Y Asai

Summary

Affiliation: Eisai Co
Country: Japan

Publications

  1. ncbi request reprint Structural differences in aqueous dispersions of alpha-tocopheryl acetate and phosphatidylcholine upon varying their molar fractions
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co Ltd, Gifu, Japan
    Pharmazie 59:849-53. 2004
  2. ncbi request reprint Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Gifu, Japan
    Pharm Dev Technol 10:11-6. 2005
  3. ncbi request reprint Formation of the dispersed particles composed of retinol and phosphatidylchiline
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd 1 Takehaya machi, Kawashima cho, Hashima gun, Gifu 501 6195, Japan
    Int J Pharm 253:89-95. 2003
  4. ncbi request reprint Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Gifu, Japan
    Pharmazie 60:201-4. 2005
  5. ncbi request reprint Cryoprotective effects of saccharides on the freeze-drying of sonicated vesicles of the novel lipid A analog, E5531
    Yasuyuki Asai
    Formulation Research Laboratory Kawashima Eisai Co, Ltd 1 Takahaya machi, Kawashima cho, Hashima gun, Gifu 501 6195, Japan
    Pharm Dev Technol 11:229-33. 2006
  6. ncbi request reprint Characterization of the physicochemical properties of micelles composed of the novel platelet activating factor receptor antagonist, E5880 in an aqueous environment
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, 1 Takehaya machi, Kawashima cho, Hashima gun, 501 6195 Gifu, Japan
    Chem Phys Lipids 124:103-9. 2003
  7. ncbi request reprint Formation and stability of the dispersed particles composed of retinoic acid, sesame oil and phosphatidylcholine
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co Ltd, Takehaya machi, Kawashima cho, Hashima gun, Gifu, Japan
    Int J Pharm 193:189-96. 2000
  8. ncbi request reprint Formation of spherical micelles by the novel platelet activating factor receptor antagonist, E5880
    T Nomura
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Hashima gun, Gifu, Japan
    Chem Pharm Bull (Tokyo) 48:947-50. 2000
  9. ncbi request reprint Interaction of sesame oil with soybean phosphatidylcholine and their formation of small dispersed particles
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co Ltd, Gifu, Japan
    J Microencapsul 16:705-13. 1999
  10. ncbi request reprint Development of an injectable formulation for the novel lipid A analog E5531 using a 'pH-jump method'
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Gifu 510 6195, Japan
    Yakugaku Zasshi 124:965-72. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Structural differences in aqueous dispersions of alpha-tocopheryl acetate and phosphatidylcholine upon varying their molar fractions
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co Ltd, Gifu, Japan
    Pharmazie 59:849-53. 2004
    ....
  2. ncbi request reprint Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Gifu, Japan
    Pharm Dev Technol 10:11-6. 2005
    ..09 mg/mL, and the structure was spherical. The micelle size was 5.6 nm. The number of molecules per micelle was 46. The micropolarity around the hydrocarbon region in the micelle was similar to that of isobutanol...
  3. ncbi request reprint Formation of the dispersed particles composed of retinol and phosphatidylchiline
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd 1 Takehaya machi, Kawashima cho, Hashima gun, Gifu 501 6195, Japan
    Int J Pharm 253:89-95. 2003
    ....
  4. ncbi request reprint Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Gifu, Japan
    Pharmazie 60:201-4. 2005
    ..The hydrocarbon region in the micelle was more rigid and less hydrated than that of other surfactants, stearyltrimethylammonium chloride and cetyltrimethylammonium chloride...
  5. ncbi request reprint Cryoprotective effects of saccharides on the freeze-drying of sonicated vesicles of the novel lipid A analog, E5531
    Yasuyuki Asai
    Formulation Research Laboratory Kawashima Eisai Co, Ltd 1 Takahaya machi, Kawashima cho, Hashima gun, Gifu 501 6195, Japan
    Pharm Dev Technol 11:229-33. 2006
    ..This variety in cryoprotective ability of saccharide species can be attributed to differences in their interaction with the E5531 head group...
  6. ncbi request reprint Characterization of the physicochemical properties of micelles composed of the novel platelet activating factor receptor antagonist, E5880 in an aqueous environment
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, 1 Takehaya machi, Kawashima cho, Hashima gun, 501 6195 Gifu, Japan
    Chem Phys Lipids 124:103-9. 2003
    ..The hydrocarbon region in the micelle was more rigid and less hydrated than that of other surfactants, stearyltrimethylammonium chloride (STAC) and cetyltrimethylammonium chloride (CTAC)...
  7. ncbi request reprint Formation and stability of the dispersed particles composed of retinoic acid, sesame oil and phosphatidylcholine
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co Ltd, Takehaya machi, Kawashima cho, Hashima gun, Gifu, Japan
    Int J Pharm 193:189-96. 2000
    ..These results indicate that the interaction of RA with PC bilayers and the structure of RA/PC mixture will be changed by the addition of SO...
  8. ncbi request reprint Formation of spherical micelles by the novel platelet activating factor receptor antagonist, E5880
    T Nomura
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Hashima gun, Gifu, Japan
    Chem Pharm Bull (Tokyo) 48:947-50. 2000
    ..The diameter of a micelle was 8.1 nm. The fluidity and micropolarity around the hydrocarbon region of the micelles were evaluated and compared to the surfactants, stearyltrimethylammmonium chloride and cetyltrimethylammonium chloride...
  9. ncbi request reprint Interaction of sesame oil with soybean phosphatidylcholine and their formation of small dispersed particles
    Y Asai
    Formulation Research Laboratory, Kawashima, Eisai Co Ltd, Gifu, Japan
    J Microencapsul 16:705-13. 1999
    ..The results showed that the coexistence of emulsion particles (surface monolayer of PC + core of SO) with vesicular particles (bilayer) was critically important for the formation of stably dispersed particles of the lipid mixture...
  10. ncbi request reprint Development of an injectable formulation for the novel lipid A analog E5531 using a 'pH-jump method'
    Yasuyuki Asai
    Formulation Research Laboratory, Kawashima, Eisai Co, Ltd, Gifu 510 6195, Japan
    Yakugaku Zasshi 124:965-72. 2004
    ..003 mol/l NaOH in the pH-jump method, and the addition of Ca(2+) to the solution. The membrane fluidity was correlated with the pharmacokinetics in rats...
  11. ncbi request reprint Immunobiological activities of a chemically synthesized lipid A of Porphyromonas gingivalis
    T Ogawa
    Department of Microbiology, Asahi University, School of Dentistry, Gifu, Japan
    FEMS Immunol Med Microbiol 28:273-81. 2000
    ..Thus, this study demonstrates that the chemical synthesis of lipid A, mimicking the natural lipid A portion of LPS from P. gingivalis, confirms its low endotoxic potency and immunobiological activity...
  12. ncbi request reprint Chemical structure and immunobiological activity of lipid A from Serratia marcescens LPS
    Yutaka Makimura
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, Japan
    J Med Microbiol 56:1440-6. 2007
    ..These results indicate that S. marcescens possesses a penta-acylated lipid A, which is nearly identical to E. coli lipid A in regard to biological activities, while it also may be a crucial virulence factor of the bacterium...
  13. ncbi request reprint Chemical structure and immunobiological activity of Porphyromonas gingivalis lipid A
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Front Biosci 12:3795-812. 2007
    ..Based on the history of studies of ligands acting on TLR4, Bacteroides species LPS findings were reviewed and are presented here. In particular, we investigated P. gingivalis LPS and its lipid A...
  14. ncbi request reprint Soluble CD14 discriminates slight structural differences between lipid as that lead to distinct host cell activation
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    J Immunol 179:7674-83. 2007
    ..These results suggest that sCD14 is able to discriminate the slight structural differences between these lipid As, which causes their distinct host cell activation activities...
  15. ncbi request reprint Chemical structure and immunobiological activity of lipid A from Prevotella intermedia ATCC 25611 lipopolysaccharide
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, 501 0296, Gifu, Japan
    FEBS Lett 543:98-102. 2003
    ..Our results indicate that P. intermedia lipid A activates cells through a TLR4-dependent pathway similar to E. coli-type lipid A, even though these have structural differences...
  16. pmc Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4
    Riyoko Tamai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Immunology 110:66-72. 2003
    ..These findings suggest that monosaccharide lipid A analogues similar to disaccharide lipid As are capable of activating both murine and human cells through TLR4...
  17. ncbi request reprint Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    Int Immunol 14:1325-32. 2002
    ..gingivalis lipid A molecule induces cell activation via a TLR4/MD2-MyD88-dependent pathway, and suggest the possibility that unknown bacterial components in P. gingivalis LPS and its lipid A may induce cell activation via TLR2...
  18. ncbi request reprint Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1
    Tomohiko Ogawa
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Hozumi cho, Motosu gun, Gifu 501 0296, Japan
    FEMS Immunol Med Microbiol 36:1-7. 2003
    ..pylori strain 206-1, has a low endotoxic potency and immunobiological activities, and is recognized by TLR4...
  19. ncbi request reprint Toll-like receptor 2-mediated dendritic cell activation by a Porphyromonas gingivalis synthetic lipopeptide
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu 501 0296, Japan
    J Med Microbiol 56:459-65. 2007
    ..Taken together, these results indicate that the fatty acid residue at the glycerol position in the P. gingivalis lipopeptide plays a pivotal role in TLR2-mediated dendritic cell activation...
  20. ncbi request reprint Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    Int Immunol 16:1431-7. 2004
    ..Pg-LP, as well as Ec-LPS, was potent in inducing IL-8 production in human gingival fibroblasts. From our results, we propose that Pg-LP is a powerful inflammatory factor of P. gingivalis...
  21. ncbi request reprint Osteoclast differentiation by human osteoblastic cell line SaOS-2 primed with bacterial lipid A
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Hozumi cho, Motosu gun, 501 0296 Gifu, Japan
    FEMS Immunol Med Microbiol 38:71-9. 2003
    ..These findings suggest that the TLR signaling cascade in osteoblastic cells is involved in regulating the function of osteoclastogenesis...
  22. ncbi request reprint Protein-bound polysaccharide isolated from basidiomycetes inhibits endotoxin-induced activation by blocking lipopolysaccharide-binding protein and CD14 functions
    Yasuyuki Asai
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    FEMS Immunol Med Microbiol 43:91-8. 2005
    ..These findings indicate that PSK, which also has an ability to regulate LBP/CD14 functions, may be useful for clinical control of endotoxic sepsis...
  23. ncbi request reprint Treponemal phospholipids inhibit innate immune responses induced by pathogen-associated molecular patterns
    Masahito Hashimoto
    Department of Oral Microbiology, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu 501 0296, Japan
    J Biol Chem 278:44205-13. 2003
    ..These results suggest that treponemal phospholipid interfere the function of LBP/CD14 and act as a modulator of innate immune responses...