Masaki Goto

Summary

Affiliation: Eisai Co
Country: Japan

Publications

  1. doi request reprint E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1
    Masaki Goto
    Eisai Tsukuba Research Laboratories, Ibaraki, Japan
    J Pharmacol Exp Ther 331:485-95. 2009
  2. doi request reprint E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory respon
    Kenzo Muramoto
    Eisai Co, Ltd, Tsukuba Research Laboratories, Ibaraki, Japan
    J Pharmacol Exp Ther 335:23-31. 2010
  3. doi request reprint Docking simulation study and kinase selectivity of f152A1 and its analogs
    Megumi Ikemori-Kawada
    Eisai Tsukuba Research Laboratories, 1 3, Tokodai 5 chome, Tsukuba shi, Ibaraki 300 2635, Japan
    J Chem Inf Model 52:2059-68. 2012
  4. doi request reprint Conformational analyses and MO studies of f152A1 and its analogues as potent protein kinase inhibitors
    Megumi Ikemori-Kawada
    Eisai Tsukuba Research Laboratories, 1 3, Tokodai 5 chome, Tsukuba shi, Ibaraki 300 2635, Japan
    J Chem Inf Model 49:2650-9. 2009

Collaborators

Detail Information

Publications4

  1. doi request reprint E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1
    Masaki Goto
    Eisai Tsukuba Research Laboratories, Ibaraki, Japan
    J Pharmacol Exp Ther 331:485-95. 2009
    ....
  2. doi request reprint E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory respon
    Kenzo Muramoto
    Eisai Co, Ltd, Tsukuba Research Laboratories, Ibaraki, Japan
    J Pharmacol Exp Ther 335:23-31. 2010
    ..These results indicate that topically administered E6201 may be a useful agent for the prevention and treatment of cutaneous inflammatory and hyperproliferative diseases such as psoriasis...
  3. doi request reprint Docking simulation study and kinase selectivity of f152A1 and its analogs
    Megumi Ikemori-Kawada
    Eisai Tsukuba Research Laboratories, 1 3, Tokodai 5 chome, Tsukuba shi, Ibaraki 300 2635, Japan
    J Chem Inf Model 52:2059-68. 2012
    ..Considering the molecular docking analysis of these inhibitors in these kinases, molecular shape will be most important to their corresponding kinases activities...
  4. doi request reprint Conformational analyses and MO studies of f152A1 and its analogues as potent protein kinase inhibitors
    Megumi Ikemori-Kawada
    Eisai Tsukuba Research Laboratories, 1 3, Tokodai 5 chome, Tsukuba shi, Ibaraki 300 2635, Japan
    J Chem Inf Model 49:2650-9. 2009
    ..Reactivity of the cis-enone moiety and the M1(8) conformation make important contributions to the inhibitory activity of MAP kinases...