM 4 N (9.8%) and 115 mg of AM 9 (7.7%)...
  2. doi request reprint Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicol Sci 142:137-57. 2014
    ..As human hepatocytes are refractory to the mitogenic effects of NaPB, the MOA for NaPB-induced rodent liver tumor formation is thus not relevant for humans. ..
  3. ncbi request reprint Functional genomics may allow accurate categorization of the benzimidazole fungicide benomyl: lack of ability to act via steroid-receptor-mediated mechanisms
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Osaka, Japan
    Toxicol Appl Pharmacol 205:11-30. 2005
    ..The study furthermore suggests that functional genomics may provide a reliable evidence for accurate categorization of test chemicals...
  4. ncbi request reprint Reliable safety assessment depends on species differences in epigenetic mechanisms of gene regulation
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd, Osaka, Japan
    Yakugaku Zasshi 127:481-90. 2007
    ....
  5. ncbi request reprint Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicology 186:227-39. 2003
    ....
  6. ncbi request reprint Comparative evaluation of a 5-day Hershberger assay utilizing mature male rats and a pubertal male assay for detection of flutamide's antiandrogenic activity
    T Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Osaka, Japan
    Toxicol Sci 53:289-96. 2000
    ..Our findings support that the Hershberger assay, in the current conditions, is the most sensitive among the assays examined and a useful short-term screening method for the detection of antiandrogenic compounds...
  7. doi request reprint Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, 1 98, 3 Chome, Kasugade Naka, Konohana ku, Osaka, Japan
    Toxicol Sci 108:59-68. 2009
    ..Based on the evidence, including a comparison with the results with another chemical, phenobarbital, acting by a similar MOA, it is reasonable to conclude that Metofluthrin will not have any hepatocarcinogenic activity in humans...
  8. ncbi request reprint Dissection and weighing of accessory sex glands after formalin fixation, and a 5-day assay using young mature rats are reliable and feasible in the Hershberger assay
    T Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98, Kasugade Naka, Konohana ku, Osaka, Japan
    Toxicology 162:103-19. 2001
    ..Furthermore, we confirmed that male pubertal assay with use of dissection and weighing of fixed tissues also reliable...
  9. ncbi request reprint Development of a novel CHL/IU cell line with an incorporated gpt shuttle vector for concurrent analysis of gene mutations and chromosome aberrations
    T Yamada
    Environmental and Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Mutat Res 393:295-306. 1997
    ..These results suggest that this transgenic CHL/IU cell line can be a useful tool for analyzing the relation between gene mutations and chromosome aberrations...
  10. ncbi request reprint In vitro and in vivo electrocardiographic evaluation of the novel calcium antagonist monatepil on cardiac conduction system
    I Nose
    Department of Pharmacology, Dainippon Pharmaceutical Co, Ltd, Suita, Osaka, Japan
    Arzneimittelforschung 43:722-8. 1993
    ..The above results suggest that monatepil is a highly safe drug in the treatment of hypertension...
  11. ncbi request reprint Pharmacological properties of YM-11124, a selective immunosuppressive agent for cell-mediated immunity
    K Tomioka
    Department of Pharmacology, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    Pharmacology 39:28-38. 1989
    ....
  12. ncbi request reprint Evaluation of styrene oligomers eluted from polystyrene for estrogenicity in estrogen receptor binding assay, reporter gene assay, and uterotrophic assay
    K Ohno
    Central Research Institute, Nissin Food Products Co, Ltd, 2247, Noji Cho, Kusatsu, Shiga 525 0055, Japan
    Food Chem Toxicol 41:131-41. 2003
    ..In these tests, styrene oligomers showed no estrogenic activity...
  13. ncbi request reprint Ethylnitrosourea-induced mutation and molecular analysis of transgenic mice containing the gpt shuttle vector
    T Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical, 1 98, 3 Chome, Kasugade Naka, Konohana, Osaka 554 8558, Japan
    Mutat Res 441:59-72. 1999
    ..These results demonstrate that this transgenic mouse, in combination with the transgenic CHL/IU cell line, is a useful system to study in vivo and in vitro mutational events at the same target gene...
  14. ncbi request reprint Isolated tissue and binding studies of YM-17690, a novel and non-analogous leukotriene agonist
    K Tomioka
    Department of Pharmacology, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    J Pharm Pharmacol 39:819-24. 1987
    ..These results suggest that YM-17690 is a selective leukotriene (LTD4 and LTE4) agonist and that it will therefore be a valuable tool in the study of actions of leukotrienes and for the characterization of their receptors...
  15. ncbi request reprint Assessment of styrene oligomers eluted from polystyrene-made food containers for estrogenic effects in in vitro assays
    K Ohno
    Central Research Institute, Nissin Food Products Co, Ltd, 2247, Noji Cho, Kusatsu, 525 0055, Shiga, Japan
    Food Chem Toxicol 39:1233-41. 2001
    ..In all three tests, none of the SM, SDs and STs showed any significant activity. Accordingly, we concluded that these substances have no estrogenic activity...
  16. ncbi request reprint Ca2+ mobilization and activation of extracellular acidification by carbachol in acutely dispersed cells from guinea pig detrusor: Fura 2 fluorometry and microphysiometry using the cytosensor
    K Ikeda
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    Life Sci 65:1569-77. 1999
    ..Since this finding agrees with a number of other studies using in vivo and in vitro models (1), cell suspensions such as these may prove to be simple tools for the pharmacological study of urinary bladder smooth muscle tissue...
  17. ncbi request reprint Inhibitory effect of the new calcium antagonist AJ-2615 on progression of atherosclerosis in cholesterol-fed rabbits
    H Minato
    Department of Pharmacology, Dainippon Pharmaceutical Company, Osaka, Japan
    J Cardiovasc Pharmacol 21:663-9. 1993
    ..These results suggest that in addition to its calcium antagonistic and alpha 1-adrenoceptor blocking actions, some other yet-unidentified properties of AJ-2615 might contribute to the antiatherosclerotic effect of this agent...
  18. ncbi request reprint Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs
    M Aoki
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 297:165-73. 2001
    ..In conclusion, YM976 may have potential therapeutic value in the treatment of asthma through its anti-inflammatory activities...
  19. ncbi request reprint Effect of a novel anti-inflammatory compound, YM976, on antigen-induced eosinophil infiltration into the lungs in rats, mice, and ferrets
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 295:1149-55. 2000
    ..In conclusion, YM976 is a promising drug for the treatment of diseases involving eosinophil activity, such as asthma...
  20. ncbi request reprint Identification, determination, and biological evaluation of a novel styrene trimer contained in polystyrene food containers. 2
    S Hirano
    Central Research Institute, Nissin Food Products Company, Ltd, 2247 Noji, Kusatsu, Shiga 525 0055, Japan
    J Agric Food Chem 49:4127-31. 2001
    ..Furthermore, an endocrine-disrupting effect was tested using in vitro and in vivo assays of the compound. In conclusion, it seems that the compound does not present the effect...
  21. doi request reprint Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation
    Yoshihito Deguchi
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicol Sci 108:69-80. 2009
    ....
  22. ncbi request reprint A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki 305 8585, Japan
    J Pharmacol Exp Ther 295:255-60. 2000
    ..In conclusion, YM976 is a novel and orally active PDE4 inhibitor and possesses a good separation of emetogenicity from anti-inflammatory activity...
  23. ncbi request reprint Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines
    T Morokata
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Immunol Lett 70:127-34. 1999
    ..Thus, the genotype of laboratory strains partially determines whether Th1- or Th2-type immune responses are elicited...
  24. ncbi request reprint YM-40461 improves airway clearance in guinea pigs with induced subacute bronchitis
    A Kimoto
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 23:1441-4. 2000
    ..These results suggest that YM-40461 ameliorates MCT dysfunction in animals with SO2 gas-induced bronchitis by increasing the DSPC-to-protein ratio in the airway...
  25. ncbi request reprint Pharmacological properties of the orally active leukotriene antagonist [[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]thio]-1,3,4- thiadiazol-2-yl]thio]acetic acid
    K Tomioka
    Department of Pharmacology, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    Arzneimittelforschung 38:682-5. 1988
    ..These results indicate that YM-16638 is a selective, potent and orally active leukotriene antagonist...
  26. ncbi request reprint Enhanced rat Hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators
    Tomoya Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicol Sci 79:64-74. 2004
    ..In order to evaluate whether the sensitivity and specificity of such a thyroid assay is great enough for routine screening purposes, future experiments including dose-response studies using lower dose levels have to be performed...
  27. doi request reprint The utility of intra-operative three-dimensional transoesophageal echocardiography for dynamic measurement of stroke volume
    K Suehiro
    Department of Anaesthesiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Anaesthesia 70:150-9. 2015
    ..Three-dimensional transoesophageal echocardiography was clinically acceptable for measuring stroke volume; however, it was not sufficiently reliable for tracking stroke volume changes after haemodynamic interventions...
  28. ncbi request reprint Antigen dose defines T helper 1 and T helper 2 responses in the lungs of C57BL/6 and BALB/c mice independently of splenic responses
    T Morokata
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba shi, 305 8585, Ibaraki, Japan
    Immunol Lett 72:119-26. 2000
    ....
  29. doi request reprint Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression
    H Maeshima
    Food Safety Research Institute, Nissin Foods Holdings Co, Ltd, 2247 Noji Cho, Kusatsu, Shiga 525 0055, Japan
    Toxicol In Vitro 24:995-1001. 2010
    ..8%, 97.0% and 96.7%, respectively. These results indicate that the tumor promoting activity assay, based on the expression of 22 marker genes, will become a valuable tool for rapid screening of potential tumor promoters...
  30. ncbi request reprint Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs
    Y Arakida
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Miyukigaoka, Tsukuba shi, Ibaraki, Japan
    J Pharmacol Exp Ther 290:1285-91. 1999
    ..Therefore, broad-acting compounds such as YM158 are expected to have antiasthmatic efficacies in a broader class of asthmatic patients than single-acting drugs...
  31. ncbi request reprint NTE-122, an acyl-coa:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits
    Y Azuma
    Central Research Institute, Nissin Food Products Co, Ltd, Kusatsu, Shiga, Japan
    Jpn J Pharmacol 86:120-3. 2001
    ..These results suggest that NTE-122 is capable of exhibiting anti-atherosclerotic effects...
  32. ncbi request reprint Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo
    S Kobayashi
    Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    Jpn J Pharmacol 86:281-8. 2001
    ..These results show that YM905 ameliorates a wide spectrum of bowel dysfunctions through the blockade of M3 receptors, suggesting its therapeutic potential for treating IBS...
  33. ncbi request reprint Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays
    Takeshi Kunimatsu
    Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Regul Toxicol Pharmacol 35:227-37. 2002
    ....
  34. ncbi request reprint Calcium polycarbophil, a water absorbing polymer, increases bowel movement and prevents sennoside-induced diarrhea in dogs
    T Saito
    Research and Development Division, Hokuriku Seiyaku, CO, Ltd, Katsuyama, Fukui, Japan
    Jpn J Pharmacol 83:206-14. 2000
    ....
  35. ncbi request reprint Endocrine-disrupting effects of styrene oligomers that migrated from polystyrene containers into food
    K Date
    Central Research Institute, Nissin Food Products Co, Ltd, 2247, Noji Cho, Shiga 525 0055, Kusatsu, Japan
    Food Chem Toxicol 40:65-75. 2002
    ..From the above these results, we concluded that SM, SD and ST exhibit no apparent estrogenic, androgenic, anti-androgenic and thyroid activity...
  36. ncbi request reprint Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d-allethrin
    Ryozo Tsuji
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka Japan
    J Appl Toxicol 22:423-9. 2002
    ..The effects of allethrins on developmental neurotoxicity that Eriksson and co-workers reported previously were not reproduced in the present study...
  37. ncbi request reprint Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes
    Yukihiro Hirose
    Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicology 258:64-9. 2009
    ....
  38. doi request reprint Prevention of gastroduodenal content reflux and delayed gastric emptying after esophagectomy: gastric tube reconstruction with duodenal diversion plus Roux-en-Y anastomosis
    M Yano
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Dis Esophagus 25:181-7. 2012
    ..The benefits of this procedure need to be further assessed in a large-scale, randomized controlled trial...
  39. ncbi request reprint [Effects of YM-13650 on type I to type IV allergic reactions and immune responses in animals]
    T Yamada
    Central Research Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Nihon Yakurigaku Zasshi 97:75-84. 1991
    ..These results indicate that YM-13650 suppresses not only cell-mediated immune responses but also type III allergic reactions without any influence on type I and type II allergic reactions as well as an acute inflammatory reaction...
  40. doi request reprint Relationship between noise characteristics in protein expressions and regulatory structures of amino acid biosynthesis pathways
    T Yamada
    Osaka University, Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka, Japan
    IET Syst Biol 4:82-9. 2010
    ..Furthermore, we found that the response time as a result of environmental changes is generally longer in the former case. This result provides a basis for understanding the role of natural regulatory networks better...
  41. ncbi request reprint Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor
    M Aoki
    Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    J Pharmacol Exp Ther 298:1142-9. 2001
    ..In conclusion, YM976 shows an apparent dissociation between its anti-inflammatory effects and emetogenicity, perhaps because of the poor brain penetration...
  42. ncbi request reprint Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide
    Takeshi Kunimatsu
    Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicology 200:77-89. 2004
    ..The results demonstrate that the protocol can reliably detect antiandrogenic effects of flutamide...
  43. ncbi request reprint Structural determination of unknown subsidiary colors in commercial food red Nos. 2 and 102
    M Yamada
    San Ei Gen F F I, Inc, Osaka, Japan
    Chem Pharm Bull (Tokyo) 46:494-9. 1998
    ..Sub D was identified as Sub B...
  44. ncbi request reprint Effect of YM-40461, a novel surfactant secretagogue, on chronic obstructive pulmonary diseases and similar symptoms in guinea pigs
    A Kimoto
    Applied Pharmacology Lab, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Japan
    Arzneimittelforschung 51:743-7. 2001
    ..8 +/- 1.9 cm H2O (p < 0.05). These results suggest that YM-40461 ameliorates chronic obstructive pulmonary disease (COPD)-like symptoms in bronchitis models due to increased surfactant in the airway...
  45. ncbi request reprint Metastin suppresses the motility and growth of CHO cells transfected with its receptor
    A Hori
    Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 286:958-63. 2001
    ....
  46. ncbi request reprint Preoperative hydroperoxide concentrations are associated with a risk of postoperative complications after cardiac surgery
    K Suehiro
    Department of Anaesthesiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Anaesth Intensive Care 42:487-94. 2014
    ..00 to 1.02), after adjusting for age, gender and EuroSCORE. In conclusion, an increased hydroperoxide concentration before cardiac surgery is an independent risk factor for severe postoperative complications. ..
  47. doi request reprint Esophageal submucosal dissection under steady pressure automatically controlled endoscopy (SPACE): a randomized preclinical trial
    K Nakajima
    Department of Gastroenterological Surgery, Osaka University, Osaka, Japan
    Endoscopy 44:1139-48. 2012
    ..The objectives of this study were to validate the feasibility and safety of SPACE in the esophagus, and to evaluate its potential advantages over conventional (manually insufflating) endoscopy in endoscopic submucosal dissection (ESD)...
  48. ncbi request reprint Effects of the new calcium antagonist monatepil on cardiac function and myocardial oxygen supply and demand in animals
    T Kataoka
    Department of Pharmacology, Dainippon Pharmaceutical Co, Ltd, Osaka, Japan
    Arzneimittelforschung 43:1303-9. 1993
    ..5. Monatepil and diltiazem showed almost the same effects on cardiac function and myocardial oxygen supply and demand, but the negative chronotropic and negative dromotropic effects of monatepil were less potent than those of diltiazem...
  49. doi request reprint Dietary intake of antioxidant vitamins and risk of Parkinson's disease: a case-control study in Japan
    Y Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka Department of Public Health, Osaka, Japan
    Eur J Neurol 18:106-13. 2011
    ..We investigated the relationship between dietary intake of selected antioxidant vitamins, vegetables and fruit and the risk of PD in Japan using data from a multicenter hospital-based case-control study...
  50. ncbi request reprint In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease
    T Kitada
    Third Department of Internal Medicine, Osaka City University Medical School, Abeno-ku, Osaka, 545-8585, Japan
    J Hepatol 35:613-8. 2001
    ..CONCLUSIONS: These results indicate that oxidative DNA damage is common in various forms of chronic liver disease suggesting a possible link between chronic inflammation and hepatocarcinogenesis...
  51. ncbi request reprint A method for measurement of muscarinic receptor-mediated responses in dissociated single colon longitudinal smooth muscle cells
    S Kobayashi
    Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    J Pharmacol Toxicol Methods 45:199-205. 2001
    ....
  52. ncbi request reprint A two-step, one-pot synthesis of diverse N-pyruvoyl amino acid derivatives using the Ugi reaction
    M Nakamura
    Kobe Creative Center, Research Division of Senju Pharmaceutical Co, Ltd, Japan
    Bioorg Med Chem Lett 10:2807-10. 2000
    ..A two-step one-pot synthesis, in which the Ugi reaction followed by pyridinium dichromate (PDC) oxidation was employed in the same reaction vessel, easily afforded the alpha-ketoamides in a short time...
  53. ncbi request reprint Concurrent detection of gene mutations and chromosome aberrations induced by five chemicals in a CHL/IU cell line incorporating a gpt shuttle vector
    T Yamada
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 1 98, 3 Chome, Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    Mutat Res 471:29-36. 2000
    ..The characteristics of test chemicals indicated by this system should be useful for understanding endpoints in chemical mutagenesis...
  54. ncbi request reprint Inclusion complex of 3,9-bis(N,N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) with heptakis(2,6-di-O-methyl)-beta-cyclodextrin: interaction and dissolution properties
    T Yamada
    Pharmaceutical Laboratories, Kissei Pharmaceutical Co, Ltd, Minamiazumi, Nagano, Japan
    Chem Pharm Bull (Tokyo) 48:1264-9. 2000
    ..These data indicate that poorly water-soluble KCA-098 interacts with DM-beta-CyD in water and in the solid state and that a fast-dissolving form of KCA-098 can be obtained by evaporating with DM-beta-CyD using organic solvents...
  55. ncbi request reprint Altered sarcoplasmic reticulum function in rat diaphragm after high-intensity exercise
    S Matsunaga
    Institute of Health Sciences and Physical Education, Osaka City University, Osaka Shi, Osaka, Japan
    Acta Physiol Scand 176:227-32. 2002
    ..These changes in the SR of the diaphragm may contribute, at least in part, to deteriorations in exercise tolerance and work productivity resulting from repetitive physical activities...
  56. ncbi request reprint K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors
    H Ohigashi
    MD, Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3 Nakamichi, 1 chome, Higashinari ku, Osaka, 537 8511, Japan
    Arch Surg 135:1450-5. 2000
    ....
  57. ncbi request reprint A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers
    H Onda
    Discovery Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 10 Wadai Tsukuba, Ibaraki 300 4293, Japan
    Biochem Biophys Res Commun 285:235-43. 2001
    ..Mutational analysis of ALCAN suggested that the GPI-anchored position was the Ser(216) residue. These findings indicate that ALCAN may be a potential target for cancer diagnosis or therapy...
  58. ncbi request reprint Effect of asymmetric modification on the conformation of ascidiacyclamide analogs
    A Asano
    Osaka University of Pharmaceutical Sciences, Osaka, Japan
    J Pept Res 60:10-22. 2002
    ..In the cytotoxicity test using P388 cells, [Val1]ASC exhibited the strongest activity, whereas the epimers of ASC ([d-Ile1] and [Val3]ASCs), showed fairly moderate activities...
  59. pmc OECD validation of the Hershberger assay in Japan: phase 2 dose response of methyltestosterone, vinclozolin, and p,p'-DDE
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita, Japan
    Environ Health Perspect 111:1912-9. 2003
    ..Therefore, the Japanese studies support the Hershberger assay as a reliable and reproducible screening assay for the detection of androgen agonistic and antagonistic effects...
  60. ncbi request reprint Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea
    Tomoya Yamada
    Department of Pharmacology, Kyoritsu College of Pharmacy, Tokyo 105 8512, Japan
    Life Sci 77:1935-44. 2005
    ....