Haruhiko Osawa

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. pmc A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population
    Hiroshi Onuma
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    PLoS ONE 5:e9718. 2010
  2. ncbi request reprint Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin-resistant patients
    H Osawa
    Department of Laboratory Medicine, Kitamuro Clinic, Department of Pediatrics, Ehime University School of Medicine, Ehime, Japan
    Clin Genet 59:194-7. 2001
  3. ncbi request reprint Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 335:596-602. 2005
  4. ncbi request reprint Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime, University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 355:342-6. 2007
  5. ncbi request reprint Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Diabetes Care 30:1501-6. 2007
  6. ncbi request reprint Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Prefectural Hospital, Ehime, Japan
    Clin Endocrinol (Oxf) 69:74-80. 2008
  7. ncbi request reprint Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Japan
    Mol Genet Metab 79:43-51. 2003
  8. ncbi request reprint The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Japan
    Clin Endocrinol (Oxf) 69:36-44. 2008
  9. ncbi request reprint Systematic search for single nucleotide polymorphisms in the FOXC2 gene: the absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Japan
    Diabetes 52:562-7. 2003
  10. doi request reprint PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Clin Endocrinol (Oxf) 71:341-5. 2009

Collaborators

Detail Information

Publications55

  1. pmc A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population
    Hiroshi Onuma
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    PLoS ONE 5:e9718. 2010
    ..In Caucasians, the association between SNP-420 and plasma resistin is not strong, and A at -358 may not exist, suggesting that SNP-358 could explain this ethnic difference...
  2. ncbi request reprint Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin-resistant patients
    H Osawa
    Department of Laboratory Medicine, Kitamuro Clinic, Department of Pediatrics, Ehime University School of Medicine, Ehime, Japan
    Clin Genet 59:194-7. 2001
    ..This mutant receptor could not be expressed on a cell membrane since the transmembrane domain is missing. Other significant mutations were not found for the entire coding regions and splice/donor sites...
  3. ncbi request reprint Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 335:596-602. 2005
    ..In 23 healthy volunteers, monocyte resistin mRNA was positively correlated with its simultaneous serum levels and was higher in G/G genotype. Thus, SNP-420 determines monocyte mRNA and serum levels of resistin, which could induce T2DM...
  4. ncbi request reprint Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime, University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 355:342-6. 2007
    ..0318) or serum creatinine (P=0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM...
  5. ncbi request reprint Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Diabetes Care 30:1501-6. 2007
    ..We report here on the relation between plasma resistin and either SNP -420 genotype or factors related to insulin resistance...
  6. ncbi request reprint Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Prefectural Hospital, Ehime, Japan
    Clin Endocrinol (Oxf) 69:74-80. 2008
    ..The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM...
  7. ncbi request reprint Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Japan
    Mol Genet Metab 79:43-51. 2003
    ..Thus, the identified polymorphisms are unlikely to have major effects on susceptibility to Japanese type 2 diabetes...
  8. ncbi request reprint The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Japan
    Clin Endocrinol (Oxf) 69:36-44. 2008
    ..The aim of this study was to determine the relationship between single nucleotide polymorphisms (SNPs) of MAPK8 and type 2 diabetes (T2DM)...
  9. ncbi request reprint Systematic search for single nucleotide polymorphisms in the FOXC2 gene: the absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Japan
    Diabetes 52:562-7. 2003
    ..5%) than in control subjects (0.3%). Thus, the SNPs identified in the FOXC2 gene are unlikely to have major effects on susceptibility to Japanese type 2 diabetes...
  10. doi request reprint PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Clin Endocrinol (Oxf) 71:341-5. 2009
    ..The aim of this study was to determine the relationship among PPARgamma Pro12Ala polymorphism, resistin SNP-420, and plasma resistin...
  11. ncbi request reprint Systematic search for single nucleotide polymorphisms in the insulin gene: evidence for a high frequency of -23T-->A in Japanese subjects
    H Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime, 791 0295, Japan
    Biochem Biophys Res Commun 286:451-5. 2001
    ..Thus, the A/A genotype at the g.-23 of insulin gene was generally high in Japanese subjects, which could account for the fact that they typically secrete lower levels of insulin...
  12. pmc Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Cardiovasc Diabetol 8:60. 2009
    ..In the present study, the association between serum resistin concentration and cardiovascular disease (CVD) was investigated in a general Japanese population...
  13. ncbi request reprint Systematic search for single nucleotide polymorphisms in the resistin gene: the absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan
    Diabetes 51:863-6. 2002
    ..These identified SNPs, which were in linkage disequilibrium, represent potentially useful tools for searching for their association with specific phenotypes of diabetes...
  14. pmc The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan
    Am J Hum Genet 75:678-86. 2004
    ..Therefore, the specific recognition of -420G by Sp1/3 increases RETN promoter activity, leading to enhanced serum resistin levels, thereby inducing human T2DM...
  15. ncbi request reprint A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes
    Hideichi Makino
    Institute of Diabetes Research Center, Takanoko Hospital, Ehime, Japan
    Endocr J 56:1049-58. 2009
    ..511, P=0.044). Therefore, this pilot study suggests that the G/G genotype of resistin SNP -420 may be an independent predictor of the reduction of fasting plasma glucose and HOMA-IR by pioglitazone...
  16. ncbi request reprint The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes
    Masaaki Ochi
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, 791 0295 Ehime, Japan
    Diabetes Res Clin Pract 61:191-8. 2003
    ..Therefore, the frequent SNP +299G>A in the resistin gene is unlikely to have major effects on susceptibility to insulin resistance syndrome associated with type 2 diabetes in Japanese subjects...
  17. doi request reprint Serum resistin is reduced by glucose and meal loading in healthy human subjects
    Junko Yamauchi
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Metabolism 57:149-56. 2008
    ..Fasting resistin was correlated with SNP -420 and white blood cell count...
  18. doi request reprint No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population
    Yasuharu Tabara
    Department of Basic Medical Research, Education, Ehime University Graduate School of Medicine, Ehime, Japan
    Obesity (Silver Spring) 16:211-5. 2008
    ..937) and homeostasis of minimal assessment of insulin resistance (P = 0.634). These results indicate a lack of association between SNP rs7566605 and being overweight among the Japanese (in the middle-aged and elderly population)...
  19. ncbi request reprint Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size
    Takahiro Ogura
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    FEBS Lett 542:65-8. 2003
    ..Basal PDE activity tended to be decreased to 70% of wild-type levels, and, similarly, insulin-induced PDE activity was significantly decreased to 70%. Thus, PPAR gamma is required for PDE3B gene expression independent of adipocyte size...
  20. pmc Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor, the decorin gene, in the general Japanese population
    Hiroshi Onuma
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Diabetes 62:649-52. 2013
    ..Therefore, plasma resistin was associated with some tag SNPs around DCN in the general Japanese population. The possibility that human decorin is a human resistin receptor should be pursued...
  21. doi request reprint Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell failure in patients with latent autoimmune diabetes in adults (LADA)--a 5-year follow-up of the Ehime study
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes Res Clin Pract 80:114-21. 2008
    ..To clarify the natural course and factors involved in beta cell failure in Japanese latent autoimmune diabetes in adults (LADA) patients...
  22. ncbi request reprint Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes 53:2684-90. 2004
    ....
  23. ncbi request reprint Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes
    Masaaki Ochi
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Diabetes 56:2834-8. 2007
    ..The aim of the present study was to determine the relevance of SNP -120 in a large number of subjects...
  24. pmc Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Diabetes 58:493-8. 2009
    ..A total of 11 previously reported single-nucleotide polymorphisms (SNPs) from the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, and KCNJ11 genes were analyzed...
  25. doi request reprint The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
    Hiroshi Onuma
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    J Hum Genet 55:600-4. 2010
    ..We replicated GCKR rs780094 as a marker of T2DM susceptibility in Japanese subjects. This suggests that GCKR rs780094 is a common variant for T2DM susceptibility in various ethnic groups...
  26. doi request reprint Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Metabolism 60:1634-40. 2011
    ..00-1.25; P = .049). Type 2 diabetes mellitus-susceptible genetic variants identified by a cross-sectional genomewide association study were significantly associated with the future development of T2DM in a general population sample...
  27. doi request reprint Hyperresistinemia is associated with coexistence of hypertension and type 2 diabetes
    Yasunori Takata
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Hypertension 51:534-9. 2008
    ..These results suggest that hyperresistinemia would contribute to the pathogenesis of hypertension in patients with T2DM, significantly linked to vascular complications and cardiovascular events...
  28. doi request reprint Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Proteo Medicine Research Center, Ehime, Japan
    J Hypertens 29:1948-54. 2011
    ..However, the effect of insulin sensitivity and resistance on central BP is not fully understood. Here, we evaluated the associations between insulin sensitivity/resistance and central BP using the oral glucose tolerance test...
  29. ncbi request reprint Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study)
    Haruyo Takeda
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime, Japan
    Diabetes Care 25:995-1001. 2002
    ..To characterize the clinical, autoimmune, and genetic features in Japanese adult-onset diabetic patients with GAD autoantibodies...
  30. ncbi request reprint A newly identified 50 kDa protein, which is associated with phosphodiesterase 3B, is phosphorylated by insulin in rat adipocytes
    Hiroshi Onuma
    Department of Laboratory Medicine, Ehime University School of Medicine, Toon shi, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 337:976-82. 2005
    ..Therefore, it appears likely that this is a new protein which is associated with PDE3B...
  31. ncbi request reprint A nonsense mutation in the Arg345 of the insulin receptor gene in a Japanese type A insulin-resistant patient
    Mitsuru Hashiramoto
    Department of Diabetology and Clinical Laboratory Medicine, National University Corporation, Ehime University School of Medicine, Ehime
    Endocr J 52:499-504. 2005
    ..Using direct sequencing, we identified a nonsense mutation causing premature termination after amino acid 345 in the alpha subunit of the insulin receptor...
  32. ncbi request reprint Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population: the Shimanami Health Promoting Program Study
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicines, Toon, Ehime 791 0295, Japan
    J Clin Endocrinol Metab 93:715-22. 2008
    ..Measurement of HMW complex of adiponectin is one of the novelties of this study...
  33. ncbi request reprint [Current status of study for type 2 diabetes susceptibility genes]
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine
    Nihon Rinsho 60:271-6. 2002
  34. ncbi request reprint [Role of resistin in insulin resistance]
    Hiroshi Onuma
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon 791 0295
    Rinsho Byori 56:698-704. 2008
    ..Together, the specific recognition of 420G by Sp1/3 increases human resistin promoter activity in monocytes, leading to enhanced serum resistin levels, thereby inducing insulin resistance, T2DM, and its complications...
  35. doi request reprint High frequency of HLA B62 in fulminant type 1 diabetes with the drug-induced hypersensitivity syndrome
    Hiroshi Onuma
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, To on, Ehime, 791 0295 Japan
    J Clin Endocrinol Metab 97:E2277-81. 2012
    ..Fulminant type 1 diabetes (FT1D) is a subtype of type 1 diabetes characterized by an extremely abrupt onset. FT1D cases associated with the drug-induced hypersensitivity syndrome (DIHS) have recently been reported...
  36. ncbi request reprint Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein
    Hiroshi Onuma
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Diabetes 51:3362-7. 2002
    ..Because insulin receptor substrate-1 also associates with 14-3-3, the dimeric 14-3-3 beta could function as a scaffolding protein in the activation of PDE3B by insulin...
  37. ncbi request reprint Serum total and high molecular weight adiponectin levels are correlated with the severity of diabetic retinopathy and nephropathy
    Kenichi Kato
    Ehime Prefectural Hospital, Ehime, Japan
    Clin Endocrinol (Oxf) 68:442-9. 2008
    ..Of its isoforms, the high molecular weight (HMW) complex is thought to be the most active. The aim of this study was to determine the relationship between serum total or HMW adiponectin and diabetic microangiopathy...
  38. ncbi request reprint Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice
    Masaaki Hasegawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Diabetes Res Clin Pract 58:79-85. 2002
    ..7-fold in control mice, but was reduced to 1.35-fold in IRS-1 (-/-) mice. Thus, PDE3B gene expression may be inversely correlated with a fat cell size, whereas insulin-induced PDE3B activation is mediated through IRS-1...
  39. ncbi request reprint [Clinical significance of serum-glycated apolipoprotein B measured by the digestion LDL sediment fraction with protease]
    Koji Shishino
    Central Laboratory Department, Ehime University School of Medicine, Toon
    Rinsho Byori 54:583-8. 2006
    ..Therefore, the G-apo B levels might be considered an independent risk marker of diabetes hyperlipidemia and atherogenesis...
  40. ncbi request reprint [Convenient assay for glycated apolipoprotein B using protease]
    Koji Shishino
    Department of Clinical Laboratory, Ehime University School of Medicine, Toon, Ehime pref 791 0295
    Rinsho Byori 53:504-8. 2005
    ..This assay should further be investigated to establish the validity of glycated apolipoprotein B measurement in clinical field...
  41. ncbi request reprint [Genetic testing and gene-based testing for type 2 diabetes]
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine
    Nihon Rinsho 63:295-300. 2005
  42. ncbi request reprint [A simple separative method for measuring serum amyloid A in high-density-lipoprotein and low-density-lipoprotein fractions using the phosphotungstic acid-Mg2+ precipitation procedure]
    Koji Shishino
    Department of Clinical Support, Ehime University Hospital, Toon, Ehime 791 0295
    Rinsho Byori 55:319-24. 2007
    ..The present methods for detecting SAA, especially in the LDL fraction, might benefit from analyzing patho-physiological events in various lipid disorders...
  43. ncbi request reprint Insulin administration may trigger pancreatic beta-cell destruction in patients with type 2 diabetes
    Mai Nakamura
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon shi, Ehime 791 0295, Japan
    Diabetes Res Clin Pract 79:220-9. 2008
    ..The above findings suggest that insulin administration may have triggered pancreatic beta-cell destruction in these patients...
  44. ncbi request reprint [Clinical significance of small, dense LDL cholesterol in patients with hyperlipidemia and type 2 diabetes]
    Koji Shishino
    Department of Clinical Support, Ehime University School of Medicine, Toon
    Rinsho Byori 55:705-11. 2007
    ..Therefore, the determination of sd LDL-C levels can be useful in the diagnosis of patients with hyperlipidemia and polydisperse LDL and in patients with type 2 diabetes with complications of hyperlipidemia and atherosclerosis...
  45. ncbi request reprint A simple precipitation method for measuring sialic acid in apolipoprotein B-containing lipoproteins in plasma
    Koji Shishino
    Central Laboratory Department, Ehime University School of Medicine, Toon City, 791 0295, Ehime Prefecture, Japan
    Ann Clin Biochem 42:298-300. 2005
    ..A convenient method for the measurement of sialic acid in plasma apoB-containing lipoproteins is described...
  46. doi request reprint Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study
    Y Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Int J Obes (Lond) 33:1243-8. 2009
    ..Here, we investigated the involvement of FTO rs9939609 and MC4R rs17782313 polymorphisms in the development of obesity. Association with type 2 diabetes mellitus (T2DM) was also investigated...
  47. ncbi request reprint Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse
    Y Tang
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791-0295, Japan
    Eur J Endocrinol 145:93-9. 2001
    ..CONCLUSIONS: PDE3B gene expression was specifically reduced in the adipose tissues of KKAy mice. JTT-501 restored this reduced gene expression with an accompanying improvement in elevated serum FFA and insulin resistance...
  48. ncbi request reprint Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin resistant db/db mouse
    Y Tang
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Diabetes Res Clin Pract 54:145-55. 2001
    ..The enhanced PDE3B gene expression may correlate with changes in triglyceride storage in the liver of these mice...
  49. ncbi request reprint Association of fulminant type 1 diabetes with pregnancy
    I Shimizu
    Ehime Prefectural Hospital, Ehime, Japan
    Diabetes Res Clin Pract 62:33-8. 2003
    ..004), whereas the frequency of DRB1*0405-DQB1*0401 was similar (type 1A 4/18 vs. fulminant 6/18). Therefore, pregnancy, possible viral infection, or HLADRB1*0405-DQB1*0401 may contribute to the onset of fulminant type 1 diabetes...
  50. ncbi request reprint Serum resistin level is associated with insulin sensitivity in Japanese patients with type 2 diabetes mellitus
    Yoshiharu Tokuyama
    Diabetes Center, Chiba Central Medical Center, Chiba, Japan
    Metabolism 56:693-8. 2007
    ....
  51. ncbi request reprint [Combined use of fasting plasma glucose and HbA1c (as a screening test)]
    Haruhiko Osawa
    Department of Laboratory Medicine Diabetes, Ehime University School of Medicine
    Nihon Rinsho 63:390-3. 2005
  52. ncbi request reprint Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
    Kazuaki Miyake
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Hum Genet 53:174-80. 2008
    ..However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population...
  53. ncbi request reprint Resistin, glomerular filtration rate, and insulin resistance
    Yasuharu Tabara
    Hypertension 51:e11; author reply e12. 2008
  54. ncbi request reprint A case of insulin-induced localized lobular panniculitis with evidence for the phagocytosis of insulin by histiocytes
    Ikki Shimizu
    Department of Diabetes and Endocrinology, Ehime Prefectural Central Hospital, Matsuyama, Japan
    Endocr J 54:477-80. 2007
    ..Thus, the phagocytosis of insulin by histiocytes appears to occur in this region. Therefore, the activation of subcutaneous macrophages by the complex of insulin and insulin antibodies may account for the initial autoimmune process...