T Okura

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. pmc Osteopontin plays a critical role in interstitial fibrosis but not glomerular sclerosis in diabetic nephropathy
    Tomoaki Nagao
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Ehime, Japan
    Nephron Extra 2:87-103. 2012
  2. ncbi request reprint Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells
    T Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime 791 0295, Japan
    Eur J Pharmacol 407:227-35. 2000
  3. ncbi request reprint Intrarenal and carotid hemodynamics in patients with essential hypertension
    Takafumi Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime 791 0295, Japan
    Am J Hypertens 17:240-4. 2004
  4. doi request reprint Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Japan
    Kidney Blood Press Res 33:66-71. 2010
  5. ncbi request reprint Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Ehime Japan
    J Nephrol 23:175-80. 2010
  6. ncbi request reprint Elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stenosis: subanalysis of the Japanese Coronary Artery Disease (JCAD) Study
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
    Circ J 73:885-91. 2009
  7. ncbi request reprint Case of membranoproliferative glomerulonephritis due to essential cryoglobulinemia without hepatitis C virus infection
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Geriatr Gerontol Int 9:92-6. 2009
  8. ncbi request reprint Light chain deposition disease developing 15 years following the diagnosis of monoclonal gammopathy of undetermined significance
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan
    Intern Med 48:101-4. 2009
  9. doi request reprint A case of hyperreninemic hypertension with bilateral positive captopril renography but without renovascular stenosis
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan
    Hypertens Res 31:383-6. 2008
  10. ncbi request reprint Coexistence of three distinct adrenal tumors in the same adrenal gland in a patient with primary aldosteronism and preclinical Cushing's syndrome
    Takafumi Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Toon, Ehime 791 0295, Japan
    Clin Exp Nephrol 10:127-30. 2006

Collaborators

Detail Information

Publications58

  1. pmc Osteopontin plays a critical role in interstitial fibrosis but not glomerular sclerosis in diabetic nephropathy
    Tomoaki Nagao
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Ehime, Japan
    Nephron Extra 2:87-103. 2012
    ..Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of this study was to clarify the roles of OPN in diabetic nephropathy...
  2. ncbi request reprint Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells
    T Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime 791 0295, Japan
    Eur J Pharmacol 407:227-35. 2000
    ..These results strongly suggest that troglitazone can induce vascular smooth muscle cell apoptosis and that this effect is caused primarily by activation of the p53 and Gadd45 pathway but not by PPARgamma activation...
  3. ncbi request reprint Intrarenal and carotid hemodynamics in patients with essential hypertension
    Takafumi Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime 791 0295, Japan
    Am J Hypertens 17:240-4. 2004
    ..In the present study, we evaluated intrarenal PI and RI in patients with essential hypertension...
  4. doi request reprint Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Japan
    Kidney Blood Press Res 33:66-71. 2010
    ..Serum ucOC was an independent determinant of carotid calcification, suggesting that circulating ucOC may be an important biomarker of carotid artery calcification...
  5. ncbi request reprint Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Ehime Japan
    J Nephrol 23:175-80. 2010
    ..Cystatin C is has been reported to be related to TOD in EHT. The aim of the present study was to clarify whether the RI predicts future renal function assessed by cystatin C levels in EHT...
  6. ncbi request reprint Elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stenosis: subanalysis of the Japanese Coronary Artery Disease (JCAD) Study
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
    Circ J 73:885-91. 2009
    ..The association of elevated serum uric acid (UA) with cardiovascular events in patients with severe coronary artery stenosis was examined...
  7. ncbi request reprint Case of membranoproliferative glomerulonephritis due to essential cryoglobulinemia without hepatitis C virus infection
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Geriatr Gerontol Int 9:92-6. 2009
    ..He was finally diagnosed with MPGN due to mixed cryoglobulinemia type II. MPGN with essential cryoglobulinemia type II without evidence of hepatitis C virus infection, like that found in the present case, is very rare...
  8. ncbi request reprint Light chain deposition disease developing 15 years following the diagnosis of monoclonal gammopathy of undetermined significance
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan
    Intern Med 48:101-4. 2009
    ..These findings confirmed a diagnosis of light chain deposit disease (LCDD) with MGUS. The development of LCDD in patients with MGUS for fifteen years is very rare...
  9. doi request reprint A case of hyperreninemic hypertension with bilateral positive captopril renography but without renovascular stenosis
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan
    Hypertens Res 31:383-6. 2008
    ....
  10. ncbi request reprint Coexistence of three distinct adrenal tumors in the same adrenal gland in a patient with primary aldosteronism and preclinical Cushing's syndrome
    Takafumi Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Toon, Ehime 791 0295, Japan
    Clin Exp Nephrol 10:127-30. 2006
    ..Clinically and pathophysiologically, this was a very rare case...
  11. ncbi request reprint Inhibition of matrix metalloproteinase and hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan
    Hypertens Res 30:477-8. 2007
  12. doi request reprint Association between cystatin C and inflammation in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Clin Exp Nephrol 14:584-8. 2010
    ..It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we investigated the relationship between cystatin C and proinflammatory cytokines...
  13. ncbi request reprint A patient with myeloperoxidase antineutrophil cytoplasmic antibody-positive polyangiitis who developed sensorineural hearing loss and scleritis
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
    Intern Med 50:1725-8. 2011
    ..She was diagnosed with MPO-ANCA-associated polyangiitis. ANCA-related polyangiitis should be considered in the differential diagnosis of sudden deafness or scleritis...
  14. ncbi request reprint Relationship between cardio-ankle vascular index (CAVI) and carotid atherosclerosis in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Japan
    Hypertens Res 30:335-40. 2007
    ..492, r<0.0001) were independent determinants of CAVI. These results suggest that CAVI is a useful clinical marker for evaluating atherosclerosis and arteriolosclerosis in patients with essential hypertension...
  15. ncbi request reprint Platelet-derived growth factor induces apoptosis in vascular smooth muscle cells: roles of the Bcl-2 family
    T Okura
    Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime 791 0295, Japan
    Biochim Biophys Acta 1403:245-53. 1998
    ..PDGF-BB treatment reduced bcl-2 mRNA and bcl-xl mRNA expression, in contrast, induced bcl-xs mRNA expression, linked with the induction of apoptosis in cultured VSMC...
  16. ncbi request reprint Giant unruptured aneurysm of the thoracic aorta--a case report
    T Okura
    The Second Department of Internal Medicine, Ehime University School of Medicine, Japan
    Angiology 50:865-9. 1999
    ..Retrospectively, the natural progression of the aneurysm was able to be followed on a series of chest x-ray films obtained over 18 years...
  17. doi request reprint Long-term effects of angiotensin II receptor blockade with valsartan on carotid arterial stiffness and hemodynamic alterations in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Clin Exp Hypertens 30:415-22. 2008
    ..These results suggest that long-term treatment with valsartan improves vascular wall function and hemodynamics in patients with essential hypertension...
  18. ncbi request reprint Peroxisome proliferator-activated receptor-gamma activation inhibits interleukin-1beta -mediated platelet-derived growth factor-alpha receptor gene expression via CCAAT/enhancer-binding protein-delta in vascular smooth muscle cells
    Y Takata
    Second Department of Internal Medicine, Ehime University School of Medicine, Ehime 791-0295, Japan
    J Biol Chem 276:12893-7. 2001
    ..Regulation of C/EBPdelta by PPARgamma activators probably plays critical roles in modulating inflammatory responses in the arterial wall...
  19. ncbi request reprint Valsartan reduces serum cystatin C and the renal vascular resistance in patients with essential hypertension
    Sanae Watanabe
    The Second Department of Internal Medicine, Ehime University School of Medicine, Toon City, Ehime, Japan
    Clin Exp Hypertens 28:451-61. 2006
    ....
  20. ncbi request reprint Postprandial hypotension is associated with asymptomatic cerebrovascular damage in essential hypertensive patients
    K Kohara
    Department of Geriatric Medicine, Ehime University School of Medicine, Onsen gun
    Hypertension 33:565-8. 1999
    ..1+/-0.7, respectively (F[2,67]=4.3, P<0.05). These findings indicate that elderly hypertensive patients with marked PPH should be considered to have advanced cerebrovascular damage even in the absence of abnormal neurological findings...
  21. ncbi request reprint Role of GADD153 (growth arrest- and DNA damage-inducible gene 153) in vascular smooth muscle cell apoptosis
    M Igase
    Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime 791-0295, Japan
    Clin Sci (Lond) 100:275-81. 2001
    ..These results demonstrate an important role for GADD153 in the molecular mechanisms of VSMC apoptosis...
  22. ncbi request reprint Molecular structure and function of rat platelet-derived growth factor beta-receptor gene promoter
    Y Kitami
    The Second Department of Internal Medicine, Ehime University School of Medicine, Japan
    J Hypertens 16:437-45. 1998
    ..To understand the regulatory mechanism of platelet-derived growth factor beta-receptor gene expression...
  23. ncbi request reprint Postprandial hypotension: evaluation by ambulatory blood pressure monitoring
    K Kohara
    Department of Geriatric Medicine, Ehime University School of Medicine, Onsen gun, Japan
    Am J Hypertens 11:1358-63. 1998
    ..36, P < .001). These findings indicate that PPH increases blood pressure variability independently of nocturnal change in blood pressure...
  24. ncbi request reprint Asymptomatic cerebrovascular damages in essential hypertension in the elderly
    K Kohara
    Second Department of Internal Medicine, Ehime University School of Medicine, Japan
    Am J Hypertens 10:829-35. 1997
    ..A different approach to the treatment of hypertension in the elderly appears necessary...
  25. ncbi request reprint Nuclear factor 1 is a negative regulator of gadd153 gene expression in vascular smooth muscle cells
    M Nakamura
    Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Hypertension 37:419-24. 2001
    ..These results suggest that gadd153 gene expression in VSMCs is negatively regulated by an NF1-binding motif, and NF1 may act as an antiapoptotic factor by continuously suppressing gadd153 gene expression in growing VSMCs...
  26. ncbi request reprint Coronary spastic angina induced by anticholinesterase medication for myasthenia gravis--a case report
    M Suzuki
    Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Japan
    Angiology 51:1031-4. 2000
    ..The appearance of coronary spastic angina in the present case is likely mediated through the increase of acethylcholine by anticholinesterase medication...
  27. ncbi request reprint Targeted overexpression of CCAAT/enhancer-binding protein-delta evokes enhanced gene transcription of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells
    Z H Yang
    Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Circ Res 89:503-8. 2001
    ..The results obtained reveal evidence of a new role and new functional significance of C/EBP-delta on VSMC growth via the PDGFalphaR during the process of vascular remodeling and atherosclerosis...
  28. doi request reprint Angiotensin II receptor blockade with valsartan decreases plasma osteopontin levels in patients with essential hypertension
    M Kurata
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    J Hum Hypertens 25:334-9. 2011
    ..332, P=0.026; ln CRP reduction: β=0.366, P=0.015). These results suggest that suppression of the RAAS and inflammation may decrease plasma OPN levels...
  29. ncbi request reprint [Mild hypertension in middle aged adults]
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
    Nihon Rinsho 66:1481-5. 2008
    ..Early therapeutic intervention including life style modification is needed to prevent the sustained mild hypertension...
  30. ncbi request reprint Osteopontin and carotid atherosclerosis in patients with essential hypertension
    Mie Kurata
    The Second Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Toon City, Ehime, 791 0295, Japan
    Clin Sci (Lond) 111:319-24. 2006
    ..These results suggest that OPN plays a role in the development of atherosclerosis and may be a potential clinical marker for the prediction of atherosclerosis in patients with EHT...
  31. ncbi request reprint Association between carotid haemodynamics and inflammation in patients with essential hypertension
    S Manabe
    The Second Department of Internal Medicine, Ehime University School of Medicine, Toon City, Ehime, Japan
    J Hum Hypertens 19:787-91. 2005
    ..These results suggested that carotid haemodynamic parameters such as PI and RI are associated with atherosclerosis and inflammation in hypertensive patients...
  32. ncbi request reprint Serum cystatin C level is a marker of end-organ damage in patients with essential hypertension
    Sanae Watanabe
    Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Hypertens Res 26:895-9. 2003
    ..The present study was the first to demonstrate that s-CC level is a useful and convenient parameter of renal function, and may also prove to be an early marker of the severity of end-organ damage in patients with essential hypertension...
  33. ncbi request reprint Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertension
    Seiko Manabe
    Second Department of Internal Medicine, National University Corporation, Ehime University, Toon City, Ehime, Japan
    J Cardiovasc Pharmacol 46:735-9. 2005
    ..However, C-reactive protein and serum amyloid A did not change. The angiotensin II receptor blocker, valsartan, may inhibit the development of atherosclerosis by lowering serum pro-inflammatory cytokines...
  34. ncbi request reprint Soluble Fas ligand and atherosclerosis in hypertensive patients
    Takafumi Okura
    Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gen, Ehime, Japan
    J Hypertens 20:895-8. 2002
    ..The inflammatory response has an important role in the development of atherosclerosis, whereas C-reactive protein (CRP) is associated with the presence and severity of atherosclerosis...
  35. doi request reprint Hyperresistinemia is associated with coexistence of hypertension and type 2 diabetes
    Yasunori Takata
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Hypertension 51:534-9. 2008
    ..These results suggest that hyperresistinemia would contribute to the pathogenesis of hypertension in patients with T2DM, significantly linked to vascular complications and cardiovascular events...
  36. ncbi request reprint Carotid hemodynamic alterations in hypertensive patients with insulin resistance
    Sanae Watanabe
    The Second Department of Internal Medicine, Ehime University School of Medicine, Japan
    Am J Hypertens 15:851-6. 2002
    ..Hypertensive patients with IR have greater intima-media thickness (IMT) in the common carotid artery (CCA) than those without IR. However, the relationship between IR and hemodynamic alterations of the CCA has not been clarified...
  37. ncbi request reprint [VALUE]
    Takafumi Okura
    Second Department of Internal Medicine, Ehime University School of Medicine
    Nihon Rinsho 64:419-24. 2006
  38. ncbi request reprint Association between carotid hemodynamics and asymptomatic white and gray matter lesions in patients with essential hypertension
    Mie Kurata
    Second Department of Internal Medicine, Ehime University School of Medicine, Toon, Japan
    Hypertens Res 28:797-803. 2005
    ..418, p=0.0038). Carotid structure and hemodynamics are potentially related to asymptomatic lesions in the cerebrum, and might be predictors of future cerebral vascular events in patients with EHT...
  39. ncbi request reprint [A case of "pure" progressive autonomic failure in an elderly male]
    T Kuwahara
    Second Department of Internal Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 29:790-3. 1992
    ..It shows symptoms of autonomic failure without other neurological disturbances which manifest as Shy-Drager syndrome. Treatment with L-DOPS increased his blood pressure level and attenuated his symptoms due to orthostatic hypotension...
  40. ncbi request reprint Hypoglycemic syncope induced by a combination of cibenzoline and angiotensin converting enzyme inhibitor
    A Ogimoto
    Second Department of Internal Medicine, Ehime University School of Medcine, Japan
    Jpn Heart J 42:255-9. 2001
    ..Therefore, the possibility of a hypoglycemic attack associated with these drugs should be explained to patients who are in poor condition...
  41. ncbi request reprint Attenuation of biventricular pressure gradients by cibenzo-line in an 18-year-old patient with hypertrophic obstructive cardiomyopathy
    Go Hiasa
    The Second Department of Internal Medicine, Ehime University School of Medicine, Japan
    Circ J 66:1173-5. 2002
    ..He was then given 300 mg daily of cibenzoline, and both pressure gradients remained low without any complications 8 months later at the time of discharge...
  42. doi request reprint [Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and single-pill combination]
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
    Clin Calcium 20:61-8. 2010
    ..Hypertensive patients are also sometimes combined with dyslipidemia. In these reasons, a single pill combination of CCB and ARB or statin play an important role in hypertensive and anti-atherosclerotic therapy...
  43. ncbi request reprint Plasma osteopontin levels are higher in patients with primary aldosteronism than in patients with essential hypertension
    Jun Irita
    The Second Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    Am J Hypertens 19:293-7. 2006
    ..Elevated serum inflammatory cytokine is an independent cardiovascular risk factor in patients with EHT. In the present study, we compared levels of inflammatory cytokines between patients with PA and EHT...
  44. doi request reprint Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney
    Jun Irita
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Am J Physiol Renal Physiol 301:F833-44. 2011
    ....
  45. ncbi request reprint Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells
    Jia rong Tang
    Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime, 791 0295, Japan
    Biochem Biophys Res Commun 290:1255-9. 2002
    ..These results revealed that induction of the GADD153 gene by oxidative stress is regulated mainly by two nuclear factors, NF1 and AP-1...
  46. ncbi request reprint [Gene mutation and polymorphism as risk factors in the development of hypertensive organ damage]
    Takafumi Okura
    Second Department of Internal Medicine, Ehime University School of Medicine
    Nihon Rinsho 62:92-7. 2004
  47. ncbi request reprint Granulomatous interstitial nephritis due to isolated renal sarcoidosis
    Ken ichi Miyoshi
    Second Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Clin Exp Nephrol 8:279-82. 2004
    ..It is important to consider renal sarcoidosis as a differential diagnosis in patients with severely progressive renal failure, because corticosteroid therapy is very effective...
  48. ncbi request reprint [Case of 131I-meta-iodobenzylguanidine (MIBG) scintigraphy-negative and 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)-positive pheochromocytoma]
    Masanori Jotoku
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Ehime, Japan
    Nihon Jinzo Gakkai Shi 51:563-8. 2009
    ..However, FDG-PET may be useful for detecting local recurrence or distant metastasis, in patients with MIBG-negative pheochromocytoma...
  49. ncbi request reprint [Combination therapy of ARB with other class of antihypertensive agents (including fixed combination)]
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
    Nihon Rinsho 67:819-25. 2009
    ..In near future, we may be able to use many fixed-dose combination antihypertensive agents, ARB with diuretics or CCB...
  50. ncbi request reprint [Repeated changes of electrocardiogram caused by Takotsubo-type cardiomyopathy: a case with hypertrophic nonobstructive cardiomyopathy]
    Seigo Miyoshi
    Second Department of Internal Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 42:112-5. 2005
    ..After five months, ECG showed an improvement of the QT interval and a decrease in the negative T-wave. We considered that the repeated changes of ECG were caused by Takotsubo-type cardiomyopathy...
  51. ncbi request reprint [A 73-year-old man with primary pulmonary hypertension]
    Tamami Kono
    The Second Department of Internal Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 42:116-20. 2005
    ..Because there was no apparent etiology of pulmonary hypertension, primary pulmonary hypertension was diagnosed and appropriate conventional therapy was started...
  52. ncbi request reprint Fibrillary glomerulonephritis associated with monoclonal gammopathy of undetermined significance showing lambda-type Bence Jones protein
    Tomoaki Nagao
    Second Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    Clin Exp Nephrol 9:247-51. 2005
    ..A Congo red stain for amyloid was negative. These findings corresponded with the diagnosis of fibrillary glomerulonephritis. Therefore, this case showed a rare combination of fibrillary glomerulonephritis and MGUS...
  53. ncbi request reprint The effect of losartan and amlodipine on serum adiponectin in Japanese adults with essential hypertension
    Sanae Watanabe
    Department of Integrated Medicine and Informatics, Ehime Graduate School of Medicine, Ehime, Japan
    Clin Ther 28:1677-85. 2006
    ..The purpose of this study was to evaluate the influence of an ARB and a calcium channel blocker on serum adiponectin levels in Japanese patients with hypertension who were treated with losartan or amlodipine for 3 months...
  54. ncbi request reprint Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone
    Jun Irita
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791 0295, Japan
    Hypertension 51:507-13. 2008
    ..These results indicate that aldosterone induced MR-mediated OPN expression through AP-1 and NF kappaB activation and suggest that aldosterone plays an important role in renal fibrosis through the induction of OPN...
  55. ncbi request reprint CCAAT/enhancer-binding protein-delta is induced in mesangial area during the early stages of anti-Thy1.1 glomerulonephritis and regulates cell proliferation and inflammatory gene expression in cultured rat mesangial cells
    Ken ichi Miyoshi
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Clin Exp Nephrol 11:26-33. 2007
    ..The promoter regions of these genes contain CCAAT/enhancer-binding protein (C/EBP)-binding sites. In this study, we investigated the role of C/EBP-delta in mesangial cells (MCs)...
  56. ncbi request reprint Exercise-related syncope induced by vasodilator therapy in an elderly hypertensive patient
    Akiyoshi Ogimoto
    J Am Geriatr Soc 53:351-2. 2005
  57. ncbi request reprint C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells
    Florian Blaschke
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Circulation 110:579-87. 2004
    ....
  58. ncbi request reprint [Etiology of essential hypertension]
    Takafumi Okura
    Nihon Naika Gakkai Zasshi 96:4-8. 2007