N Yuki

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint [Pathogenesis of axonal Guillain-Barré syndrome]
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine
    Rinsho Shinkeigaku 47:1-7. 2007
  2. pmc Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity
    Eduardo N Taboada
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
    BMC Genomics 8:359. 2007
  3. ncbi request reprint Anti-ganglioside antibody and neuropathy: review of our research
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Peripher Nerv Syst 3:3-18. 1998
  4. ncbi request reprint Current cases in which epitope mimicry is considered a component cause of autoimmune disease: Guillain-Barré syndrome
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Cell Mol Life Sci 57:527-33. 2000
  5. ncbi request reprint Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neuroimmunol 70:1-6. 1996
  6. ncbi request reprint Ganglioside mimicry as a cause of Guillain-Barré syndrome
    Nobuhiro Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Curr Opin Neurol 18:557-61. 2005
  7. ncbi request reprint Carbohydrate mimicry: a new paradigm of autoimmune diseases
    Nobuhiro Yuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Curr Opin Immunol 17:577-82. 2005
  8. pmc Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome
    Nobuhiro Yuki
    Department of Neurology, Institute for Medical Science, Dokkyo University School of Medicine, Shimotsuga, Tochigi 321 0293, Japan
    Proc Natl Acad Sci U S A 101:11404-9. 2004
  9. ncbi request reprint Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Shimotsuga, Japan
    Ann Neurol 49:712-20. 2001
  10. ncbi request reprint Bacterial infections in Guillain-Barré and Fisher syndromes
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Curr Opin Neurol 19:451-7. 2006

Collaborators

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint [Pathogenesis of axonal Guillain-Barré syndrome]
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine
    Rinsho Shinkeigaku 47:1-7. 2007
    ..This new concept that carbohydrate mimicry can cause an autoimmune disease provides a clue to the resolution of the pathogenesis of other immune-mediated diseases...
  2. pmc Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity
    Eduardo N Taboada
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
    BMC Genomics 8:359. 2007
    ..jejuni factors associated with GBS/MFS to date and has allowed us to analyze the genetic background of neuropathogenic C. jejuni strains with an unprecedented level of resolution...
  3. ncbi request reprint Anti-ganglioside antibody and neuropathy: review of our research
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Peripher Nerv Syst 3:3-18. 1998
    ..Since a tryptophan-immobilized column effectively adsorb anti-GQ1b IgG antibody, immunoadsorption with the column should be considered as an alternative form of plasmapheresis for the anti-GQ1b IgG antibody syndrome...
  4. ncbi request reprint Current cases in which epitope mimicry is considered a component cause of autoimmune disease: Guillain-Barré syndrome
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Cell Mol Life Sci 57:527-33. 2000
    ..This sugar mimicry is one possible cause of the Guillain-Barré and Miller Fisher syndromes; however, unidentified host factors may contribute to the development of these syndromes...
  5. ncbi request reprint Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neuroimmunol 70:1-6. 1996
    ..Immunoelectrophoresis failed to detect IgM M-protein in 3 of the patients. IgM anti-SGPG antibody could be a diagnostic marker for a subgroup of CIDP with or without paraprotein...
  6. ncbi request reprint Ganglioside mimicry as a cause of Guillain-Barré syndrome
    Nobuhiro Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Curr Opin Neurol 18:557-61. 2005
    ..jejuni isolated from an acute motor axonal neuropathy patient. Progress has been made in Guillain-Barré syndrome research, especially on acute motor axonal neuropathy subsequent to C. jejuni enteritis...
  7. ncbi request reprint Carbohydrate mimicry: a new paradigm of autoimmune diseases
    Nobuhiro Yuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Curr Opin Immunol 17:577-82. 2005
    ..This new concept that carbohydrate mimicry can cause an autoimmune disease provides a clue to inducing the resolution of pathogenesis of other immune-mediated diseases...
  8. pmc Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome
    Nobuhiro Yuki
    Department of Neurology, Institute for Medical Science, Dokkyo University School of Medicine, Shimotsuga, Tochigi 321 0293, Japan
    Proc Natl Acad Sci U S A 101:11404-9. 2004
    ..These findings show that carbohydrate mimicry is an important cause of autoimmune neuropathy...
  9. ncbi request reprint Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Shimotsuga, Japan
    Ann Neurol 49:712-20. 2001
    ..This model may help to clarify the molecular pathogenesis of the syndrome and to develop new treatments for it...
  10. ncbi request reprint Bacterial infections in Guillain-Barré and Fisher syndromes
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Curr Opin Neurol 19:451-7. 2006
    ..Progress has been made in our understanding of Guillain-Barré syndrome, especially in identifying the Campylobacter jejuni genes responsible for the development of clinical features...
  11. ncbi request reprint Overlapping Guillain-Barré syndrome and Bickerstaff's brainstem encephalitis associated with anti-GQ1b IgG antibody after herpes simplex virus infection
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Japan
    Acta Neurol Scand 104:57-60. 2001
    ....
  12. ncbi request reprint Ganglioside mimicry and peripheral nerve disease
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Muscle Nerve 35:691-711. 2007
    ..Acute and chronic inflammatory demyelinating polyneuropathies may be produced by mechanisms other than ganglioside mimicry...
  13. ncbi request reprint Infectious origins of, and molecular mimicry in, Guillain-Barré and Fisher syndromes
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Lancet Infect Dis 1:29-37. 2001
    ..Some patients develop FS after C jejuni infection, and the lipopolysaccharide present bears the GQ1b epitope. Molecular mimicry is a possible cause of GBS and FS...
  14. ncbi request reprint Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barré syndrome
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan
    J Neurochem 103:150-8. 2007
    ..The cst-II gene is responsible for the development of Guillain-Barré and Fisher syndromes, and the polymorphism (Thr/Asn51) determines which syndrome develops after C. jejuni enteritis...
  15. ncbi request reprint Ataxic Guillain-Barré syndrome with anti-GQ1b antibody: relation to Miller Fisher syndrome
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Neurology 54:1851-3. 2000
    ..The finding that ataxic GBS and MFS have in common an autoantibody with the same fine specificity suggests that they form a continuous spectrum...
  16. ncbi request reprint Antibodies to fucogangliosides in neurological diseases
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neurol Sci 150:81-4. 1997
    ..These fucogangliosides may be the target molecules for serum antibodies in some patients with sensory ataxic neuropathy...
  17. ncbi request reprint Is Campylobacter lipopolysaccharide bearing a GD3 epitope essential for the pathogenesis of Guillain-Barré syndrome?
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Acta Neurol Scand 102:132-4. 2000
    ..jejuni had been isolated than were other antiganglioside antibodies, such as anti-GM1 antibodies. These results could not support the above hypothesis...
  18. ncbi request reprint Pathogenesis of the neurotoxicity caused by anti-GD2 antibody therapy
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neurol Sci 149:127-30. 1997
    ..We assume that the binding of anti-GD2 MAb to peripheral nerve myelin and the pituicytes in the posterior pituitary causes sensorimotor demyelinating neuropathy and SIADH...
  19. ncbi request reprint Acute cytomegalovirus infection and IgM anti-GM2 antibody
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neurol Sci 154:14-7. 1998
    ..Our results did not support the conclusion of Irie et al. that anti-GM2 antibodies were closely associated with acute CMV infection in GBS, but acute CMV infection, with and without GBS, was associated with IgM anti-GM2 antibody...
  20. ncbi request reprint Close association of Guillain-Barré syndrome with antibodies to minor monosialogangliosides GM1b and GM1 alpha
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neuroimmunol 74:30-4. 1997
    ....
  21. ncbi request reprint Overlap of Guillain-Barre syndrome and Bickerstaff's brainstem encephalitis
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Japan
    J Neurol Sci 145:119-21. 1997
    ..We report results of the autopsy of a patient for whom overlapping BBE and GBS was diagnosed clinically. This and similar cases support the original authors' hypothesis that BBE is closely related to GBS...
  22. ncbi request reprint Pathogenesis of Guillain-Barré and Miller Fisher syndromes subsequent to Campylobacter jejuni enteritis
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Jpn J Infect Dis 52:99-105. 1999
    ..This sugar mimicry is one possible cause for GBS and MFS, and unidentified host factor may contribute to the development of these syndromes...
  23. ncbi request reprint Antibody to GalNAc-GD1a and GalNAc-GM1b in Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis
    N Yuki
    Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    J Neuroimmunol 71:155-61. 1996
    ....
  24. ncbi request reprint Acute motor axonal neuropathy and acute motor-sensory axonal neuropathy share a common immunological profile
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Neurol Sci 168:121-6. 1999
    ..The patients with AMSAN had anti-GM1, anti-GM1b, and anti-GD1a IgG antibodies, indicative that AMAN and AMSAN share a common immunological profile...
  25. ncbi request reprint Does Campylobacter jejuni infection elicit "demyelinating" Guillain-Barre syndrome?
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Neurology 63:529-33. 2004
    ..C. jejuni-related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy [AIDP]) after C. jejuni infection...
  26. ncbi request reprint Acute motor axonal neuropathy after Mycoplasma infection: Evidence of molecular mimicry
    K Susuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Neurology 62:949-56. 2004
    ..Patients with Guillain-Barré syndrome (GBS) after Mycoplasma pneumoniae infection often have antibodies to galactocerebroside (GalC). Electrodiagnosis may show acute inflammatory demyelinating polyneuropathy (AIDP)...
  27. ncbi request reprint Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathies
    K Kimoto
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Neurology 67:1837-43. 2006
    ....
  28. ncbi request reprint Patterns and serial changes in electrodiagnostic abnormalities of axonal Guillain-Barré syndrome
    A Hiraga
    Department of Neurology, Chiba University Graduate School of Medicine, Japan
    Neurology 64:856-60. 2005
    ....
  29. ncbi request reprint Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicry
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Neurology 64:1605-11. 2005
    ..To assess the production mechanism of anti-GQ1b autoantibody in Fisher syndrome (FS)...
  30. ncbi request reprint Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a
    M Tatsumoto
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neuroimmunol 177:201-8. 2006
    ..A method to prepare GM1b was developed...
  31. doi request reprint Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous spectrum: clinical analysis of 581 cases
    M Ito
    Dept of Neurology, Dokkyo Medical University, Kitakobayashi 880, Mibu Shimotsuga, Tochigi 321 0293, Japan
    J Neurol 255:674-82. 2008
    ....
  32. pmc Isolated absence of F waves and proximal axonal dysfunction in Guillain-Barré syndrome with antiganglioside antibodies
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 68:191-5. 2000
    ..Some patients with GBS show the absence of F waves as an isolated conduction abnormality, which has been interpreted as demyelination in the proximal nerve segments...
  33. pmc Hyperreflexia in Guillain-Barré syndrome: relation with acute motor axonal neuropathy and anti-GM1 antibody
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    J Neurol Neurosurg Psychiatry 67:180-4. 1999
    ..It was reported that patients with AMAN in northern China often had hyperreflexia in the recovery phase...
  34. ncbi request reprint Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barré syndrome
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Neurology 65:1376-81. 2005
    ..A C jejuni gene, cst-II, involved in the biosynthesis of ganglioside-like lipo-oligosaccharide, shows a polymorphism (Asn/Thr51) that affects ganglioside epitopes...
  35. pmc IgG anti-GQ1b positive acute ataxia without ophthalmoplegia
    M Mori
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    J Neurol Neurosurg Psychiatry 67:668-70. 1999
    ..The clinical presentation and laboratory results for this patient resemble those of Miller Fisher syndrome, except for the lack of ophthalmoplegia. This case may represent part of an IgG anti-GQ1b syndrome...
  36. ncbi request reprint Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    J Neurol Sci 164:134-8. 1999
    ..Infection by C. jejuni may induce IgG anti-GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation...
  37. ncbi request reprint Intravenous immunoglobulin therapy for Guillain-Barré syndrome with IgG anti-GM1 antibody
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 24:54-8. 2001
    ..4 of 14, P = 0.06). CMAP sum score at 6 months tended to be greater for the IVIg group (P = 0.07). For the IgG anti-GM1-positive subgroup of GBS patients, IVIg therapy may be a more efficacious treatment than plasmapheresis...
  38. ncbi request reprint Acute ophthalmoparesis (without ataxia) associated with anti-GQ1b IgG antibody: clinical features
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Ophthalmology 108:196-200. 2001
    ..AO can be considered a mild form of Miller Fisher syndrome or a regional variant of Guillain-Barré syndrome...
  39. ncbi request reprint Anti-GM1 antibody IgG subclass: a clinical recovery predictor in Guillain-Barré syndrome
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Neurology 60:1514-8. 2003
    ..To determine whether the anti-GM1 antibody IgG subclass (IgG1 to 4) is associated with clinical profiles and patterns of recovery in Guillain-Barré syndrome (GBS)...
  40. ncbi request reprint Fine specificity of anti-GQ1b IgG and clinical features
    K Susuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan
    J Neurol Sci 185:5-9. 2001
    ..02). This is the first study to show that the fine specificity of anti-GQ1b IgG is heterogeneous and that the difference is correlated with the presence of a particular clinical sign...
  41. ncbi request reprint Parameters for monitoring treatment effects in CIDP with anti-MAG/SGPG IgM antibody
    Y Tagawa
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Muscle Nerve 24:701-4. 2001
    ..The percentage of CD57-positive lymphocytes and natural killer cell activity had also returned to normal. Our findings indicate that serial measurements of these parameters are useful for monitoring treatment effect in this disease...
  42. pmc Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin
    M Odaka
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Neurosurg Psychiatry 76:1115-20. 2005
    ..Because of the propensity for relapse, CIDP requires maintenance therapy after the initial response to treatment. There is no consensus regarding this in the published literature...
  43. doi request reprint Clinical predictors of mechanical ventilation in Fisher/Guillain-Barré overlap syndrome
    K Funakoshi
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    J Neurol Neurosurg Psychiatry 80:60-4. 2009
    ..Some patients with Fisher syndrome (FS) developed subsequent descending tetraparesis (Fisher/Guillain-Barré overlapping syndrome: FS/GBS). The assumption is that such descending progression may frequently lead to respiratory failure...
  44. doi request reprint BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide
    Yukie Matsumoto
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    J Neuroimmunol 218:67-72. 2010
    ..jejuni LOS and did not alter IgG subclasses, evidence that BAFF aids but is not essential for the generation of IgG anti-ganglioside antibodies in response to C. jejuni LOS...
  45. ncbi request reprint Antecedent symptoms in Guillain-Barré syndrome: an important indicator for clinical and serological subgroups
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Acta Neurol Scand 103:278-87. 2001
    ..This association is not necessarily dependent on infection by the known trigger pathogens...
  46. ncbi request reprint Immunoglobulin improves a model of acute motor axonal neuropathy by preventing axonal degeneration
    Y Nishimoto
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Neurology 62:1939-44. 2004
    ..The action mechanism of IV immunoglobulin (IVIg) for Guillain-Barré syndrome has yet to be clarified...
  47. ncbi request reprint Acute motor axonal neuropathy rabbit model: immune attack on nerve root axons
    Keiichiro Susuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Ann Neurol 54:383-8. 2003
    ..Initial lesions were located mainly on nerve root axons, as in human AMAN. This study thus provides supportive evidence that the rabbits constitute a model of AMAN...
  48. ncbi request reprint Hyperreflexia in axonal Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo, Chiba 260 8670, Japan
    J Neurol Sci 199:89-92. 2002
    ..This case provides further evidence that patients with AMAN can develop increased motor neuron excitability, and possible mechanisms for the hyperreflexia are discussed...
  49. pmc Ambiguous value of Haemophilus influenzae isolation in Guillain-Barre and Fisher syndromes
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Neurosurg Psychiatry 76:1736-8. 2005
    ..Haemophilus influenzae is considered a causative agent of Guillain-Barré syndrome (GBS) and Fisher syndrome, but the frequency of this infection in GBS is controversial...
  50. pmc Range of cross reactivity of anti-GM1 IgG antibody in Guillain-Barré syndrome
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan
    J Neurol Neurosurg Psychiatry 71:123-4. 2001
    ..Anti-GM1 IgG antibody has a broad range of cross reactivity which may contribute to various clinical variations of Guillain-Barré syndrome...
  51. ncbi request reprint Fisher's syndrome and group A streptococcal infection
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    J Neurol Sci 160:64-6. 1998
    ..In a series, however, the association of FS with group A streptococcal infection was not shown. Some patients may develop FS after group A streptococcal infection, but the bacterium is not a major antecedent agent in FS...
  52. ncbi request reprint Miller Fisher syndrome and Haemophilus influenzae infection
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Neurology 57:686-91. 2001
    ..To examine the association between Miller Fisher syndrome (MFS) and antecedent Haemophilus influenzae infection...
  53. pmc Comparative study of preceding Campylobacter jejuni infection in Guillain-Barré syndrome in Japan and The Netherlands
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan
    J Neurol Neurosurg Psychiatry 70:693-5. 2001
    ....
  54. ncbi request reprint Clinical features and prognosis of Miller Fisher syndrome
    M Mori
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Neurology 56:1104-6. 2001
    ..Patients with MFS usually had good recovery and no residual deficits...
  55. ncbi request reprint Cerebral white matter lesions in acute motor axonal neuropathy
    K Sekiguchi
    Department of Neurology, Hyogo Chuo Hospital, Hyogo, Japan
    Neurology 61:272-3. 2003
  56. ncbi request reprint Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination
    Y Nishimoto
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neuroimmunol 148:200-5. 2004
    ..Statistically, anti-GQ1b antibody testing was superior to a CSF examination in supporting a diagnosis of FS during the first 3 weeks of illness, especially in the first week...
  57. ncbi request reprint Acute facial diplegia and hyperreflexia: A Guillain-Barré syndrome variant
    K Susuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Osaka, Japan
    Neurology 62:825-7. 2004
    ..IV immunoglobulin produced recovery. Hyperreflexia does not necessarily exclude the diagnosis of a GBS variant. Antiganglioside antibodies can help with diagnosis in difficult cases...
  58. pmc Indicators of rapid clinical recovery in Guillain-Barré syndrome
    S Kuwabara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Neurol Neurosurg Psychiatry 70:560-2. 2001
    ..Among the axonal subgroup of patients with Guillain-Barré syndrome, preserved tendon reflexes, H influenzae infection, and the patient having received immunoglobulin treatment may be indicators of rapid recovery...
  59. doi request reprint IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy
    N Yuki
    Department of Neurology, Niigata National Hospital, Niigata, Japan
    J Neurol Neurosurg Psychiatry 82:87-91. 2011
    ..MMN patients often carry anti-GM1 IgM antibodies, suggesting an autoimmune process involving complement. Intravenous immunoglobulin (IVIG) is the first line treatment, but its action mechanism is unknown...
  60. ncbi request reprint Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis
    Masakazu Onodera
    Department of Neurology, Chiba Rosai Hospital, Chiba, Japan
    J Neurol Sci 205:83-4. 2002
    ..This case suggests that an acute isolated bulbar palsy may be caused by a pathology relating to Guillain-Barré syndrome (GBS), in which anti-GT1a IgG antibody may have a role...
  61. ncbi request reprint CDR3 spectratyping analysis of the T cell receptor repertoire in Guillain-Barré and Fisher syndromes
    Michiaki Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Neuroimmunol 141:112-7. 2003
    ..The predominant phenotypes vary, even within subgroups of patients with a syndrome of single etiological origin or those with uniform serological features...
  62. ncbi request reprint Continuous spectrum of pharyngeal-cervical-brachial variant of Guillain-Barré syndrome
    Takahide Nagashima
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Arch Neurol 64:1519-23. 2007
    ..Pharyngeal-cervical-brachial weakness (PCB) is considered a variant of Guillain-Barré syndrome (GBS). Because of its rarity, there have been no studies of large numbers of patients with PCB...
  63. ncbi request reprint Campylobacter coli enteritis and Guillain-Barré syndrome: no evidence of molecular mimicry and serological relationship
    Kei Funakoshi
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Sci 246:163-8. 2006
    ..jejuni protein. We concluded that a C. coli infection was not the cause of GBS in our patients. Both isolation of a microorganism from, and the positive infectious serology of, GBS patients do not always indicate the causal agent...
  64. ncbi request reprint Anti-GM1b IgG antibody is associated with acute motor axonal neuropathy and Campylobacter jejuni infection
    Kazue Ogawara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Sci 210:41-5. 2003
    ..Of 10 patients with anti-GM1 antibody alone, four had AMAN, and two had C. jejuni infection. These results showed that GM1b could be a target molecule of autoantibody in the AMAN form of GBS subsequent to C. jejuni infection...
  65. ncbi request reprint Side effects of combined therapy of methylprednisolone and intravenous immunoglobulin in Guillain-Barré syndrome
    M Odaka
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Eur Neurol 53:194-6. 2005
    ..Headache occurred in 2 in both groups, indicative that pre-infusion with steroids does not prevent headache. Transient liver function disturbances were present in 2 patients of the former group and in 6 of the latter...
  66. doi request reprint Neuromuscular transmission is not impaired in axonal Guillain--Barré syndrome
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurol Neurosurg Psychiatry 82:1174-7. 2011
    ..If anti-GM1 and -GD1a antibodies have similar effects on the neuromuscular junction (NMJ) in human limb muscles, this may explain selective motor involvement in axonal Guillain--Barré syndrome (GBS)...
  67. ncbi request reprint Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers
    Keiichiro Susuki
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Glia 55:746-57. 2007
    ..These results indicate that gangliosides are lipid raft components that contribute to stability and maintenance of neuron-glia interactions at paranodes...
  68. ncbi request reprint Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice
    Yukie Matsumoto
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    J Immunol 180:39-43. 2008
    ..Thus, these results indicate CD1-independent pathways for anti-ganglioside Ab production...
  69. ncbi request reprint Isolated abducens nerve palsy as a regional variant of Guillain-Barré syndrome
    Muneto Tatsumoto
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, 321 0293, Japan
    J Neurol Sci 243:35-8. 2006
    ..Serum anti-GQ1b antibody was positive in 25. These findings suggest that some cases of isolated abducens nerve palsy can be categorized as a regional variant of Guillain-Barré syndrome or mild form of Fisher syndrome...
  70. ncbi request reprint Differences in membrane properties of axonal and demyelinating Guillain-Barré syndromes
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Ann Neurol 52:180-7. 2002
    ..These results support the view that the predominantly distal targets of immune attack are different for AMAN and AIDP. Possible mechanisms for the reduced safety factor in AMAN are discussed...
  71. ncbi request reprint Ganglioside mimicry as a cause of Guillain-Barré syndrome
    Tomoko Komagamine
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    CNS Neurol Disord Drug Targets 5:391-400. 2006
    ..An approach for evaluating intravenous immune globulin, a treatment for GBS, based on our animal model of AMAN is also discussed in this review, and recent advances made in this field are described...
  72. pmc Anti-GT1a IgG in Guillain-Barré syndrome
    M Koga
    Department of Neurology and Clinical Neuroscience Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Neurol Neurosurg Psychiatry 72:767-71. 2002
    ..To investigate the presence of serum anti-GT1a IgG in Guillain-Barré syndrome (GBS) and its relation to clinical manifestations...
  73. doi request reprint Conduction block in acute motor axonal neuropathy
    Norito Kokubun
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan
    Brain 133:2897-908. 2010
    ....
  74. ncbi request reprint Fine specificities of anti-LM1 IgG antibodies in Guillain-Barré syndrome
    Keiichiro Susuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, 321 0293, Tochigi, Japan
    J Neurol Sci 195:145-8. 2002
    ..In addition, whether monospecific anti-LM1 IgG antibody is associated with AIDP remains to be concluded. Larger studies are needed to verify whether monospecific anti-LM1 IgG antibody could be a marker of AIDP...
  75. ncbi request reprint Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barré syndrome
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Brain 126:2279-90. 2003
    ..A considerable number of BBE patients have associated axonal Guillain-Barré syndrome, indicative that the two disorders are closely related and form a continuous spectrum...
  76. ncbi request reprint Axonal Guillain-Barré syndrome associated with axonal Charcot-Marie-Tooth disease
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Sci 211:93-7. 2003
    ..The association may be coincidental, but a particular susceptibility to axonal damage of CMT2 cannot be excluded...
  77. ncbi request reprint Comprehensive analysis of bacterial risk factors for the development of Guillain-Barre syndrome after Campylobacter jejuni enteritis
    Michiaki Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Infect Dis 193:547-55. 2006
    ..Guillain-Barre syndrome (GBS), a postinfectious autoimmune-mediated neuropathy, is a serious complication after Campylobacter jejuni enteritis...
  78. ncbi request reprint Longitudinal changes of anti-ganglioside antibodies before and after Guillain-Barré syndrome onset subsequent to Campylobacter jejuni enteritis
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Sci 210:99-103. 2003
    ..Sci. 190 (2001) 41] reported that anti-ganglioside antibody titers peaked during the recovery phase, but our findings are counter to theirs. We speculate that anti-ganglioside antibodies are the primary effectors of nerve damage in GBS...
  79. ncbi request reprint Clinical deterioration in Bickerstaff's brainstem encephalitis caused by overlapping Guillain-Barré syndrome
    Keiichiro Susuki
    Department of Neurology, Medical Center, Yokohama City University, Yokohama, Japan
    J Neurol Sci 211:89-92. 2003
    ..When unusual worsening is observed in clinically suspected encephalitis, neurologists must take into account the possibility of associated Guillain-Barré syndrome and related disorders...
  80. ncbi request reprint Guillain-Barré syndrome presenting with loss of taste
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Neurology 58:1437-8. 2002
  81. ncbi request reprint [Axonal Guillain-Barré syndrome and physiological role of gangliosides in saltatory conduction of myelinated nerve fibers]
    Keiichiro Susuki
    Tanpakushitsu Kakusan Koso 49:2479-84. 2004
  82. ncbi request reprint Plasma levels of alpha-defensins 1-3 are an indicator of neutrophil activation in pregnant and post-partum women
    Takayuki Okazaki
    Department of Obstetrics and Gynecology, Dokkyo Medical University School of Medicine, Tochigi, Japan
    J Obstet Gynaecol Res 33:645-50. 2007
    ..The objective of this study was to determine whether elevated plasma levels of alpha-defensins 1-3 could be used as an indicator of neutrophil activation in pregnant and post-partum women...
  83. ncbi request reprint Various immunization protocols for an acute motor axonal neuropathy rabbit model compared
    Keiichiro Susuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Neurosci Lett 368:63-7. 2004
    ..These results provide useful information for the confirmation of and further research on the model...
  84. ncbi request reprint [Campylobacter jejuni enteritis and Guillain-Barre syndrome]
    Michiaki Koga
    Department of Neurology, Dokkyo University School of Medicine
    Kansenshogaku Zasshi 77:418-22. 2003
  85. ncbi request reprint Unilateral oculomotor nerve palsy associated with anti-GQ1b IgG antibody
    H Ichikawa
    Department of Neurology, Showa University School of Medicine, Tokyo, Japan
    Neurology 59:957-8. 2002
  86. ncbi request reprint Trochlear nerve enhancement on three-dimensional magnetic resonance imaging in Fisher syndrome
    H Tanaka
    Department of Neurology, Dokkyo University School of Medicine
    Am J Ophthalmol 126:322-4. 1998
    ..To examine the lesion associated with external ophthalmoplegia in Fisher syndrome using three-dimensional magnetic resonance imaging (3-D MRI)...
  87. ncbi request reprint [Atypical Fisher syndrome with optic nerve involvement]
    Y Sasaki
    Department of Neurology, Koshigaya City Hospital, Japan
    No To Shinkei 53:571-3. 2001
    ..Human optic and ocular nerves contain high amount of GQ 1 b. This may be a underlying mechanism for optic nerve involvement in Fisher syndrome. We thought that she had an atypical Fisher syndrome associated with optic nerve involvement...
  88. ncbi request reprint [Clinical features of patients associated with anti-GM1b antibody]
    Muneto Tatsumoto
    Department of Neurology, Dokkyo University School of Medicine
    Rinsho Shinkeigaku 43:149-53. 2003
    ..In addition, anti-GM1b antibody was detected in 18 patients with Fisher syndrome and the related conditions associated with anti-GQ1b IgG antibody, and 3 patients with ataxic GBS associated with anti-GD1b IgG antibody...
  89. ncbi request reprint Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscle
    Satoshi Kuwabara
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neuroimmunol 189:158-62. 2007
    ..Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscles. The different findings in mouse and human may be explained by the extent of expression of GQ1b on the motor nerve terminals in the muscle examined...
  90. ncbi request reprint [Clinical features of neuropathies in a group of patients associated with anti-GalNAc-GD1a antibody]
    Muneto Tatsumoto
    Department of Neurology, Dokkyo University School of Medicine
    Rinsho Shinkeigaku 44:508-12. 2004
    ..Our study suggests that the anti-GalNAc-GD1a antibody testing is useful for supporting the diagnosis of GBS. In addition, fine specificity of the antibody also was clarified...
  91. ncbi request reprint Fisher syndrome or Bickerstaff brainstem encephalitis? Anti-GQ1b IgG antibody syndrome involving both the peripheral and central nervous systems
    Kazue Ogawara
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Muscle Nerve 26:845-9. 2002
    ..These two conditions may represent a single autoimmune disease mediated by anti-GQ1b antibody, usually involving the peripheral and occasionally the central nervous systems...
  92. doi request reprint Bickerstaff's brainstem encephalitis after an outbreak of Campylobacter jejuni enteritis
    Masahiro Mori
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Neuroimmunol 196:143-6. 2008
    ..These findings suggest that host susceptibility may play a role in inducing the production of anti-ganglioside antibodies and the development of Bickerstaff's brainstem encephalitis...
  93. ncbi request reprint Ataxic Guillain-Barré syndrome associated with anti-GM1b and anti-GalNAc-GD1a antibodies
    Masaaki Odaka
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol 251:24-9. 2004
    ..This is the first report of ataxic GBS or FS associated with anti-GM1b or anti-GalNAc-GD1a IgG antibodies. These autoantibodies, as well as anti-GQ1b IgG antibody, may function in the development of some patients with ataxic GBS and FS...
  94. ncbi request reprint Clinical correlates of serum anti-GT1a IgG antibodies
    Takahide Nagashima
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neurol Sci 219:139-45. 2004
    ..The presence of a common autoantibody (anti-GT1a IgG) and overlapping illnesses suggests that PCB is closely related not only to GBS but to FS and BBE as well...
  95. ncbi request reprint Unilateral cranial and phrenic nerve involvement in axonal Guillain-Barré syndrome
    Yumi Sakakibara
    Department of Neurology, Narita Red Cross Hospital, Narita, Japan
    Muscle Nerve 25:297-9. 2002
    ..The present report indicates that the cranial and phrenic nerves may be affected unilaterally in Guillain-Barré syndrome, and that there is clinical variability in the axonal subtype of this syndrome...
  96. ncbi request reprint [Pathophysiological diagnosis of facial paralysis using 3-D MRI]
    T Ishihara
    Department of Neurology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibumachi, Shimotsuga-gun, Tochigi 321-0293, Japan
    No To Shinkei 53:341-4. 2001
    ..In conclusion, the observation of facial nerve using 3-D MRI was very useful to know the condition of the facial diplesia in GBS and its variants...
  97. ncbi request reprint [Pure dysarthria due to pontine infarction]
    M Odaka
    Department of Neurology, Dokkyo University School of Medicine
    Rinsho Shinkeigaku 41:68-70. 2001
    ..This case may be useful for the somatotopy of corticopontine and corticobulbar tracts with articulation in the pontine base...
  98. doi request reprint Complement inhibitor prevents disruption of sodium channel clusters in a rabbit model of Guillain-Barré syndrome
    Vongsavanh Phongsisay
    Department of Neurology, Dokkyo Medical University, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    J Neuroimmunol 205:101-4. 2008
    ..Nafamostat mesilate inhibited complement deposition and prevented sodium channel disruption. This provided the rationale for a clinical trial...
  99. doi request reprint Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey
    Takaaki Ishizu
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 280:22-8. 2009
    ..These findings suggest that demographic features not only vary based on CMS or OSMS phenotype, but also with the presence or absence of LESCLs, and that nonetheless, these four phenotypes constitute a continuum...
  100. ncbi request reprint Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers
    Keiichiro Susuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi 321 0293, Japan
    J Neurosci 27:3956-67. 2007
    ..Our findings support the idea that acute motor axonal neuropathy is a disease that specifically disrupts the nodes of Ranvier...
  101. ncbi request reprint Axonal Guillain-Barré syndrome: carbohydrate mimicry and pathophysiology
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    J Peripher Nerv Syst 12:238-49. 2007
    ..Immunological, pathological, electrophysiological, and bacteriological studies have provided strong evidence of carbohydrate mimicry being a cause of AMAN and clarified the mechanisms of nerve conduction failure in AMAN...