Research Topics
| Naohito HatoSummaryAffiliation: Ehime University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Steroid and antiviral treatment for Bell's palsyNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Ehime 7910295, Japan
Lancet 371:1818-20. 2008
Facial nerve decompression surgery using bFGF-impregnated biodegradable gelatin hydrogel in patients with Bell palsyNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
Otolaryngol Head Neck Surg 146:641-6. 2012..The aim of this study was to evaluate the regeneration-facilitating effects of novel facial nerve decompression surgery using bFGF in a gelatin hydrogel in patients with severe Bell palsy...- Valacyclovir for the treatment of Bell's palsyNaohito Hato
Ehime University School of Medicine, Department of Otolaryngology, Shitsukawa, Toon City, Ehime 791 0295, Japan
Expert Opin Pharmacother 9:2531-6. 2008..However, considering the cost-benefit ratio of this treatment and the limitations of virological diagnoses, we recommend that valacyclovir should be used in cases of severe palsy within 3 days after the onset of Bell's palsy... - Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisoloneNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Onsen gun, Ehime, Japan
Otol Neurotol 24:948-51. 2003..To investigate the therapeutic effects of acyclovir and prednisolone in relation to the timing of treatment in Bell's palsy... - Facial nerve decompression surgery in patients with temporal bone trauma: analysis of 66 casesNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
J Trauma 71:1789-92; discussion 1792-3. 2011..The aim of this study was to examine the efficacy of facial nerve decompression surgery according to fracture location and the ideal time for surgery after trauma by analyzing the therapeutic outcome of traumatic facial nerve paralysis... - Local hypothermia in the treatment of idiopathic sudden sensorineural hearing lossNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa Toon City, Ehime 791 0295, Japan
Auris Nasus Larynx 37:626-30. 2010..The additive effects of local hypothermia and restricted activity in the treatment of idiopathic sudden sensorineural hearing loss (ISSHL) were investigated by case-matched study as a multicenter (13 hospitals) pilot trial... - A new tool for testing ossicular mobility during middle ear surgery: preliminary report of four casesNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
Otol Neurotol 27:592-5. 2006..We developed an ossicular vibration tester for the objective and quantitative assessment of ossicular mobility, which is one of the most critical factors affecting postoperative hearing after tympanoplasty... - Repair of a malleus-handle fracture using calcium phosphate bone cementNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa To on City, Ehime, Japan
Laryngoscope 117:361-3. 2007..Postoperatively, the problem disappeared and her hearing recovered. This case is the first to demonstrate the efficacy of calcium phosphate bone cement for repairing a malleus-handle fracture... - Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled studyNaohito Hato
Department of Otolaryngology, Ehime University School of Medicine, Toon City, Ehime, Japan
Otol Neurotol 28:408-13. 2007..To investigate the effects of valacyclovir and prednisolone in comparison with those of placebo and prednisolone for the treatment of Bell's palsy, excluding zoster sine herpete... - Insulin-like growth factor 1 treatment via hydrogels rescues cochlear hair cells from ischemic injuryTakashi Fujiwara
Department of Otolaryngology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Japan
Neuroreport 19:1585-8. 2008..These findings showed that local rhIGF1 application using a hydrogel has the potential to protect the cochleae from ischemic injury... - Myasthenia gravis experimentally induced with muscle-specific kinaseKazuhiro Shigemoto
Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
Ann N Y Acad Sci 1132:93-8. 2008..Some of these mechanisms may also participate in the maintenance of mature NMJ. This model system would provide new knowledge about the molecular pathogenesis of MG and MuSK functions in mature NMJ... - Demyelination associated with HSV-1-induced facial paralysisHiroyuki Wakisaka
Department of Anatomy, Ehime University School of Medicine, Ehime 791-0925, Japan
Exp Neurol 178:68-79. 2002..From these findings, we concluded that facial nerve paralysis in this model is caused mainly by facial nerve demyelination in the descending root... - Basic fibroblast growth factor combined with biodegradable hydrogel promotes healing of facial nerve after compression injury: an experimental studyHayato Komobuchi
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan
Acta Otolaryngol 130:173-8. 2010..Topical application of basic fibroblast growth factor (bFGF) hydrogel facilitates faster healing from traumatic facial paralysis due to continuous release of bFGF... - Facial synkinesis after experimental compression of the facial nerve comparing intratemporal and extratemporal lesionsHiroyuki Yamada
Department of Otorhinolaryngology, Ehime University School of Medicine, Ehime, Japan
Laryngoscope 120:1022-7. 2010..The purpose of this study was to investigate the incidence of facial synkinesis and misdirection on clamping the facial nerve at the intratemporal or extratemporal portion of the facial nerve in guinea pigs... - Role of T-lymphocyte subsets in facial nerve paralysis owing to the reactivation of herpes simplex virus type 1Hisanobu Kisaki
Department of Otolaryngology, Ehime University School of Medicine, Onsen-gun, Ehime, Japan
Acta Otolaryngol 125:316-21. 2005..HSV-1 DNA was detected in 50% of the mice in both models. Histopathologically, neurons were destroyed in parts of the GG and numerous virus particles were seen in the surviving neurons... - Effects of acyclovir on facial nerve paralysis induced by herpes simplex virus type 1 in miceHirotaka Takahashi
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Shigenobu cho, Onsen gun, Ehime 791 0925, Japan
Auris Nasus Larynx 30:1-5. 2003..The purpose of this experiment was to assess the effect of acyclovir on the facial nerve paralysis included by HSV-1 infection... - Myogenin expression in facial muscle following damage to the facial nerveMasato Teraoka
Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa, To on City, Japan
Acta Otolaryngol 132:783-7. 2012..Gene analysis of facial muscle may be a promising way to detect denervation of facial muscle, helping to determine the prognosis of a facial palsy early in its progression... - Re-implantation of the Rion E-type semi-implantable hearing aid: status of long-term use and hearing outcomes in eight patientsMasahiro Komori
Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime, Japan
Auris Nasus Larynx 39:572-6. 2012..An IHA was re-implanted in 8 of the 28 cases. This study assessed the status of long-term use and hearing outcomes in the eight patients to confirm the safety and advantages of repeated implant operation... - Protection against ischemic cochlear damage by intratympanic administration of AM-111Yoshinori Omotehara
Department of Otolaryngology Head and Neck Surgery, Ehime University, Ehime, Japan
Otol Neurotol 32:1422-7. 2011..AM-111, a cell-permeable peptide inhibitor of c-Jun N-terminal kinase, was investigated for its protective effects against ischemic damage of the cochlea in gerbils... - Clinical features and outcomes of four patients with invasive fungal sinusitisHirotaka Takahashi
Department of Otolaryngology, Head and Neck Surgery, Ehime University School of Medicine, Shitsukawa, To on City, Ehime 791 0925, Japan
Auris Nasus Larynx 38:289-94. 2011..Prognostic factors facilitating an early diagnosis are described, and the usefulness of combination therapy involving systemic administration of antifungal agents and surgical intervention is discussed... - Galectin-7 as a marker of cholesteatoma residue and its detection during surgery by an immunofluorescent method--a preliminary studyDaiki Takagi
Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Ehime University, Ehime, Japan
Otol Neurotol 33:396-9. 2012..To visualize the distribution of galectin-7 in middle ear cholesteatomas using an immunofluorescent method and to establish whether galectin-7 can be used as a marker of cholesteatoma residue at the time of operation... - Pathophysiology of facial nerve paralysis induced by herpes simplex virus type 1 infectionNobumitu Honda
Department of Otolaryngology, Ehime University School of Medicine, Japan
Ann Otol Rhinol Laryngol 111:616-22. 2002.... - Ischemic tolerance in the cochleaShoichiro Takeda
Department of Otolaryngology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Japan
Neurosci Lett 462:263-6. 2009..Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea... - Objective assessment of the severity of unilateral facial palsy using OKAO Vision® facial image analysis softwareNaoki Sawai
Department of Otolaryngology Head and Neck Surgery, Ehime University School of Medicine, Ehime, Japan
Acta Otolaryngol 132:1013-7. 2012..Severity of ipsilateral facial palsy (UFP) can be assessed objectively by use of OKAO Vision®. Facial symmetry percentage (FSP) values were well correlated with the results by two conventional grading systems... - Swelling of the intratemporal facial nerve in Ramsay Hunt syndromeNobumitsu Honda
Department of Otolaryngology, Ehime University School of Medicine, Japan
Acta Otolaryngol 122:348-52. 2002..We assume that the viral inflammatory swelling involving the geniculate ganglion and horizontal segment is mostly responsible for the acute facial palsy in the acute phase... - Bilateral spontaneous cerebrospinal fluid otorrheaNobumitsu Honda
Department of Otolaryngology, Ehime University School of Medicine, Onsen gun, Japan
Am J Otolaryngol 25:68-72. 2004..In case of spontaneous CSF otorrhea, the roof of tegmen should be assessed bilaterally with care using radiologic examinations so as not to overlook a subclinical condition on the contralateral side... - Postischemic mild hypothermia alleviates hearing loss because of transient ischemiaShoichiro Takeda
Departments of aOtolaryngology bFunctional Historogy, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan
Neuroreport 19:1325-8. 2008..The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage... - Long-term results with the Rion E-type semi-implantable hearing aidMasahiro Komori
Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime, Japan
Otolaryngol Head Neck Surg 143:422-8. 2010..This study focused on the current status of the patients, device problems, postoperative difficulties, and preventive measures against them... - Lateralization of the tympanic membrane as a complication of canal wall down tympanoplasty: a report of four casesKiyofumi Gyo
Department of Otolaryngology, Ehime University, Onsen gun Shigenobu cho, Ehime, Japan
Otol Neurotol 24:145-8. 2003..To describe the pathophysiology and treatment of the lateralized tympanic membrane that occurs after canal wall down tympanoplasty... - Glutamate agonist causes irreversible degeneration of inner hair cellsJun Hyodo
Department of Otolaryngology, Ehime University School of Medicine, Ehime 791 0295, Japan
Neuroreport 20:1255-9. 2009..As cochlear ischemia involves excessive glutamate release, these results suggest that an elevated glutamate level in the cochlea is responsible for the progressive IHC death related to ischemic injury... 
Induction of myasthenia by immunization against muscle-specific kinaseKazuhiro Shigemoto
Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
J Clin Invest 116:1016-24. 2006..Thus MuSK autoantibodies rigorously inhibit AChR clustering mediated by multiple pathways, an outcome that broadens our general comprehension of the pathogenesis of MG...- One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinomaHiroyuki Goda
Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
Oral Oncol 48:958-63. 2012..However, this method takes about 3h. In this study, we attempted to develop a more efficient method for the intraoperative genetic detection of lymph node metastasis in HNSCC... - Factors contributing to bone conduction: the outer earStefan Stenfelt
Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, California, USA
J Acoust Soc Am 113:902-13. 2003..However, with the ear canal occluded, BC hearing is dominated by the sound pressure in the outer ear canal for frequencies between 0.4 and 1.2 kHz... - Three-dimensional stapes footplate motion in human temporal bonesNaohito Hato
Division of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, Calif, USA
Audiol Neurootol 8:140-52. 2003..When the cochlea was drained, stapes footplate motion became essentially piston-like for all frequencies... - Basilar membrane and osseous spiral lamina motion in human cadavers with air and bone conduction stimuliStefan Stenfelt
Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, CA, USA
Hear Res 181:131-43. 2003..The measurements reported here can be used to include a flexible OSL in cochlear models... - Fluid volume displacement at the oval and round windows with air and bone conduction stimulationStefan Stenfelt
Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, California, USA
J Acoust Soc Am 115:797-812. 2004..With BC stimulation, lesions at the OW caused only minor changes of the fluid flow at the RW... - Round window membrane motion with air conduction and bone conduction stimulationStefan Stenfelt
Department of Signals and Systems, Chalmers University of Technology, SE 41296 Goteborg, Sweden
Hear Res 198:10-24. 2004..When the mode of stimulation at the oval window was altered, by the insertion of a 0.6 mm piston, the vibration pattern of the RW membrane changed... - Experimental study of an adjustable-length prosthesis in a temporal bone modelShouqin Zhao
Department of Otolaryngology--Head and Neck Surgery, Tongren Hospital, Capital University of Medical Sciences, Beijing, People's Republic of China
Acta Otolaryngol 125:33-7. 2005..4 mm. RESULTS: The optimal-length prosthesis produced similar results to those of an intact middle ear. The slightly longer prostheses decreased middle ear sound transmission at all test frequencies, except those near 1.5 kHz... - Factors contributing to bone conduction: the middle earStefan Stenfelt
Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, California 94305 5328, USA
J Acoust Soc Am 111:947-59. 2002..Measurement of the differential motion of the umbo in one live human skull gave similar response as the average result from the temporal bone specimens...