Kenshi Sakayama

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. doi request reprint Ketoprofen in topical formulation decreases the matrix metalloproteinase-2 expression and pulmonary metastatic incidence in nude mice with osteosarcoma
    Setsuya Kamei
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    J Orthop Res 27:909-15. 2009
  2. pmc Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8
    Junichi Aizawa
    Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
    BMC Cancer 10:51. 2010
  3. doi request reprint Giant cell tumour of the hamate treated successfully by acrylic cementation: a case report
    K Sakayama
    Department of Bone and Joint Surgery and the Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, Ehime, Japan
    J Hand Surg Eur Vol 33:803-5. 2008
  4. ncbi request reprint Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Cancer Chemother Pharmacol 61:471-9. 2008
  5. ncbi request reprint A child who recovered completely after spinal cord injury complicated by C2-3 fracture dislocation: case report
    Kenshi Sakayama
    Department of Orthopedic Surgery, Ehime University School of Medicine, Ehime, Japan
    Spine (Phila Pa 1976) 30:E269-71. 2005
  6. ncbi request reprint A complete remission of sclerosing rhabdomyosarcoma with multiple lung and bone metastases treated with multi-agent chemotherapy and peripheral blood stem cell transplantation (PBSCT): a case report
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Anticancer Res 28:2361-7. 2008
  7. ncbi request reprint Elevated concentration of hyaluronan in the cerebrospinal fluid is a secondary marker of spinal disorders: hyaluronan in the cerebrospinal fluid in patients with spinal disorders
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Spinal Disord Tech 19:262-5. 2006
  8. ncbi request reprint Bipolar-type floating radial head prosthesis for the treatment of giant cell tumor of the proximal radius: a case report
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Ehime, Japan
    J Shoulder Elbow Surg 15:e9-12. 2006
  9. ncbi request reprint The synthesis and activity of lipoprotein lipase in the subcutaneous adipose tissue of patients with musculoskeletal sarcomas
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Anticancer Res 28:2081-6. 2008
  10. ncbi request reprint Diagnostic and therapeutic problems of giant cell tumor in the proximal femur
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, 791 0295, Ehime, Japan
    Arch Orthop Trauma Surg 127:867-72. 2007

Collaborators

Detail Information

Publications43

  1. doi request reprint Ketoprofen in topical formulation decreases the matrix metalloproteinase-2 expression and pulmonary metastatic incidence in nude mice with osteosarcoma
    Setsuya Kamei
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    J Orthop Res 27:909-15. 2009
    ..In conclusion, the topical treatment of osteosarcoma with KP decreased the expression of MMP-2 and VEGF, thus resulting in the suppression of tumor growth and pulmonary metastasis...
  2. pmc Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8
    Junichi Aizawa
    Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
    BMC Cancer 10:51. 2010
    ..The purpose of this study was to investigate whether troglitazone (TGZ) is considered as possible therapeutics in the treatment of growth and metastasis of osteosarcoma...
  3. doi request reprint Giant cell tumour of the hamate treated successfully by acrylic cementation: a case report
    K Sakayama
    Department of Bone and Joint Surgery and the Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, Ehime, Japan
    J Hand Surg Eur Vol 33:803-5. 2008
    ..It has not recurred 3 years after surgery, and no functional impairment has been observed. We have reviewed previously reported cases of GCTs in the hamate and discuss the best management to prevent recurrence while maintaining function...
  4. ncbi request reprint Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Cancer Chemother Pharmacol 61:471-9. 2008
    ....
  5. ncbi request reprint A child who recovered completely after spinal cord injury complicated by C2-3 fracture dislocation: case report
    Kenshi Sakayama
    Department of Orthopedic Surgery, Ehime University School of Medicine, Ehime, Japan
    Spine (Phila Pa 1976) 30:E269-71. 2005
    ..This was a case of a child who recovered completely after spinal cord surgery complicated by C2-C3 fracture dislocation...
  6. ncbi request reprint A complete remission of sclerosing rhabdomyosarcoma with multiple lung and bone metastases treated with multi-agent chemotherapy and peripheral blood stem cell transplantation (PBSCT): a case report
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Anticancer Res 28:2361-7. 2008
    ..This is a very rare case with successful treatment using PBSCT for a sclerosing RMS that presented with multiple distant metastases at the first consultation...
  7. ncbi request reprint Elevated concentration of hyaluronan in the cerebrospinal fluid is a secondary marker of spinal disorders: hyaluronan in the cerebrospinal fluid in patients with spinal disorders
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Spinal Disord Tech 19:262-5. 2006
    ..Hyaluronan (HA) was measured in cerebrospinal fluid (CSF) to ascertain the clinical significance of this substance in patients with spinal disorders, a topic that, to the best of our knowledge, has not previously been studied...
  8. ncbi request reprint Bipolar-type floating radial head prosthesis for the treatment of giant cell tumor of the proximal radius: a case report
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Ehime, Japan
    J Shoulder Elbow Surg 15:e9-12. 2006
  9. ncbi request reprint The synthesis and activity of lipoprotein lipase in the subcutaneous adipose tissue of patients with musculoskeletal sarcomas
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Anticancer Res 28:2081-6. 2008
    ..These results indicated that LPL was up-regulated at the transcriptional/translational level, thus resulting in an increased TG deposition in the adipose tissue of patients with muculoskeletal sarcoma...
  10. ncbi request reprint Diagnostic and therapeutic problems of giant cell tumor in the proximal femur
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, 791 0295, Ehime, Japan
    Arch Orthop Trauma Surg 127:867-72. 2007
    ..2 out of 30 (93.9%). Local recurrence was observed in two patients. The long-term follow-up reveals that one of the important problem is pre-operative diagnosis. Excisional biopsy is effective for surgery of GCT in the proximal femur...
  11. ncbi request reprint Mycetoma of foot: a rare case report and review of the literature
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University, School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime, Japan
    Foot Ankle Int 25:763-7. 2004
  12. ncbi request reprint Effect of ketoprofen in topical formulation on vascular endothelial growth factor expression and tumor growth in nude mice with osteosarcoma
    Kenshi Sakayama
    Department of Orthopaedic Surgery, School of Medicine, Ehime University, Shigenobu, Onsen gun, 791 0295, Japan
    J Orthop Res 22:1168-74. 2004
    ..Based on these findings, we concluded that topical administration of KP to nude mice with osteosarcoma inhibited VEGF expression, reduced the development of feeder vessels for supply of nutrients and oxygen, and suppressed tumor growth...
  13. ncbi request reprint Subdural spinal granuloma resulting from Candida albicans without immunosufficiency: case report
    Kenshi Sakayama
    Department of Orthopedic Surgery, Ehime University School of Medicine, Ehime, Japan
    Spine (Phila Pa 1976) 27:E356-60. 2002
    ..This was a case of spinal subdural granuloma of Candida albicans. A high cerebrospinal fluid protein level without pleocytosis (albuminocytologic dissociation) was observed. This case proved difficult to diagnose and treat...
  14. ncbi request reprint Definitive intraoperative radiotherapy for musculoskeletal sarcomas and malignant lymphoma in combination with surgical excision
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University, School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Int J Clin Oncol 8:174-9. 2003
    ..The purpose was to estimate retrospectively the outcome of patients with musculoskeletal sarcoma or malignant lymphoma treated with intraoperative radiotherapy (IORT)...
  15. doi request reprint Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune-Albright syndrome
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0204, Japan
    Int J Clin Oncol 16:270-4. 2011
    ..Malignant transformation was suspected in the pelvic tumor from imaging because rapid growth of the tumor by imaging was observed; however, no malignant change occurred in this case...
  16. ncbi request reprint Reconstruction using a frozen bone method for osteosarcoma of the talus. A case report and review of the literature
    Kenshi Sakayama
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295 Japan
    Anticancer Res 29:4093-8. 2009
    ..This is a rare case report of osteosarcoma of the talus without extrainvasion of the talus...
  17. ncbi request reprint A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime, Japan
    Skeletal Radiol 34:221-4. 2005
    ..No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge...
  18. ncbi request reprint Reconstruction surgery for patients with musculoskeletal tumor, using a pasteurized autogenous bone graft
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Int J Clin Oncol 9:167-73. 2004
    ..The pasteurized autogenous bone graft (PABG) is a new method to reuse resected and diseased autogenous bones after heat treatment at a comparatively low temperature (60 degrees C-65 degrees C)...
  19. ncbi request reprint Extraskeletal osteosarcoma in the thigh: a case report
    Makoto Kajihara
    Department of Radiology, Ehime University School of Medicine, Toon, Japan
    Radiat Med 23:142-6. 2005
    ..Bone scintigraphy showed extraskeletal uptake in the tumor, and thallium-201 scintigraphy revealed marked inhomogeneous accumulation...
  20. ncbi request reprint Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans
    Yoshifumi Sugawara
    Department of Radiology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Ann Nucl Med 19:461-8. 2005
    ..The purpose of this study was to evaluate whether the delayed scan is necessary and whether a dynamic scan is useful in the evaluation of bone and soft-tissue tumors...
  21. doi request reprint Perinatal and postnatal exposure to 4-tert-octylphenol inhibits cortical bone growth in width at the diaphysis in female mice
    Setsuya Kamei
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Toxicology 252:99-104. 2008
    ..In conclusion, the exposure of female mice to OP during the perinatal and postnatal periods inhibited the periosteal bone formation in the cortical bone at the diaphysis of the femur, thereby causing a reduction in bone growth in width...
  22. ncbi request reprint Measurement of tumor blood flow using dynamic contrast-enhanced magnetic resonance imaging and deconvolution analysis: a preliminary study in musculoskeletal tumors
    Yoshifumi Sugawara
    Department of Radiology, Ehime University School of Medicine, Toon, Ehime, Japan
    J Comput Assist Tomogr 30:983-90. 2006
    ..To measure tumor blood flow (TBF) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)...
  23. ncbi request reprint Evaluation of tumor blood flow in musculoskeletal lesions: dynamic contrast-enhanced MR imaging and its possibility when monitoring the response to preoperative chemotherapy-work in progress
    Makoto Kajihara
    Department of Radiology, Ehime University School of Medicine, Toon 791 0295, Japan
    Radiat Med 25:94-105. 2007
    ....
  24. pmc Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8
    Atsushi Nakamura
    Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, Tobe cho, Iyo gun, Ehime, 791 2101, Japan
    BMC Cell Biol 13:24. 2012
    ..The purpose of this study is to investigate the effect of genistein, an isoflavone found in soy, on the invasive and motile potential of osteosarcoma cells...
  25. ncbi request reprint Bisphenol A downregulates Akt signaling and inhibits adiponectin production and secretion in 3T3-L1 adipocytes
    Teruki Kidani
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Iyo gun, Ehime, Japan
    J Atheroscler Thromb 17:834-43. 2010
    ....
  26. ncbi request reprint 4-tert-octylphenol regulates the differentiation of C3H10T1/2 cells into osteoblast and adipocyte lineages
    Joji Miyawaki
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Toxicol Sci 102:82-8. 2008
    ..In conclusion, treatment of C3H10T1/2 cells with OP inhibited osteoblast differentiation, causing a lineage shift toward adipocytes...
  27. ncbi request reprint Pathological findings of an autograft containing osteosarcoma treated by liquid nitrogen retrieved 2 years after implantation
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    J Orthop Sci 11:655-6. 2006
  28. ncbi request reprint Dumbbell-shaped chondrosarcoma that primarily developed in the cervical spine: a case report
    Kenshi Sakayama
    Department of Orthopedic Surgery, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    J Orthop Sci 9:166-70. 2004
    ..We have thus experienced a patient with a rare dumbbell chondrosarcoma that primarily developed in the cervical spine for which a preoperative diagnosis was difficult...
  29. ncbi request reprint Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions
    Kenshi Sakayama
    Department of Orthopedic Surgery, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime, 791 0295, Japan
    J Orthop Sci 8:678-82. 2003
    ..There are differences in proliferative ability in the intratumoral locations within the same osteoblastic osteosarcoma. Moreover, there are differences in proliferative ability between the metastatic foci and the primary lesion...
  30. ncbi request reprint Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report
    Yoshiro Matsuda
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Ehime, Japan
    Spine (Phila Pa 1976) 31:E231-6. 2006
    ..A case report of an extremely rare malignant spinal tumor successfully treated with total en bloc spondylectomy and chemotherapy...
  31. ncbi request reprint Heerfordt syndrome initially presenting with subcutaneous mass lesions: usefulness of gallium-67 scans before and after treatment
    Yoshifumi Sugawara
    Department of Radiology, Ehime University School of Medicine, Toon, Ehime, Japan
    Clin Nucl Med 30:732-3. 2005
  32. ncbi request reprint Subcutaneous fibrolipoma in the back
    Makoto Kajihara
    Department of Radiology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Radiat Med 24:520-4. 2006
    ..After surgery, the tumor was histologically diagnosed as a fibrolipoma. Subcutaneous fibrolipoma is a rare neoplasm that is defined as a subtype of lipoma...
  33. ncbi request reprint Tl-201 and Tc-99m HMDP scintigraphic findings in extraskeletal osteosarcoma
    Makoto Kajihara
    Department of Radiology, Ehime University School of Medicine, Shigenobu, Ehime, Japan
    Clin Nucl Med 30:356-8. 2005
    ..The Tc-99m HMDP bone scan revealed increased extraskeletal uptake in the tumor...
  34. ncbi request reprint Active-dimeric form of lipoprotein lipase increases in the adipose tissue of patients with rheumatoid arthritis treated with prednisolone
    Teruki Kidani
    Department of Orthopedic Surgery, School of Medicine, Ehime University, Shigenobu, Onsen gun, Ehime 791 0295, Japan
    Biochim Biophys Acta 1584:31-6. 2002
    ..Taken together, our present results indicate that the higher level of LPL activity in the PSL-treated group was a result of the inhibition of the degradation of the active-dimeric form...
  35. ncbi request reprint Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice
    Joji Miyawaki
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
    J Atheroscler Thromb 14:245-52. 2007
    ..To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia...
  36. ncbi request reprint Evaluation of clinical prognosis and activities of daily living using functional independence measure in patients with hip fractures
    Haruhiko Takeda
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, and Ishikawa Hospital, Ehime, 791 0295, Japan
    J Orthop Sci 11:584-91. 2006
    ..The FIM has recently been used to assess disability. The purpose of this study was to standardize criteria using the FIM for determining when and to where patients can be discharged following surgery for hip fracture...
  37. doi request reprint The prognostic factors of recurrent GCT: a cooperative study by the Eastern Asian Musculoskeletal Oncology Group
    Akihiko Takeuchi
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 16:196-202. 2011
    ..Giant-cell tumor (GCT) of bone is a common primary benign tumor with high local recurrence and potential distant metastasis or malignant transformation. We have investigated the clinical behavior of recurrent GCT of bone in the extremities...
  38. ncbi request reprint Mitochondrial DNA mutations and 8-hydroxy-2'-deoxyguanosine Content in Japanese patients with urinary bladder and renal cancers
    Takashi Wada
    Department of Urology, Ehime University School of Medicine, Tohon City, Ehime, Japan
    Anticancer Res 26:3403-8. 2006
    ....
  39. ncbi request reprint Inhibitory effect of all-trans retinoic acid on androgen-induced growth of mouse seminal vesicles in vivo and its mechanism
    Hideki Sato
    Department of Urology, Ehime University, School of Medicine, Ehime, Japan
    Hum Exp Toxicol 24:467-74. 2005
    ..The present study showed that retinoid inhibited the androgen-induced growth of mouse SVs in vivo, and suggests that a decrease in AR is one of its mechanisms...
  40. ncbi request reprint Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway
    Hiroshi Masuno
    Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Iyo gun, Ehime 791 2101, Japan
    Toxicol Sci 84:319-27. 2005
    ..Two diphenylalkanes with ether bonds on hydroxyl groups and two alkylphenols (4-nonylphenol and 4-tert-octylphenol) did not have the ability to accelerate terminal adipocyte differentiation...
  41. ncbi request reprint Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes
    Hiroshi Masuno
    Department of Medical Laboratory Technology, Ehime College of Health Science, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
    J Lipid Res 43:676-84. 2002
    ..Taken together, our results indicate that BPA in combination with INS can accelerate the adipocyte conversion...
  42. doi request reprint Malignant salivary gland-type mixed tumour of the kidney
    Yuuki Miyauchi
    Pathology 40:431-4. 2008
  43. ncbi request reprint Effect of 4-nonylphenol on cell proliferation and adipocyte formation in cultures of fully differentiated 3T3-L1 cells
    Hiroshi Masuno
    Department of Medical Laboratory Technology, Ehime College of Health Science, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
    Toxicol Sci 75:314-20. 2003
    ....