Kumiko Kobayashi

Summary

Affiliation: Environmental Health Science Laboratory
Country: Japan

Publications

  1. ncbi request reprint Effects of hypothyroidism induced by perinatal exposure to PTU on rat behavior and synaptic gene expression
    Kumiko Kobayashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicology 212:135-47. 2005
  2. ncbi request reprint Perinatal exposure to PTU delays switching from NR2B to NR2A subunits of the NMDA receptor in the rat cerebellum
    Kumiko Kobayashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Neurotoxicology 27:284-90. 2006
  3. doi request reprint Perinatal exposure to PTU decreases expression of Arc, Homer 1, Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus
    Kumiko Kobayashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd 3 1 98 Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    Brain Res 1264:24-32. 2009
  4. doi request reprint Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain
    Ryozo Tsuji
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Osaka 554 8559, Japan
    Neurotoxicol Teratol 30:228-36. 2008
  5. ncbi request reprint Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d-allethrin
    Ryozo Tsuji
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka Japan
    J Appl Toxicol 22:423-9. 2002
  6. ncbi request reprint Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain
    Vittorio Fattori
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    J Appl Toxicol 28:370-6. 2008

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Effects of hypothyroidism induced by perinatal exposure to PTU on rat behavior and synaptic gene expression
    Kumiko Kobayashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    Toxicology 212:135-47. 2005
    ....
  2. ncbi request reprint Perinatal exposure to PTU delays switching from NR2B to NR2A subunits of the NMDA receptor in the rat cerebellum
    Kumiko Kobayashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Neurotoxicology 27:284-90. 2006
    ..The profile of NMDAR subunits in vehicle-dosed rats showed a shift from NR2B to NR2A during development. These results suggest PTU can delay this switching from NR2B to NR2A subunits in the maturation of NMDA receptors...
  3. doi request reprint Perinatal exposure to PTU decreases expression of Arc, Homer 1, Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus
    Kumiko Kobayashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd 3 1 98 Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    Brain Res 1264:24-32. 2009
    ..The results suggest that the alterations may be responsible for the detrimental effects caused by PTU treatment on the nervous system...
  4. doi request reprint Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain
    Ryozo Tsuji
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Osaka 554 8559, Japan
    Neurotoxicol Teratol 30:228-36. 2008
    ..These findings suggest that GDNF and the phosphorylation of Akt play a possible key role in the ethanol-induced developmental neurotoxicity...
  5. ncbi request reprint Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d-allethrin
    Ryozo Tsuji
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka Japan
    J Appl Toxicol 22:423-9. 2002
    ..The effects of allethrins on developmental neurotoxicity that Eriksson and co-workers reported previously were not reproduced in the present study...
  6. ncbi request reprint Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain
    Vittorio Fattori
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    J Appl Toxicol 28:370-6. 2008
    ..These results suggest that BDNF and its related signal pathways involving Akt, MAPK and p70S6K are potential targets of ethanol-induced developmental neurotoxicity...