Hisaaki Takahashi

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. doi request reprint Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma
    Hisaaki Takahashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime, 791 0295, Japan
    Brain Tumor Pathol 32:31-40. 2015
  2. pmc Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
    Masaaki Kanai
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Mol Brain 2:8. 2009
  3. doi request reprint Involvement of heparanase in migration of microglial cells
    Hisaaki Takahashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Biochim Biophys Acta 1780:709-15. 2008
  4. ncbi request reprint Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion
    Hisaaki Takahashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Neurosci Lett 417:250-4. 2007
  5. pmc Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain
    Anna Smirkin
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    J Cereb Blood Flow Metab 30:603-15. 2010
  6. doi request reprint Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions
    Nari Tei
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan
    J Neurosci Res 91:681-93. 2013
  7. doi request reprint Oct-3/4 promotes migration and invasion of glioblastoma cells
    Kana Kobayashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    J Cell Biochem 113:508-17. 2012
  8. ncbi request reprint Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions
    Hiroaki Matsumoto
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Ehime, Japan
    J Neurosci Res 85:994-1009. 2007
  9. ncbi request reprint Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion
    Hiroaki Matsumoto
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Japan
    Neurosci Lett 418:44-8. 2007
  10. ncbi request reprint Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion
    Hiroaki Matsumoto
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan
    J Cereb Blood Flow Metab 28:149-63. 2008

Collaborators

  • Hiroaki Matsumoto
  • Shiro Ohue
  • Mitsumasa Fukuda
  • Eiichi Ishii
  • Yuka Suzuki
  • Hironobu Harada
  • Shunji Suzuki
  • Hiroshi Imagawa
  • Yoshio Nishimura
  • Toshikazu Nakamura
  • Junya Tanaka
  • Hajime Yano
  • Takanori Ohnishi
  • Kana Sugimoto
  • Yoshiaki Kumon
  • Akihiro Inoue
  • Tasuku Nishihara
  • Kana Kobayashi
  • Takashi Fujiwara
  • Ryutaro Nishioka
  • Motoko Kanno
  • Nari Tei
  • Hitomi Hino
  • Hideaki Watanabe
  • Tatsuhiro Nakata
  • Anna Smirkin
  • Masaaki Kanai
  • Kunio Matsumoto
  • Keiko Kitajima
  • Airi Ikeda
  • Ayano Mise
  • Shirabe Matsumoto
  • Yukako Kobayashi
  • Shinichi Toshimori
  • Katsuhiro Goto
  • Michihisa Ochi
  • Kanji Kawachi
  • Hironori Izutani
  • Mitsugi Nagashima
  • Toru Okamura
  • Takumi Yasugi
  • Fumiaki Shikata
  • Masahiro Ryugo
  • Masahiko Tagawa
  • Shohei Kohno
  • Hiroshi Funakoshi
  • Tomoko Hayakawa
  • Shinya Mizuno
  • Hironobu Sugiyama
  • Akiko Yokoyama
  • Yoshinori Imai
  • Aiko Sakamoto
  • Minoru Tahara

Detail Information

Publications21

  1. doi request reprint Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma
    Hisaaki Takahashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime, 791 0295, Japan
    Brain Tumor Pathol 32:31-40. 2015
    ..Our findings suggest that Oct-3/4-expressing glioblastoma cells have the ability to adapt to low-oxygen environments within tumor masses by promoting tumor angiogenesis through AKT-HIF1 pathway...
  2. pmc Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
    Masaaki Kanai
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Mol Brain 2:8. 2009
    ..These findings demonstrate a direct molecular link between Trp metabolism and neurogenesis and anxiety-related behavior under physiological conditions...
  3. doi request reprint Involvement of heparanase in migration of microglial cells
    Hisaaki Takahashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Biochim Biophys Acta 1780:709-15. 2008
    ..The results suggest the involvement of heparanase in the migration or invasion of microglia or brain macrophages across basement membrane around brain vasculature...
  4. ncbi request reprint Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion
    Hisaaki Takahashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Neurosci Lett 417:250-4. 2007
    ..These findings suggest a novel role of heparanase in the pathophysiology of brain ischemia...
  5. pmc Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain
    Anna Smirkin
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    J Cereb Blood Flow Metab 30:603-15. 2010
    ..These results suggest that bone marrow-derived BINCs play a beneficial role in ischemic brain lesions, at least in part, through secretion of neuroprotective factors...
  6. doi request reprint Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions
    Nari Tei
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan
    J Neurosci Res 91:681-93. 2013
    ..Thus, chemokines may play a critical role in the accumulation of neuroprotective BINCs. © 2013 Wiley Periodicals, Inc...
  7. doi request reprint Oct-3/4 promotes migration and invasion of glioblastoma cells
    Kana Kobayashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    J Cell Biochem 113:508-17. 2012
    ..Therefore, Oct-3/4 might contribute to tumor promoting activity in glioblastomas...
  8. ncbi request reprint Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions
    Hiroaki Matsumoto
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Ehime, Japan
    J Neurosci Res 85:994-1009. 2007
    ..Note that the traditional microglial markers isolectin B4, CD11b, and CD68 are not specific for microglia, particularly in a pathologic brain...
  9. ncbi request reprint Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion
    Hiroaki Matsumoto
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Japan
    Neurosci Lett 418:44-8. 2007
    ..Thus, CD200 is expressed in some populations of macrophage-like cells that may be responsible for the suppression of CD200R(+) myeloid cell functions in the ischemic core...
  10. ncbi request reprint Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion
    Hiroaki Matsumoto
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan
    J Cereb Blood Flow Metab 28:149-63. 2008
    ..Taken the various functions of NG2, BINCs may be involved in not only phagocytosis of degenerated cells but also the healing and regeneration of lesion cores...
  11. ncbi request reprint Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25
    Takashi Fujiwara
    Division of Molecular and Cellular Physiology, Department of Molecular and Cellular Biology, School of Medicine, Ehime University, Toon City, Ehime 791 0295, Japan
    Exp Cell Res 312:1703-12. 2006
    ..These data suggested that the nucleolar targeting sequence might therefore play an important role in the binding of Nop25 to RNA molecules and that the RNA binding of Nop25 might be essential for the nucleolar localization of Nop25...
  12. ncbi request reprint Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity
    Akihiro Inoue
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Int J Oncol 37:1121-31. 2010
    ..The results suggest that the highly invasive potential of cancer stem cells depends on MMP-13 enzymatic activity, thus MMP-13 might be a potential therapeutic target for glioblastomas...
  13. ncbi request reprint Functional expression of CCL6 by rat microglia: a possible role of CCL6 in cell-cell communication
    Motoko Kanno
    Division of Molecular and Cellular Physiology, Department of Molecular and Cellular Biology, School of Medicine, Ehime University, Toon City, Ehime 791 0295, Japan
    J Neuroimmunol 167:72-80. 2005
    ..These findings suggest that CCL6 may be a mediator released by microglia for cell-cell communication under physiological as well as pathological conditions of CNS...
  14. doi request reprint Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats
    Tasuku Nishihara
    Ehime Proteo Medicine Research Center, Department of Basic and Clinical Neuroscience, Ehime University, Japan
    Exp Neurol 229:507-16. 2011
    ..The cytokine mixture injection significantly reduced mortality of the 5FU-treated rats. These results suggest that the combination of IL-3 and GM-CSF serves as a promising agent to ameliorate TBI via action on BINCs...
  15. doi request reprint Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages
    Tatsuhiro Nakata
    Department of Cardiothoracic Surgery and Regeneration Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Brain Res 1420:114-24. 2011
    ..Remarkably, BMDMs appear to have a beneficial effect on the spinal cord in paresis. In contrast, BMDMs seem to exhibit both beneficial and harmful effects in severe paraplegia...
  16. doi request reprint Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1
    Kana Sugimoto
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan
    Glia 62:185-98. 2014
    ..Appropriate control of NG2(+) microglia in the demarcation zone might be a novel target for the suppression of secondary neurodegeneration in the peri-infarct tissue...
  17. ncbi request reprint Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species
    Shunji Suzuki
    Division of Molecular and Cellular Physiology, Department of Molecular and Cellular Biology, School of Medicine, Ehime University, Toon City, Ehime 791 0295, Japan
    Exp Cell Res 312:1031-41. 2006
    ....
  18. doi request reprint Beta-hydroxybutyrate alters GABA-transaminase activity in cultured astrocytes
    Yuka Suzuki
    Department of Pediatrics, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Brain Res 1268:17-23. 2009
    ..These results suggest that beta-hydroxybutyrate induced by ketogenic diet may increase GABA concentration in the epileptic brain by suppressing astrocytic GABA degradation, leading to antiepileptic effects...
  19. pmc Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children
    Hitomi Hino
    Department of Pediatrics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    PLoS ONE 7:e42920. 2012
    ..Thus, it could be a possible candidate for the treatment of FS in children...
  20. doi request reprint Postnatal interleukin-1β enhances adulthood seizure susceptibility and neuronal cell death after prolonged experimental febrile seizures in infantile rats
    Mitsumasa Fukuda
    Department of Pediatrics, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime, 791 0295, Japan
    Acta Neurol Belg 114:179-85. 2014
    ..Our results are consistent with the hypothesis that excessive production of IL-1β after repeated prolonged FS can enhance adult seizure susceptibility and neuronal cell death, and might contribute to the development of TLE-HS...
  21. ncbi request reprint A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells
    Keiko Kitajima
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 309:135-42. 2003
    ..We suggested that AMSH-FPbeta had a functional role in the spermiogenesis...