Takashi Sakai

Summary

Affiliation: Eisai Co
Country: Japan

Publications

  1. ncbi request reprint Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:173-9. 2004
  2. ncbi request reprint Stereochemistry of pladienolide B
    Naoki Asai
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tokodai, Tsukuba, Ibaraki, Japan
    J Antibiot (Tokyo) 60:364-9. 2007
  3. ncbi request reprint Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:180-7. 2004
  4. ncbi request reprint Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
    Yoshiharu Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:188-96. 2004
  5. ncbi request reprint 5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin as a probe of the transition-state conformation in hydrolase-catalyzed enantioselective transesterifications
    Tadashi Ema
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700 8530, Japan
    J Org Chem 67:2144-51. 2002
  6. ncbi request reprint Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: toward practical and green access to clopidogrel
    Tadashi Ema
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700 8530, Japan
    Org Biomol Chem 5:1175-6. 2007
  7. ncbi request reprint Potential role for astroglial D-amino acid oxidase in extracellular D-serine metabolism and cytotoxicity
    Hwan Ki Park
    Department of Gene Regulatorics, The Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
    J Biochem 139:295-304. 2006
  8. ncbi request reprint Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer--in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase
    Kentarou Inoue
    Depatment of Thoracic Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Lung Cancer 49:47-54. 2005
  9. ncbi request reprint Lipase-catalyzed resolution of (2R*,3S*)- and (2R*,3R*)-3-methyl-3-phenyl-2-aziridinemethanol at low temperatures and determination of the absolute configurations of the four stereoisomers
    Takashi Sakai
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Org Chem 70:1369-75. 2005
  10. pmc Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
    Atsushi Hirao
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Ontario M5G 2C1, Canada
    Mol Cell Biol 22:6521-32. 2002

Collaborators

  • T Ema
  • Naoki Asai
  • Hajime Shimizu
  • M Fukushima
  • Robert G Bristow
  • Yu Liu
  • Hiroshi Ohta
  • Hwan Ki Park
  • Kentarou Inoue
  • Yoshiharu Mizui
  • Atsushi Hirao
  • Sanae Iwana
  • Kazuko Yorita
  • Kiyoshi Fukui
  • Koji Ono
  • Sayaka Ichise-Shishido
  • Yuji Shishido
  • Tomoya Kawazoe
  • Yumiko Tomita
  • Masanori Kaneda
  • Motoshi Takao
  • Isao Yada
  • Akira Shimamoto
  • Hideto Shimpo
  • Fumiaki Watanabe
  • Tomohito Tarukawa
  • Makoto Asada
  • Takao Yamori
  • Masao Iwata
  • Kiyoshi Okamoto
  • Kentaro Yoshimatsu
  • Toshimitsu Uenaka
  • Pierre Marie Girard
  • Toshio Suda
  • Stephen J Elledge
  • Elisa de Stanchina
  • Gordon Duncan
  • Andrew Wakeham
  • Jorge A Wong
  • Penny A Jeggo
  • Hitoshi Okada
  • Talin Sarkissian
  • Scott W Lowe
  • Andrew J Elia
  • Alison Cheung
  • Tak W Mak

Detail Information

Publications11

  1. ncbi request reprint Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:173-9. 2004
    ..They also demonstrated growth-inhibitory activity against U251 human glioma cells in vitro. Pladienolides are highly potent inhibitors of both hypoxia signals and cancer cell proliferation, and thus may be useful as antitumor agents...
  2. ncbi request reprint Stereochemistry of pladienolide B
    Naoki Asai
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tokodai, Tsukuba, Ibaraki, Japan
    J Antibiot (Tokyo) 60:364-9. 2007
    ..The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products...
  3. ncbi request reprint Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation
    Takashi Sakai
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:180-7. 2004
    ..Pladienolides are unusual 12-membered macrolides having a long side chain at the carbon that bears a lactone oxygen...
  4. ncbi request reprint Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
    Yoshiharu Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    J Antibiot (Tokyo) 57:188-96. 2004
    ..For the reason of their novel mechanism of action and excellent in vivo efficacy, pladienolides appear to have major potential for use in cancer treatment...
  5. ncbi request reprint 5-[4-(1-Hydroxyethyl)phenyl]-10,15,20-triphenylporphyrin as a probe of the transition-state conformation in hydrolase-catalyzed enantioselective transesterifications
    Tadashi Ema
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700 8530, Japan
    J Org Chem 67:2144-51. 2002
    ....
  6. ncbi request reprint Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: toward practical and green access to clopidogrel
    Tadashi Ema
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700 8530, Japan
    Org Biomol Chem 5:1175-6. 2007
    ..0 M) with recombinant E. coli overproducing a versatile carbonyl reductase...
  7. ncbi request reprint Potential role for astroglial D-amino acid oxidase in extracellular D-serine metabolism and cytotoxicity
    Hwan Ki Park
    Department of Gene Regulatorics, The Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
    J Biochem 139:295-304. 2006
    ..These results support the proposal that astroglial DAO plays an important role in metabolizing a neuromodulator, D-serine...
  8. ncbi request reprint Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer--in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase
    Kentarou Inoue
    Depatment of Thoracic Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Lung Cancer 49:47-54. 2005
    ..DPD inhibitory fluoropyrimidine and examination of the tumoral expression of DPD might be a promising chemotherapeutic strategy in NSCLC...
  9. ncbi request reprint Lipase-catalyzed resolution of (2R*,3S*)- and (2R*,3R*)-3-methyl-3-phenyl-2-aziridinemethanol at low temperatures and determination of the absolute configurations of the four stereoisomers
    Takashi Sakai
    Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Org Chem 70:1369-75. 2005
    ..The absolute configuration of (2S,3S)-3 was determined by X-ray analysis of the corresponding N-(S)-2-(6-methoxy-2-naphthyl)propanoyl derivative (S,S,S)-13...
  10. pmc Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
    Atsushi Hirao
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Ontario M5G 2C1, Canada
    Mol Cell Biol 22:6521-32. 2002
    ..ATR may thus selectively contribute to p53-mediated apoptosis. These data indicate that distinct pathways regulate the activation of p53 leading to cell cycle arrest or apoptosis...
  11. doi request reprint Chiral selector with multiple hydrogen-bonding sites in a macrocyclic cavity
    Tadashi Ema
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, Japan
    Org Lett 10:2365-8. 2008
    ..Various organic solvents could be used as the mobile phase to optimize the resolution efficiency of CSPs, and in some cases, even MeCN, MeOH, and CO(2) could be used for the complete resolution of enantiomers...