Yasuhito Abe

Summary

Affiliation: Ehime University
Country: Japan

Publications

  1. ncbi Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Clin Cancer Res 12:6884-93. 2006
  2. ncbi Therapeutic application of intravenous human natural immunoglobulin preparation
    Y Abe
    The Second Department of Surgery, Ehime University School of Medicine, Shigenobu, Ehime 791 02, Japan
    Front Biosci 1:e26-33. 1996
  3. ncbi A mitotic kinase TOPK enhances Cdk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis
    Yasuhito Abe
    Department of Molecular Pathology, Ehime University Postgraduate School of Medicine, Toh on, Ehime 791 0295, Japan
    J Mol Biol 370:231-45. 2007
  4. ncbi A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK
    Yasuhito Abe
    Department of Pathology, Division of Molecular Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 344:377-85. 2006
  5. ncbi Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells
    Y Abe
    First Department of Pathology, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    J Biol Chem 275:21525-31. 2000
  6. ncbi Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes
    Y Abe
    First Department of Pathology and Hygiene, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    J Biol Chem 276:44003-11. 2001
  7. ncbi Characterization of a MAPKK-like protein kinase TOPK
    Suguru Matsumoto
    Department of Molecular Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 325:997-1004. 2004
  8. ncbi AIP1/WDR1 supports mitotic cell rounding
    Taketsugu Fujibuchi
    Division of Molecular Pathology, Department of Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 327:268-75. 2005
  9. ncbi Expression and phosphorylation of TOPK during spermatogenesis
    Taketsugu Fujibuchi
    Department of Pathology, Division of Molecular Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Dev Growth Differ 47:637-44. 2005
  10. ncbi Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein
    Akifumi Miyoshi
    First Department of Pathology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Onsengun, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 303:399-405. 2003

Collaborators

Detail Information

Publications21

  1. ncbi Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Clin Cancer Res 12:6884-93. 2006
    ..We investigated the role of TOPK in arsenic-induced apoptosis in RPMI7951 human melanoma cells...
  2. ncbi Therapeutic application of intravenous human natural immunoglobulin preparation
    Y Abe
    The Second Department of Surgery, Ehime University School of Medicine, Shigenobu, Ehime 791 02, Japan
    Front Biosci 1:e26-33. 1996
    ..In this review, the mechanism of action of HunIgG and its application in human diseases are discussed...
  3. ncbi A mitotic kinase TOPK enhances Cdk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis
    Yasuhito Abe
    Department of Molecular Pathology, Ehime University Postgraduate School of Medicine, Toh on, Ehime 791 0295, Japan
    J Mol Biol 370:231-45. 2007
    ....
  4. ncbi A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK
    Yasuhito Abe
    Department of Pathology, Division of Molecular Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 344:377-85. 2006
    ..A Small Ras-like GTPase protein Ray was thus indicated to modulate p53 transcriptional activity of PRPK...
  5. ncbi Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells
    Y Abe
    First Department of Pathology, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    J Biol Chem 275:21525-31. 2000
    ..These data suggest that TOPK is a newly identified member of a novel MEK3/6-related MAPKK that may be enrolled in the activation of lymphoid cells and support testicular functions...
  6. ncbi Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes
    Y Abe
    First Department of Pathology and Hygiene, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    J Biol Chem 276:44003-11. 2001
    ..PRPK was shown to bind to p53 and to phosphorylate p53 at Ser-15. These results indicate that PRPK may play an important role in the cell cycle and cell apoptosis through phosphorylation of p53...
  7. ncbi Characterization of a MAPKK-like protein kinase TOPK
    Suguru Matsumoto
    Department of Molecular Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 325:997-1004. 2004
    ..When TOPK expression was suppressed, formation of spindle midzone was thinned and dimmed and cytokinesis was disturbed. We propose that TOPK plays a role in the formation of spindle midzone and in cytokinesis...
  8. ncbi AIP1/WDR1 supports mitotic cell rounding
    Taketsugu Fujibuchi
    Division of Molecular Pathology, Department of Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 327:268-75. 2005
    ..This mechanism could be required to induce cell morphologic changes, especially mitotic cell rounding...
  9. ncbi Expression and phosphorylation of TOPK during spermatogenesis
    Taketsugu Fujibuchi
    Department of Pathology, Division of Molecular Pathology, National University Corporation, Ehime University School of Medicine, Toh on, Ehime 791 0295, Japan
    Dev Growth Differ 47:637-44. 2005
    ..As TOPK-Thr-9 was phosphorylated during both mitosis and meiosis, TOPK was indicted to play a role in cytokinesis and/or chromosomal segregation but not in DNA replication...
  10. ncbi Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein
    Akifumi Miyoshi
    First Department of Pathology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Onsengun, Ehime 791 0295, Japan
    Biochem Biophys Res Commun 303:399-405. 2003
    ..In addition, coprecipitation of p53 using recombinant PRPK was inhibited by adding recombinant CGI-121 in vitro, suggesting that CGI-121 could act as a potent inhibitor of the binding of PRPK to p53...
  11. ncbi Myasthenia gravis experimentally induced with muscle-specific kinase
    Kazuhiro Shigemoto
    Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
    Ann N Y Acad Sci 1132:93-8. 2008
    ..Some of these mechanisms may also participate in the maintenance of mature NMJ. This model system would provide new knowledge about the molecular pathogenesis of MG and MuSK functions in mature NMJ...
  12. ncbi Differences in lectin-binding properties between the common mucosal epithelium and follicle-associated epithelium in the rabbit small intestine
    Takashi Takeuchi
    Department of Molecular Pathology, Ehime University School of Medicine, Toh on, Ehime, Japan
    J Vet Med Sci 69:645-7. 2007
    ..The variety of lectin-binding properties of villous epithelial cells and M cells may reflect specificity for the recognizing luminal substances such as antigenic molecules and bacterial elements...
  13. ncbi Human scribble accumulates in colorectal neoplasia in association with an altered distribution of beta-catenin
    Yoshiaki Kamei
    Division of Molecular Pathology, Department of Pathology, Ehime University School of Medicine, Shitsukawa, Toonshi, Ehime 791 0295, Japan
    Hum Pathol 38:1273-81. 2007
    ..We herein demonstrate that the accumulation of hScrib protein might therefore be involved in colon carcinogenesis while also providing a possible link between hScrib and beta-catenin...
  14. ncbi Serum anti-PDIK1L autoantibody as a novel marker for endometriosis
    Motowo Nabeta
    Department of Molecular Pathology, Ehime University Graduate School of Medicine, Ehime, Japan
    Fertil Steril 94:2552-7.e1. 2010
    ..To establish a novel serum marker for endometriosis, serum autoantibodies (autoAbs) were investigated using a proteomic approach...
  15. ncbi Serum autoantibody to sideroflexin 3 as a novel tumor marker for oral squamous cell carcinoma
    Ryuichi Murase
    Department of Molecular Pathology, Ehime University Postgraduate School of Medicine, Toh on, Ehime, Japan Department of Olomaxilosurgery, Ehime University Postgraduate School of Medicine, Toh on, Ehime, Japan
    Proteomics Clin Appl 2:517-27. 2008
    ..These findings demonstrated that the serum anti-SFXN3-autoAb is worthy of clinical evaluation as a potentially of the novel tumor maker for the early detection of oral squamous cell carcinoma...
  16. ncbi Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis
    Motowo Nabeta
    Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toh on, Ehime 791 0295, Japan
    J Reprod Immunol 91:48-55. 2011
    ..We conclude that serum anti-STX5 autoantibody, which was discovered by a proteomic approach, is a potential new serum marker for the diagnosis of endometriosis. This initial study now requires validation by further clinical evaluation...
  17. ncbi Induction of myasthenia by immunization against muscle-specific kinase
    Kazuhiro Shigemoto
    Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
    J Clin Invest 116:1016-24. 2006
    ..Thus MuSK autoantibodies rigorously inhibit AChR clustering mediated by multiple pathways, an outcome that broadens our general comprehension of the pathogenesis of MG...
  18. ncbi Identification of anti-α-enolase autoantibody as a novel serum marker for endometriosis
    Motowo Nabeta
    Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toh on, Ehime, Japan Department of Obstetrics and Gynecology, Ehime University Graduate School of Medicine, Toh on, Ehime, Japan
    Proteomics Clin Appl 3:1201-10. 2009
    ..Serum anti-Eno1-autoAb can be a new serum endometriotic marker and it is useful as a supplement assay for CA125. This study validates further clinical evaluation of this novel marker...
  19. ncbi [Lymphotoxin (lymphotoxin/TNF-beta)]
    Yasuhito Abe
    Division of Molecular Pathology, Department of Pathology, National Corporation Ehime University School of Medicine
    Nippon Rinsho 63:86-8. 2005
  20. ncbi NEDD8 protein is involved in ubiquitinated inclusion bodies
    Afroz Dil Kuazi
    First Department of Pathology, Ehime University School of Medicine, Ehime, Japan
    J Pathol 199:259-66. 2003
    ..These findings suggest the possibility that the NEDD8 system is involved in the metabolism of these inclusion bodies via the ubiquitin-proteasome system...
  21. ncbi Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells
    Feng Zhu
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Gastroenterology 133:219-31. 2007
    ....