Yoichi Hiasa

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
  2. doi request reprint Diabetes pattern on the 75 g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus
    Ichiro Konishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Liver Int 29:1194-201. 2009
  3. doi request reprint Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis
    Yosuke Murata
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, 791 0295, Japan
    J Gastroenterol 43:632-6. 2008
  4. doi request reprint Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity
    Keitarou Kawasaki
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Lab Invest 93:311-21. 2013
  5. doi request reprint Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases
    Hironori Ochi
    Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatology 56:1271-8. 2012
  6. doi request reprint Des-gamma-carboxy prothrombin identified by P-11 and P-16 antibodies reflects prognosis for patients with hepatocellular carcinoma
    Satoru Takeji
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    J Gastroenterol Hepatol 28:671-7. 2013
  7. doi request reprint Regulatory natural killer cells in murine liver and their immunosuppressive capacity
    Osamu Yoshida
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Liver Int 30:906-12. 2010
  8. ncbi request reprint Heterogeneity of hepatitis B virus genotype D in Japan
    Kojiro Michitaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Intervirology 50:150-5. 2007
  9. pmc Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection
    Takao Watanabe
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    PLoS ONE 8:e67750. 2013
  10. doi request reprint Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity
    Sachiko Utsunomiya
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Regul Pept 180:17-25. 2013

Collaborators

Detail Information

Publications87

  1. pmc No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
    Hiromi Sawai
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    BMC Med Genet 13:47. 2012
    ....
  2. doi request reprint Diabetes pattern on the 75 g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus
    Ichiro Konishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Liver Int 29:1194-201. 2009
    ..Patients with hepatitis C virus (HCV) frequently show glucose intolerance. Diabetes mellitus (DM) has been proposed to be a risk factor for hepatocellular carcinoma (HCC)...
  3. doi request reprint Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis
    Yosuke Murata
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, 791 0295, Japan
    J Gastroenterol 43:632-6. 2008
    ..The course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC...
  4. doi request reprint Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity
    Keitarou Kawasaki
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Lab Invest 93:311-21. 2013
    ..Collectively, these data indicated that, in addition to its known functions in inflammation and glucose metabolism, BAFF has a protective role in hepatic steatosis by regulating lipid metabolism in the liver...
  5. doi request reprint Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases
    Hironori Ochi
    Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatology 56:1271-8. 2012
    ..Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real-time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD...
  6. doi request reprint Des-gamma-carboxy prothrombin identified by P-11 and P-16 antibodies reflects prognosis for patients with hepatocellular carcinoma
    Satoru Takeji
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    J Gastroenterol Hepatol 28:671-7. 2013
    ....
  7. doi request reprint Regulatory natural killer cells in murine liver and their immunosuppressive capacity
    Osamu Yoshida
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Liver Int 30:906-12. 2010
    ..However, the control of compromised immunity in the liver may be accomplished by a population of regulatory NK cells possessing suppressive or tolerogenic functions...
  8. ncbi request reprint Heterogeneity of hepatitis B virus genotype D in Japan
    Kojiro Michitaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Intervirology 50:150-5. 2007
    ..The purpose of this study was to determine whether the HBV/D isolates from these different areas of Japan are closely related...
  9. pmc Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection
    Takao Watanabe
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    PLoS ONE 8:e67750. 2013
    ..These modulations resulted in HCC cell proliferation with HCV infection. These findings suggest that PKR-related proliferation pathways could be an attractive therapeutic target. ..
  10. doi request reprint Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity
    Sachiko Utsunomiya
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Regul Pept 180:17-25. 2013
    ..These data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands...
  11. ncbi request reprint Long-term branched-chain amino acid supplementation improves glucose tolerance in patients with nonalcoholic steatohepatitis-related cirrhosis
    Teruki Miyake
    Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
    Intern Med 51:2151-5. 2012
    ..We conclude that in the absence of an effective conventional therapy for NASH-related liver cirrhosis, BCAA supplementation should be considered as an alternative treatment...
  12. doi request reprint Splenic elasticity measured with real-time tissue elastography is a marker of portal hypertension
    Masashi Hirooka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Radiology 261:960-8. 2011
    ..To prospectively correlate spleen elasticity and degree of portal hypertension estimated with the hepatic venous pressure gradient (HVPG) and to evaluate splenic elasticity as a predictor of gastroesophageal varices...
  13. doi request reprint Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8
    Yoshio Tokumoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    J Infect Dis 205:1121-30. 2012
    ..The manner in which ribavirin (RBV) enhances the antiviral effects of interferon (IFN) against hepatitis C virus (HCV) remains unknown. We investigated whether RBV modifies IFN-stimulated genes (ISGs) in vivo and in vitro...
  14. doi request reprint Efficacy of laparoscopic radiofrequency ablation for hepatocellular carcinoma compared to percutaneous radiofrequency ablation with artificial ascites
    Masashi Hirooka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Dig Endosc 21:82-6. 2009
    ..The purpose of the present study was to assess the efficacy and safety of these two methods...
  15. doi request reprint Contrast-enhanced sonography with abdominal virtual sonography in monitoring radiofrequency ablation of hepatocellular carcinoma
    Yoshiyasu Kisaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, Ehime 791 0295, Japan
    J Clin Ultrasound 38:138-44. 2010
    ..The present prospective randomized control trial compared the number of CT scans needed to assess the efficacy of RFA of HCC using VUS-contrast-enhanced ultrasonography (CEUS) versus CT...
  16. doi request reprint Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease
    Teruki Miyake
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    J Gastroenterol 45:859-67. 2010
    ..Because antigen-specific immunity was diminished in NAFLD mice, the underlying mechanisms were evaluated through analysis of the functions of antigen-presenting dendritic cells (DC) and other immunocytes...
  17. doi request reprint Mass reduction by radiofrequency ablation before hepatic arterial infusion chemotherapy improved prognosis for patients with huge hepatocellular carcinoma and portal vein thrombus
    Masashi Hirooka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
    AJR Am J Roentgenol 194:W221-6. 2010
    ..In this study, we first performed mass reduction using radiofrequency ablation (RFA), followed by HAI chemotherapy. Prognosis after this treatment was evaluated...
  18. ncbi request reprint Modified technique for determining therapeutic response to radiofrequency ablation therapy for hepatocellular carcinoma using US-volume system
    Atsushi Hiraoka
    Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, Japan
    Oncol Rep 23:493-7. 2010
    ..03+/-0.17 vs. 1.12+/-0.32; P<0.01). In HCC patients undergoing RFA, our modified US-volume system accurately demonstrated therapeutic response, which led to a reduced number of RFA sessions...
  19. doi request reprint Wilms' tumour 1 gene expression is increased in hepatocellular carcinoma and associated with poor prognosis
    Toshiki Sera
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Sitsukawa, Toon, Ehime 791 0295, Japan
    Eur J Cancer 44:600-8. 2008
    ....
  20. doi request reprint Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal cohort study
    Teruki Miyake
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, 791 0295, Japan
    J Gastroenterol 48:413-22. 2013
    ..To prevent NAFLD onset, clinicians must be able to easily identify high-risk NAFLD patients so that intervention can begin at an earlier stage. We sought to identify the predictive factors for NAFLD onset...
  21. doi request reprint Metabolic markers and ALT cutoff level for diagnosing nonalcoholic fatty liver disease: a community-based cross-sectional study
    Teruki Miyake
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, 791 0295, Japan
    J Gastroenterol 47:696-703. 2012
    ....
  22. doi request reprint Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738) through enhancing interferon-beta
    Yoichi Hiasa
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatology 48:59-69. 2008
    ..Interferon-beta knockdown by small interfering RNA abrogated the anti-HCV effect of ME3738. Moreover, the anti-HCV effects were synergistic when ME3738 was combined with IFN-alpha...
  23. ncbi request reprint Portal biliopathy diagnosed using color Doppler and contrast-enhanced ultrasound
    Hiroaki Nunoi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
    Intern Med 52:1055-9. 2013
    ..Color Doppler and contrast-enhanced US findings are useful for diagnosing or ruling out portal biliopathy in patients who present with EHPVO...
  24. doi request reprint A relationship between motilin and growth hormone secretagogue receptors
    Hiroaki Nunoi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Regul Pept 176:28-35. 2012
    ..These data suggested that in species expressing both motilin-MR and ghrelin-GHSR, there is a compensatory relationship in vivo...
  25. doi request reprint Recent trends of Japanese hepatocellular carcinoma due to HCV in aging society
    Atsushi Hiraoka
    Gastroenterology Center, Ehime Prefectural Central Hospital, Ehime, Japan
    Hepatogastroenterology 59:1893-5. 2012
    ..The mean age of hepatocellular carcinoma (HCC) patients has increased (=65 years old). We want to identify the recent trend of the clinical features of HCC patients due to hepatitis C virus (HCV) (HCV-HCC)...
  26. doi request reprint Rapid alternative absorption of dietary long-chain fatty acids with upregulation of intestinal glycosylated CD36 in liver cirrhosis
    Yasunori Yamamoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Am J Clin Nutr 96:90-101. 2012
    ..Dietary long-chain fatty acid (LCFA) intake is an important risk factor for hepatic inflammation and hepatocarcinogenesis. An alternate route of dietary LCFA absorption has been suggested in patients with liver cirrhosis (LC)...
  27. ncbi request reprint Prospective study of chronic hepatitis C treated with reduced initial ribavirin dose
    Ichiro Konishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Hepatogastroenterology 57:1227-31. 2010
    ....
  28. doi request reprint Congenital hepatic fibrosis without any symptoms as diagnosed by laparoscopy
    Yoshiyasu Kisaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine Endoscopy Center, Ehime, Japan
    Dig Endosc 22:357-9. 2010
    ..The findings obtained from elastography and laparoscopy were useful for making the diagnosis of CHF...
  29. ncbi request reprint Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices
    Yosuke Murata
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, To on, Ehime 791 0295, Japan
    J Gastroenterol 41:1220-6. 2006
    ..The prognosis is usually poorer for patients with symptomatic PBC than for those with asymptomatic PBC. Nevertheless, the clinical features and prognosis of patients with PBC whose initial symptoms are EV have not been clarified...
  30. ncbi request reprint A familial case of autoimmune hepatitis
    Osamu Yoshida
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To on
    Intern Med 48:315-9. 2009
    ..Our familial study suggests that in addition to genetic background, medication use and other environmental factors may be related to the onset of autoimmune hepatitis...
  31. ncbi request reprint Transcatheter arterial chemoembolization with fine-powder cisplatin-lipiodol for HCC
    Yohei Koizumi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatogastroenterology 58:512-5. 2011
    ..The aim of this study is to evaluate the efficacy and toxicity of transcatheter arterial chemoembolization (TACE) with fine-powder cisplatin and lipiodol suspension against advanced hepatocellular carcinoma (HCC)...
  32. doi request reprint Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3-CD4+CD25- T cells
    Kenichirou Mori
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Leukoc Biol 93:963-72. 2013
    ....
  33. doi request reprint Hepatic elasticity in patients with ascites: evaluation with real-time tissue elastography
    Masashi Hirooka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    AJR Am J Roentgenol 196:W766-71. 2011
    ..The aim of this study was to determine whether measurements of liver stiffness with real-time tissue elastography can be altered for patients with ascites...
  34. ncbi request reprint Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase
    Huaiqi Yao
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime ken, 791 0295, Japan
    World J Gastroenterol 13:1618-21. 2007
    ..We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy...
  35. ncbi request reprint Hepatic resection assisted by ablative therapy for advanced hepatocellular carcinoma
    Atsushi Hiraoka
    Center of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, Japan
    Hepatogastroenterology 58:955-9. 2011
    ..We attempted combinations of resection and ablative therapies (ethanol injection (EI) or radiofrequency therapy (RFA)) in hepatocellular carcinoma (HCC) patients...
  36. ncbi request reprint Risk factors for death in 224 cases of hepatocellular carcinoma after transcatheter arterial chemoembolization
    Atsushi Hiraoka
    Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, Japan
    Hepatogastroenterology 56:213-7. 2009
    ..To determine risk factors for death and try to predict the prognosis, we evaluated clinical data...
  37. doi request reprint Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patients
    Atsushi Hiraoka
    Department of Gastroenterology, Ehime University Graduate School of Medicine, Ehime, Japan
    J Gastroenterol Hepatol 25:403-7. 2010
    ..We investigated the efficacy and safety of radiofrequency ablation therapy (RFA) in patients in the second elderly stage in comparison with other HCC patients, retrospectively...
  38. ncbi request reprint Anti-HBs-positive liver failure due to hepatitis B virus reactivation induced by rituximab
    Toshiki Sera
    Ehime University Graduate School of Medicine, Department of Gastroenterology and Metabology, Shitsukawa, Toon
    Intern Med 45:721-4. 2006
    ..Rituximab appears likely to have induced HBV reactivation in this case. Anti-viral agents should be administered for both HBsAg-positive and anti-HBs-positive patients who are scheduled to receive rituximab...
  39. doi request reprint Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells
    Hirofumi Yamanishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Immunol 188:2164-72. 2012
    ..In conclusion, Reg-DCs(CA1) protected progression of colitis induced by CD4(+)CD25(-) T cell transfer in an Ag-specific manner by inducing the differentiation of regulatory T cells...
  40. doi request reprint Liver fibrosis in patients with chronic hepatitis C: noninvasive diagnosis by means of real-time tissue elastography--establishment of the method for measurement
    Yohei Koizumi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Radiology 258:610-7. 2011
    ..To prospectively measure liver stiffness with real-time tissue elastography in patients with chronic hepatitis C and to compare the results with those of clinical assessment of fibrosis by using histologic stage as the reference standard...
  41. doi request reprint Present status of autoimmune hepatitis in Japan: a nationwide survey
    Masanori Abe
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Gastroenterol 46:1136-41. 2011
    ..A nationwide survey of autoimmune hepatitis (AIH) was conducted in Japan, and the clinical features of patients with AIH were analyzed...
  42. ncbi request reprint Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis
    Kojiro Michitaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatol Res 38:1069-75. 2008
    ..Conclusion: The percentage of patients with neuropsychiatric function impairment was high in both LC and CH, especially in stage F3. Neuropsychiatric dysfunction may initiate in CH in a considerable number of patients...
  43. ncbi request reprint Characteristics of lamivudine-resistant hepatitis B virus (HBV) strains with and without breakthrough hepatitis in patients with chronic hepatitis B evaluated by serial HBV full-genome sequences
    Norio Horiike
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    J Med Virol 79:911-8. 2007
    ..Although monoclonal lamivudine-resistant strain emerged at HBV-DNA breakthrough in patients with CHB, there were no common amino acid changes, suggesting viral factor may have insignificant role in breakthrough hepatitis...
  44. doi request reprint Etiology of liver cirrhosis in Japan: a nationwide survey
    Kojiro Michitaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    J Gastroenterol 45:86-94. 2010
    ..Little is understood about worldwide changes in the epidemiological distribution of the etiology of liver cirrhosis (LC). The present study examines the etiology of liver cirrhosis in Japan using a nationwide survey...
  45. doi request reprint Wilms' tumor 1 gene modulates Fas-related death signals and anti-apoptotic functions in hepatocellular carcinoma
    Kazuhiro Uesugi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    J Gastroenterol 48:1069-80. 2013
    ..The Wilms' tumor 1 (WT1) gene is known to be overexpressed in hepatocellular carcinoma (HCC) and to upregulate tumor growth and oncogenic potential, although the detailed mechanisms remain to be elucidated...
  46. doi request reprint Non-alcoholic fatty liver disease: factors associated with its presence and onset
    Teruki Miyake
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    J Gastroenterol Hepatol 28:71-8. 2013
    ....
  47. ncbi request reprint Complete response of a patient with advanced primary splenic histiocytic sarcoma by treatment with chemotherapeutic drugs selected using the collagen gel droplet-embedded culture drug sensitivity test
    Yasunori Yamamoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
    Intern Med 51:2893-7. 2012
    ..The patient achieved complete remission (CR) after this therapy and remained alive without recurrence at the final follow-up. This is the first known case of CR in response to chemotherapy for advanced splenic HS...
  48. doi request reprint High serum palmitic acid is associated with low antiviral effects of interferon-based therapy for hepatitis C virus
    Teruki Miyake
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Lipids 47:1053-62. 2012
    ..These results suggest that the effect of IFN-based antiviral therapy in patients with HCV infection might be enhanced by treatment that modulates palmitic acid levels...
  49. ncbi request reprint Epithelial cyst arising in an intrapancreatic accessory spleen: a diagnostic dilemma
    Hirofumi Yamanishi
    Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
    Intern Med 50:1947-52. 2011
    ..ECIAS is another lesion to be considered in the differential diagnosis of MCN...
  50. ncbi request reprint Percutaneous ultrasound-guided radiofrequency ablation of hepatocellular carcinoma with artificially induced pleural effusion and ascites
    Takahide Uehara
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    J Gastroenterol 42:306-11. 2007
    ..We investigated the safety and efficacy of radiofrequency ablation (RFA) with artificial pleural effusion and/or artificial ascites...
  51. ncbi request reprint Hepatitis C virus expression and interferon antiviral action is dependent on PKR expression
    Yoshio Tokumoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Med Virol 79:1120-7. 2007
    ..Based on these results, it appears that HCV protein expression is directly dependent on PKR expression. PKR is antiviral toward HCV and responsible for IFN's effect against HCV...
  52. ncbi request reprint Ulcerative colitis complicated with primary biliary cirrhosis
    Fujimasa Tada
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
    Intern Med 50:2323-7. 2011
    ..Ulcerative colitis should be considered in the differential diagnosis of bowel disease in patients with PBC. The possible genetic associations between 2 diseases are also discussed...
  53. doi request reprint Clinical significance of B cell-activating factor in autoimmune pancreatitis
    Hirofumi Yamanishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Japan
    Pancreas 40:840-5. 2011
    ..The aim of this study was to investigate the role of BAFF in the diagnosis and pathogenesis of AIP...
  54. ncbi request reprint Occupational liver injury due to N,N-dimethylformamide in the synthetics industry
    Maho Hamada
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To on, Japan
    Intern Med 48:1647-50. 2009
    ..After removal of exposure, all patients recovered without specific treatment. A careful evaluation of occupational history is necessary when liver dysfunction develops in industrial workers...
  55. doi request reprint Virtual puncture line in radiofrequency ablation for hepatocellular carcinoma of the caudate lobe
    Masashi Hirooka
    Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Shizukawa 454, Toon shi, Ehime 791 0295, Japan
    AJR Am J Roentgenol 193:W149-51. 2009
    ..In this study, we evaluated the feasibility of using a virtual puncture line in 3D CT for the treatment of 21 hepatocellular carcinoma (HCC) nodules in the caudate lobe...
  56. doi request reprint Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a
    Teruhisa Ueda
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Regul Pept 166:28-35. 2011
    ....
  57. pmc Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer
    Mitsuhito Koizumi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    PLoS ONE 8:e71367. 2013
    ..Elucidation of the precise role and mechanism of control of BAFF may lead to new therapeutic approaches with the aim of improving pancreatic cancer survival. ..
  58. pmc Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma
    Fujimasa Tada
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To on, Ehime 791 0925, Japan
    Int J Oncol 41:1601-9. 2012
    ..However, clinical response was detected only in one patient. Future trials may consider applying this therapy in a less advanced stage to obtain better clinical responses...
  59. doi request reprint B cell-activating factor controls the production of adipokines and induces insulin resistance
    Maho Hamada
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Obesity (Silver Spring) 19:1915-22. 2011
    ..We propose that autocrine or paracrine BAFF and BAFF-receptor (BAFF-R) interaction in VAT leads to impaired insulin sensitivity via inhibition of insulin signaling pathways and alterations in adipokine production...
  60. ncbi request reprint Induction of anti-HBs in HB vaccine nonresponders in vivo by hepatitis B surface antigen-pulsed blood dendritic cells
    Sk Md Fazle Akbar
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon City, Ehime 791 0295, Japan
    J Hepatol 47:60-6. 2007
    ....
  61. ncbi request reprint Impaired dendritic cell function resulting from chronic undernutrition disrupts the antigen-specific immune response in mice
    Tetsuji Niiya
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan 791 0295
    J Nutr 137:671-5. 2007
    ..05). We suggest that chronic undernutrition disrupts antigen-specific immune responses and that this disruption can be attributed at least in part to reduced frequencies and impaired functions of DC...
  62. ncbi request reprint Clinical profile of primary biliary cirrhosis that was diagnosed as symptomatic primary biliary cirrhosis according to the revised diagnostic criteria in Japan
    Nobuaki Azemoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime
    Intern Med 49:1073-8. 2010
    ..This study investigated the prevalence and prognosis of "newly-diagnosed" symptomatic-PBC (ns-PBC), which was defined as asymptomatic PBC (a-PBC) in Japan until 2004...
  63. doi request reprint Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus
    Ichiro Konishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine Nutrition Division, Ehime University Hospital, Ehime, Japan
    Hepatol Res 41:928-35. 2011
    ..002). Conclusion:  Patients with CH-C could safely walk as aerobic exercise. Furthermore, walking improved insulin resistance and decreased body fat while lowering serum levels of leptin...
  64. ncbi request reprint Efficacy of splenectomy for hypersplenic patients with advanced hepatocellular carcinoma
    Masashi Hirooka
    Department of Gastroenterology and Metabology, Graduate School of Medicine, Ehime University, Onsen, Japan
    Hepatol Res 38:1172-7. 2008
    ..Conclusions: Splenectomy is an efficient method for advanced HCC patients with hypersplenism treated by chemotherapy...
  65. ncbi request reprint Clinicopathologic features of the severe form of acute type 1 autoimmune hepatitis
    Masanori Abe
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Clin Gastroenterol Hepatol 5:255-8. 2007
    ..In this study, we analyzed the clinicopathologic features of patients who were diagnosed as having acute AIH...
  66. ncbi request reprint Recent clinical features of Wilson's disease with hepatic presentation
    Teru Kumagi
    Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime, 791 0295, Japan
    J Gastroenterol 39:1165-9. 2004
    ..We carried out this study to evaluate recent clinical features of Wilson's disease (WD) with hepatic presentation, especially in terms of age, degree of liver injury, and association with hepatocellular carcinoma (HCC)...
  67. ncbi request reprint Diabetes mellitus reduces the therapeutic effectiveness of interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C
    Ichiro Konishi
    Department of Gastroenterology and Metabology, and Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Japan
    Hepatol Res 37:331-6. 2007
    ..462-51.276; P = 0.014) were independently associated with not becoming a sustained-responder. Conclusions: The findings indicate that DM reduces the response to IFN-alpha2b plus ribavirin therapy in CHC patients...
  68. doi request reprint Early biochemical response to ursodeoxycholic acid predicts symptom development in patients with asymptomatic primary biliary cirrhosis
    Nobuaki Azemoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To on, Ehime 791 0295, Japan
    J Gastroenterol 44:630-4. 2009
    ..We examined the impact of biochemical response to ursodeoxycholic acid in the development of symptoms in patients with a-PBC...
  69. ncbi request reprint CCR5 promoter polymorphism influences the interferon response of patients with chronic hepatitis C in Japan
    Ichiro Konishi
    Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Intervirology 47:114-20. 2004
    ....
  70. doi request reprint Characteristics of small bowel tumors detected by double balloon endoscopy
    Hiroya Imaoka
    Internal Medicine, Saiseikai Imabari Hospital, and Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine, Ehime, Japan
    Dig Dis Sci 56:2366-71. 2011
    ..A few reports suggest that the emergence of double balloon endoscopy (DBE) has likely changed the clinical picture of small bowel tumors (SBTs)...
  71. doi request reprint Characteristic endoscopic features of portal hypertensive enteropathy
    Naoyuki Higaki
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791 0295, Japan
    J Gastroenterol 43:327-31. 2008
    ..Although DBE has been widely used for diagnosis and treatment of different lesions in the small intestine, there is a paucity of information regarding endoscopic features of the small intestine in patients with liver cirrhosis (LC)...
  72. doi request reprint Biochemical response to ursodeoxycholic acid predicts long-term outcome in Japanese patients with primary biliary cirrhosis
    Nobuaki Azemoto
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatol Res 41:310-7. 2011
    ..Finally, Ehime criteria should be validated in a different patient cohort...
  73. ncbi request reprint Budd-Chiari syndrome associated with hypereosinophilic syndrome; a case report
    Ai Inoue
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon City
    Intern Med 46:1095-100. 2007
    ..He was diagnosed with Budd-Chiari syndrome associated with HES. Liver function tests improved after interventional therapy followed by steroid therapy. It is important to diagnose the cause of Budd-Chiari syndrome...
  74. ncbi request reprint Doppler waveform pattern changes in a patient with primary Budd-Chiari syndrome before and after angioplasty
    Kana Hirooka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan
    Intern Med 47:91-5. 2008
    ..Doppler sonography was very useful for evaluating the effect of angioplasty and to diagnose re-stenosis...
  75. ncbi request reprint Usefulness of contrast-enhanced ultrasonography with abdominal virtual ultrasonography in assessing therapeutic response in hepatocellular carcinoma treated with radiofrequency ablation
    Yoshiyasu Kisaka
    Third Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Tohon shi, Ehime, Japan
    Liver Int 26:1241-7. 2006
    ..We evaluated the efficacy of virtual ultrasonography (VUS) with contrast-enhanced ultrasonography (CEUS) vs. CECT for assessing the response to RFA...
  76. ncbi request reprint Usefulness of the hyperechoic rim for assessing the therapeutic efficacy of radiofrequency ablation in hepatocellular carcinoma patients
    Takahide Uehara
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
    Hepatol Res 39:954-62. 2009
    ..Conclusion: This study shows that the hyperechoic rim is related to the presence of dead and necrotic tissues. Thus, assessment of the hyperechoic rim's characteristics allows one to evaluate the efficacy of RFA...
  77. ncbi request reprint Tracing the history of hepatitis B virus genotype D in western Japan
    Kojiro Michitaka
    Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    J Med Virol 78:44-52. 2006
    ..From the history of the area and the genetic analysis, HBV/D in this area was speculated to be of Russian origin...
  78. doi request reprint Protective role of interleukin-10-producing regulatory dendritic cells against murine autoimmune gastritis
    Masamoto Torisu
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, 791 0295, Japan
    J Gastroenterol 43:100-7. 2008
    ..In this study, we assessed whether Reg-DCs modulate the course of autoimmune processes in a murine model of autoimmune gastritis (AIG)...
  79. ncbi request reprint Dietary habits and nutrient intake in non-alcoholic steatohepatitis
    Kumiko Toshimitsu
    Nutrition Division, Ehime University Hospital, Ehime, Japan
    Nutrition 23:46-52. 2007
    ..However, there are few reports about the intake of various nutrients in non-alcoholic fatty liver disease. In this work, we identified the characteristics of dietary habits and nutrient intake in patients with NASH...
  80. ncbi request reprint Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan
    Kana Matsuura
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon shi, Japan
    Hepatol Res 37:255-62. 2007
    ..The major infectious route for patients with AH is sexual transmission, regardless of HBV genotype...
  81. ncbi request reprint Engineering immune therapy against hepatitis B virus
    Fazle Akbar
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatol Res 37:S351-6. 2007
    ..Based on present understandings about vaccine/host interactions, we provide herein an outline for engineering more potent regimen of HBV-specific immune therapy against HBV...
  82. ncbi request reprint Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine
    Toshie Mashiba
    Department of Gastroenterology and Metabology, Graduate School of Medicine, Ehime University, Toh on, Ehime, Japan
    Immunogenetics 59:197-209. 2007
    ..Finally, an analysis of the viral population isolated in Japan suggested no obvious changes due to immune evasion in the viral genome even in a host population highly biased toward HLA-A*2402...
  83. ncbi request reprint Prevalence of hepatitis E virus among wild boar in the Ehime area of western Japan
    Kojiro Michitaka
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Hepatol Res 37:214-20. 2007
    ..Conclusion: HEV infection is endemic in wild boar in the Ehime area, and we should regard the wild boar as an important reservoir of HEV...
  84. doi request reprint ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members
    Shuichiro Shigematsu
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
    Exp Cell Res 317:1851-9. 2011
    ..ZNF689 may be a promising chemotherapeutic target against liver cancer...
  85. ncbi request reprint Diagnostic value of sonazoid for hepatic metastasis: comparison with FDG PET/CT
    Atsushi Hiraoka
    Gastroenterology Center, Ehime Prefectural Central Hospital, Ehime, Japan
    Hepatogastroenterology 57:1237-40. 2010
    ....
  86. ncbi request reprint Significance of laparoscopic splenectomy in patients with hypersplenism
    Yuji Watanabe
    Department of Surgery II, School of Medicine, Ehime University, Shitsukawa, Toon shi, 791 0295, Ehime, Japan
    World J Surg 31:549-55. 2007
    ..This study was aimed at investigating the efficacy and safety of minimally invasive laparoscopic splenectomy in patients with hypersplenism secondary to cirrhosis...
  87. ncbi request reprint Earlier recurrence of esophageal varices, following therapy, in patients with primary biliary cirrhosis (PBC) compared with non-PBC patients
    Eiji Takeshita
    Third Department of Internal Medicine, Ehime University School of Medicine, 791 0295, Ehime, Shigenobu cho, Japan
    J Gastroenterol 39:1085-9. 2004
    ..In this study, we investigated the recurrence of esophageal varices in PBC patients and attempted to identify predictive factors for the recurrence of esophageal varices...