K Sagane

Summary

Affiliation: Eisai Co
Country: Japan

Publications

  1. pmc Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain
    K Sagane
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tokodai 5 1 3, Tsukuba, Ibaraki, Japan
    Biochem J 334:93-8. 1998
  2. ncbi request reprint Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
    K Sagane
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 236:79-86. 1999
  3. ncbi request reprint Genetic mapping of mouse tumor necrosis factor-alpha converting enzyme (TACE) to chromosome 12
    K Yamazaki
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Genomics 49:336-7. 1998
  4. ncbi request reprint cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter
    Y Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 233:67-74. 1999
  5. ncbi request reprint Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene
    Y Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Mol Biol Rep 27:167-73. 2000
  6. ncbi request reprint Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9
    K Yamazaki
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Genomics 46:528-9. 1997
  7. ncbi request reprint Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HIT-T15 cells
    Y Shinozuka
    Department of Biology, Faculty of Science, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan
    Biochem Biophys Res Commun 287:229-35. 2001

Collaborators

Detail Information

Publications7

  1. pmc Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain
    K Sagane
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tokodai 5 1 3, Tsukuba, Ibaraki, Japan
    Biochem J 334:93-8. 1998
    ..Northern blot analysis revealed that the mRNAs of MDC2, MDC3 and MDC/ADAM11 are highly expressed in the brain. These findings suggest that these proteins may function as integrin ligands in the brain...
  2. ncbi request reprint Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
    K Sagane
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 236:79-86. 1999
    ..The structures of these ADAM proteins strongly suggest that they could function as integrin receptors. The implications of the cellular disintegrins in neural development are discussed...
  3. ncbi request reprint Genetic mapping of mouse tumor necrosis factor-alpha converting enzyme (TACE) to chromosome 12
    K Yamazaki
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Genomics 49:336-7. 1998
  4. ncbi request reprint cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter
    Y Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 233:67-74. 1999
    ..Finally, we found that the mouse TACE promoter at nt -2304 to -1 also worked in NIH3T3, 3T3L1 and C6 cell lines...
  5. ncbi request reprint Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene
    Y Mizui
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Mol Biol Rep 27:167-73. 2000
    ..Thus, the NFI site is involved in negative regulation of the human ADAMTS4 promoter activity in chondrocytes...
  6. ncbi request reprint Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9
    K Yamazaki
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Genomics 46:528-9. 1997
  7. ncbi request reprint Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HIT-T15 cells
    Y Shinozuka
    Department of Biology, Faculty of Science, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan
    Biochem Biophys Res Commun 287:229-35. 2001
    ..These results suggest that glucocorticoids impair insulin synthesis in HIT-T15 cells by decreasing PDX-1 and BETA2/NeuroD and that enhancement of HES-1 expression is involved in this regulation...