Y Shirakata

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. ncbi A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation
    Yoko Yahata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon, Japan
    J Biol Chem 281:13209-16. 2006
  2. ncbi Regulation of epidermal keratinocytes by growth factors
    Yuji Shirakata
    Department of Dermatology, Center for Regenerative Medicine, Ehime University Graduate School of Medicine, Shitsukawa 454, Toon City, Ehime 791 0295, Japan
    J Dermatol Sci 59:73-80. 2010
  3. ncbi Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Cell Sci 118:2363-70. 2005
  4. ncbi So-called biological dressing effects of cultured epidermal sheets are mediated by the production of EGF family, TGF-beta and VEGF
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Ehime Onsengun, 791 0295, Japan
    J Dermatol Sci 32:209-15. 2003
  5. ncbi TGF-beta is not involved in early phase growth inhibition of keratinocytes by 1alpha,25(OH)2vitamin D3
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Onsengun, Ehime 791 0295, Japan
    J Dermatol Sci 36:41-50. 2004
  6. ncbi Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes
    Y Shirakata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    J Biol Chem 275:5748-53. 2000
  7. ncbi SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Toon City, Ehime, Japan
    J Invest Dermatol 126:1574-81. 2006
  8. ncbi Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation
    Yoko Yahata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Sgigenobucho, Onsengun, Ehime 791-0295, Japan
    J Biol Chem 278:40026-31. 2003
  9. ncbi Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37
    Sho Tokumaru
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Immunol 175:4662-8. 2005
  10. ncbi An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression
    Daisuke Nanba
    Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Cell Physiol 214:465-73. 2008

Detail Information

Publications52

  1. ncbi A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation
    Yoko Yahata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon, Japan
    J Biol Chem 281:13209-16. 2006
    ....
  2. ncbi Regulation of epidermal keratinocytes by growth factors
    Yuji Shirakata
    Department of Dermatology, Center for Regenerative Medicine, Ehime University Graduate School of Medicine, Shitsukawa 454, Toon City, Ehime 791 0295, Japan
    J Dermatol Sci 59:73-80. 2010
    ..This review focuses on the regulation of keratinocytes by growth factors, cytokines, and chemokines...
  3. ncbi Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Cell Sci 118:2363-70. 2005
    ....
  4. ncbi So-called biological dressing effects of cultured epidermal sheets are mediated by the production of EGF family, TGF-beta and VEGF
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Ehime Onsengun, 791 0295, Japan
    J Dermatol Sci 32:209-15. 2003
    ..However, the profile of growth factor expression in CESs is unclear...
  5. ncbi TGF-beta is not involved in early phase growth inhibition of keratinocytes by 1alpha,25(OH)2vitamin D3
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Onsengun, Ehime 791 0295, Japan
    J Dermatol Sci 36:41-50. 2004
    ....
  6. ncbi Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes
    Y Shirakata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    J Biol Chem 275:5748-53. 2000
    ..This indicates that these four growth factors have distinct, non-redundant biological functions...
  7. ncbi SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Toon City, Ehime, Japan
    J Invest Dermatol 126:1574-81. 2006
    ..However, SOCS1 did not affect NF-kappaB signaling. Thus, the STAT1-SOCS1 pathway regulates the innate immune response via TLR3 signaling in epidermal keratinocytes...
  8. ncbi Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation
    Yoko Yahata
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Sgigenobucho, Onsengun, Ehime 791-0295, Japan
    J Biol Chem 278:40026-31. 2003
    ..These data demonstrate that STAT3 and its phosphorylation are involved in the downstream pathway of VEGF/VEGFR interaction and regulate VEGF-induced HDMEC migration and tube formation...
  9. ncbi Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37
    Sho Tokumaru
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Immunol 175:4662-8. 2005
    ..The results of this study suggest that LL-37 closes skin wounds by the induction of keratinocyte migration...
  10. ncbi An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression
    Daisuke Nanba
    Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Cell Physiol 214:465-73. 2008
    ....
  11. ncbi SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration
    Sho Tokumaru
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    Biochem Biophys Res Commun 327:100-5. 2005
    ..In conclusion, SOCS3/CIS3 regulates HGF-induced keratinocyte migration by inhibiting STAT3 phosphorylation...
  12. ncbi dsRNA-mediated innate immunity of epidermal keratinocytes
    Mikiko Tohyama
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon-city, Ehime 791-0295, Japan
    Biochem Biophys Res Commun 335:505-11. 2005
    ..In conclusion, normal human keratinocytes produce MIP-1alpha in response to dsRNA via TLR3, and this production is regulated by IFN-alpha/beta...
  13. ncbi The NF-kappaB, p38 MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidermal keratinocytes
    Xiuju Dai
    Department of Dermatology, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    Int Immunol 20:901-9. 2008
    ..In conclusion, the NF-kappaB, p38 MAPK and STAT1 pathways differentially regulate dsRNA-mediated innate immune responses in epidermal keratinocytes...
  14. ncbi All-trans-retinoic acid induces interleukin-8 via the nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Invest Dermatol 123:1078-85. 2004
    ..In summary, ATRA induces IL-8 production in both NF-kappaB- and p38 MAPK-dependent manners in normal human keratinocytes...
  15. ncbi Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis
    M Tohyama
    Department of Dermatology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Br J Dermatol 166:322-30. 2012
    ..Although monocytes abundantly infiltrate the epidermis in SJS/TEN skin lesions, the properties and functions of these cells have not been fully examined...
  16. ncbi Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression
    K Shiraishi
    Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Oncogene 26:339-48. 2007
    ..These findings suggest that deregulation of Pbx1 expression owing to loss of PLZF expression contributes to the progression and/or pathogenesis of melanoma...
  17. ncbi Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence
    K Sayama
    Department of Dermatology, Ehime University School of Medicine, Japan
    J Cell Physiol 179:40-4. 1999
    ..Therefore, induction of p16 appeared not to be associated with senescence in long life-span strains. In conclusion, p21 but not p16 or p53 may play roles in keratinocyte senescence...
  18. ncbi Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes
    Y Hanakawa
    Department of Dermatology, School of Medicine, Ehime University, Ehime, Japan
    J Cell Sci 113:1803-11. 2000
    ..These findings lead us to speculate that Dsc interacts with components of the adherens junctions through beta-catenin, and plays a role in nucleating desmosomes after the adherens junctions have been established...
  19. ncbi Possible roles of IL-27 in the pathogenesis of psoriasis
    Sayaka Shibata
    Faculty of Medicine, Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 130:1034-9. 2010
    ..These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis...
  20. ncbi Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation
    K Sayama
    Department of Dermatology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Biol Chem 276:999-1004. 2001
    ..We propose that the ASK1-p38 MAP kinase cascade is a new intracellular regulator of keratinocyte differentiation...
  21. ncbi CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes
    Mikiko Tohyama
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Int Immunol 19:1095-102. 2007
    ..Killing activity was retained at the physiological salt concentration in the presence of carbonate. In conclusion, CXCL16 is a novel mediator of the innate immune reactivities of epidermal keratinocytes...
  22. ncbi Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members
    Shin ichi Morita
    Department of Ophthalmology, Ehime University School of Medicine, Ehime, Japan
    Mol Vis 13:2119-28. 2007
    ..To investigate the effects of epiregulin, a newly identified member of the epidermal growth factor (EGF) family, on the proliferation of human corneal epithelial cells (HCECs)...
  23. ncbi Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections
    Yuko Hara
    Department of Ophthalmology, Ehime University School of Medicine, Shitsukawa, Japan
    Mol Vis 15:937-48. 2009
    ..In addition, we determined the effects of immunosuppressive drugs on the innate responses...
  24. ncbi Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis
    Koji Sayama
    Department of Dermatology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Biol Chem 281:22013-20. 2006
    ..In conclusion, TAK1 is essential in the regulation of keratinocyte growth, differentiation, and apoptosis...
  25. ncbi Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration
    Hiroshi Nagai
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Dermatol 34:523-30. 2007
    ..In conclusion, PDGF induces fibroblast migration under the control of STAT3-SOCS3...
  26. ncbi Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes
    Koji Sayama
    Department of Dermatology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Biol Chem 277:40390-6. 2002
    ..In conclusion, loss of PI3K activity results in keratinocytes leaving the basement membrane and the initiation of a "default" differentiation mechanism...
  27. ncbi IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression
    Mikiko Tohyama
    Department of Dermatology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Eur J Immunol 39:2779-88. 2009
    ....
  28. ncbi Keratinocyte growth inhibition by high-dose epidermal growth factor is mediated by transforming growth factor beta autoinduction: a negative feedback mechanism for keratinocyte growth
    Kenshi Yamasaki
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Invest Dermatol 120:1030-7. 2003
    ..These data demonstrate that an autocrine transforming growth factor beta1-ALK5 pathway is a negative feedback mechanism for epidermal growth factor-induced normal human keratinocyte growth...
  29. ncbi Identification of the human IAI.3B promoter element and its use in the construction of a replication-selective adenovirus for ovarian cancer therapy
    Katsuyuki Hamada
    Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Japan
    Cancer Res 63:2506-12. 2003
    ..These results demonstrate the usefulness of the IAI.3B promoter for generation of ovarian cancer-specific adenoviral vectors and provide a potential for the development of ovarian cancer-specific oncolytic viral therapies...
  30. ncbi Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice
    Koji Sayama
    Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan
    PLoS ONE 5:e11275. 2010
    ..These studies provide the first evidence that the inflammatory mediator TAK1 regulates hair follicle induction and morphogenesis, and is required for anagen induction and anagen maintenance...
  31. ncbi Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Invest Dermatol 122:1356-64. 2004
    ..In conclusion, the induction of Cdc2 phosphorylation due to the increase of Wee1 and Myt1 as well as the reduction of Cdc2 and cyclin B1 are involved in 1,25[OH]2VD3-induced G2/M arrest of keratinocytes...
  32. ncbi E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity
    Koji Sayama
    Department of Dermatology, Ehime University Graduate School of Medicine, Ehime 791 0295, Japan
    J Biol Chem 285:30042-9. 2010
    ..In conclusion, Ubc13 appears to be essential for epidermal integrity in mice...
  33. ncbi Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes
    Kenshi Yamasaki
    Department of Dermatology, Ehime University School of Medicine, Japan
    J Invest Dermatol 120:571-80. 2003
    ....
  34. ncbi Lack of evidence for TARC/CCL17 production by normal human keratinocytes in vitro
    Teruko Tsuda
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Onsengun, Ehime 791 0295, Japan
    J Dermatol Sci 31:37-42. 2003
    ..However, keratinocyte TARC production has been described only in the transformed keratinocyte cell line HaCaT...
  35. ncbi New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2
    Koji Sayama
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    Eur J Immunol 35:1886-95. 2005
    ..Moreover, the p38 inhibitor reduced this induction. In conclusion, the ASK1-p38 cascade regulates the innate immunity of the skin by forming an immune barrier consisting of hBD, LL37, and TLR2 during epidermal differentiation...
  36. ncbi Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease
    Satoshi Hirakawa
    Department of Dermatology, Integrated Center for Sciences, Ehime University, Japan
    Am J Pathol 175:2235-48. 2009
    ..Our findings reveal that EMT-related features likely promote lymphatic metastasis of EMPD by activating the CXCR4-SDF-1 axis...
  37. ncbi Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation
    Yasushi Hanakawa
    Department of Dermatology, School of Medicine, Ehime University, Ehime, Japan
    J Invest Dermatol 119:1231-6. 2002
    ..Our findings provide biologic evidence that desmoglein 1 and desmoglein 3 play a different functional role in cell-cell adhesion of keratinocytes...
  38. ncbi Living skin equivalents constructed using human amnions as a matrix
    Lujun Yang
    Department of Dermatology, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    J Dermatol Sci 56:188-95. 2009
    ..The amnionic membrane (AM) is known to have useful properties as a dermal matrix and can be used to construct a LSE...
  39. ncbi PPAR gamma is an important transcription factor in 1 alpha,25-dihydroxyvitamin D3-induced involucrin expression
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Dermatol Sci 50:53-60. 2008
    ..Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors. It has been reported that PPARs stimulate keratinocyte differentiation and regulate the expression of differentiation molecules...
  40. ncbi BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid
    Masakazu Kobayashi
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Dermatol Sci 30:224-32. 2002
    ..These findings indicate that NC16a ELISA will be a valuable tool not only for the diagnosis of patients with BP but also for the monitoring of the disease activity...
  41. ncbi In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris
    Ken Ishii
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 124:939-46. 2005
    ..These findings indicate that this dissociation assay will provide a simple and objective biological method to measure the pathogenic strength of pemphigus autoantibodies...
  42. ncbi Microbubble-enhanced ultrasound for gene transfer into living skin equivalents
    Lujun Yang
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan
    J Dermatol Sci 40:105-14. 2005
    ..CONCLUSION: Gene transfer into LSE using ultrasound with microbubble enhancement is an effective alternative to viral and non-viral methods...
  43. ncbi STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    J Invest Dermatol 127:1728-35. 2007
    ..This report provides early evidence of a major role for STAT5a in the differentiation of keratinocytes, where it contributes to involucrin expression by activating the PPARgamma signal...
  44. ncbi Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes
    Lujun Yang
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Dermatol Sci 42:111-9. 2006
    ..However, the crosstalk between BMP-2 and the Wnt/beta-catenin signaling pathway is not clear...
  45. ncbi Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1
    Y Shirakata
    Department of Dermatology, Ehime University School of Medicine, Shigenobu, Japan
    J Invest Dermatol 110:76-8. 1998
    ....
  46. ncbi A Japanese case of segmental Darier's disease caused by mosaicism for the ATP2A2 mutation
    T Wada
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Onsengun, Ehime 791-0295, Japan
    Br J Dermatol 149:185-8. 2003
    ..This novel mutation was present in the affected skin, but not in the unaffected skin or peripheral leucocytes. This is the first report of segmental Darier's disease caused by mosaicism for an ATP2A2 mutation in Japan...
  47. ncbi New skin-equivalent model from de-epithelialized amnion membrane
    Lujun Yang
    Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan
    Cell Tissue Res 326:69-77. 2006
    ..The better epidermal morphology and better-developed BM in AM-LSE in vitro and in vivo indicates its superiority over LSE without AM for clinical applications...
  48. ncbi Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex
    Yuji Shirakata
    Department of Dermatology, Ehime University School of Medicine, Japan
    J Dermatol 30:135-40. 2003
    ..Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts...
  49. ncbi Phospholipase Cdelta1 is required for skin stem cell lineage commitment
    Yoshikazu Nakamura
    Department of Biochemistry, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    EMBO J 22:2981-91. 2003
    ..From these results, we conclude that PLCdelta(1) is required for skin stem cell lineage commitment...
  50. ncbi Hair follicle regeneration using grafted rodent and human cells
    Ritsuko Ehama
    Life Science Research Center, Shiseido Research Center, Yokohama, Kanagawa, Japan
    J Invest Dermatol 127:2106-15. 2007
    ..This study emphasizes the importance of EMI in follicular generation and the differentiation potential of epidermal keratinocytes...
  51. ncbi Essential roles of perforin in antigen-specific cytotoxicity mediated by human CD4+ T lymphocytes: analysis using the combination of hereditary perforin-deficient effector cells and Fas-deficient target cells
    Fumio Yanai
    Department of Pediatrics, Fukuoka University School of Medicine, Fukuoka, Japan
    J Immunol 170:2205-13. 2003
    ..The present data demonstrate that perforin-negative CD4+ CTLs can exert cytotoxicity against Fas-sensitive target cells; however, perforin plays essential roles in Ag-specific cytotoxicity mediated by human CD4+ as well as CD8+ CTLs...
  52. ncbi Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis
    Yuji Shirakata
    J Dermatol Sci 45:69-72. 2007