Research Topics
Species | Akihiro WadaSummaryAffiliation: Ehime University Country: Japan Publications
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Publications
Helicobacter pylori vacuolating cytotoxin, VacA, is responsible for gastric ulcerationAkihiro Wada
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
J Biochem 136:741-6. 2004..As the potential roles of VacA as a ligand for RPTPalpha and RPTPbeta are only poor understood, further studies are needed to determine the importance of VacA in the pathogenisis of disease due to H. pylori infection...- Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cellsKen ichi Ogushi
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852 8523, Japan
J Biol Chem 279:12213-9. 2004..These results suggest that gangliosides act as co-receptors with TLR5 for FliC and promote hBD-2 expression via mitogen-activated protein kinase... - Essential domain of receptor tyrosine phosphatase beta (RPTPbeta) for interaction with Helicobacter pylori vacuolating cytotoxinKinnosuke Yahiro
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
J Biol Chem 279:51013-21. 2004.... - Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPalpha and RPTPbeta, by Helicobacter pylori m2VacABlanquita B De Guzman
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
Cell Microbiol 7:1285-93. 2005..Different post-translational modifications of RPTPalpha in HeLa cells may be responsible for the reduced susceptibility to m2VacA... - Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 CellsMasaaki Nakayama
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
Infect Immun 74:6571-80. 2006..Thus, receptor-dependent translocation of VacA to lipid rafts is critical for signaling pathways leading to p38 MAP kinase/ATF-2 activation and vacuolation... - High molecular weight factor in FCS inhibits Helicobacter pylori VacA-binding to its receptor, RPTPbeta, on AZ-521Takahiro Kimura
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Nagasaki 852-8523, Japan
Microbiol Immunol 47:105-7. 2003..These data show that the high molecular weight fraction of FCS inhibits VacA action though its ability to block toxin binding to its receptor, RPTPbeta, on AZ-521 cells... - Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptorKinnosuke Yahiro
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
J Biol Chem 278:19183-9. 2003..These data suggest that RPTP alpha acts as a receptor for VacA in G401 cells. Thus, two receptor tyrosine phosphatases, RPTP alpha and RPTP beta, serve as VacA receptors... - [Structure and intoxication of VacA]Toshiya Hirayama
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University
Nippon Rinsho 63:53-7. 2005 - Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cellsMasaaki Nakayama
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
J Biol Chem 279:7024-8. 2004..The cytotoxin may thus act independently on several cellular targets, leading to disruption of signaling, regulatory, and metabolic pathways... - Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activityAkihiro Wada
Department of Bacteriology, Nagasaki University, Nagasaki, Japan
Glycobiology 20:668-78. 2010..pylori VacA to free gangliosides neutralizes the toxin activity of VacA. These findings offer an alternative insight into the role of gangliosides in VacA toxicity and the pathogenesis of H. pylori... - Helicobacter pylori vacuolating cytotoxin, VacAToshiya Hirayama
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
Jpn J Infect Dis 55:1-5. 2002..Recent molecular and cellular studies of VacA action have begun to unravel its structure and the details of the mechanism of gastric injury caused by H. pylori infection... - [Studies on biological activity of antimicrobial peptides, defensins, and the inducible mechanism in mammalian cells]Akihiro Wada
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University
Nippon Saikingaku Zasshi 58:595-602. 2003 - In vitro gene transfection using dendritic poly(L-lysine)Mio Ohsaki
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 852-8521, Japan
Bioconjug Chem 13:510-7. 2002..We also expect to be able to easily construct DPK-based functional gene carriers, e.g., DPKs modified by ligands such as a sugar chain, which can enable advanced gene delivery in vivo... - Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokinesVolaluck Supajatura
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
J Immunol 168:2603-7. 2002..The present study suggests that early activation of mast cells by VacA may be the host early response to clear the bacteria and also may contribute to the pathogenesis of H. pylori-induced gastritis... - Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolationEiki Yamasaki
PRESTO, Japan Science and Technology Corporation, Saitama 332 0012, Japan
J Biol Chem 281:11250-9. 2006..These results suggest that VacA acts through different signaling pathways to induce apoptosis via Bax activation, independent of vacuolation... - Vacuolating cytotoxin A is associated with increased thrombin generation in gastric mucosaYuko Suzuki
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
Helicobacter 10:323-31. 2005..The present study was undertaken to assess in vivo the relationship between gastric intramucosal generation of thrombin and Helicobacter pylori infection... - Relationship between gastric ulcer and Helicobacter pylori VacA detected in gastric juice using bead-ELISA methodDaisuke Shirasaka
Division of Diabetes, Digestive, and Kidney Disease, Department of Clinical Molecular Medicine, Kobe University School of Medicine, Kobe, Hyogo, Japan
Helicobacter 7:281-6. 2002..Therefore, not only the quality but also the quantity of VacA is important etiological factors in the pathogenesis of mucosal damage... - Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxinKinnosuke Yahiro
Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
Helicobacter 10:231-9. 2005..pylori VacA, suggesting that HBT may be useful as a new type of therapeutic agent for the prevention of gastric ulcer and inflammation caused by VacA... - Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pyloriAkihiro Fujikawa
Division of Molecular Neurobiology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji cho, Okazaki 444 8585, Japan
Nat Genet 33:375-81. 2003..Furthermore, pleiotrophin (PTN), an endogenous ligand of Ptprz, also induced gastritis specifically in Ptprz+/+ mice when administered orally. Taken together, these data indicate that erroneous Ptprz signaling induces gastric ulcers... - Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacAJunko Suzuki
Department of Gastroenterology, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
J Biol Chem 278:25585-90. 2003..We suggest that syntaxin 7 is involved in the intracellular vacuolation induced by VacA... - Helicobacter pylori strain-specific modulation of gastric inflammation in Mongolian gerbilsKen Ohnita
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan
World J Gastroenterol 11:1549-53. 2005..CONCLUSION: Our results indicate that the cag PAI could be directly involved in gastric immune and inflammatory responses in the Mongolian gerbils, leading to a more advanced gastric disease... - Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cellsKazuyuki Yokoyama
Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
Proc Natl Acad Sci U S A 102:9661-6. 2005..pylori infection... - High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infectionHajime Isomoto
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
World J Gastroenterol 11:4782-7. 2005..Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice during H pylori infection... - Concentrations of alpha- and beta-defensins in gastric juice of patients with various gastroduodenal diseasesYoshito Nishi
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
World J Gastroenterol 11:99-103. 2005..CONCLUSION: HNPs 1-3 and HBD-2 levels in gastric juice are diverse among various gastrointestinal diseases, reflecting the inflammatory and atrophic events of the background gastric mucosa affected by H pylori... - Elevated concentrations of alpha-defensins in gastric juice of patients with Helicobacter pylori infectionHajime Isomoto
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Am J Gastroenterol 99:1916-23. 2004..pylori infection. The elevation of HNPs is presumably secondary to H.pylori-associated gastric inflammation involving neutrophil infiltration... - Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaBNaoki Mori
Department of Virology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
Gastroenterology 124:983-92. 2003..The aim of this study was to analyze the molecular mechanism responsible for Helicobacter pylori-mediated MMP expression... - Helicobacter pylori induces RANTES through activation of NF-kappa BNaoki Mori
Department of Virology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
Infect Immun 71:3748-56. 2003..pylori induced NF-kappa B activation through an intracellular signaling pathway that involved IKK and NIK, leading to RANTES gene transcription. RANTES induction by H. pylori may play an important role in gastric inflammation...