N Mitsuda

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. ncbi request reprint Reelin signals survival through Src-family kinases that inactivate BAD activity
    Nobutaka Ohkubo
    Department of Physiology, Graduate School of Medicine, Ehime University, Shitsukawa, Toon, Ehime, Japan
    J Neurochem 103:820-30. 2007
  2. ncbi request reprint A novel alternative splice variant of nicastrin and its implication in Alzheimer disease
    Noriaki Mitsuda
    Department of Integrated Basic Medical Science, School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791 0295, Japan
    Life Sci 78:2444-8. 2006
  3. ncbi request reprint Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1
    N Mitsuda
    Department of Anatomy and Neuroscience and Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    J Biol Chem 276:9688-98. 2001
  4. ncbi request reprint A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2
    M Tamatani
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Neurochem 75:683-93. 2000
  5. ncbi request reprint Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway
    N Ohkubo
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
    J Biol Chem 276:3046-53. 2001
  6. ncbi request reprint Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53
    A Yamaguchi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Biol Chem 276:5256-64. 2001
  7. ncbi request reprint Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade
    Nobutaka Ohkubo
    Department of Physiology, School of Medicine, Ehime University, Onsen gun, Ehime 791 0295, Japan
    FASEB J 17:295-7. 2003
  8. ncbi request reprint ORP150 protects against hypoxia/ischemia-induced neuronal death
    M Tamatani
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 7:317-23. 2001
  9. ncbi request reprint Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population
    Y Hatanaka
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Clin Genet 58:319-23. 2000
  10. doi request reprint Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions
    Mamoru Aoto
    Department of Physiology, Graduate School of Medicine, Ehime University, Shitsukawa, Toon, Ehime, Japan
    FEBS Lett 583:1611-8. 2009

Detail Information

Publications18

  1. ncbi request reprint Reelin signals survival through Src-family kinases that inactivate BAD activity
    Nobutaka Ohkubo
    Department of Physiology, Graduate School of Medicine, Ehime University, Shitsukawa, Toon, Ehime, Japan
    J Neurochem 103:820-30. 2007
    ....
  2. ncbi request reprint A novel alternative splice variant of nicastrin and its implication in Alzheimer disease
    Noriaki Mitsuda
    Department of Integrated Basic Medical Science, School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791 0295, Japan
    Life Sci 78:2444-8. 2006
    ..Further investigation in larger scale population would be necessary to address its potential implication in Alzheimer disease...
  3. ncbi request reprint Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1
    N Mitsuda
    Department of Anatomy and Neuroscience and Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    J Biol Chem 276:9688-98. 2001
    ..Our findings suggest a hypothesis where stimulation of N-methyl-d-aspartate receptors signals CREB activation to enhance PS-1 gene product expression that contributes to normal neuronal functions...
  4. ncbi request reprint A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2
    M Tamatani
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Neurochem 75:683-93. 2000
    ..These findings suggest a pathway where NFkappaB activation induces overexpression of Bcl-2 and Bcl-x, which function to prevent apoptotic cell death following H/R treatments...
  5. ncbi request reprint Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway
    N Ohkubo
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
    J Biol Chem 276:3046-53. 2001
    ..Treatment with an apoE peptide was also found to facilitate transcription of the CREB-dependent genes, c-fos and Bcl-2. In contrast to treatment with apoE3, our findings suggest apoE4 and apoE-peptide induce a novel signaling pathway...
  6. ncbi request reprint Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53
    A Yamaguchi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Biol Chem 276:5256-64. 2001
    ..These results suggest a mechanism where Akt kinase activation reduces p53's transcriptional activity that ultimately rescues neurons from hypoxia- or NO-mediated cell death...
  7. ncbi request reprint Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade
    Nobutaka Ohkubo
    Department of Physiology, School of Medicine, Ehime University, Onsen gun, Ehime 791 0295, Japan
    FASEB J 17:295-7. 2003
    ..These data support a novel, ligand-mediated signal transduction cascade--initiated by the assembly of a RAD complex that suppresses kinase activity and controls tau phosphorylation...
  8. ncbi request reprint ORP150 protects against hypoxia/ischemia-induced neuronal death
    M Tamatani
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 7:317-23. 2001
    ..These data indicate that ORP150 is an integral participant in ischemic cytoprotective pathways...
  9. ncbi request reprint Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population
    Y Hatanaka
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Clin Genet 58:319-23. 2000
    ..03), and this trend was more evident among non-APOE-epsilon4 carriers (p = 0.008). These results support the possibility that ApoE and LRP may contribute to the development of AD...
  10. doi request reprint Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions
    Mamoru Aoto
    Department of Physiology, Graduate School of Medicine, Ehime University, Shitsukawa, Toon, Ehime, Japan
    FEBS Lett 583:1611-8. 2009
    ..These results demonstrate that the ROS/p38/PLA(2) signaling axis has a crucial role in caspase-independent cell death induced by hypoxia...
  11. ncbi request reprint N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression
    Masaki Mori
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Japan
    Life Sci 70:2567-80. 2002
    ..Our study demonstrated that mutant PS-2 induces apoptosis accompanied by increased caspase-3-like activity and decreased bcl-2 expression in neuronal cells after serum-deprivation...
  12. ncbi request reprint Protective effect of vitamin E against focal brain ischemia and neuronal death through induction of target genes of hypoxia-inducible factor-1
    B Zhang
    Department of Physiology, School of Medicine, Ehime University, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Neuroscience 126:433-40. 2004
    ....
  13. ncbi request reprint Suppression of Stat3 promotes neurogenesis in cultured neural stem cells
    Feng Gu
    Department of Anatomy, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Neurosci Res 81:163-71. 2005
    ..These data indicated that suppression of Stat3 directly induced neurogenesis and inhibited astrogliogenesis in neural stem cells...
  14. ncbi request reprint NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha
    Atsuyuki Morishima
    Department of Physiology, School of Medicine, Ehime University, Shigenobu, Japan
    J Biol Chem 278:38188-93. 2003
    ..Our data suggest a new aspect of lipid metabolism and may lead to a new paradigm for prevention and treatment of atherosclerotic disease...
  15. ncbi request reprint Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression
    Bo Zhang
    Department of Integrated Basic Medical Science, Division of Functional Histology, Ehime University School of Medicine, Shitukawa, Toon, Ehime, Japan
    J Cereb Blood Flow Metab 26:708-21. 2006
    ..Ginsenoside Rb(1) appears to be a promising agent not only for the treatment of cerebral stroke, but also for the treatment of other diseases involving activation of mitochondrial cell death signaling...
  16. ncbi request reprint Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain
    Shin ichi Miyake
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 100:67-73. 2002
    ..Our results suggest that this tricarboxylate carrier protein may contribute to biosynthesis and bioenergetics in neuronal cells in brain...
  17. ncbi request reprint [Recent research progress in Alzheimer's disease: relationship with APOE genotype]
    Noriaki Mitsuda
    Nihon Ronen Igakkai Zasshi 43:610-2. 2006
  18. ncbi request reprint The 4,752 C/T polymorphism in the presenilin 1 gene increases the risk of Alzheimer's disease in apolipoprotein E4 carriers
    Miho Matsubara-Tsutsui
    Department of Geriatric Medicine, Ehime University School of Medicine
    Intern Med 41:823-8. 2002
    ..We sought to establish an association between sporadic Alzheimer's disease (AD) and presenilin 1 (PSEN1) gene polymorphisms in the Japanese population...