Yoshiyuki Kimura

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. ncbi request reprint Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Int Immunopharmacol 7:963-72. 2007
  2. doi request reprint Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    Phytomedicine 20:328-36. 2013
  3. doi request reprint Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Fitoterapia 84:163-9. 2013
  4. pmc Effects of ginsenoside Rb₁ on skin changes
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Biomed Biotechnol 2012:946242. 2012
  5. doi request reprint Effects of various flavonoids isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    J Pharm Pharmacol 63:1613-23. 2011
  6. pmc Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
    Li Kun Han
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide, Kumamoto 862 8502, Japan
    BMC Complement Altern Med 5:9. 2005
  7. doi request reprint Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Fitoterapia 82:827-33. 2011
  8. doi request reprint Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, 791 0295, Japan
    Eur J Pharmacol 584:415-23. 2008
  9. ncbi request reprint Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Shigenobu Station, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Cancer Sci 95:758-64. 2004
  10. doi request reprint Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Toon City Ehime, Japan
    J Nutr 139:2079-86. 2009

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Int Immunopharmacol 7:963-72. 2007
    ..These findings suggest that anti-food allergic action of LMW-beta-Glucan may be due to the inducing IFN-gamma production in the small intestine and splenocytes...
  2. doi request reprint Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    Phytomedicine 20:328-36. 2013
    ....
  3. doi request reprint Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Fitoterapia 84:163-9. 2013
    ..zedoaria extract on drunkenness might be due to an active substance, curcumenone, and decreases in the elevation of blood alcohol concentrations through increased liver alcohol dehydrogenase activity...
  4. pmc Effects of ginsenoside Rb₁ on skin changes
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Biomed Biotechnol 2012:946242. 2012
    ..Furthermore, to clarify the mechanisms behind these pharmacological actions, human primary keratinocytes and the human keratinocyte cell line HaCaT were used in experiments in vitro...
  5. doi request reprint Effects of various flavonoids isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    J Pharm Pharmacol 63:1613-23. 2011
    ....
  6. pmc Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
    Li Kun Han
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide, Kumamoto 862 8502, Japan
    BMC Complement Altern Med 5:9. 2005
    ..Obesity is closely associated with life-style-related diseases. This study was performed to clarify whether chikusetsusaponins prevent obesity induced in mice by a high-fat diet for 9 weeks...
  7. doi request reprint Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Fitoterapia 82:827-33. 2011
    ..These findings suggest that the powder and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D(2) receptor...
  8. doi request reprint Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, 791 0295, Japan
    Eur J Pharmacol 584:415-23. 2008
    ....
  9. ncbi request reprint Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Shigenobu Station, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Cancer Sci 95:758-64. 2004
    ..This is the first report showing that sodium pyroglutamate isolated from A. blazei as an anti-angiogenic substance has potent antitumor and antimetastatic actions, as well as immune-modulatory activity, in tumor-bearing mice...
  10. doi request reprint Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Toon City Ehime, Japan
    J Nutr 139:2079-86. 2009
    ....
  11. ncbi request reprint Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
    Planta Med 70:211-9. 2004
    ..These results suggest that the antitumor and antimetastatic activities of 4-hydroxyderricin may be modulated by the immune system and the inhibition of angiogenesis...
  12. doi request reprint Antitumor activities of synthetic and natural stilbenes through antiangiogenic action
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Toon City, Ehime, Japan
    Cancer Sci 99:2083-96. 2008
    ....
  13. ncbi request reprint New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants
    Yoshiyuki Kimura
    Department of Molecular and Cellular Biology, School of Medicine, Ehime University, Shitsukawa Toh on City, Ehime 791 0295, Japan
    In Vivo 19:37-60. 2005
    ..It is suggested that these substances of basidiomycete also inhibited tumor growth and metastasis to the lung through the inhibition of tumor-induced neovascularization and/or the inhibition of immune suppression caused by tumors...
  14. doi request reprint Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice
    Yoshiyuki Kimura
    Department of Basic Medical Research, Division of Biochemical Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Cancer Sci 99:2336-48. 2008
    ....
  15. doi request reprint Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    J Nat Med 62:308-13. 2008
    ..In conclusion, it seems likely that the antitumor and antimetastatic actions of cnidimoside A may be partly associated with the stimulation of immune response in the small intestine...
  16. ncbi request reprint High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime, Japan
    Nutr Cancer 59:207-16. 2007
    ..These findings suggest that the acceleration of tumor growth and metastasis by feeding the 3 diets may be due to the increase of angiogenic factors and the reduction of antiangiogenic factors...
  17. ncbi request reprint Effects of water-soluble low-molecular-weight beta-1, 3-D-glucan (branch beta-1, 6) isolated from Aureobasidium pullulans 1A1 strain black yeast on restraint stress in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Pharm Pharmacol 59:1137-44. 2007
    ..Thus, water-soluble low-molecularweight beta-glucan may be an effective dietary supplement for the prevention of stress...
  18. ncbi request reprint Effects of Astilbe thunbergii rhizomes on wound healing Part 1. Isolation of promotional effectors from Astilbe thunbergii rhizomes on burn wound healing
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Ethnopharmacol 109:72-7. 2007
    ..The effective dose (ED(50)) of compounds 1, 2 and 3 on burn wound healing were 4, 190 and 64 microg/wound, respectively. Among these three compounds, eucryphin (1) promoted the burn wound healing most strongly...
  19. ncbi request reprint Antitumor and antimetastatic activity of a novel water-soluble low molecular weight beta-1, 3-D-glucan (branch beta-1,6) isolated from Aureobasidium pullulans 1A1 strain black yeast
    Yoshuiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Anticancer Res 26:4131-41. 2006
    ..These findings suggest that the antitumor and antimetastatic actions of LMW beta-(1,3-1,6) glucan may involve the enhancement of intestinal immune functions through increases in NK- and IFN-gamma-positive cell numbers...
  20. ncbi request reprint Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelol
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Int J Cancer 106:429-37. 2003
    ....
  21. ncbi request reprint Pharmacological studies on resveratrol
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
    Methods Find Exp Clin Pharmacol 25:297-310. 2003
  22. ncbi request reprint Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice
    Y Kimura
    2nd Department of Medical Biochemistry, School of Medicine, Ehime University
    Jpn J Cancer Res 90:765-74. 1999
    ..Therefore, it is concluded that the combination of chitosan and 5-FU might be useful for the prevention of side effects such as gastrointestinal toxicity, immunotoxicity and myelotoxicity caused by 5-FU...
  23. doi request reprint Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Cancer Lett 265:84-97. 2008
    ..3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice...
  24. ncbi request reprint Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 2)
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan
    Anticancer Res 20:2923-30. 2000
    ..Therefore, it is suggested that the antimetastatic activities of piceatannol might be due to the inhibition of tube formation (angiogenesis) of HUVECs...
  25. pmc Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Fundamental Medical Science, Ehime University School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Br J Pharmacol 148:860-70. 2006
    ....
  26. ncbi request reprint Effects of carp and tuna oils on 5-fluorouracil-induced antitumor activity and side effects in sarcoma 180-bearing mice
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan
    Lipids 36:353-9. 2001
    ..On the other hand, AUC (0-4 h) of 5-FU incorporation into tumor RNA fraction was not affected by the oral co-administration of 5-FU with carp oil or tuna oil...
  27. ncbi request reprint Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    J Nutr 131:1844-9. 2001
    ..that the antitumor and antimetastatic activities of resveratrol might be due to the inhibition of DNA synthesis in LLC cells and the inhibition of LLC-induced neovascularization and tube formation (angiogensis) of HUVEC by resveratrol..
  28. ncbi request reprint Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells
    Y Kimura
    2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
    Planta Med 67:331-4. 2001
    ..67 +/- 1.28 microM. In addition, baicalein inhibited the expressions of ELAM-1 and ICAM-1 stimulated by protein kinase C (PKC) activator phorbol myristate acetate (PMA)...
  29. ncbi request reprint Antitumour activity and adverse reactions of combined treatment with chitosan and doxorubicin in tumour-bearing mice
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Onsen gun, Japan
    J Pharm Pharmacol 53:1373-8. 2001
    ..In conclusion, our data suggest that the oral administration of chitosan prevents the gastrointestinal mucositis associated with doxorubicin therapy...
  30. ncbi request reprint Antitumour activity and side effects of combined treatment with chitosan and cisplatin in sarcoma 180-bearing mice
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan
    J Pharm Pharmacol 52:883-90. 2000
    ....
  31. ncbi request reprint French maritime pine bark (Pinus maritima Lam.) extract (Flavangenol) prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    Photochem Photobiol 86:955-63. 2010
    ..The antiphotoaging and anticarcinogenetic activities of flavangenol may be due to inhibition of the expression of Ki-67, 8-OHdG and VEGF through a scavenging effect on reactive oxygen species...
  32. doi request reprint Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Japan
    Eur J Pharmacol 661:124-32. 2011
    ..Furthermore, the inhibitory effects of baicalein on UVB-irradiated hyperplasia of skin epidermis may be due to the stimulation of HIF-1α expression...
  33. ncbi request reprint Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    J Nutr 132:2069-75. 2002
    ..These inhibitory actions of oleic acid may be attributable to the inhibition of angiogenesis induced by the tumor. Linoleic acid and linolenic acid had no effect on tumor growth or metastasis to the liver...
  34. ncbi request reprint Anti-obesity action of Salix matsudana leaves (Part 2). Isolation of anti-obesity effectors from polyphenol fractions of Salix matsudana
    Li Kun Han
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Phytother Res 17:1195-8. 2003
    ..Furthermore, three flavonoid glucosides enhanced norepinephrine-induced lipolysis in fat cells...
  35. ncbi request reprint Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    J Nat Med 68:83-94. 2014
    ..The anti-tumor actions of UVA plus furocoumarins having a methoxy group might be due to the arrest of the cell cycle at G2/M through an increase in phospho-Chk1 and reduction in phospho-cdc2...
  36. ncbi request reprint Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals
    Li Kun Han
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Phytother Res 17:1188-94. 2003
    ....
  37. ncbi request reprint Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 095, Japan
    Anticancer Res 22:3309-18. 2002
    ..Compound I was isolated from the acidic fraction as an active substance that inhibited the Martigel-induced angiogenesis. Compound I was identified as ganoderic acid F based on the data of IR, 1H- and 13C-NMR and MS analyses...
  38. ncbi request reprint Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumour growth and lung metastasis in Lewis lung carcinoma-bearing mice
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Onsen gun, Japan
    J Pharm Pharmacol 52:1287-95. 2000
    ..We suggest that the antitumour and antimetastatic activity of the stilbene glucosides, piceid and 2,3,5,4'-tetrahydroxystilbene-2-O-D-glucoside, might be due to the inhibition of DNA synthesis in LLC cells and angiogenesis of HUVECs...
  39. doi request reprint Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    J Ethnopharmacol 141:530-6. 2012
    ....
  40. doi request reprint Effects of Red Ginseng extract on ultraviolet B-irradiated skin change in C57BL mice
    Young Gon Kim
    Division of Functional Histology, Department of Functional Biomedicine, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Phytother Res 22:1423-7. 2008
    ..In conclusion, the oral administration of Red Ginseng extract may be useful as a health supplement for protection against photoageing...
  41. doi request reprint Chronic intake of a high-cholesterol diet resulted in hepatic steatosis, focal nodular hyperplasia and fibrosis in non-obese mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Br J Nutr 103:378-85. 2010
    ..Thus, it seems likely that the liver fibrosis and FNH caused by the long-term consumption of a HC diet may be partly due to an elevation of plasma MCP-1 and hepatic PDGF expression...
  42. doi request reprint Protective effects of water-soluble low-molecular-weight beta-(1,3-1,6)d-glucan purified from Aureobasidium pullulans GM-NH-1A1 against UFT toxicity in mice
    Maho Sumiyoshi
    Department of Basic Medical Research, Division of Biochemical Pharmacology, Ehime University Graduate School of Medicicne, Shitsukawa, Toon City, Ehime, Japan
    J Pharm Pharmacol 61:795-800. 2009
    ....
  43. ncbi request reprint Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Integrated Basic Medical Science, School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Pharm Pharmacol 58:201-7. 2006
    ..It was concluded that water-soluble 46-kDa chitosan is a safe functional food...
  44. doi request reprint Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Graduate School of Medicine, Ehime University, Toon City, Ehime 791 0295, Japan
    Phytomedicine 16:1137-43. 2009
    ..Prevention of UVB-induced skin aging by turmeric may be due to the inhibition of increases in MMP-2 expression caused by chronic irradiation...
  45. ncbi request reprint Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Integrated Basic Medical Science, Ehime University, Shitsukawa, Toon City, Japan
    J Nutr 136:582-7. 2006
    ..It is important to consider the effects of macronutrients in lean as well as obese mice to clarify the pathogenesis of the metabolic disorders...
  46. doi request reprint Whey peptides prevent chronic ultraviolet B radiation-induced skin aging in melanin-possessing male hairless mice
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, and
    J Nutr 144:27-32. 2014
    ..Overall, these results demonstrate the considerable benefit of WPs for protection against solar UV-irradiated skin aging as a supplemental nutrient...
  47. doi request reprint Effects of olive leaf extract and its main component oleuroepin on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Phytother Res 24:995-1003. 2010
    ....
  48. ncbi request reprint Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action
    T Takaku
    Second Department of Medical Biochemistry and. Central Research Laboratory, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
    J Nutr 131:1409-13. 2001
    ..From these results, it seems likely that the antitumor activity of ergosterol might be due to direct inhibition of angiogenesis induced by solid tumors. This is the first report of ergosterol as an antiangiogenic substance...
  49. ncbi request reprint Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan
    J Nat Med 63:130-6. 2009
    ..Prevention of UVB-induced aging of the skin by topical application of the nonsugar fraction of brown sugar may be due to inhibition of increases in MMP-2 and VEGF expression...
  50. doi request reprint Enhancing effects of a chromone glycoside, eucryphin, isolated from Astilbe rhizomes on burn wound repair and its mechanism
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Phytomedicine 17:820-9. 2010
    ....
  51. doi request reprint Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Ethnopharmacol 132:206-12. 2010
    ..Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear...
  52. doi request reprint Effects of ginsenoside Rb1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas during the process of acute burn wound repair
    Kazuhiro Kawahira
    Division of Functional Histology, Department of Functional Biomedicine, Graduate School of Medicine, Ehime University, Toon City, Ehime 791 0295, Japan
    J Ethnopharmacol 117:278-84. 2008
    ..Increased histamine, substance P (SP), and monocyte chemoattractant protein (MCP)-1 levels caused inflammation, and pain following severe burn wound injury...
  53. doi request reprint Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice
    Young Gon Kim
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Eur J Pharmacol 602:148-56. 2009
    ....
  54. ncbi request reprint Antitumor and antimetastatic actions of eicosapentaenoic acid ethylester and its by-products formed during accelerated stability testing
    Yoshiyuki Kimura
    Division of Biochemistry, Department of Molecular and Cellular Biology, School of Medicine, Ehime, Japan
    Cancer Sci 96:441-50. 2005
    ....
  55. doi request reprint In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells
    Yoshiyuki Kimura
    Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Toon City, Japan
    Photochem Photobiol 89:1216-25. 2013
    ..We suggest that the antitumor actions of UVA plus furocoumarins with an alkoxy group at C-5 or C-8 were due to G2/M arrest of the cell cycle by an increase in phosphor-Chk1 and decrease in phospho-cdc2...
  56. doi request reprint Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Br J Nutr 109:162-72. 2013
    ..Various fractions of the hop extract inhibited lipid accumulation and PPARγ expression in 3T3-L1 adipocytes. Hop extracts might be useful for preventing obesity and glucose intolerance caused by a HF diet...
  57. ncbi request reprint Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice
    Yoshiyuki Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University Shigenobu cho, Onsen gun, Ehime 719 0295, Japan
    J Ethnopharmacol 95:447-53. 2004
    ..Therefore, it is suggested that eleutheroside E may be contributed to the anti-fatigue action, the recovery of the reduction of NK activity and the inhibition of corticosterone elevation induced by swimming stress...
  58. ncbi request reprint Effect of ketoprofen in topical formulation on vascular endothelial growth factor expression and tumor growth in nude mice with osteosarcoma
    Kenshi Sakayama
    Department of Orthopaedic Surgery, School of Medicine, Ehime University, Shigenobu, Onsen gun, 791 0295, Japan
    J Orthop Res 22:1168-74. 2004
    ..Based on these findings, we concluded that topical administration of KP to nude mice with osteosarcoma inhibited VEGF expression, reduced the development of feeder vessels for supply of nutrients and oxygen, and suppressed tumor growth...
  59. ncbi request reprint Prevention by carp extract of myelotoxicity and gastrointestinal toxicity induced by 5-fluorouracil without loss of antitumor activity in mice
    Y Kimura
    2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Onsen gun, Japan
    J Ethnopharmacol 68:39-45. 1999
    ....
  60. ncbi request reprint Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes
    Y Kimura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan
    Biochim Biophys Acta 922:278-86. 1987
    ..Furthermore, baicalein was found to inhibit dose-dependently Ca2+ uptake into the cells and Ca2+ mobilization from the intracellular stores...
  61. ncbi request reprint Artery relaxation by chalcones isolated from the roots of Angelica keiskei
    M Matsuura
    Second Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
    Planta Med 67:230-5. 2001
    ....
  62. ncbi request reprint Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor
    L K Han
    2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
    Int J Obes Relat Metab Disord 25:1459-64. 2001
    ..CONCLUSIONS: The anti-obesity effects of teasaponin in high-fat diet-treated mice may be partly mediated through delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity...
  63. ncbi request reprint T cell-specific loss of Pten leads to defects in central and peripheral tolerance
    A Suzuki
    Department of Molecular and Cellular Biology, Osaka University, 565 0871, Osaka, Japan
    Immunity 14:523-34. 2001
    ..Peripheral tolerance to SEB is also impaired in Pten(flox/-) mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance...
  64. ncbi request reprint Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus
    N Mino-Miyagawa
    Department of Radiology, School of Medicine, Ehime University, Japan
    Cancer 66:1505-12. 1990
    ..These results indicate that TA-4 is an antigen related to the differentiation of squamous cells and that tumor cells of SCC can release a large amount of TA-4 into circulation whereas normal squamous epithelia cannot...
  65. pmc Serum CA125 level is a good prognostic indicator in lung cancer
    Y Kimura
    Department of Radiology, Ehime University School of Medicine, Japan
    Br J Cancer 62:676-8. 1990
    ..01). The existence of a pleural effusion did not correlate with the survival time. We conclude that CA125 is a good indicator of disease extent and serum levels correlate to the length of survival...
  66. ncbi request reprint Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice
    Li Kun Han
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide, Japan
    J Nutr 132:2241-5. 2002
    ..Therefore, the antiobesity effect of the crude saponins in mice fed a high fat diet may be due to the inhibition of intestinal absorption of dietary fat by platycodin D...
  67. ncbi request reprint Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice
    Yasunori Maeda
    Laboratory of Maeda Kampo Medicine, Kure City, Hiroshima 737 0889, Japan
    J Nutr 134:945-50. 2004
    ..Thus, the low-molecular-weight chitosans or oligochitosan might be useful in preventing tumor growth through the activation of intestinal immune functions...
  68. ncbi request reprint [Antiobesity actions of Zingiber officinale Roscoe]
    Li Kun Han
    Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto City 862 8502, Japan
    Yakugaku Zasshi 125:213-7. 2005
    ..officinale Roscoe in mice fed a high-fat diet may be due in part to the inhibition of intestinal absorption of dietary fat by the active compounds of Z. officinale Roscoe...
  69. ncbi request reprint Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae)
    Jiang Ning Hu
    Department of Food Science and Technology, Chungnam National University, Republic of Korea
    Chem Pharm Bull (Tokyo) 56:12-6. 2008
    ..The reason for this may be due to a delay in the intestinal absorption of dietary fat by inhibiting PL activity...
  70. ncbi request reprint Reduction of fat storage in mice fed a high-fat diet long term by treatment with saponins prepared from Kochia scoparia fruit
    Li Kun Han
    Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide 3 1 100, Kumamoto City, Kumamoto 862 8502, Japan
    Phytother Res 20:877-82. 2006
    ..These findings suggest that the anti-obesity actions of K. scoparia extract in mice fed a high-fat diet may be partly mediated through delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity...
  71. ncbi request reprint [Perioperative management of a patient with polycythemia who developed massive hemorrhage]
    Shinsuke Hamaguchi
    Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi 321 0293
    Masui 53:785-7. 2004
    ..After the surgery, we administered the minimum amount of FFP according to his blood analysis. Although red cell concentrated was not administered in the perioperative period, his general condition remained stable...
  72. ncbi request reprint Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism
    Yi Nan Zheng
    Chinese Material Medicine College of Jilin Agricultural University, Changchun City, Jilin 130118, China
    Yakugaku Zasshi 125:1005-8. 2005
    ..In addition, the aglycon apigenin inhibited not only 12-HETE but also thromboxane B(2) (TXB(2)). The effect of compound (4) on arachidonic acid metabolism is now under investigation...