Naohito Hato

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. doi request reprint Steroid and antiviral treatment for Bell's palsy
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime 7910295, Japan
    Lancet 371:1818-20. 2008
  2. doi request reprint Infantile inflammatory pseudotumor of the facial nerve as a complication of epidermal nevus syndrome with cholesteatoma
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Auris Nasus Larynx 40:569-72. 2013
  3. doi request reprint Facial nerve decompression surgery using bFGF-impregnated biodegradable gelatin hydrogel in patients with Bell palsy
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Otolaryngol Head Neck Surg 146:641-6. 2012
  4. doi request reprint Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa Toon City, Ehime 791 0295, Japan
    Auris Nasus Larynx 37:626-30. 2010
  5. doi request reprint Facial nerve decompression surgery in patients with temporal bone trauma: analysis of 66 cases
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    J Trauma 71:1789-92; discussion 1792-3. 2011
  6. ncbi request reprint Valacyclovir for the treatment of Bell's palsy
    Naohito Hato
    Ehime University School of Medicine, Department of Otolaryngology, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Expert Opin Pharmacother 9:2531-6. 2008
  7. ncbi request reprint A new tool for testing ossicular mobility during middle ear surgery: preliminary report of four cases
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Otol Neurotol 27:592-5. 2006
  8. ncbi request reprint Repair of a malleus-handle fracture using calcium phosphate bone cement
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa To on City, Ehime, Japan
    Laryngoscope 117:361-3. 2007
  9. ncbi request reprint Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Onsen gun, Ehime, Japan
    Otol Neurotol 24:948-51. 2003
  10. ncbi request reprint Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Toon City, Ehime, Japan
    Otol Neurotol 28:408-13. 2007

Collaborators

Detail Information

Publications48

  1. doi request reprint Steroid and antiviral treatment for Bell's palsy
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime 7910295, Japan
    Lancet 371:1818-20. 2008
  2. doi request reprint Infantile inflammatory pseudotumor of the facial nerve as a complication of epidermal nevus syndrome with cholesteatoma
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Auris Nasus Larynx 40:569-72. 2013
    ..The facial paralysis gradually improved to House-Blackmann grade III 5 years after the second operation. ..
  3. doi request reprint Facial nerve decompression surgery using bFGF-impregnated biodegradable gelatin hydrogel in patients with Bell palsy
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Otolaryngol Head Neck Surg 146:641-6. 2012
    ..The aim of this study was to evaluate the regeneration-facilitating effects of novel facial nerve decompression surgery using bFGF in a gelatin hydrogel in patients with severe Bell palsy...
  4. doi request reprint Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa Toon City, Ehime 791 0295, Japan
    Auris Nasus Larynx 37:626-30. 2010
    ..The additive effects of local hypothermia and restricted activity in the treatment of idiopathic sudden sensorineural hearing loss (ISSHL) were investigated by case-matched study as a multicenter (13 hospitals) pilot trial...
  5. doi request reprint Facial nerve decompression surgery in patients with temporal bone trauma: analysis of 66 cases
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    J Trauma 71:1789-92; discussion 1792-3. 2011
    ..The aim of this study was to examine the efficacy of facial nerve decompression surgery according to fracture location and the ideal time for surgery after trauma by analyzing the therapeutic outcome of traumatic facial nerve paralysis...
  6. ncbi request reprint Valacyclovir for the treatment of Bell's palsy
    Naohito Hato
    Ehime University School of Medicine, Department of Otolaryngology, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Expert Opin Pharmacother 9:2531-6. 2008
    ..However, considering the cost-benefit ratio of this treatment and the limitations of virological diagnoses, we recommend that valacyclovir should be used in cases of severe palsy within 3 days after the onset of Bell's palsy...
  7. ncbi request reprint A new tool for testing ossicular mobility during middle ear surgery: preliminary report of four cases
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Otol Neurotol 27:592-5. 2006
    ..We developed an ossicular vibration tester for the objective and quantitative assessment of ossicular mobility, which is one of the most critical factors affecting postoperative hearing after tympanoplasty...
  8. ncbi request reprint Repair of a malleus-handle fracture using calcium phosphate bone cement
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa To on City, Ehime, Japan
    Laryngoscope 117:361-3. 2007
    ..Postoperatively, the problem disappeared and her hearing recovered. This case is the first to demonstrate the efficacy of calcium phosphate bone cement for repairing a malleus-handle fracture...
  9. ncbi request reprint Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Onsen gun, Ehime, Japan
    Otol Neurotol 24:948-51. 2003
    ..To investigate the therapeutic effects of acyclovir and prednisolone in relation to the timing of treatment in Bell's palsy...
  10. ncbi request reprint Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Toon City, Ehime, Japan
    Otol Neurotol 28:408-13. 2007
    ..To investigate the effects of valacyclovir and prednisolone in comparison with those of placebo and prednisolone for the treatment of Bell's palsy, excluding zoster sine herpete...
  11. doi request reprint Insulin-like growth factor 1 treatment via hydrogels rescues cochlear hair cells from ischemic injury
    Takashi Fujiwara
    Department of Otolaryngology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Japan
    Neuroreport 19:1585-8. 2008
    ..These findings showed that local rhIGF1 application using a hydrogel has the potential to protect the cochleae from ischemic injury...
  12. ncbi request reprint Myasthenia gravis experimentally induced with muscle-specific kinase
    Kazuhiro Shigemoto
    Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
    Ann N Y Acad Sci 1132:93-8. 2008
    ..Some of these mechanisms may also participate in the maintenance of mature NMJ. This model system would provide new knowledge about the molecular pathogenesis of MG and MuSK functions in mature NMJ...
  13. ncbi request reprint Demyelination associated with HSV-1-induced facial paralysis
    Hiroyuki Wakisaka
    Department of Anatomy, Ehime University School of Medicine, Ehime 791 0925, Japan
    Exp Neurol 178:68-79. 2002
    ..From these findings, we concluded that facial nerve paralysis in this model is caused mainly by facial nerve demyelination in the descending root...
  14. ncbi request reprint Basic fibroblast growth factor combined with biodegradable hydrogel promotes healing of facial nerve after compression injury: an experimental study
    Hayato Komobuchi
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
    Acta Otolaryngol 130:173-8. 2010
    ..Topical application of basic fibroblast growth factor (bFGF) hydrogel facilitates faster healing from traumatic facial paralysis due to continuous release of bFGF...
  15. doi request reprint Facial synkinesis after experimental compression of the facial nerve comparing intratemporal and extratemporal lesions
    Hiroyuki Yamada
    Department of Otorhinolaryngology, Ehime University School of Medicine, Ehime, Japan
    Laryngoscope 120:1022-7. 2010
    ..The purpose of this study was to investigate the incidence of facial synkinesis and misdirection on clamping the facial nerve at the intratemporal or extratemporal portion of the facial nerve in guinea pigs...
  16. ncbi request reprint Role of T-lymphocyte subsets in facial nerve paralysis owing to the reactivation of herpes simplex virus type 1
    Hisanobu Kisaki
    Department of Otolaryngology, Ehime University School of Medicine, Onsen gun, Ehime, Japan
    Acta Otolaryngol 125:316-21. 2005
    ..Although both T-cell subsets are essential for inhibiting HSV-1 reactivation in the GG, CD4 + T cells play a more important role in host defense against virus replication...
  17. doi request reprint Role of nitric oxide in the onset of facial nerve palsy by HSV-1 infection
    Naohito Hato
    Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa Toon City, Ehime, Japan
    JAMA Otolaryngol Head Neck Surg 139:1339-42. 2013
    ..Although herpes simplex virus type 1 (HSV-1) is a causative agent of Bell palsy, the precise mechanism of the paralysis remains unknown. It is necessary to investigate the pathogenesis and treatment of Bell palsy due to HSV-1 infection...
  18. ncbi request reprint Effects of acyclovir on facial nerve paralysis induced by herpes simplex virus type 1 in mice
    Hirotaka Takahashi
    Department of Otolaryngology, Ehime University School of Medicine, Ehime, Shigenobu cho, Onsen gun, Ehime 791 0925, Japan
    Auris Nasus Larynx 30:1-5. 2003
    ..The purpose of this experiment was to assess the effect of acyclovir on the facial nerve paralysis included by HSV-1 infection...
  19. doi request reprint Myogenin expression in facial muscle following damage to the facial nerve
    Masato Teraoka
    Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa, To on City, Japan
    Acta Otolaryngol 132:783-7. 2012
    ..Gene analysis of facial muscle may be a promising way to detect denervation of facial muscle, helping to determine the prognosis of a facial palsy early in its progression...
  20. ncbi request reprint Liposome-encapsulated hemoglobin alleviates hearing loss after transient cochlear ischemia: an experimental study in the gerbil
    Masahiro Okada
    Ehime University Graduate School of Medicine, Otolaryngology Head and Neck Surgery, Shitsukawa, Toon, Ehime 791 0295, Japan Electronic address
    Neurosci Lett 553:176-80. 2013
    ..These results suggest that LEH is an efficient agent with regard to protection against hearing loss and underlying hair cell damager due to ischemic insult...
  21. doi request reprint Prosaposin-derived peptide alleviates ischaemia-induced hearing loss
    Takehiro Terashita
    Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Acta Otolaryngol 133:462-8. 2013
    ..PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss...
  22. doi request reprint Re-implantation of the Rion E-type semi-implantable hearing aid: status of long-term use and hearing outcomes in eight patients
    Masahiro Komori
    Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime, Japan
    Auris Nasus Larynx 39:572-6. 2012
    ..An IHA was re-implanted in 8 of the 28 cases. This study assessed the status of long-term use and hearing outcomes in the eight patients to confirm the safety and advantages of repeated implant operation...
  23. doi request reprint Protection against ischemic cochlear damage by intratympanic administration of AM-111
    Yoshinori Omotehara
    Department of Otolaryngology Head and Neck Surgery, Ehime University, Ehime, Japan
    Otol Neurotol 32:1422-7. 2011
    ..AM-111, a cell-permeable peptide inhibitor of c-Jun N-terminal kinase, was investigated for its protective effects against ischemic damage of the cochlea in gerbils...
  24. doi request reprint Clinical features and outcomes of four patients with invasive fungal sinusitis
    Hirotaka Takahashi
    Department of Otolaryngology, Head and Neck Surgery, Ehime University School of Medicine, Shitsukawa, To on City, Ehime 791 0925, Japan
    Auris Nasus Larynx 38:289-94. 2011
    ..Prognostic factors facilitating an early diagnosis are described, and the usefulness of combination therapy involving systemic administration of antifungal agents and surgical intervention is discussed...
  25. doi request reprint Galectin-7 as a marker of cholesteatoma residue and its detection during surgery by an immunofluorescent method--a preliminary study
    Daiki Takagi
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Ehime University, Ehime, Japan
    Otol Neurotol 33:396-9. 2012
    ..To visualize the distribution of galectin-7 in middle ear cholesteatomas using an immunofluorescent method and to establish whether galectin-7 can be used as a marker of cholesteatoma residue at the time of operation...
  26. ncbi request reprint Pathophysiology of facial nerve paralysis induced by herpes simplex virus type 1 infection
    Nobumitu Honda
    Department of Otolaryngology, Ehime University School of Medicine, Japan
    Ann Otol Rhinol Laryngol 111:616-22. 2002
    ....
  27. ncbi request reprint Ischemic tolerance in the cochlea
    Shoichiro Takeda
    Department of Otolaryngology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Japan
    Neurosci Lett 462:263-6. 2009
    ..Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea...
  28. doi request reprint Air-bone gap in ears with a well-repaired tympanic membrane after Type III and Type IV tympanoplasty
    Masahiro Okada
    Department of Otolaryngology Head and Neck Surgery, Ehime University, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Auris Nasus Larynx 41:153-9. 2014
    ..To investigate the air-bone conduction hearing gap (A-B gap) after Type III and Type IV stapes columella tympanoplasty in ears with mobile stapes and a well repaired tympanic membrane (TM)...
  29. doi request reprint Treatment of neural anosmia by topical application of basic fibroblast growth factor-gelatin hydrogel in the nasal cavity: an experimental study in mice
    Jumpei Nota
    Department of Otolaryngology Head and Neck Surgery, Ehime University, School of Medicine, Ehime, Japan
    JAMA Otolaryngol Head Neck Surg 139:396-400. 2013
    ..A new treatment of neural anosmia...
  30. doi request reprint Objective assessment of the severity of unilateral facial palsy using OKAO Vision® facial image analysis software
    Naoki Sawai
    Department of Otolaryngology Head and Neck Surgery, Ehime University School of Medicine, Ehime, Japan
    Acta Otolaryngol 132:1013-7. 2012
    ..Severity of ipsilateral facial palsy (UFP) can be assessed objectively by use of OKAO Vision®. Facial symmetry percentage (FSP) values were well correlated with the results by two conventional grading systems...
  31. ncbi request reprint Swelling of the intratemporal facial nerve in Ramsay Hunt syndrome
    Nobumitsu Honda
    Department of Otolaryngology, Ehime University School of Medicine, Japan
    Acta Otolaryngol 122:348-52. 2002
    ..We assume that the viral inflammatory swelling involving the geniculate ganglion and horizontal segment is mostly responsible for the acute facial palsy in the acute phase...
  32. ncbi request reprint Bilateral spontaneous cerebrospinal fluid otorrhea
    Nobumitsu Honda
    Department of Otolaryngology, Ehime University School of Medicine, Onsen gun, Japan
    Am J Otolaryngol 25:68-72. 2004
    ..In case of spontaneous CSF otorrhea, the roof of tegmen should be assessed bilaterally with care using radiologic examinations so as not to overlook a subclinical condition on the contralateral side...
  33. ncbi request reprint Lateralization of the tympanic membrane as a complication of canal wall down tympanoplasty: a report of four cases
    Kiyofumi Gyo
    Department of Otolaryngology, Ehime University, Onsen gun Shigenobu cho, Ehime, Japan
    Otol Neurotol 24:145-8. 2003
    ..To describe the pathophysiology and treatment of the lateralized tympanic membrane that occurs after canal wall down tympanoplasty...
  34. doi request reprint Glutamate agonist causes irreversible degeneration of inner hair cells
    Jun Hyodo
    Department of Otolaryngology, Ehime University School of Medicine, Ehime 791 0295, Japan
    Neuroreport 20:1255-9. 2009
    ..As cochlear ischemia involves excessive glutamate release, these results suggest that an elevated glutamate level in the cochlea is responsible for the progressive IHC death related to ischemic injury...
  35. doi request reprint Long-term results with the Rion E-type semi-implantable hearing aid
    Masahiro Komori
    Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime, Japan
    Otolaryngol Head Neck Surg 143:422-8. 2010
    ..This study focused on the current status of the patients, device problems, postoperative difficulties, and preventive measures against them...
  36. ncbi request reprint Postischemic mild hypothermia alleviates hearing loss because of transient ischemia
    Shoichiro Takeda
    Departments of aOtolaryngology bFunctional Historogy, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Neuroreport 19:1325-8. 2008
    ..The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage...
  37. ncbi request reprint Clinical features, presenting symptoms, and surgical results of congenital cholesteatoma based on Potsic's staging system
    Taro Takagi
    Department of Otolaryngology, Ehime University, School of Medicine, Ehime, Japan
    Acta Otolaryngol 134:462-7. 2014
    ..Potsic's staging system is a clinically useful procedure for evaluating the extent of congenital cholesteatoma (CC)...
  38. doi request reprint Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration
    Nobuhiro Hakuba
    Department of Otolaryngology Head and Neck Surgery, Ehime University School of Medicine, Ehime and Department of Biomaterials, Field of Tissue Engineering, Kyoto University School of Medicine, Kyoto, Japan
    Otol Neurotol 35:540-4. 2014
    ..In this developmental research study that aimed to develop tympanic membrane regeneration therapy, we devised a method of sustained bFGF formulation release using gelatin hydrogel in a guinea pig eardrum perforation model...
  39. ncbi request reprint Prognostic factors of Bell's palsy: prospective patient collected observational study
    Takashi Fujiwara
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime, 791 0295, Japan
    Eur Arch Otorhinolaryngol 271:1891-5. 2014
    ..The AUROC of the facial grading score was 0.793. The Y-system score at 1 week moderate accurately predicted non-recovery at 6 months in Bell's palsy. ..
  40. pmc Induction of myasthenia by immunization against muscle-specific kinase
    Kazuhiro Shigemoto
    Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
    J Clin Invest 116:1016-24. 2006
    ..Thus MuSK autoantibodies rigorously inhibit AChR clustering mediated by multiple pathways, an outcome that broadens our general comprehension of the pathogenesis of MG...
  41. doi request reprint One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma
    Hiroyuki Goda
    Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Oral Oncol 48:958-63. 2012
    ..However, this method takes about 3h. In this study, we attempted to develop a more efficient method for the intraoperative genetic detection of lymph node metastasis in HNSCC...
  42. ncbi request reprint Factors contributing to bone conduction: the outer ear
    Stefan Stenfelt
    Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, California, USA
    J Acoust Soc Am 113:902-13. 2003
    ..However, with the ear canal occluded, BC hearing is dominated by the sound pressure in the outer ear canal for frequencies between 0.4 and 1.2 kHz...
  43. ncbi request reprint Factors contributing to bone conduction: the middle ear
    Stefan Stenfelt
    Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, California 94305 5328, USA
    J Acoust Soc Am 111:947-59. 2002
    ..Measurement of the differential motion of the umbo in one live human skull gave similar response as the average result from the temporal bone specimens...
  44. ncbi request reprint Three-dimensional stapes footplate motion in human temporal bones
    Naohito Hato
    Division of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, Calif, USA
    Audiol Neurootol 8:140-52. 2003
    ..When the cochlea was drained, stapes footplate motion became essentially piston-like for all frequencies...
  45. ncbi request reprint Basilar membrane and osseous spiral lamina motion in human cadavers with air and bone conduction stimuli
    Stefan Stenfelt
    Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, CA, USA
    Hear Res 181:131-43. 2003
    ..The measurements reported here can be used to include a flexible OSL in cochlear models...
  46. ncbi request reprint Fluid volume displacement at the oval and round windows with air and bone conduction stimulation
    Stefan Stenfelt
    Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, California, USA
    J Acoust Soc Am 115:797-812. 2004
    ..With BC stimulation, lesions at the OW caused only minor changes of the fluid flow at the RW...
  47. ncbi request reprint Experimental study of an adjustable-length prosthesis in a temporal bone model
    Shouqin Zhao
    Department of Otolaryngology Head and Neck Surgery, Tongren Hospital, Capital University of Medical Sciences, Beijing, People s Republic of China
    Acta Otolaryngol 125:33-7. 2005
    ..This prosthesis has the advantage of rapid adjustment at the time of insertion in order to achieve optimal tension and, as a result, optimal sound transmission...
  48. ncbi request reprint Round window membrane motion with air conduction and bone conduction stimulation
    Stefan Stenfelt
    Department of Signals and Systems, Chalmers University of Technology, SE 41296 Goteborg, Sweden
    Hear Res 198:10-24. 2004
    ..When the mode of stimulation at the oval window was altered, by the insertion of a 0.6 mm piston, the vibration pattern of the RW membrane changed...