Keisuke Suzuki

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Co-occurrence of multiple cerebral infarctions due to hypercoagulability associated with malignancy and meningeal carcinomatosis as the initial manifestation of gastric cancer
    Akiko Kawasaki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga 321 0293, Tochigi, Japan
    BMC Neurol 14:160. 2014
  2. pmc Sleep disturbances associated with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Parkinsons Dis 2011:219056. 2011
  3. ncbi request reprint Snoring is associated with an impaired motor function, disease severity and the quality of life but not with excessive daytime sleepiness in patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Japan
    Intern Med 52:863-9. 2013
  4. ncbi request reprint Hypothermia, hypotension, hypersomnia, and obesity associated with hypothalamic lesions in a patient positive for the anti-aquaporin 4 antibody: a case report and literature review
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Arch Neurol 69:1355-9. 2012
  5. ncbi request reprint Nocturnal disturbances and restlessness in Parkinson's disease: using the Japanese version of the Parkinson's disease sleep scale-2
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    J Neurol Sci 318:76-81. 2012
  6. ncbi request reprint Extensive callosal infarction showing difficulty in knitting as an initial symptom
    Keisuke Suzuki
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya
    Intern Med 47:1431-5. 2008
  7. doi request reprint Excessive daytime sleepiness and sleep episodes in Japanese patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    J Neurol Sci 271:47-52. 2008
  8. ncbi request reprint Magnetic resonance images in rhombencephalitis due to Listeria monocytogenes mimicking Wernicke encephalopathy
    Keisuke Suzuki
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya
    Intern Med 47:817-8. 2008
  9. doi request reprint Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Parkinsonism Relat Disord 15:15-9. 2009
  10. doi request reprint Circadian variation of core body temperature in Parkinson disease patients with depression: a potential biological marker for depression in Parkinson disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Neuropsychobiology 56:172-9. 2007

Detail Information

Publications83

  1. ncbi request reprint Co-occurrence of multiple cerebral infarctions due to hypercoagulability associated with malignancy and meningeal carcinomatosis as the initial manifestation of gastric cancer
    Akiko Kawasaki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga 321 0293, Tochigi, Japan
    BMC Neurol 14:160. 2014
    ..The co-occurrence of meningeal carcinomatosis and cerebral infarction related to hypercoagulability associated with malignancy in an individual as the initial manifestation of malignancy has not been previously reported...
  2. pmc Sleep disturbances associated with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Parkinsons Dis 2011:219056. 2011
    ..In the present paper, we review the current literature concerning sleep disorders in PD...
  3. ncbi request reprint Snoring is associated with an impaired motor function, disease severity and the quality of life but not with excessive daytime sleepiness in patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Japan
    Intern Med 52:863-9. 2013
    ..The aim of this study was to investigate the relationship between snoring and its clinical correlates in patients with PD...
  4. ncbi request reprint Hypothermia, hypotension, hypersomnia, and obesity associated with hypothalamic lesions in a patient positive for the anti-aquaporin 4 antibody: a case report and literature review
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Arch Neurol 69:1355-9. 2012
    ..To describe a patient positive for the anti-aquaporin 4 antibody with hypothalamic lesions showing hypothermia, hypotension, hypersomnia, and obesity...
  5. ncbi request reprint Nocturnal disturbances and restlessness in Parkinson's disease: using the Japanese version of the Parkinson's disease sleep scale-2
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    J Neurol Sci 318:76-81. 2012
    ..The aim of this study was to assess the validity and the reliability of the Japanese version of the Parkinson's disease sleep scale (PDSS)-2 and to use this scale to identify nocturnal symptoms and their impact on patient's quality of life...
  6. ncbi request reprint Extensive callosal infarction showing difficulty in knitting as an initial symptom
    Keisuke Suzuki
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya
    Intern Med 47:1431-5. 2008
    ..We suggest that difficulty in knitting may be an important early manifestation of a callosal disconnection syndrome and that follow-up clinical and imaging examinations would contribute to confirmation of the diagnosis...
  7. doi request reprint Excessive daytime sleepiness and sleep episodes in Japanese patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    J Neurol Sci 271:47-52. 2008
    ..ESS score of >or=10 had 75% sensitivity and 82.4% specificity for sleep episodes. These results suggest that sleepiness in PD is dependent on disease itself and dopaminergic treatment rather than nocturnal disturbances...
  8. ncbi request reprint Magnetic resonance images in rhombencephalitis due to Listeria monocytogenes mimicking Wernicke encephalopathy
    Keisuke Suzuki
    Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya
    Intern Med 47:817-8. 2008
  9. doi request reprint Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Parkinsonism Relat Disord 15:15-9. 2009
    ....
  10. doi request reprint Circadian variation of core body temperature in Parkinson disease patients with depression: a potential biological marker for depression in Parkinson disease
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Neuropsychobiology 56:172-9. 2007
    ..For early diagnosis or clarification of the pathologic condition of comorbidity of depression and PD, the present study investigated the presence of circadian rhythm abnormalities in patients with depression...
  11. doi request reprint The core body temperature rhythm is altered in progressive supranuclear palsy
    Keisuke Suzuki
    Dept of Neurology, Dokkyo Medical University, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi, Japan
    Clin Auton Res 19:65-8. 2009
    ..We measured circadian rhythmicity in rectal temperature change and found that the amplitude of body temperature was significantly reduced in patients with progressive supranuclear palsy compared to those with Parkinson disease...
  12. ncbi request reprint Dilated fourth ventricle on brain computed tomography scan in the diagnosis of Chiari I malformation with syringomyelia
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Intern Med 47:185-6. 2008
  13. ncbi request reprint Lymphocytic hypophysitis accompanied by aseptic meningitis mimics subacute meningoencephalitis
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Japan
    Intern Med 50:2025-30. 2011
    ..A diagnosis of lymphocytic hypophysitis with aseptic meningitis was made after the exclusion of secondary hypophysitis. Lymphocytic hypophysitis with aseptic meningitis can mimic subacute meningoencephalitis...
  14. ncbi request reprint Insulinoma with early-morning abnormal behavior
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Intern Med 46:405-8. 2007
    ..Hypoglycemia caused by insulinoma should be considered as one of the mechanisms underlying abnormal nocturnal behaviors since the symptoms are very similar to those of sleep-related epilepsy, parasomnia, and night delirium...
  15. ncbi request reprint Nocturnal hypersalivation caused by distigmine bromide in a patient with multiple system atrophy
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi
    Intern Med 47:983-4. 2008
  16. pmc Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson's disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    BMC Neurol 13:18. 2013
    ..Increasing evidence provides a clear association between rapid eye movement sleep behavior disorders (RBD) and Parkinson's disease (PD), but the clinical features that determine the co-morbidity of RBD and PD are not yet fully understood...
  17. ncbi request reprint Characteristics of sleep disturbances in Japanese patients with Parkinson's disease. A study using Parkinson's disease sleep scale
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Mov Disord 22:1245-51. 2007
    ..We speculate that the reduction of neurotransmitters involved in the sleep-wakefulness mechanism and degeneration of neurons progress together in parallel with deterioration of motor function...
  18. ncbi request reprint Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy
    Atsushi Hashizume
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Brain 135:2838-48. 2012
    ....
  19. ncbi request reprint Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy
    Haruhiko Banno
    Department of Neurology, Nagoya University Graduate School of Medicine, Aichi, Japan
    Ann Neurol 65:140-50. 2009
    ..Animal studies have shown that the pathogenesis of SBMA is dependent on serum testosterone level. This study is aimed at evaluating the efficacy and safety of androgen deprivation by leuprorelin acetate in patients with SBMA...
  20. ncbi request reprint Myeloperoxidase-antineutrophil cytoplasmic antibody-related crescentic glomerulonephritis after treatment for clinically amyopathic dermatomyositis: a coincidental combination or not?
    Hirohisa Kawai
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute cyo, Aichi 480 1195, Japan
    Clin Exp Nephrol 15:577-81. 2011
    ..This case is the first English language report of MPO-ANCA-related crescentic glomerulonephritis in a patient who had recovered from CADM...
  21. ncbi request reprint Myeloperoxidase anti-cytoplasmic antibody related crescentic glomerulonephritis in a patient with IgG3λ monoclonal immunoglobulin deposition disease with membranous features
    Ayano Ito
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
    Intern Med 51:2393-7. 2012
    ..This is the first English-language case report describing MPO-ANCA positive crescentic glomerulonephritis in a patient demonstrating monoclonal immunoglobulin deposition disease with mainly membranous features...
  22. doi request reprint Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials
    Tetsuo Hama
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya 466 8550, Japan
    Muscle Nerve 45:169-74. 2012
    ..We hypothesized that a sensory nerve conduction study (NCS) could be used to discriminate SBMA from ALS...
  23. doi request reprint Odor identification test as an indicator of idiopathic REM sleep behavior disorder
    Tomoyuki Miyamoto
    Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Mov Disord 24:268-73. 2009
    ..The results suggest that OSIT-J, which is a short and simple nonlexical olfactory identification test, can be useful as a clinical indicator for iRBD with Lewy body formation and is appropriate in the Japanese elderly population...
  24. doi request reprint Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Japan
    Cephalalgia 33:868-78. 2013
    ..However, the relationship between migraine and REM sleep behaviour disorder (RBD) remains unclear...
  25. ncbi request reprint Glomerular tip adhesions predict the progression of IgA nephropathy
    Kunihiro Maeda
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Aichi 480 1195, Japan
    BMC Nephrol 14:272. 2013
    ..This single center, retrospective cohort study was designed to clarify which clinical and pathological factors are predictive of decreased estimated glomerular filtration rate (eGFR) at 5 and 10 years in IgA nephropathy patients...
  26. pmc 123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder
    Tomoyuki Miyamoto
    Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Sleep 31:717-23. 2008
    ..We tested whether the degree of accumulation of cardiac 123I-MIBG scintigraphy can distinguish the clinical syndromes associated with Lewy body-related disease from the syndrome of PSP (a tauopathy) and MSA...
  27. ncbi request reprint Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lancet Neurol 9:875-84. 2010
    ..We aimed to assess the efficacy and safety of leuprorelin for spinal and bulbar muscular atrophy...
  28. doi request reprint Comparison of severity of obstructive sleep apnea and degree of accumulation of cardiac 123I-MIBG radioactivity as a diagnostic marker for idiopathic REM sleep behavior disorder
    Tomoyuki Miyamoto
    Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321 0293, Japan
    Sleep Med 10:577-80. 2009
    ..We investigated cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphic assessment as a supportive diagnostic indicator for idiopathic REM sleep behavior disorder (RBD) complicated by moderate to severe obstructive sleep apnea (OSA)...
  29. ncbi request reprint [Obese woman presenting as vocal cord abductor paralysis and floppy arytenoid associated with early signs of multiple system atrophy]
    Hideki Sakuta
    Department of Neurology, Dokkyo Medical University
    Rinsho Shinkeigaku 52:421-4. 2012
    ..We suggest that detection of VCAP and laryngopharyngeal abnormalities such as floppy arytenoid in the early stage of MSA is important for determining treatment options...
  30. doi request reprint Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy
    Tomoo Mano
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Muscle Nerve 46:692-7. 2012
    ..The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA...
  31. doi request reprint Evaluation of contributing factors to restless legs syndrome in migraine patients
    Shiho Suzuki
    Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    J Neurol 258:2026-35. 2011
    ..These findings may provide a better understanding of RLS pathogenesis in migraine...
  32. ncbi request reprint The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy
    Keisuke Suzuki
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 81:567-71. 2010
    ..It is, however, difficult to evaluate clinically the degree of motor neuron degeneration, which stresses the need for biomarkers to detect the remaining neuronal function...
  33. ncbi request reprint Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA)
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Adv Exp Med Biol 685:64-74. 2010
    ..Results of animal studies suggest that androgen deprivation and activation of protein quality control systems are potential therapies for SBMA...
  34. ncbi request reprint Isolated body lateropulsion in a patient with pontine infarction
    Madoka Okamura
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    J Stroke Cerebrovasc Dis 22:e247-9. 2013
    ..However, it has rarely been reported in pontine lesions. We suggest that physicians should be aware that pontine lesions can cause isolated body lateropulsion without other neurological deficits...
  35. ncbi request reprint Clinicopathological analysis of glomerulopathy with fibronectin deposits (GFND): a case of sporadic, elderly-onset GFND with codeposition of IgA, C1q, and fibrinogen
    Masabumi Yoshino
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
    Intern Med 52:1715-20. 2013
    ..Anti-fibronectin immunostaining demonstrated that the subendothelial deposits were positive for fibronectin. The administration of prednisolone and mizoribine improved the nephrotic syndrome. ..
  36. doi request reprint Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Prog Neurobiol 99:246-56. 2012
    ..Pharmacological activation of cellular defense machineries, such as molecular chaperones, ubiquitin-proteasome system, and autophagy, also exerts neuroprotective effects in experimental models of SBMA...
  37. pmc Correlation between severity of obstructive sleep apnea and prevalence of silent cerebrovascular lesions
    Momoka Nishibayashi
    Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University, Tochigi, Japan
    J Clin Sleep Med 4:242-7. 2008
    ..We investigated the prevalence of silent cerebrovascular lesions in patients with obstructive sleep apnea (OSA) and the correlation between OSA severity and prevalence of silent cerebrovascular lesions in Japanese patients...
  38. doi request reprint Difference in chronological changes of outcome measures between untreated and placebo-treated patients of spinal and bulbar muscular atrophy
    Atsushi Hashizume
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol 259:712-9. 2012
    ..These findings should be thoroughly considered when designing clinical trials for slowly progressive neurodegenerative diseases such as SBMA...
  39. ncbi request reprint Walking capacity evaluated by the 6-minute walk test in spinal and bulbar muscular atrophy
    Yu Takeuchi
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Muscle Nerve 38:964-71. 2008
    ..982). In a 1-year follow-up the 6MWD significantly decreased at a rate of 11.3% per year. Our observations suggest that the 6MWT is a biomarker that can be used to monitor progression of motor impairment in SBMA...
  40. ncbi request reprint Brugada syndrome in spinal and bulbar muscular atrophy
    Amane Araki
    From the Department of Neurology A A, M K, K S, H B, N S, A H, T Mano, Y H, H N, H W, G S, Nagoya University Graduate School of Medicine Institute for Advanced Research H B, Nagoya University Department of Speech Pathology and Audiology M Y, Aichi Gakuin University School of Health Science, Nisshin Department of Cardiovascular Medicine T Makiyama, Kyoto University Graduate School of Medicine Department of Cardiovascular and Respiratory Medicine S O, M F, M H, Shiga University of Medical Science, Ohtsu and Division of Cardiology S i M, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
    Neurology 82:1813-21. 2014
    ..The aim of this study was to clarify myocardial involvement and its clinical implications in subjects with spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease affecting both neuronal and nonneuronal tissues...
  41. doi request reprint Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm
    Seiya Tanaka
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan Department of Speech Pathology and Audiology, Aichi Gakuin University School of Health Science, 12 Araike, Iwasaki cho, Nisshin 470 0195, Japan
    J Neurol Sci 337:193-200. 2014
    ..The purpose of the study was to analyze the voice characteristics of SBMA patients with laryngospasm using acoustic voice analysis...
  42. doi request reprint Isolated shoulder palsy due to cortical infarction: a case report and literature review of clinicoradiological correlations
    Akiko Kawasaki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    J Stroke Cerebrovasc Dis 22:e687-90. 2013
    ..In line with the previous reports, a responsible cortical lesion in our patient corresponded to motor shoulder area in the motor homunculus reported to be located more medially to the hand area. ..
  43. pmc Current status of treatment of spinal and bulbar muscular atrophy
    Fumiaki Tanaka
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neural Plast 2012:369284. 2012
    ..Other treatments targeted for mitochondrial function, ubiquitin-proteasome system (UPS), and autophagy could be applicable for all types of polyglutamine diseases...
  44. ncbi request reprint [The impact of sleep disturbances on neuroendocrine and autonomic functions]
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University
    Nihon Rinsho 70:1169-76. 2012
    ..Additionally, we discuss the effect of sleep curtailment on the risk of developing metabolic diseases such as diabetes and obesity...
  45. ncbi request reprint [Sleep disturbances in patients with Parkinson disease]
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan
    Brain Nerve 64:342-55. 2012
    ..In this review, we discuss the current understanding of sleep disturbances in PD and the existing treatments...
  46. ncbi request reprint Influence of barometric pressure in patients with migraine headache
    Kazuhito Kimoto
    Department of Neurology, Dokkyo Medical University, Japan
    Intern Med 50:1923-8. 2011
    ..The relationship between barometric pressure changes and migraine headaches was prospectively examined...
  47. ncbi request reprint Molecular pathophysiology and disease-modifying therapies for spinal and bulbar muscular atrophy
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Arch Neurol 69:436-40. 2012
    ..Pathogenic AR-induced myopathy also contributes to the degeneration of motor neurons. Several potential therapies, including hormonal manipulation, have emerged from animal studies, some of which have been tested in clinical trials...
  48. ncbi request reprint Hypocomplementemic urticarial vasculitis syndrome is associated with high levels of serum IgG4: a clinical manifestation that mimics IgG4-related disease
    Ryo Wakamatsu
    Department of Internal Medicine, Department of Clinical Pathology, Aichi Medical University School of Medicine, Japan
    Intern Med 50:1109-12. 2011
    ..A chromosomal analysis of an enlarged lymph node, without phytohemagglutinin (PHA) stimulation, demonstrated that one in every three analyzed cells had abnormalities, such as 44, XX, -13, add(15)(p11), -17, -17, and mar...
  49. ncbi request reprint Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3
    Noriaki Suga
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuropathol Appl Neurobiol 40:628-39. 2014
    ..Although the loss of neurones in the dorsal root ganglion (DRG) has been postulated to be the cause of this neuropathy, the precise mechanism remains to be elucidated...
  50. pmc Neuropathology and therapeutic intervention in spinal and bulbar muscular atrophy
    Haruhiko Banno
    Department of Neurology, Nagoya University Graduate School of Medicine, Showa Ku, Japan
    Int J Mol Sci 10:1000-12. 2009
    ..Heat shock proteins, ubiquitin-proteasome system and transcriptional regulation are also potential targets of therapy development for SBMA...
  51. ncbi request reprint [Diagnosis and novel treatment approaches in restless legs syndrome: I. Pathophysiology and diagnosis]
    Koichi Hirata
    Department of Neurology, Dokkyo Medical University
    Brain Nerve 65:1185-97. 2013
    ....
  52. ncbi request reprint [A 56-year-old woman with adult-onset ophthalmoplegic migraine presenting with recurrent bilateral abducens nerve palsy]
    Ayaka Numao
    Department of Neurology, Dokkyo Medical University
    Rinsho Shinkeigaku 52:239-44. 2012
    ..There have been a few similar case reports of adult patients with OM showing left and right abducens nerve palsy at different time points. In this case report, we discuss the possible mechanisms related to OM...
  53. ncbi request reprint [Disease-modifying therapy for spinal and bulbar muscular atrophy (SBMA)]
    Keisuke Suzuki
    Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    Brain Nerve 64:237-44. 2012
    ..To optimize translational research related to the process of testing candidate therapies in humans, it is important to identify biomarkers that can be used as surrogate endpoints in clinical trials for neurodegenerative diseases...
  54. doi request reprint Progressive renal failure despite long-term biweekly enzyme replacement therapy in a patient with Fabry disease secondary to a new α-galactosidase mutation of Leu311Arg (L311R)
    Keisuke Suzuki
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Clin Exp Nephrol 15:916-20. 2011
    ..Patients with Fabry disease have been reported to have a mean decrease in GFR of 12.2 ± 8.1 mL/min/1.73 m(2) per year. This result suggests that biweekly ERT is only mildly effective at preventing loss of kidney function...
  55. ncbi request reprint [Neurosarcoidosis presenting with severe hyposmia and polyradiculopathy]
    Madoka Okamura
    Department of Neurology, Dokkyo Medical University
    Rinsho Shinkeigaku 53:821-6. 2013
    ..Methylprednisolone pulse therapy improved the olfactory and sensory disturbances. Neurosarcoidosis should be considered in the differential diagnosis of olfactory impairment. ..
  56. ncbi request reprint Gemcitabine-induced hemolytic uremic syndrome mimicking scleroderma renal crisis presenting with Raynaud's phenomenon, positive antinuclear antibodies and hypertensive emergency
    Yuichiro Yamada
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
    Intern Med 53:445-8. 2014
    ..Gemcitabine induces hemolytic uremic syndrome with accelerated hypertension and Raynaud's phenomenon, mimicking scleroderma renal crisis. ..
  57. doi request reprint Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA)
    Haruhiko Banno
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Tissue Res 349:313-20. 2012
    ..These observations suggest that pharmacological inhibition of the toxic accumulation of mutant AR is a potential therapy for SBMA...
  58. ncbi request reprint [Molecular-targeted therapy for motor neuron disease]
    Haruhiko Banno
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Brain Nerve 61:891-900. 2009
    ..Oral administration of sodium butyrate--a histone deacetylase inhibitor--resulted in the improvement of neurological dysfunction in the SBMA mouse model, although its therapeutic dose range is narrow...
  59. doi request reprint Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurosci 30:5702-12. 2010
    ..The present study thus indicates that disruption of TGF-beta due to the transcriptional dysregulation of TbetaRII is associated with polyglutamine-induced motor neuron damage in SBMA...
  60. ncbi request reprint [A 62-year-old woman presenting with progressive nonfluent aphasia, apraxia of eyelid opening, supranuclear gaze palsy, and asymmetric rigidity]
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Tochigi, Japan
    Brain Nerve 63:884-9. 2011
    ....
  61. doi request reprint Acute peritonitis due to Corynebacterium ulcerans in a patient receiving continuous ambulatory peritoneal dialysis: a case report and literature review
    Yukihiro Kimura
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute cho, Aichi 480 1195, Japan
    Clin Exp Nephrol 15:171-4. 2011
    ..ulcerans, which may produce diphtheria toxin, be resistant to multiple antibiotics, and frequently become recurrent...
  62. doi request reprint A case of chronic kidney disease with thrombotic microangiopathy in a hematopoietic stem cell transplant recipient
    Kunihiro Maeda
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute cyo, Aichi, 480 1195, Japan
    Clin Exp Nephrol 14:474-8. 2010
    ..His kidney function is stable on immunosuppressive drugs at 2 years after transplantation. This report reflects the growing number of patients with chronic kidney disease with thrombotic microangiopathy all over the world...
  63. ncbi request reprint [Diagnosis and novel treatment approaches in restless legs syndrome: II. Treatment]
    Koichi Hirata
    Department of Neurology, Dokkyo Medical University
    Brain Nerve 65:1391-9. 2013
    ..In this review, we focus on the pathophysiology, comorbidity, differential diagnosis, and novel treatment approaches of RLS...
  64. ncbi request reprint [Case of unilateral thalamo-mesencephalic infarction with enlargement to bilateral vertical gaze palsy due to vertical one-and-a-half syndrome]
    Keisuke Suzuki
    Department of Neurology, Dokkyo Medical University, Mibu, Tochigi, Japan
    Brain Nerve 60:92-6. 2008
    ..Since there are various patterns of ocular movement disorder in the thalamo-mesencephalic portion, careful observations are required to localize the lesions...
  65. ncbi request reprint [Pathophysiology of restless legs syndrome]
    Masayuki Miyamoto
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Brain Nerve 61:523-32. 2009
    ..In conclusion, disturbances in the central dopaminergic system, disturbances in iron metabolism, and genetics seem to be the primary factors in the pathophysiology of RLS...
  66. doi request reprint Pathogenesis-targeting therapeutics for spinal and bulbar muscular atrophy (SBMA)
    Keisuke Suzuki
    Department of Neurology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Neuropathology 29:509-16. 2009
    ..Advances in basic and clinical research on SBMA are now paving the way for clinical application of pathogenesis-targeting therapeutics...
  67. doi request reprint Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies
    Hitoshi Watanabe
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute cyo, Aichi 480 1195, Japan
    Clin Exp Nephrol 14:598-601. 2010
    ..This case is an uncommon example of combined double antibody-positive crescentic glomerulonephritis and refractory TTP...
  68. ncbi request reprint CAG repeat size correlates to electrophysiological motor and sensory phenotypes in SBMA
    Keisuke Suzuki
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain 131:229-39. 2008
    ..In conclusion, our results suggest that there are unequivocal electrophysiological phenotypes influenced by CAG repeat size in SBMA...
  69. ncbi request reprint [Paradigm shift in clinical trials for neurodegenerative diseases]
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Brain Nerve 59:367-74. 2007
    ..The striking success of androgen deprivation therapy in SBMA mouse models has been translated into phase 2, and then phase 3, clinical trials...
  70. doi request reprint Risk factor profiles of stroke, myocardial infarction, and atrial fibrillation: a Japanese Multicenter Cooperative Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 19:190-7. 2010
    ....
  71. ncbi request reprint Acute renal failure due to IgM-lambda glomerular thrombi and MPGN-like lesions in a patient with angioimmunoblastic T-Cell lymphoma
    Naoto Miura
    Department of Internal Medicine, Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Aichi, Japan
    Am J Kidney Dis 48:e3-9. 2006
    ..These findings suggest that cryoglobulin, which consists of monoclonal IgM-lambda, induced glomerular thrombi and acute renal failure in a patient with angioimmunoblastic T-cell lymphoma...
  72. ncbi request reprint Comparative analysis of systolic and isolated diastolic dysfunction: Sado heart failure study
    Mahmoud M Ramadan
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int Heart J 49:459-69. 2008
    ..769-4.808]) was independently associated with SD. In conclusion, some factors/comorbidities were more likely to associate with IDD (female gender, stroke, and malignancy) or SD (previous MI) when IDD and SD were compared with each other...
  73. ncbi request reprint Systolic dysfunction in urban Japan
    Mahmoud M Ramadan
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:349-57. 2008
    ....
  74. ncbi request reprint Relationship between number of present teeth and nutritional intake in institutionalized elderly
    Keisuke Suzuki
    Department of Epidemiology and Public Health, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    Bull Tokyo Dent Coll 46:135-43. 2005
    ..This study found that recovery of chewing ability in seniors was essential not only to maintain nutritional status, but also to fully bring out all the functions of the foods themselves...
  75. ncbi request reprint Follow-up for patients with obstructive sleep apnea syndrome using a portable recording device
    Seiko Miyata
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 69:37-43. 2007
    ..It may prove to be a useful tool for following up patients...
  76. ncbi request reprint Characterization of outpatients with systolic dysfunction in a Japanese community by total enumeration
    Yuji Okura
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi, Niigata, Japan
    Circ J 71:1004-12. 2007
    ..Management of patients with systolic dysfunction (SD) is important for prevention of CHF, but there is little information regarding the burden of SD on Japanese communities...
  77. ncbi request reprint The Japan Thrombosis Registry for Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE): a nation-wide, prospective large cohort study; the study design
    Hideki Origasa
    Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 72:991-7. 2008
    ....
  78. ncbi request reprint Characterization of outpatients with isolated diastolic dysfunction and evaluation of the burden in a Japanese community: Sado Heart Failure Study
    Yuji Okura
    Division of Cardiology, First Department of Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi, Niigata, Japan
    Circ J 71:1013-21. 2007
    ..However, very little information is available about such patients in the Japanese community...
  79. ncbi request reprint Impending epidemic: future projection of heart failure in Japan to the year 2055
    Yuji Okura
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:489-91. 2008
    ..The future burden of heart failure in Japan was projected to 2055 in order to prospectively estimate of the number of these patients...
  80. ncbi request reprint Plasma concentrations of cytokines and neurohumoral factors in a case of fulminant myocarditis successfully treated with intravenous immunoglobulin and percutaneous cardiopulmonary support
    Satoru Abe
    Division of Cardiology, Hematology and Endocrinology Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi, Niigata, Japan
    Circ J 68:1223-6. 2004
    ..Immunological parameters in those who have been treated with IVIG and PCPS and survived without complications are of great value for evaluation of the therapy. Further analysis with more cases in a multicenter study is necessary...