Research Topics
| Morio TakahashiSummaryAffiliation: Dokkyo University School of Medicine Country: Japan Publications
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Detail Information
Publications
Reversal of the tolerance phenomenon by the intermittent administration of a histamine H2-receptor antagonistMorio Takahashi
Department of Gastroenterology and Hepatology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan
J Gastroenterol Hepatol 25:1493-7. 2010..pylori) infection prevents the occurrence of tolerance to H2RA. In the present study, we investigated whether intermittent (every other day) administration prevents the tolerance phenomenon in H. pylori-negative patients...
The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblastsM Takahashi
Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan
Aliment Pharmacol Ther 14:44-9. 2000..However, despite the bacterium's toxicity, the majority of H. pylori infections are not accompanied by gastric ulcers. This implies the existence of a host mechanism offsetting H. pylori toxicity...- Gastric restitution is inhibited by dexamethasone, which is reversed by hepatocyte growth factor and rebamipideM Takahashi
Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan
Aliment Pharmacol Ther 18:126-32. 2003..HGF expression is induced by PGs in gastric fibroblasts. We hypothesized that dexamethasone (DEX) may inhibit PG production and HGF expression, thus inhibiting HGF-induced gastric epithelial restitution... - Proton pump inhibitors and recurrent bleeding in peptic ulcer diseaseAkihiro Tajima
Department of Gastroenterology, Dokkyo Medical University, Koshigaya Hospital, Koshigaya, Japan
J Gastroenterol Hepatol 23:S237-41. 2008..The metabolism of PPIs is dependent upon P450 2C19 genotypes and the clinical usefulness of genotypic analysis remains to be determined... - [PPI-test]Morio Takahashi
Department of Gastroenterology, Koshigaya Hospital, Dokkyo University School of Medicine
Nihon Rinsho 65:852-63. 2007..This diagnostic entity is practical in a sense that anti-acid treatment is very effective for this disease. Besides, PPI test is a very useful tool to differentiate acid associated disorder from GERD and/or FD... - Effects of rabeprazole or famotidine during cardiac surgery on perioperative gastric and esophageal pH readingsShigeyoshi Gon
Department of Cardiovascular Surgery, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
Jpn J Thorac Cardiovasc Surg 54:278-84. 2006..CONCLUSION: The FAM group and RPZ group revealed a sufficient effect of gastric acid suppression. It was indicated that FAM had an insufficient effect of gastric acid suppression for HP-negative patients... - [Polaprezinc]Hajime Kuwayama
Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University School of Medicine
Nippon Rinsho 60:717-20. 2002 - Helicobacter pylori causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophagesYasumi Katayama
Department of Gastroenterology and Hepatology, Dokkyo Medical University, Koshigaya Hospital, Saitama, Japan
Biochem Biophys Res Commun 388:496-500. 2009..Additionally, we demonstrated that lipopolysaccharide, as well as H. pylori, induces NO-mediated methylation, indicating that other inflammation inducers beside H. pylori might induce aberrant methylation of runx3... - [Significance of PPI-test in the diagnosis of GERD]Morio Takahashi
Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine
Nippon Rinsho 62:1465-74. 2004..Characteristics of PPI-test including extra-esophageal GERD diagnosis are discussed in this review... - [Continuation of acid suppression therapy after H. pylori eradication]Morio Takahashi
Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University of Medicine
Nippon Rinsho 60:531-5. 2002 - Protective effect of n-3 polyunsaturated fatty acid on primary culture of rat hepatocytesRyoichi Sohma
Koshigaya Division of Clinical Research, Institute for Medical Science, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
J Gastroenterol Hepatol 22:1965-70. 2007..In this study we examined the effect of EPA on rat hepatocytes in primary culture... - [Complication of peptic ulcer disease]Hajime Kuwayama
Department of Gastroenterology and Hepatology, Koshigaya Hospital, Dokkyo University School of Medicine
Nippon Rinsho 60:357-61. 2002 - Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barré syndromeM Koga
Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Neurology 65:1376-81. 2005..A C jejuni gene, cst-II, involved in the biosynthesis of ganglioside-like lipo-oligosaccharide, shows a polymorphism (Asn/Thr51) that affects ganglioside epitopes... - [Guillain-barré syndrome associated Campylobacter jejuni serotype Penner 2: a case report]M Watanabe
Department of Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital, 3-15 Mori-machi, Nagasaki 852-8511, Japan
No To Shinkei 53:759-62. 2001..In general, C. jejuni with the serotype Penner 19 has been isolated from many GBS patients. In this patient, C. jejuni with the serotype of Penner 2 was isolated. The serotype is detected commonly in Miller Fisher syndrome... - Haem oxygenase-1 prevents cell death by regulating cellular ironC D Ferris
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Cell Biol 1:152-7. 1999..Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability... - [Anti-GQ1b IgG-negative case of overlapping Fisher's and Gullain-Barré syndromes after Campylobacter jejuni (PEN 19) enteritis]Y Hayashi
Department of Neurology, National Okayama Medical Center
Rinsho Shinkeigaku 41:801-4. 2001..jejuni, the isolate from our case belonged to PEN 19. C. jejuni serotype may be associated with clinical manifestations and anti-ganglioside antibody species... - Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathiesK Kimoto
Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan
Neurology 67:1837-43. 2006.... - Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicryM Koga
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Neurology 64:1605-11. 2005..To assess the production mechanism of anti-GQ1b autoantibody in Fisher syndrome (FS)... - The role of cellular migration in the repair process of gastric epithelial cellsA Terano
Department of Gastroenterology, Dokkyo University School of Medicine, Tochigi, Japan
Life Sci 69:3083-9. 2001..In this review, we also report that HGF plays a leading role in the mucosal repair after damage by using a novel cell culture model... - The molecular basis for the alternative stable phenotype in a behavioral mutant of Paramecium tetraureliaA Matsuda
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
Genes Genet Syst 76:289-94. 2001..Therefore, the alternative phenotype of strain d4-662 seems to be caused by an alternative excision of the mutant IES... - Distribution of soluble N-ethylmaleimide fusion protein attachment proteins (SNAPs) in the rat nervous systemT Nishiki
Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan
Neuroscience 107:363-71. 2001..From these results we suggest that both alpha- and beta-SNAP may play an important role in neurotransmitter release as well as in constitutive vesicular transport... - Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblastsT Saitoh
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
FEBS Lett 509:365-9. 2001..Our results suggest that myosin IIA may be highly activated by diphosphorylation of RLCs and primarily involved in cell migration... - Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissueC M Halleux
Endocrinology and Metabolism Unit, University of Louvain, UCL 5530 Avenue Hippocrate, 55, B 1200 Brussels, Belgium
Biochem Biophys Res Commun 288:1102-7. 2001..This regulation could contribute to the decreased apM1/ApN levels in insulin-resistant patients with obesity and the Metabolic Syndrome... - Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transferS Iyama
Sapporo Medical University School of Medicine, Japan
Arthritis Rheum 44:2160-7. 2001..50 +/- 1.13 and 4.13 +/- 1.88 in the untreated and transgene-treated groups, respectively; P < 0.05). CONCLUSION: These results indicate that EC-SOD gene transfer may be an effective form of therapy for rheumatoid arthritis... - Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in ratsT Ueyama
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Rokkodai-cho, Nada-ku, Kobe, Japan
J Neurochem 79:903-13. 2001..These results suggest that the constitutively active 55-kDa fragment of PKN does not contribute to apoptosis, but may contribute to a function of microglia/macrophages... - Highly polymerized procyanidins in brown soybean seed coat with a high radical-scavenging activityY Takahata
National Agricultural Research Center for Kyushu Okinawa Region, National Agricultural Research Organization (KONARC/NARO, Nishigoshi, Kumamoto 861-1192, Japan
J Agric Food Chem 49:5843-7. 2001..Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis showed that the degree of polymerization (DP) of the procyanidins contained in the brown or black soybean seed coat was as high as DP30... 
Guillain-Barré syndrome associated with central nervous system lesionsA Okumura
Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan Department of Pediatrics, Kamo Hospital, Japan
Arch Dis Child 86:304-6. 2002..Her symptoms resolved within two months. Subsequent magnetic resonance imaging revealed cavity formation in the deep white matter and atrophic changes in the right occipital lobes...- Ecological and genetic effects of cutting in an Alnus trabeculosa Hand.-Mazz. (Betulaceae) populationN Miyamoto
Hokkaido Regional Breeding Office, Forest Tree Breeding Center, 561 Midori machi, Bunkyodai, Ebetsu, Hokkaido 069 0836, Japan
Heredity (Edinb) 91:331-6. 2003.... - Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus AnellovirusM Ninomiya
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi, Japan
Arch Virol 152:1961-75. 2007..These results indicate that TTMDV with a circular DNA genome of 3.2 kb, has an extremely high degree of genomic variability, and is classifiable into a third group in the genus Anellovirus... - Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancerH Yoshitake
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan
Int J Gynecol Cancer 17:1300-6. 2007.... - Predictive population pharmacokinetic/pharmacodynamic model for a novel COX-2 inhibitorS Rohatagi
Clinical Pharmacology and Pharmacokinetics, Daiichi Sankyo Pharma Development, 399 Thornall Street, 11th Floor, Edison, NJ 08837, USA
J Clin Pharmacol 47:358-70. 2007..There was good correlation between COX-1 inhibition and the incidence of 7-day gastroduodenal mucosal injury. A dose of less than 25 mg bid could be adequate to inhibit COX-2 activity with a low risk of gastrointestinal mucosal injury... - Development of a rapid strain differentiation method for methicillin-resistant Staphylococcus aureus isolated in Japan by detecting phage-derived open-reading framesM Suzuki
Department of Microbiology, Aichi Prefectural Institute of Public Health, Tsuji machi, Kita ku, Nagoya, Japan
J Appl Microbiol 101:938-47. 2006..To develop a rapid genotyping method for investigating outbreaks of methicillin-resistant strains of Staphylococcus aureus (MRSA) isolated in Japan... - Large haematoxylin-stainable keratohyaline granules in solar keratoses: immunohistochemical comparison using anti-Ted-H-1 antibody and antiloricrin antibodyM Takahashi
Department of Dermatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
Br J Dermatol 153:976-80. 2005..This finding indicated that the Ted-H-1 antigenic protein is a haematoxylin-stainable protein in KHG... - Effect of prostaglandin E2, lipopolysaccharide, IFN-gamma and cytokines on the generation and function of fast-DCL Alldawi
First Department of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan
Cytotherapy 7:195-202. 2005..DISCUSSION: fast-DC are very effective; they not only reduce the labor, cost and time required for in vitro DC development, but may also represent a model more closely resembling DC differentiation from monocytes in vivo... - Association of clinical features with HLA in chronic pulmonary thromboembolismN Tanabe
Dept of Respirology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuou ku, Chiba 260 8670, Japan
Eur Respir J 25:131-8. 2005..These observations suggested that both the susceptibility and clinical characteristics of chronic thromboembolic pulmonary hypertension were controlled in part by the HLA-B and -DPB1 loci... - Downregulation of prostaglandin E receptor subtype EP3 during colon cancer developmentY Shoji
Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
Gut 53:1151-8. 2004..In the present study, we examined expression of PGE(2) receptor subtypes EP(1), EP(2), EP(3), and EP(4) in normal colon mucosa and colon cancers, and assessed the contribution of EP(3) to colon cancer development... - Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift-deletion in exon 4N Obuchi
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Tissue Antigens 57:520-35. 2001..MICA*048, which was different in exon 5 from MICA*008, was identified in an HLA-B61 homozygous cell (TA21), while MICA*00901 identified in HLA-B51 homozygous cells (LUY and KT2) was distinguished from MICA*009 by exon 6... - Stable maintenance of duplicated chromosomes carrying the mutant pwB gene in Paramecium tetraureliaA Matsuda
Institute of Biological Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan
Genet Res 78:1-12. 2001.... - Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transductionK Kurokawa
Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Oncogene 20:1929-38. 2001.... - A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesisT Igakura
Department of Biochemistry, Nagoya University School of Medicine, Japan
Dev Biol 194:152-65. 1998..In conclusion, basigin is an important cell-surface molecule involved in early embryogenesis and reproduction... - Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min miceS Nakatsugi
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo
Jpn J Cancer Res 88:1117-20. 1997..The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity... - Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylaseN Nakamura
Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565, Japan
J Biol Chem 272:15834-40. 1997..This orientation of PIG-L protein is consistent with the notion that the second step of GPI anchor biosynthesis occurs on the cytoplasmic side of the endoplasmic reticulum... - Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus spM Takahashi
Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 272:3437-43. 1997..soil strain selected on fructosyl adamantanamine and induced by fructosyl propylamine. In contrast to previous described enzymes, these novel amadoriase enzymes can deglycate both glycated amines and amino acids... - [Evolution of susceptibilities of Campylobacter jejuni isolated from diarrhoeal cases to fluoroquinolones in Tokyo]K Tadano
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
Kansenshogaku Zasshi 70:1227-33. 1996..The susceptibility to TC was variable, and MICs gave a bimobal distribution, as pointed out previously. The resistance pattern of NFLX, OFLX, CPFX and NA were observed most frequently in those isolates... - Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuriaJ Takeda
Department of Immunoregulation, Osaka University, Japan
Cell 73:703-11. 1993..We localized PIG-A to the X chromosome, which accounts for expression of the recessive phenotype of the somatic mutation and the fact that the same one of the multiple biosynthetic steps is affected in all patients so far characterized... - [Serological study of Campylobacter jejuni infections in patients with Guillain-Barré syndrome]M Takahashi
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
Kansenshogaku Zasshi 68:467-73. 1994..0%) of the 8 patients without any symptoms, respectively. These findings support that there may be a close relationship between C. jejuni infection and the GBS with preceding diarrhea... - The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesisT Miyata
Department of Immunoregulation, Osaka University, Japan
Science 259:1318-20. 1993..PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis... - Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complexT Kaidoh
Proc Natl Acad Sci U S A 78:3794-8. 1981..The recombination frequency between the C4-Bp locus and the S region was 0.017. By phenotyping appropriate intra-H-2 recombinants of three different backgrounds (B10, A, and HT), this locus was assigned to the right of the H-2D region... - Structural polymorphism of murine factor B controlled by a locus closely linked to the H-2 complex and demonstration of multiple allelesS Natsuume-Sakai
Immunogenetics 18:117-24. 1983..The results indicated that murine Bf was controlled by a single codominant locus located close to the H-2 complex because no mouse showing recombination between Bf locus and S locus was found... - Structural polymorphism of mouse complement C2 detected by microscale peptide mapping: linkage to H-2S Takahashi
Immunogenetics 19:493-501. 1984..It is concluded that an H-2-linked codominant locus controls the structure of mouse complement C2, further confirming the extensive homology of the major histocompatibility complex among higher vertebrate species... - [The serotype distribution of Campylobacter jejuni strains among gastroenteritis in hospitals over 7 year period in Tokyo]K Saito
Tokyo Metropolitan Research Laboratory for Public Health
Kansenshogaku Zasshi 64:787-93. 1990..Serogroups TCK 1, 7, 4 and 21 were consistently the common serogroups every year during the 7 year study. Isolation frequency of serogroup TCK 30 have increased remarkably since 1986, while TCK 23, 14 and 9 have decreased... - [Serological studies on Campylobacter jejuni/coli: establishment of national reference system for serological typing in Japan]K Saito
Tokyo Metropolitan Research Laboratory of Public Health
Kansenshogaku Zasshi 66:340-8. 1992..We conclude from the experiment described above that this Lior's serogrouping system by combining with TCK serogroup for Campylobacter jejuni/coli is useful in epidemiological investigations in Japan... - Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2k miceS Pattanakitsakul
Department of Immunobiology, Cancer Research Institute, Kanazawa University, Japan
J Biol Chem 267:7814-20. 1992.... - Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopesR Yamaguchi
Central Research Laboratories, Ajinomoto Co, Inc, Kawasaki, Japan
Infect Immun 60:1210-6. 1992..This mapping method would be useful in the development of a subunit vaccine consisting of an immunodominant B-cell epitope linked to a T-cell epitope in the vicinity... - Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretionR Horai
Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
J Exp Med 187:1463-75. 1998..The importance of IL-1ra both in normal physiology and under stress is also suggested... - The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb developmentM Takahashi
The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037 1099, USA
Development 125:4417-25. 1998..Our data suggest the existence of a negative feedback loop between Alx-4 and Shh during vertebrate limb outgrowth... - Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebratesY Endo
Department of Biochemistry, Fukushima Medical College, Japan
J Immunol 161:4924-30. 1998..Furthermore, the presence of MASP or MASP-like sequences in most vertebrate species suggests that the lectin pathway functions extensively in vertebrates and that its origin is traced back to the invertebrate stage... - Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genesM Takahashi
Laboratory of Plant Molecular Physiology, The University of Tokyo, Tokyo 113-8657, Japan
Nat Biotechnol 19:466-9. 2001..Consequently, the transgenic rice showed an enhanced tolerance to low iron availability and had 4.1 times greater grain yields than that of the nontransformant rice in an alkaline soil... - G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entryT Blackmer
Department of Molecular Pharmacology and Biological Chemistry, Department of Physiology, Northwestern University Institute for Neuroscience, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
Science 292:293-7. 2001..Thus, Gbetagamma blocked neurotransmitter release downstream of Ca2+ entry and may directly target the exocytotic fusion machinery at the presynaptic terminal... - Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase CM Matsumoto
Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 276:14400-6. 2001..These results suggest that epsilonKD inhibits the insulin-induced phosphorylation and activation of Akt by interfering with the ability of PDK1 to phosphorylate Akt... - Role of Thr(11) in the binding of omega-conotoxin MVIIC to N-type Ca2+ channelsK Minami
Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan
FEBS Lett 491:127-30. 2001..Inhibition of Ba2+ current by the analogs did not completely correlate with binding affinity, although binding to BHK cells was comparable to rat cerebellar membranes... - Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell lineM Nishioka
Biology Division National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
Oncogene 19:6251-60. 2000.... - Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in JapaneseM Takahashi
Department of Molecular Pathogenesis, Division of Adult Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Tissue Antigens 57:66-9. 2001..We found no association at all between the TNFR2 polymorphism and any autoimmune diseases including SLE in Japanese... - Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathyT Arimura
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Japan
Hum Genet 107:440-51. 2000..92-20.29), while this association was not found in familial IDC patients (n=24). These observations suggest that the nebulette polymorphism in the actin-binding motif was a novel genetic marker of susceptibility to nonfamilial IDC... - Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell lineM Ohira
Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
Oncogene 19:4302-7. 2000..Full-sequencing and gene prediction for the region of homozygous deletion would elucidate more detailed structure of this region and might lead to discovery of additional candidate genes. Oncogene (2000) 19, 4302 - 4307.. - Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAPM Takahashi
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 275:34592-6. 2000..These results suggest that CG-NAP anchors hypophosphorylated PKCepsilon at the Golgi/centrosome area during maturation and serves as a scaffold for the phosphorylation reaction... - TOM1, an Arabidopsis gene required for efficient multiplication of a tobamovirus, encodes a putative transmembrane proteinT Yamanaka
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
Proc Natl Acad Sci U S A 97:10107-12. 2000..Taken into account that the tobamovirus replication complex is associated with membranes, we propose that TOM1 participates in the in vivo formation of the replication complex by serving as a membrane anchor... - Identification of the familial cylindromatosis tumour-suppressor geneG R Bignell
1 Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
Nat Genet 25:160-5. 2000..CYLD also has sequence homology to the catalytic domain of ubiquitin carboxy-terminal hydrolases (UCH)... - Nerve growth factor-induced phosphorylation of SNAP-25 in PC12 cells: a possible involvement in the regulation of SNAP-25 localizationM Kataoka
Project Research Center, Mitsubishikasei Institute of Life Sciences, Tokyo, Japan
J Neurochem 74:2058-66. 2000..Our results suggest a close temporal relationship between the up-regulation of SNAP-25 phosphorylation and its relocation, and NGF-induced differentiation of PC12 cells... - P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout miceK Yokogawa
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Japan
Pharm Res 16:1213-8. 1999..This study was performed to evaluate the involvement of P-glycoprotein in disposition kinetics of tacrolimus (FK506), a substrate of P-glycoprotein, in the body... - 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophreniaK Toyooka
National Saigata Hospital, Ogata, Japan
Am J Med Genet 88:164-7. 1999..3, 95% CI = 1.1-9.7). The 14-3-3 eta chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia... - Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patientsT Sato
Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
Hum Mol Genet 8:99-106. 1999.... - Genetic polymorphism of murine C3 controlled by a single co-dominant locus on chromosome 17S Natsuume-Sakai
J Immunol 121:491-8. 1978