Michiya Igase

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. pmc The Association between Hypertension and Dementia in the Elderly
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    Int J Hypertens 2012:320648. 2012
  2. doi request reprint Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    J Neurol Sci 325:137-41. 2013
  3. doi request reprint Low-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Menopause 19:1294-9. 2012
  4. doi request reprint Predictive value of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for the prevention of stroke recurrence in Japanese patients treated with rosuvastatin
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Japan
    Clin Drug Investig 32:513-21. 2012
  5. doi request reprint Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade
    Michiya Igase
    Department of Geriatric Medicine, Ehime University School of Medicine, Toon, Japan
    Hypertens Res 31:553-9. 2008
  6. ncbi request reprint Asymptomatic cerebral microbleeds seen in healthy subjects have a strong association with asymptomatic lacunar infarction
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Sitsukawa, Toon 791 0295, Japan
    Circ J 73:530-3. 2009
  7. ncbi request reprint Association of angiotensin II type 2 receptor gene variant with hypertension
    Jing Ji Jin
    Department of Geriatric Medicine, School of Medicine, Ehime University, Onsen gun, Ehime, Japan
    Hypertens Res 26:547-52. 2003
  8. ncbi request reprint Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese
    Miyuki Yamamoto
    Department of Geriatric Medicine, School of Medicine, Ehime University, Toon, Japan
    Hypertens Res 29:227-32. 2006
  9. doi request reprint Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
    Masayuki Ochi
    Department of Geriatric Medicine, Ehime Graduate School of Medicine, Toon City, Japan
    Atherosclerosis 212:327-32. 2010
  10. doi request reprint Postprandial hypertension, an overlooked risk marker for arteriosclerosis
    Eri Uetani
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    Atherosclerosis 224:500-5. 2012

Collaborators

Detail Information

Publications44

  1. pmc The Association between Hypertension and Dementia in the Elderly
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    Int J Hypertens 2012:320648. 2012
    ..Future trials primarily designed to investigate the effects of antihypertensive agents on impaired cognition are needed...
  2. doi request reprint Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    J Neurol Sci 325:137-41. 2013
    ..Cerebral microbleeds (CMBs) detected on T2*-weighted MRI gradient-echo have been associated with increased risk of cerebral infarction. We evaluated risk factors for these lesions in a cohort of first-time ischemic stroke patients...
  3. doi request reprint Low-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Menopause 19:1294-9. 2012
    ....
  4. doi request reprint Predictive value of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for the prevention of stroke recurrence in Japanese patients treated with rosuvastatin
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Japan
    Clin Drug Investig 32:513-21. 2012
    ..Moreover, the degree of decrease in LDL-C that is required to prevent the recurrence of stroke is unknown...
  5. doi request reprint Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade
    Michiya Igase
    Department of Geriatric Medicine, Ehime University School of Medicine, Toon, Japan
    Hypertens Res 31:553-9. 2008
    ..These studies suggest that changes in ACE2 within the vascular system of SHR are regulated by a factor other than arterial pressure...
  6. ncbi request reprint Asymptomatic cerebral microbleeds seen in healthy subjects have a strong association with asymptomatic lacunar infarction
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Sitsukawa, Toon 791 0295, Japan
    Circ J 73:530-3. 2009
    ..CMBs have been detected even in neurologically healthy persons, who also seem prone to be affected by stroke, not only ICH but also cerebral infarction...
  7. ncbi request reprint Association of angiotensin II type 2 receptor gene variant with hypertension
    Jing Ji Jin
    Department of Geriatric Medicine, School of Medicine, Ehime University, Onsen gun, Ehime, Japan
    Hypertens Res 26:547-52. 2003
    ..The female-specific association may be helpful in conducting further molecular and biological studies on the relationship among sex, the renin-angiotensin system, and hypertension...
  8. ncbi request reprint Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese
    Miyuki Yamamoto
    Department of Geriatric Medicine, School of Medicine, Ehime University, Toon, Japan
    Hypertens Res 29:227-32. 2006
    ..054). Thus, the present study suggests that the 5-HT2A T102C and ET-1 G/T polymorphisms are interactively associated with hypertension...
  9. doi request reprint Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
    Masayuki Ochi
    Department of Geriatric Medicine, Ehime Graduate School of Medicine, Toon City, Japan
    Atherosclerosis 212:327-32. 2010
    ..In this study, we investigated our hypothesis that sarcopenia and atherosclerosis are associated with each other to facilitate mutual abnormalities...
  10. doi request reprint Postprandial hypertension, an overlooked risk marker for arteriosclerosis
    Eri Uetani
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    Atherosclerosis 224:500-5. 2012
    ..Here, we aimed to clarify the possible association between postprandial BP dysregulation and arteriosclerosis...
  11. ncbi request reprint Genome-wide linkage disequilibrium mapping of hypertension in Japan
    Zhihong Wu
    Department of Geriatric Medicine, School of Medicine, Ehime University, Onsen gun, Ehime, Japan
    Hypertens Res 26:533-40. 2003
    ..044; OR=1.27; 95% CI=1.01-1.59). D10S537 was more significantly associated with hypertension in subjects with normotriglyceridemia in our population (p=0.007; OR=1.47; 95% CI=1.11-1.95)...
  12. doi request reprint Postural instability is associated with brain atrophy and cognitive impairment in the elderly: the J-SHIPP study
    Tomoko Kido
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Tōn City, Japan
    Dement Geriatr Cogn Disord 29:379-87. 2010
    ..We investigated a possible association between static postural instability and brain abnormalities and cognitive decline...
  13. doi request reprint Association of central systolic blood pressure with intracerebral small vessel disease in Japanese
    Namiko Ochi
    Department of Geriatric Medicine, Ehime Graduate School of Medicine, Toon City, Japan
    Am J Hypertens 23:889-94. 2010
    ..The carotid flow augmentation index (AI) has been proposed as an index of pulsatile flow to the brain. We compared its association with brain SVD with that of central BP in a general population...
  14. ncbi request reprint Association of endothelin-1 gene variant with hypertension
    Jing Ji Jin
    Department of Geriatric Medicine, School of Medicine, Ehime University, Onsen gun, Ehime, Japan
    Hypertension 41:163-7. 2003
    ..Considering the combined impact of obesity and hypertension on the development of cardiovascular and cerebrovascular disorders, T allele carriers might represent elective targets for therapy to lower their body weight...
  15. doi request reprint Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study
    Kenji Kamogawa
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan
    Dement Geriatr Cogn Disord 30:432-9. 2010
    ..However, abdominal fat distribution under conditions of mild cognitive impairment (MCI) and the possible involvement of leptin and adiponectin in MCI have not been fully investigated...
  16. ncbi request reprint Association of the GNAS1 gene variant with hypertension is dependent on alcohol consumption
    Yusen Chen
    Department of Geriatric Medicine, School of Medicine, Ehime University, Ehime, Japan
    Hypertens Res 26:439-44. 2003
    ..026). These findings may be helpful in conducting further molecular and biological studies on the relationship among the effects of alcohol, the beta-AR-Gs protein system, and hypertension...
  17. doi request reprint Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population
    Masayuki Ochi
    Department of Geriatric Medicine, Ehime Proteo Medicine Research Center, Ehime Graduate School of Medicine, Ehime, Japan
    Geriatr Gerontol Int 10:233-43. 2010
    ..We investigated the association between age-related quadriceps (Qc) sarcopenia and visceral obesity, as measured by cross-sectional area (CSA), on postural instability...
  18. doi request reprint Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study
    Haiyan Guo
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Hypertens Res 33:32-6. 2010
    ..Abnormal nocturnal BP profile was found to be a strong indicator of MCI in otherwise apparently healthy community-dwelling elderly persons...
  19. doi request reprint Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject
    Namiko Ochi
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Hypertens Res 32:255-60. 2009
    ..These findings indicate an association between arterial stiffness and the presence of MBs. Assessment of arterial stiffness may be useful in identifying subjects at high risk for the presence of MBs...
  20. ncbi request reprint Association of GNAS1 gene variant with hypertension depending on smoking status
    Michiko Abe
    Department of Geriatric Medicine, School of Medicine, Ehime University, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Hypertension 40:261-5. 2002
    ..These findings may be helpful in conducting further molecular and biological studies on the relationship among cigarette smoking, the beta-AR-G(s) protein system, and hypertension...
  21. ncbi request reprint Liver enzyme and adipocytokine profiles are synergistically associated with insulin resistance: the J-SHIPP study
    Eri Uetani
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan
    J Atheroscler Thromb 19:577-84. 2012
    ..To clarify this hypothesis, we conducted a cross-sectional epidemiological study in a Japanese general population...
  22. ncbi request reprint Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness
    Yasuharu Tabara
    Department of Medical Genetics, Ehime University School of Medicine, Ehime, Japan
    Hypertens Res 26:677-83. 2003
    ..These findings indicate that plasma MCP-1 is associated with carotid atherosclerosis. Although -2518 SNP is associated with the plasma level of MCP-1, it was not directly associated with carotid atherosclerosis...
  23. ncbi request reprint Migraine is associated with enhanced arterial stiffness
    Tokihisa Nagai
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan
    Hypertens Res 30:577-83. 2007
    ..001). In a separate analysis by sex, migraine was also a significant determinant for AI (male, beta=0.246, p=0.019; female, beta=0.159, p=0.008). Migraine in the elderly could be a clinical manifestation of enhanced arterial stiffness...
  24. ncbi request reprint Plasma hepatocyte growth factor and the relationship between risk factors and carotid atherosclerosis
    Yoshikuni Yamamoto
    Department of Geriatric Medicine Ehime University School of Medicine, Onsen gun, Ehime, Japan
    Hypertens Res 25:661-7. 2002
    ..In conclusion, these findings indicate that risk factor-dependent augmentation of carotid atherosclerosis could be influenced by circulating HGF...
  25. doi request reprint Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7)
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Ther Adv Cardiovasc Dis 5:297-304. 2011
    ..Controversy exists as to whether angiotensin (1-7) (Ang (1-7)) acts as a protective hormone against renal injury...
  26. doi request reprint Composition of lower extremity in relation to a high ankle-brachial index
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Ehime, Japan
    J Hypertens 27:167-73. 2009
    ..The involvement of atherosclerotic vascular changes as well as a close positive association with body weight has been postulated. We evaluated possible associations between a high ABI and atherosclerotic and anthropometric parameters...
  27. ncbi request reprint Chlamydia pneumoniae seropositivity is associated with increased plasma levels of soluble cellular adhesion molecules in community-dwelling subjects: the Shimanami Health Promoting Program (J-SHIPP) study
    Katsuhiko Kohara
    Department of Geriatric Medicine, Ehime University School of Medicine, Ehime University, Japan
    Stroke 33:1474-9. 2002
    ..However, whether chronic C pneumoniae infection increases these molecules in vivo has not been elucidated...
  28. doi request reprint Postprandial hypotension as a risk marker for asymptomatic lacunar infarction
    Yasuharu Tabara
    aCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto bDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    J Hypertens 32:1084-90. 2014
    ..Here, we investigated the possible associations between postprandial BP decline and asymptomatic cerebral damage in community residents...
  29. doi request reprint Associations between short one-leg standing time and speed of sound of calcaneal bone in a general population: the Shimanami Health Promoting Program (J-SHIPP) study
    Tomoko Kido
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime University, Toon City, Japan
    Geriatr Gerontol Int 10:138-44. 2010
    ....
  30. doi request reprint Visit-to-visit variability in systolic blood pressure is a novel risk factor for the growth of intracranial aneurysms
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Japan
    Cerebrovasc Dis 36:401-6. 2013
    ..With this factor in mind, here we conducted a prospective analysis of the results of 2 years of observation of UIAs by magnetic resonance angiography (MRA) and sought to identify risk factors for UIA growth and rupture...
  31. doi request reprint Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects: J-SHIPP study
    Miwako Kido
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Geriatr Gerontol Int 12:733-40. 2012
    ..Recently, perceived age was reported to be a better predictor for mortality than chronological age. Based on these findings, we investigated whether or not perceived age was related to atherosclerosis in a general population...
  32. pmc Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes
    Katsuhiko Kohara
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    PLoS ONE 6:e24633. 2011
    ..These findings indicate that sarcopenic visceral obesity is a more advanced, and suggest that leptin may link visceral obesity and sarcopenia...
  33. ncbi request reprint Genotype-specific association between circulating soluble cellular adhesion molecules and carotid intima-media thickness in community residents: J-SHIPP study. Shimanami Health Promoting Program
    Katsuhiko Kohara
    Department of Geriatric Medicine, Ehime University School of Medicine, Japan
    Hypertens Res 25:31-9. 2002
    ..Similarly, the plasma level of sICAM-1 was independently associated with carotid IMT in AGT M carriers. These findings suggest that genetic background could be involved in the association between plasma CAMs and atherosclerosis...
  34. ncbi request reprint [Effect of elapsed time after standing up on orthostatic blood pressure change in the elderly]
    Yasuharu Tabara
    Department of Geriatric Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 39:193-6. 2002
    ..However, if abnormal variation of blood pressure was not observed at 1 minute after standing up, repeated measurement at 3 minutes would be necessary...
  35. ncbi request reprint [Migraine improved by amlodipine medication in a case with hypertension]
    Tokihisa Nagai
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 45:546-9. 2008
    ..The findings in this case may suggest that amlodipine administration might be a useful strategy to control migraine attack...
  36. ncbi request reprint [A case of Werner syndrome with chromosomal abnormality]
    Masayuki Ochi
    Department of Geriatric Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 43:639-42. 2006
    ..We need to follow her carefully because she might be vulnerable to malignant disease, including leukemia and malignant meningioma...
  37. ncbi request reprint [Multiple metastases from renal carcinoma 15 years after nephrectomy]
    Tokihisa Nagai
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 44:747-51. 2007
    ..Since this case confirms the potential of RCC for late and multiple distant metastases, careful long-term follow-up after radical nephrectomy is needed...
  38. ncbi request reprint [An elderly fludrocortison-responsive woman with hyponatoremia]
    Tokihisa Nagai
    Department of Geriatric Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 43:122-5. 2006
    ..This is a rare case of a critically ill elderly patient with hyponatremia caused by hypoaldosteronism possibly due to mineral corticoid-responsive hyponatremia of the elderly...
  39. ncbi request reprint [Elements necessary for end-of-life care for terminal cancer patients and standardization of discharge planning]
    Michiya Igase
    Department of Geriatric Medicine, Ehime University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 44:734-9. 2007
    ..How, recently, home health care services have received much attention instead of the hospital care. In this study, we investigated important factors affecting smooth transition to home health care from hospital care...
  40. doi request reprint Initial experience in evaluating the prevalence of unruptured intracranial aneurysms detected on 3-tesla MRI
    Keiji Igase
    Department of Neurosurgery, Washokai Sadamoto Hospital, Matsuyama, Ehime, Japan
    Cerebrovasc Dis 33:348-53. 2012
    ..However, few reports have investigated the prevalence of intracranial aneurysms with high-tesla MRI. Here, we evaluated the prevalence of intracranial aneurysms and the effectiveness of a 3T MRI system in their detection...
  41. ncbi request reprint [Relation between gene polymorphism and acute coronary syndrome]
    Michiya Igase
    Department of Geriatric Medicine, Ehime University School of Medicine
    Nihon Rinsho 64:647-50. 2006
    ..Such genes are likely to be relevant to the combined processes of plaque instability and coronary thrombosis...
  42. ncbi request reprint [Medical students' understanding of geriatric medicine]
    Michiya Igase
    Department of Geriatric Medicine, Ehime University School of Medicine
    Nihon Ronen Igakkai Zasshi 40:53-7. 2003
    ..The present study indicates that to develop education in geriatric medicine, it is important to make a recommendable text book for medical students, which is easily understood with high quality and originality...
  43. ncbi request reprint Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats
    Michiya Igase
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H1013-9. 2005
    ....
  44. ncbi request reprint Resistin, glomerular filtration rate, and insulin resistance
    Yasuharu Tabara
    Hypertension 51:e11; author reply e12. 2008