Takashi Sakai

Summary

Affiliation: Eisai Co
Country: Japan

Publications

  1. ncbi Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:173-9. 2004
  2. ncbi Stereochemistry of pladienolide B
    Naoki Asai
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tokodai, Tsukuba, Ibaraki, Japan
    J Antibiot (Tokyo) 60:364-9. 2007
  3. ncbi Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:180-7. 2004
  4. ncbi Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
    Yoshiharu Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:188-96. 2004
  5. ncbi 5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin as a probe of the transition-state conformation in hydrolase-catalyzed enantioselective transesterifications
    Tadashi Ema
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700 8530, Japan
    J Org Chem 67:2144-51. 2002
  6. ncbi Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: toward practical and green access to clopidogrel
    Tadashi Ema
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700 8530, Japan
    Org Biomol Chem 5:1175-6. 2007
  7. ncbi Potential role for astroglial D-amino acid oxidase in extracellular D-serine metabolism and cytotoxicity
    Hwan Ki Park
    Department of Gene Regulatorics, The Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan
    J Biochem (Tokyo) 139:295-304. 2006
  8. ncbi Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer--in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase
    Kentarou Inoue
    Depatment of Thoracic Surgery, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
    Lung Cancer 49:47-54. 2005
  9. ncbi Lipase-catalyzed resolution of (2R*,3S*)- and (2R*,3R*)-3-methyl-3-phenyl-2-aziridinemethanol at low temperatures and determination of the absolute configurations of the four stereoisomers
    Takashi Sakai
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Org Chem 70:1369-75. 2005
  10. ncbi Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
    Atsushi Hirao
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Ontario M5G 2C1, Canada
    Mol Cell Biol 22:6521-32. 2002

Collaborators

  • T Ema
  • Naoki Asai
  • Hajime Shimizu
  • Yu Liu
  • M Fukushima
  • Robert G Bristow
  • Hiroshi Ohta
  • Hwan Ki Park
  • Kentarou Inoue
  • Yoshiharu Mizui
  • Atsushi Hirao
  • Koji Ono
  • Sayaka Ichise-Shishido
  • Kazuko Yorita
  • Kiyoshi Fukui
  • Tomoya Kawazoe
  • Yumiko Tomita
  • Sanae Iwana
  • Yuji Shishido
  • Masanori Kaneda
  • Isao Yada
  • Hideto Shimpo
  • Fumiaki Watanabe
  • Motoshi Takao
  • Akira Shimamoto
  • Tomohito Tarukawa
  • Makoto Asada
  • Kentaro Yoshimatsu
  • Toshimitsu Uenaka
  • Masao Iwata
  • Kiyoshi Okamoto
  • Takao Yamori
  • Toshio Suda
  • Stephen J Elledge
  • Talin Sarkissian
  • Pierre Marie Girard
  • Gordon Duncan
  • Hitoshi Okada
  • Elisa de Stanchina
  • Andrew Wakeham
  • Jorge A Wong
  • Penny A Jeggo
  • Alison Cheung
  • Tak W Mak
  • Pierre-Marie Girard
  • Scott W Lowe
  • Andrew J Elia

Detail Information

Publications11

  1. ncbi Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:173-9. 2004
    ..They also demonstrated growth-inhibitory activity against U251 human glioma cells in vitro. Pladienolides are highly potent inhibitors of both hypoxia signals and cancer cell proliferation, and thus may be useful as antitumor agents...
  2. ncbi Stereochemistry of pladienolide B
    Naoki Asai
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tokodai, Tsukuba, Ibaraki, Japan
    J Antibiot (Tokyo) 60:364-9. 2007
    ..The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products...
  3. ncbi Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:180-7. 2004
    ..Pladienolides are unusual 12-membered macrolides having a long side chain at the carbon that bears a lactone oxygen...
  4. ncbi Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
    Yoshiharu Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:188-96. 2004
    ..For the reason of their novel mechanism of action and excellent in vivo efficacy, pladienolides appear to have major potential for use in cancer treatment...
  5. ncbi 5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin as a probe of the transition-state conformation in hydrolase-catalyzed enantioselective transesterifications
    Tadashi Ema
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700 8530, Japan
    J Org Chem 67:2144-51. 2002
    ....
  6. ncbi Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: toward practical and green access to clopidogrel
    Tadashi Ema
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700 8530, Japan
    Org Biomol Chem 5:1175-6. 2007
    ..0 M) with recombinant E. coli overproducing a versatile carbonyl reductase...
  7. ncbi Potential role for astroglial D-amino acid oxidase in extracellular D-serine metabolism and cytotoxicity
    Hwan Ki Park
    Department of Gene Regulatorics, The Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan
    J Biochem (Tokyo) 139:295-304. 2006
    ..These results support the proposal that astroglial DAO plays an important role in metabolizing a neuromodulator, D-serine...
  8. ncbi Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer--in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase
    Kentarou Inoue
    Depatment of Thoracic Surgery, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
    Lung Cancer 49:47-54. 2005
    ..DPD inhibitory fluoropyrimidine and examination of the tumoral expression of DPD might be a promising chemotherapeutic strategy in NSCLC...
  9. ncbi Lipase-catalyzed resolution of (2R*,3S*)- and (2R*,3R*)-3-methyl-3-phenyl-2-aziridinemethanol at low temperatures and determination of the absolute configurations of the four stereoisomers
    Takashi Sakai
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Org Chem 70:1369-75. 2005
    ..The absolute configuration of (2S,3S)-3 was determined by X-ray analysis of the corresponding N-(S)-2-(6-methoxy-2-naphthyl)propanoyl derivative (S,S,S)-13...
  10. ncbi Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
    Atsushi Hirao
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Ontario M5G 2C1, Canada
    Mol Cell Biol 22:6521-32. 2002
    ..ATR may thus selectively contribute to p53-mediated apoptosis. These data indicate that distinct pathways regulate the activation of p53 leading to cell cycle arrest or apoptosis...
  11. ncbi Chiral selector with multiple hydrogen-bonding sites in a macrocyclic cavity
    Tadashi Ema
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, Japan
    Org Lett 10:2365-8. 2008
    ..Various organic solvents could be used as the mobile phase to optimize the resolution efficiency of CSPs, and in some cases, even MeCN, MeOH, and CO(2) could be used for the complete resolution of enantiomers...