Morio Takahashi

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Reversal of the tolerance phenomenon by the intermittent administration of a histamine H2-receptor antagonist
    Morio Takahashi
    Department of Gastroenterology and Hepatology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan
    J Gastroenterol Hepatol 25:1493-7. 2010
  2. ncbi request reprint The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts
    M Takahashi
    Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan
    Aliment Pharmacol Ther 14:44-9. 2000
  3. ncbi request reprint Gastric restitution is inhibited by dexamethasone, which is reversed by hepatocyte growth factor and rebamipide
    M Takahashi
    Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan
    Aliment Pharmacol Ther 18:126-32. 2003
  4. doi request reprint Proton pump inhibitors and recurrent bleeding in peptic ulcer disease
    Akihiro Tajima
    Department of Gastroenterology, Dokkyo Medical University, Koshigaya Hospital, Koshigaya, Japan
    J Gastroenterol Hepatol 23:S237-41. 2008
  5. ncbi request reprint [PPI-test]
    Morio Takahashi
    Department of Gastroenterology, Koshigaya Hospital, Dokkyo University School of Medicine
    Nihon Rinsho 65:852-63. 2007
  6. ncbi request reprint Effects of rabeprazole or famotidine during cardiac surgery on perioperative gastric and esophageal pH readings
    Shigeyoshi Gon
    Department of Cardiovascular Surgery, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Jpn J Thorac Cardiovasc Surg 54:278-84. 2006
  7. ncbi request reprint [Polaprezinc]
    Hajime Kuwayama
    Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University School of Medicine
    Nihon Rinsho 60:717-20. 2002
  8. doi request reprint Helicobacter pylori causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophages
    Yasumi Katayama
    Department of Gastroenterology and Hepatology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan
    Biochem Biophys Res Commun 388:496-500. 2009
  9. ncbi request reprint [Significance of PPI-test in the diagnosis of GERD]
    Morio Takahashi
    Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine
    Nihon Rinsho 62:1465-74. 2004
  10. ncbi request reprint [Continuation of acid suppression therapy after H. pylori eradication]
    Morio Takahashi
    Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University of Medicine
    Nihon Rinsho 60:531-5. 2002

Detail Information

Publications73

  1. ncbi request reprint Reversal of the tolerance phenomenon by the intermittent administration of a histamine H2-receptor antagonist
    Morio Takahashi
    Department of Gastroenterology and Hepatology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan
    J Gastroenterol Hepatol 25:1493-7. 2010
    ..pylori) infection prevents the occurrence of tolerance to H2RA. In the present study, we investigated whether intermittent (every other day) administration prevents the tolerance phenomenon in H. pylori-negative patients...
  2. ncbi request reprint The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts
    M Takahashi
    Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan
    Aliment Pharmacol Ther 14:44-9. 2000
    ..However, despite the bacterium's toxicity, the majority of H. pylori infections are not accompanied by gastric ulcers. This implies the existence of a host mechanism offsetting H. pylori toxicity...
  3. ncbi request reprint Gastric restitution is inhibited by dexamethasone, which is reversed by hepatocyte growth factor and rebamipide
    M Takahashi
    Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan
    Aliment Pharmacol Ther 18:126-32. 2003
    ..HGF expression is induced by PGs in gastric fibroblasts. We hypothesized that dexamethasone (DEX) may inhibit PG production and HGF expression, thus inhibiting HGF-induced gastric epithelial restitution...
  4. doi request reprint Proton pump inhibitors and recurrent bleeding in peptic ulcer disease
    Akihiro Tajima
    Department of Gastroenterology, Dokkyo Medical University, Koshigaya Hospital, Koshigaya, Japan
    J Gastroenterol Hepatol 23:S237-41. 2008
    ..The metabolism of PPIs is dependent upon P450 2C19 genotypes and the clinical usefulness of genotypic analysis remains to be determined...
  5. ncbi request reprint [PPI-test]
    Morio Takahashi
    Department of Gastroenterology, Koshigaya Hospital, Dokkyo University School of Medicine
    Nihon Rinsho 65:852-63. 2007
    ..This diagnostic entity is practical in a sense that anti-acid treatment is very effective for this disease. Besides, PPI test is a very useful tool to differentiate acid associated disorder from GERD and/or FD...
  6. ncbi request reprint Effects of rabeprazole or famotidine during cardiac surgery on perioperative gastric and esophageal pH readings
    Shigeyoshi Gon
    Department of Cardiovascular Surgery, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Jpn J Thorac Cardiovasc Surg 54:278-84. 2006
    ..Upper gastrointestinal bleeding, particularly from a stress-induced duodenal ulcer, is an extremely important perioperative complication in cardiovascular surgery...
  7. ncbi request reprint [Polaprezinc]
    Hajime Kuwayama
    Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University School of Medicine
    Nihon Rinsho 60:717-20. 2002
  8. doi request reprint Helicobacter pylori causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophages
    Yasumi Katayama
    Department of Gastroenterology and Hepatology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan
    Biochem Biophys Res Commun 388:496-500. 2009
    ..Additionally, we demonstrated that lipopolysaccharide, as well as H. pylori, induces NO-mediated methylation, indicating that other inflammation inducers beside H. pylori might induce aberrant methylation of runx3...
  9. ncbi request reprint [Significance of PPI-test in the diagnosis of GERD]
    Morio Takahashi
    Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine
    Nihon Rinsho 62:1465-74. 2004
    ..Characteristics of PPI-test including extra-esophageal GERD diagnosis are discussed in this review...
  10. ncbi request reprint [Continuation of acid suppression therapy after H. pylori eradication]
    Morio Takahashi
    Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University of Medicine
    Nihon Rinsho 60:531-5. 2002
  11. ncbi request reprint Protective effect of n-3 polyunsaturated fatty acid on primary culture of rat hepatocytes
    Ryoichi Sohma
    Koshigaya Division of Clinical Research, Institute for Medical Science, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    J Gastroenterol Hepatol 22:1965-70. 2007
    ..In this study we examined the effect of EPA on rat hepatocytes in primary culture...
  12. ncbi request reprint [Complication of peptic ulcer disease]
    Hajime Kuwayama
    Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University School of Medicine
    Nihon Rinsho 60:357-61. 2002
  13. ncbi request reprint Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barré syndrome
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Neurology 65:1376-81. 2005
    ..A C jejuni gene, cst-II, involved in the biosynthesis of ganglioside-like lipo-oligosaccharide, shows a polymorphism (Asn/Thr51) that affects ganglioside epitopes...
  14. ncbi request reprint [Guillain-barré syndrome associated Campylobacter jejuni serotype Penner 2: a case report]
    M Watanabe
    Department of Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital, 3-15 Mori-machi, Nagasaki 852-8511, Japan
    No To Shinkei 53:759-62. 2001
    ..In general, C. jejuni with the serotype Penner 19 has been isolated from many GBS patients. In this patient, C. jejuni with the serotype of Penner 2 was isolated. The serotype is detected commonly in Miller Fisher syndrome...
  15. ncbi request reprint Haem oxygenase-1 prevents cell death by regulating cellular iron
    C D Ferris
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 1:152-7. 1999
    ..Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability...
  16. ncbi request reprint [Anti-GQ1b IgG-negative case of overlapping Fisher's and Gullain-Barré syndromes after Campylobacter jejuni (PEN 19) enteritis]
    Y Hayashi
    Department of Neurology, National Okayama Medical Center
    Rinsho Shinkeigaku 41:801-4. 2001
    ..jejuni, the isolate from our case belonged to PEN 19. C. jejuni serotype may be associated with clinical manifestations and anti-ganglioside antibody species...
  17. ncbi request reprint Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathies
    K Kimoto
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Neurology 67:1837-43. 2006
    ....
  18. ncbi request reprint Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicry
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Neurology 64:1605-11. 2005
    ..To assess the production mechanism of anti-GQ1b autoantibody in Fisher syndrome (FS)...
  19. ncbi request reprint The role of cellular migration in the repair process of gastric epithelial cells
    A Terano
    Department of Gastroenterology, Dokkyo University School of Medicine, Tochigi, Japan
    Life Sci 69:3083-9. 2001
    ..In this review, we also report that HGF plays a leading role in the mucosal repair after damage by using a novel cell culture model...
  20. ncbi request reprint The molecular basis for the alternative stable phenotype in a behavioral mutant of Paramecium tetraurelia
    A Matsuda
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Genes Genet Syst 76:289-94. 2001
    ..Therefore, the alternative phenotype of strain d4-662 seems to be caused by an alternative excision of the mutant IES...
  21. ncbi request reprint Distribution of soluble N-ethylmaleimide fusion protein attachment proteins (SNAPs) in the rat nervous system
    T Nishiki
    Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan
    Neuroscience 107:363-71. 2001
    ..From these results we suggest that both alpha- and beta-SNAP may play an important role in neurotransmitter release as well as in constitutive vesicular transport...
  22. ncbi request reprint Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts
    T Saitoh
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    FEBS Lett 509:365-9. 2001
    ..Our results suggest that myosin IIA may be highly activated by diphosphorylation of RLCs and primarily involved in cell migration...
  23. ncbi request reprint Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue
    C M Halleux
    Endocrinology and Metabolism Unit, University of Louvain, UCL 5530 Avenue Hippocrate, 55, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 288:1102-7. 2001
    ..This regulation could contribute to the decreased apM1/ApN levels in insulin-resistant patients with obesity and the Metabolic Syndrome...
  24. ncbi request reprint Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transfer
    S Iyama
    Sapporo Medical University School of Medicine, Japan
    Arthritis Rheum 44:2160-7. 2001
    ..50 +/- 1.13 and 4.13 +/- 1.88 in the untreated and transgene-treated groups, respectively; P < 0.05). CONCLUSION: These results indicate that EC-SOD gene transfer may be an effective form of therapy for rheumatoid arthritis...
  25. ncbi request reprint Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats
    T Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Rokkodai-cho, Nada-ku, Kobe, Japan
    J Neurochem 79:903-13. 2001
    ..These results suggest that the constitutively active 55-kDa fragment of PKN does not contribute to apoptosis, but may contribute to a function of microglia/macrophages...
  26. ncbi request reprint Highly polymerized procyanidins in brown soybean seed coat with a high radical-scavenging activity
    Y Takahata
    National Agricultural Research Center for Kyushu Okinawa Region, National Agricultural Research Organization (KONARC/NARO, Nishigoshi, Kumamoto 861-1192, Japan
    J Agric Food Chem 49:5843-7. 2001
    ..Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis showed that the degree of polymerization (DP) of the procyanidins contained in the brown or black soybean seed coat was as high as DP30...
  27. pmc Guillain-Barré syndrome associated with central nervous system lesions
    A Okumura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan Department of Pediatrics, Kamo Hospital, Japan
    Arch Dis Child 86:304-6. 2002
    ..Her symptoms resolved within two months. Subsequent magnetic resonance imaging revealed cavity formation in the deep white matter and atrophic changes in the right occipital lobes...
  28. ncbi request reprint Ecological and genetic effects of cutting in an Alnus trabeculosa Hand.-Mazz. (Betulaceae) population
    N Miyamoto
    Hokkaido Regional Breeding Office, Forest Tree Breeding Center, 561 Midori machi, Bunkyodai, Ebetsu, Hokkaido 069 0836, Japan
    Heredity (Edinb) 91:331-6. 2003
    ....
  29. ncbi request reprint Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus Anellovirus
    M Ninomiya
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi, Japan
    Arch Virol 152:1961-75. 2007
    ..These results indicate that TTMDV with a circular DNA genome of 3.2 kb, has an extremely high degree of genomic variability, and is classifiable into a third group in the genus Anellovirus...
  30. ncbi request reprint Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer
    H Yoshitake
    Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan
    Int J Gynecol Cancer 17:1300-6. 2007
    ....
  31. ncbi request reprint Predictive population pharmacokinetic/pharmacodynamic model for a novel COX-2 inhibitor
    S Rohatagi
    Clinical Pharmacology and Pharmacokinetics, Daiichi Sankyo Pharma Development, 399 Thornall Street, 11th Floor, Edison, NJ 08837, USA
    J Clin Pharmacol 47:358-70. 2007
    ..There was good correlation between COX-1 inhibition and the incidence of 7-day gastroduodenal mucosal injury. A dose of less than 25 mg bid could be adequate to inhibit COX-2 activity with a low risk of gastrointestinal mucosal injury...
  32. ncbi request reprint Development of a rapid strain differentiation method for methicillin-resistant Staphylococcus aureus isolated in Japan by detecting phage-derived open-reading frames
    M Suzuki
    Department of Microbiology, Aichi Prefectural Institute of Public Health, Tsuji machi, Kita ku, Nagoya, Japan
    J Appl Microbiol 101:938-47. 2006
    ..To develop a rapid genotyping method for investigating outbreaks of methicillin-resistant strains of Staphylococcus aureus (MRSA) isolated in Japan...
  33. ncbi request reprint Large haematoxylin-stainable keratohyaline granules in solar keratoses: immunohistochemical comparison using anti-Ted-H-1 antibody and antiloricrin antibody
    M Takahashi
    Department of Dermatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Br J Dermatol 153:976-80. 2005
    ..This finding indicated that the Ted-H-1 antigenic protein is a haematoxylin-stainable protein in KHG...
  34. ncbi request reprint Effect of prostaglandin E2, lipopolysaccharide, IFN-gamma and cytokines on the generation and function of fast-DC
    L Alldawi
    First Department of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan
    Cytotherapy 7:195-202. 2005
    ..We compared the ability of various maturation stimuli with the generation of Ag-specific T-cell responses and generation of functional fast-DC...
  35. ncbi request reprint Association of clinical features with HLA in chronic pulmonary thromboembolism
    N Tanabe
    Dept of Respirology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuou ku, Chiba 260 8670, Japan
    Eur Respir J 25:131-8. 2005
    ..These observations suggested that both the susceptibility and clinical characteristics of chronic thromboembolic pulmonary hypertension were controlled in part by the HLA-B and -DPB1 loci...
  36. pmc Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development
    Y Shoji
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Gut 53:1151-8. 2004
    ..In the present study, we examined expression of PGE(2) receptor subtypes EP(1), EP(2), EP(3), and EP(4) in normal colon mucosa and colon cancers, and assessed the contribution of EP(3) to colon cancer development...
  37. ncbi request reprint Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4
    N Obuchi
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Tissue Antigens 57:520-35. 2001
    ..MICA*048, which was different in exon 5 from MICA*008, was identified in an HLA-B61 homozygous cell (TA21), while MICA*00901 identified in HLA-B51 homozygous cells (LUY and KT2) was distinguished from MICA*009 by exon 6...
  38. ncbi request reprint Stable maintenance of duplicated chromosomes carrying the mutant pwB gene in Paramecium tetraurelia
    A Matsuda
    Institute of Biological Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan
    Genet Res 78:1-12. 2001
    ....
  39. ncbi request reprint Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction
    K Kurokawa
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Oncogene 20:1929-38. 2001
    ....
  40. ncbi request reprint A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis
    T Igakura
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Dev Biol 194:152-65. 1998
    ..In conclusion, basigin is an important cell-surface molecule involved in early embryogenesis and reproduction...
  41. ncbi request reprint Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice
    S Nakatsugi
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 88:1117-20. 1997
    ..The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity...
  42. ncbi request reprint Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase
    N Nakamura
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565, Japan
    J Biol Chem 272:15834-40. 1997
    ..This orientation of PIG-L protein is consistent with the notion that the second step of GPI anchor biosynthesis occurs on the cytoplasmic side of the endoplasmic reticulum...
  43. ncbi request reprint Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus sp
    M Takahashi
    Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 272:3437-43. 1997
    ..soil strain selected on fructosyl adamantanamine and induced by fructosyl propylamine. In contrast to previous described enzymes, these novel amadoriase enzymes can deglycate both glycated amines and amino acids...
  44. ncbi request reprint [Evolution of susceptibilities of Campylobacter jejuni isolated from diarrhoeal cases to fluoroquinolones in Tokyo]
    K Tadano
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 70:1227-33. 1996
    ..The susceptibility to TC was variable, and MICs gave a bimobal distribution, as pointed out previously. The resistance pattern of NFLX, OFLX, CPFX and NA were observed most frequently in those isolates...
  45. ncbi request reprint Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria
    J Takeda
    Department of Immunoregulation, Osaka University, Japan
    Cell 73:703-11. 1993
    ..We localized PIG-A to the X chromosome, which accounts for expression of the recessive phenotype of the somatic mutation and the fact that the same one of the multiple biosynthetic steps is affected in all patients so far characterized...
  46. ncbi request reprint [Serological study of Campylobacter jejuni infections in patients with Guillain-Barré syndrome]
    M Takahashi
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
    Kansenshogaku Zasshi 68:467-73. 1994
    ..0%) of the 8 patients without any symptoms, respectively. These findings support that there may be a close relationship between C. jejuni infection and the GBS with preceding diarrhea...
  47. ncbi request reprint The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis
    T Miyata
    Department of Immunoregulation, Osaka University, Japan
    Science 259:1318-20. 1993
    ..PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis...
  48. pmc Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex
    T Kaidoh
    Proc Natl Acad Sci U S A 78:3794-8. 1981
    ..The recombination frequency between the C4-Bp locus and the S region was 0.017. By phenotyping appropriate intra-H-2 recombinants of three different backgrounds (B10, A, and HT), this locus was assigned to the right of the H-2D region...
  49. ncbi request reprint Structural polymorphism of murine factor B controlled by a locus closely linked to the H-2 complex and demonstration of multiple alleles
    S Natsuume-Sakai
    Immunogenetics 18:117-24. 1983
    ..The results indicated that murine Bf was controlled by a single codominant locus located close to the H-2 complex because no mouse showing recombination between Bf locus and S locus was found...
  50. ncbi request reprint Structural polymorphism of mouse complement C2 detected by microscale peptide mapping: linkage to H-2
    S Takahashi
    Immunogenetics 19:493-501. 1984
    ..It is concluded that an H-2-linked codominant locus controls the structure of mouse complement C2, further confirming the extensive homology of the major histocompatibility complex among higher vertebrate species...
  51. ncbi request reprint [The serotype distribution of Campylobacter jejuni strains among gastroenteritis in hospitals over 7 year period in Tokyo]
    K Saito
    Tokyo Metropolitan Research Laboratory for Public Health
    Kansenshogaku Zasshi 64:787-93. 1990
    ..Serogroups TCK 1, 7, 4 and 21 were consistently the common serogroups every year during the 7 year study. Isolation frequency of serogroup TCK 30 have increased remarkably since 1986, while TCK 23, 14 and 9 have decreased...
  52. ncbi request reprint [Serological studies on Campylobacter jejuni/coli: establishment of national reference system for serological typing in Japan]
    K Saito
    Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 66:340-8. 1992
    ..We conclude from the experiment described above that this Lior's serogrouping system by combining with TCK serogroup for Campylobacter jejuni/coli is useful in epidemiological investigations in Japan...
  53. ncbi request reprint Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2k mice
    S Pattanakitsakul
    Department of Immunobiology, Cancer Research Institute, Kanazawa University, Japan
    J Biol Chem 267:7814-20. 1992
    ....
  54. pmc Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopes
    R Yamaguchi
    Central Research Laboratories, Ajinomoto Co, Inc, Kawasaki, Japan
    Infect Immun 60:1210-6. 1992
    ..This mapping method would be useful in the development of a subunit vaccine consisting of an immunodominant B-cell epitope linked to a T-cell epitope in the vicinity...
  55. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..The importance of IL-1ra both in normal physiology and under stress is also suggested...
  56. ncbi request reprint The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
    M Takahashi
    The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037 1099, USA
    Development 125:4417-25. 1998
    ..Our data suggest the existence of a negative feedback loop between Alx-4 and Shh during vertebrate limb outgrowth...
  57. ncbi request reprint Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates
    Y Endo
    Department of Biochemistry, Fukushima Medical College, Japan
    J Immunol 161:4924-30. 1998
    ..Furthermore, the presence of MASP or MASP-like sequences in most vertebrate species suggests that the lectin pathway functions extensively in vertebrates and that its origin is traced back to the invertebrate stage...
  58. ncbi request reprint Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes
    M Takahashi
    Laboratory of Plant Molecular Physiology, The University of Tokyo, Tokyo 113-8657, Japan
    Nat Biotechnol 19:466-9. 2001
    ..Consequently, the transgenic rice showed an enhanced tolerance to low iron availability and had 4.1 times greater grain yields than that of the nontransformant rice in an alkaline soil...
  59. ncbi request reprint G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entry
    T Blackmer
    Department of Molecular Pharmacology and Biological Chemistry, Department of Physiology, Northwestern University Institute for Neuroscience, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Science 292:293-7. 2001
    ..Thus, Gbetagamma blocked neurotransmitter release downstream of Ca2+ entry and may directly target the exocytotic fusion machinery at the presynaptic terminal...
  60. ncbi request reprint Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C
    M Matsumoto
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:14400-6. 2001
    ..These results suggest that epsilonKD inhibits the insulin-induced phosphorylation and activation of Akt by interfering with the ability of PDK1 to phosphorylate Akt...
  61. ncbi request reprint Role of Thr(11) in the binding of omega-conotoxin MVIIC to N-type Ca2+ channels
    K Minami
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan
    FEBS Lett 491:127-30. 2001
    ..Inhibition of Ba2+ current by the analogs did not completely correlate with binding affinity, although binding to BHK cells was comparable to rat cerebellar membranes...
  62. ncbi request reprint Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line
    M Nishioka
    Biology Division National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 19:6251-60. 2000
    ....
  63. ncbi request reprint Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese
    M Takahashi
    Department of Molecular Pathogenesis, Division of Adult Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Tissue Antigens 57:66-9. 2001
    ..We found no association at all between the TNFR2 polymorphism and any autoimmune diseases including SLE in Japanese...
  64. ncbi request reprint Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy
    T Arimura
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Hum Genet 107:440-51. 2000
    ..92-20.29), while this association was not found in familial IDC patients (n=24). These observations suggest that the nebulette polymorphism in the actin-binding motif was a novel genetic marker of susceptibility to nonfamilial IDC...
  65. ncbi request reprint Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line
    M Ohira
    Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
    Oncogene 19:4302-7. 2000
    ..Full-sequencing and gene prediction for the region of homozygous deletion would elucidate more detailed structure of this region and might lead to discovery of additional candidate genes. Oncogene (2000) 19, 4302 - 4307..
  66. ncbi request reprint Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP
    M Takahashi
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 275:34592-6. 2000
    ..These results suggest that CG-NAP anchors hypophosphorylated PKCepsilon at the Golgi/centrosome area during maturation and serves as a scaffold for the phosphorylation reaction...
  67. pmc TOM1, an Arabidopsis gene required for efficient multiplication of a tobamovirus, encodes a putative transmembrane protein
    T Yamanaka
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Proc Natl Acad Sci U S A 97:10107-12. 2000
    ..Taken into account that the tobamovirus replication complex is associated with membranes, we propose that TOM1 participates in the in vivo formation of the replication complex by serving as a membrane anchor...
  68. ncbi request reprint Identification of the familial cylindromatosis tumour-suppressor gene
    G R Bignell
    1 Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 25:160-5. 2000
    ..CYLD also has sequence homology to the catalytic domain of ubiquitin carboxy-terminal hydrolases (UCH)...
  69. ncbi request reprint Nerve growth factor-induced phosphorylation of SNAP-25 in PC12 cells: a possible involvement in the regulation of SNAP-25 localization
    M Kataoka
    Project Research Center, Mitsubishikasei Institute of Life Sciences, Tokyo, Japan
    J Neurochem 74:2058-66. 2000
    ..Our results suggest a close temporal relationship between the up-regulation of SNAP-25 phosphorylation and its relocation, and NGF-induced differentiation of PC12 cells...
  70. ncbi request reprint P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice
    K Yokogawa
    Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Japan
    Pharm Res 16:1213-8. 1999
    ..This study was performed to evaluate the involvement of P-glycoprotein in disposition kinetics of tacrolimus (FK506), a substrate of P-glycoprotein, in the body...
  71. ncbi request reprint 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia
    K Toyooka
    National Saigata Hospital, Ogata, Japan
    Am J Med Genet 88:164-7. 1999
    ..3, 95% CI = 1.1-9.7). The 14-3-3 eta chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia...
  72. ncbi request reprint Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patients
    T Sato
    Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Hum Mol Genet 8:99-106. 1999
    ....
  73. ncbi request reprint Genetic polymorphism of murine C3 controlled by a single co-dominant locus on chromosome 17
    S Natsuume-Sakai
    J Immunol 121:491-8. 1978