Kensuke Kojima

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. ncbi Megakaryoblastic leukemia cell line MOLM-16 derived from minimally differentiated acute leukemia with myeloid/NK precursor phenotype
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, Fujisaki, Okayama 702 8006, Japan
    Leuk Res 27:165-71. 2003
  2. ncbi Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia
    Kensuke Kojima
    Department of Hematology, Wakayama Medical University, Wakayama, Japan
    Blood 112:2886-95. 2008
  3. ncbi FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)
    K Kojima
    First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Leukemia 18:998-1005. 2004
  4. ncbi Hypocellular acute promyelocytic leukemia with a tetraploid clone characterized by two t(15;17)
    Kensuke Kojima
    The First Department of Internal Medicine, Ehime University School of Medicine, Shingenobu, Ehime 791 0295, Japan
    Cancer Genet Cytogenet 145:169-71. 2003
  5. ncbi Cyclic thrombocytopenia and polycythemia vera
    K Kojima
    Department of Medicine II, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann Hematol 82:61-3. 2003
  6. ncbi A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)
    Kensuke Kojima
    Department of Internal Medicine II, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Br J Haematol 120:271-3. 2003
  7. ncbi Peripheral blood circulating immature cell counts predict CD34+ cell yields in G-CSF-induced PBPC mobilization in healthy donors
    Teruhiko Kozuka
    Second Department of Internal Medicine, Division of Blood Transfusion, Okayama University Medical School, Japan
    Transfusion 44:526-32. 2004
  8. ncbi Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22)
    Shiro Takata
    Department of Medicine II, Okayama University Medical School, Okayama 700-8558, Japan
    Cancer Genet Cytogenet 140:167-9. 2003
  9. ncbi Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization
    Teruhiko Kozuka
    Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Transfusion 42:1514-22. 2002
  10. ncbi Autoimmune neutropenia associated with multiple sclerosis
    Teruhiko Kozuka
    Department of Internal Medicine II, Okayama University Medical School, Okayama
    Intern Med 42:102-4. 2003

Collaborators

Detail Information

Publications25

  1. ncbi Megakaryoblastic leukemia cell line MOLM-16 derived from minimally differentiated acute leukemia with myeloid/NK precursor phenotype
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, Fujisaki, Okayama 702 8006, Japan
    Leuk Res 27:165-71. 2003
    ....
  2. ncbi Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia
    Kensuke Kojima
    Department of Hematology, Wakayama Medical University, Wakayama, Japan
    Blood 112:2886-95. 2008
    ..Our findings provide the molecular rationale for concomitant targeting of Aurora kinases and Mdm2 in AML where TP53 mutations are rare and downstream p53 signaling is mostly intact...
  3. ncbi FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)
    K Kojima
    First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Leukemia 18:998-1005. 2004
    ..The established cell line, CNLBC1, could provide a useful model for analyzing the pathogenesis of MLL-septin leukemias and chronic neutrophilic leukemia...
  4. ncbi Hypocellular acute promyelocytic leukemia with a tetraploid clone characterized by two t(15;17)
    Kensuke Kojima
    The First Department of Internal Medicine, Ehime University School of Medicine, Shingenobu, Ehime 791 0295, Japan
    Cancer Genet Cytogenet 145:169-71. 2003
    ..The unique karyotype largely contributed to the cell morphology and marrow hypoplasia, while it may not have affected on the prognosis of the acute promyelocytic leukemia...
  5. ncbi Cyclic thrombocytopenia and polycythemia vera
    K Kojima
    Department of Medicine II, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann Hematol 82:61-3. 2003
    ..We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia...
  6. ncbi A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)
    Kensuke Kojima
    Department of Internal Medicine II, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Br J Haematol 120:271-3. 2003
    ..This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS...
  7. ncbi Peripheral blood circulating immature cell counts predict CD34+ cell yields in G-CSF-induced PBPC mobilization in healthy donors
    Teruhiko Kozuka
    Second Department of Internal Medicine, Division of Blood Transfusion, Okayama University Medical School, Japan
    Transfusion 44:526-32. 2004
    ..The correlation of CIC counts in PB with CD34+ cell yield and its usefulness was evaluated in G-CSF-induced PBPC mobilization for healthy donors...
  8. ncbi Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22)
    Shiro Takata
    Department of Medicine II, Okayama University Medical School, Okayama 700-8558, Japan
    Cancer Genet Cytogenet 140:167-9. 2003
    ..To our knowledge, the t(6:8) has never been described in MDS...
  9. ncbi Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization
    Teruhiko Kozuka
    Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Transfusion 42:1514-22. 2002
    ..In an attempt to determine the optimal timing for peripheral blood progenitor cell (PBPC) collection, the usefulness of circulating immature cell (CIC) counts in PB was evaluated...
  10. ncbi Autoimmune neutropenia associated with multiple sclerosis
    Teruhiko Kozuka
    Department of Internal Medicine II, Okayama University Medical School, Okayama
    Intern Med 42:102-4. 2003
    ..Despite a wide spectrum of clinical manifestations in multiple sclerosis, autoimmune neutropenia has never been reported previously...
  11. ncbi Specificity of polymerase chain reaction-based clonality analysis of immunoglobulin heavy chain gene rearrangement for the detection of bone marrow infiltrate in B-cell lymphoma-associated haemophagocytic syndrome
    Kensuke Kojima
    Department of Medicine II, Okayama University Medical School, Okayama, Japan
    Br J Haematol 119:616-21. 2002
    ..PCR-based demonstration of clonal B-cell populations in marrow would add an extra dimension to B-LAHS diagnosis...
  12. ncbi Thymic epithelial hyperplasia with nodular sclerosis Hodgkin's disease
    Wataru Ito
    Second Department of Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
    Leuk Lymphoma 43:2229-31. 2002
    ..Our findings suggest that thymic hyperplasia might be directly involved in the pathology of at least some cases of Hodgkin's disease...
  13. ncbi Can t(8;21) oligoblastic leukemia be called a myelodysplastic syndrome?
    Kinuyo Kaneda
    Department of Medicine II, Okayama University Medical School, Okayama, Japan
    Eur J Haematol 69:165-70. 2002
    ....
  14. ncbi Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8
    Nobuharu Fujii
    Department of Internal Medicine II, Okayama University Medical School, Okayama, Japan
    Br J Haematol 119:716-9. 2002
    ..Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages...
  15. ncbi Expression of SOCS3 mRNA in bone marrow cells from CML patients associated with cytogenetic response to IFN-alpha
    Kazuto Takeuchi
    First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Leuk Res 29:173-8. 2005
    ....
  16. ncbi Follicular dendritic cell tumor as an unknown primary tumor
    Yoshihiro Yakushijin
    Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Tohon shi, Ehime 791 0295, Japan
    Int J Clin Oncol 12:56-8. 2007
    ..In conclusion, we found this unknown primary tumor to be consistent with a follicular dendritic cell tumor with anaplastic features...
  17. ncbi Risk of neutropenic fever and early infectious complications after autologous peripheral blood stem cell transplantation for malignant diseases
    Keiko Fujii
    Second Department of Internal Medicine, Okayama University Medical School, Japan
    Int J Hematol 76:186-91. 2002
    ..Although the clinical indications for auto-PBSCT can be extended to elderly patients, thorough precautions should be taken against infectious complications during the pre-engraftment phase...
  18. ncbi Induction of CD28 on the new myeloma cell line MOLP-8 with t(11;14)(q13;q32) expressing delta/lambda type immunoglobulin
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 28:869-77. 2004
    ..The novel MOLP-8 cell line together with the present myeloma cell lines will present useful model systems in the investigation of the biology of MM...
  19. ncbi Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells
    Kensuke Kojima
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, M D Anderson Cancer Center, The University of Texas, Houston, Texas, USA
    Cancer Res 67:3210-9. 2007
    ..This is the first report showing that the Raf/MEK/ERK pathway regulates the subcellular localization of p53 and the relative contribution of transcription-dependent and transcription-independent pathways in p53-mediated apoptosis...
  20. ncbi Dependence of the community effect of cultured cardiomyocytes on the cell network pattern
    Tomoyuki Kaneko
    Department of Biomedical Information, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 356:494-8. 2007
    ..This indicates that on-chip single-cell-based cardiomyocyte communities might be able to model a heart tissue accurately enough to be used in practical applications such as drug screening...
  21. ncbi Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML
    Kensuke Kojima
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Cycle 5:2778-86. 2006
    ..Our data suggest that combined targeting of Mdm2 and Bcl-2 proteins could offer considerable therapeutic promise in AML...
  22. ncbi Role of the community effect of cardiomyocyte in the entrainment and reestablishment of stable beating rhythms
    Kensuke Kojima
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro, Tokyo 153 8902, Japan
    Biochem Biophys Res Commun 351:209-15. 2006
    ....
  23. ncbi Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol
    Koji Yamazaki
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mol Reprod Dev 72:291-8. 2005
    ..These results suggest that the increased type I collagen expression is associated with the relative stromal overgrowth in the epididymis of DES-treated mice...
  24. ncbi Acute myeloid leukemia cell lines MOLM-17 and MOLM-18 derived from patient with advanced myelodysplastic syndromes
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 29:701-10. 2005
    ....
  25. ncbi Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis
    Masayuki Hashimoto
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
    Acta Neuropathol 109:165-80. 2005
    ..This system is potentially useful for identifying genes that are involved in the response to SCI...