K Kangawa

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint A new natriuretic peptide in porcine brain
    T Sudoh
    Department of Biochemistry, Miyazaki Medical College, Japan
    Nature 332:78-81. 1988
  2. ncbi request reprint Identification of a 29-amino acid natriuretic peptide in chicken heart
    A Miyata
    Department of Biochemistry, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 155:1330-7. 1988
  3. ncbi request reprint Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients
    T Ishimitsu
    Department of Cardiovascular Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    Clin Exp Pharmacol Physiol 26:500-4. 1999
  4. ncbi request reprint Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka 565, Japan
    Am J Physiol Heart Circ Physiol 279:H3031-9. 2000
  5. ncbi request reprint Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues
    M Matsumoto
    Suntory Institute for Medicinal Research and Development, 2716-1 Kurakake, Akaiwa, Chiyoda-machi, Ohra-gun, Gunma 370-0503, Japan
    Biochem Biophys Res Commun 284:655-9. 2001
  6. ncbi request reprint Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Pharmacol Ther 111:909-27. 2006
  7. doi request reprint Combination of angiotensin II receptor antagonist with calcium channel blocker or diuretic as antihypertensive therapy for patients with chronic kidney disease
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Clin Exp Hypertens 33:366-72. 2011
  8. ncbi request reprint Urinary excretion of liver fatty acid-binding protein in health-check participants
    Toshihiko Ishimitsu
    Department of Cardiovascular Medicine, Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Clin Exp Nephrol 9:34-9. 2005
  9. ncbi request reprint Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene
    T Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 321 0293, Mibu, Tochigi, Japan
    Peptides 22:1739-44. 2001
  10. ncbi request reprint Variations of human adrenomedullin gene and its relation to cardiovascular diseases
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hypertens Res 26:S129-34. 2003

Collaborators

Detail Information

Publications74

  1. ncbi request reprint A new natriuretic peptide in porcine brain
    T Sudoh
    Department of Biochemistry, Miyazaki Medical College, Japan
    Nature 332:78-81. 1988
    ..The occurrence of BNP with ANP in mammalian brain suggests the possibility that the physiological functions so far thought to be mediated by ANP may be regulated through a dual mechanism involving both ANP and BNP...
  2. ncbi request reprint Identification of a 29-amino acid natriuretic peptide in chicken heart
    A Miyata
    Department of Biochemistry, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 155:1330-7. 1988
    ..However, maximum homology was observed when the peptide was compared with a recently identified porcine brain natriuretic peptide (BNP)...
  3. ncbi request reprint Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients
    T Ishimitsu
    Department of Cardiovascular Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    Clin Exp Pharmacol Physiol 26:500-4. 1999
    ..p.m. in the combination therapy (P < 0.02). 5. These results suggest slow pharmacokinetics of amlodipine provides an advantage in controlling morning blood pressure and mitigating reflex activation of the sympathetic nervous system...
  4. ncbi request reprint Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka 565, Japan
    Am J Physiol Heart Circ Physiol 279:H3031-9. 2000
    ....
  5. ncbi request reprint Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues
    M Matsumoto
    Suntory Institute for Medicinal Research and Development, 2716-1 Kurakake, Akaiwa, Chiyoda-machi, Ohra-gun, Gunma 370-0503, Japan
    Biochem Biophys Res Commun 284:655-9. 2001
    ..Replacement of 3rd and 4th amino acid residues to D-isomer suggested that the N-terminal dipeptide contributes to shape the biologically active geometry by effecting conformation of residues in positions 3 and 4...
  6. ncbi request reprint Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Pharmacol Ther 111:909-27. 2006
    ..Because of the potential clinical benefits of AM, indications for use and optimal dosing strategies should be established...
  7. doi request reprint Combination of angiotensin II receptor antagonist with calcium channel blocker or diuretic as antihypertensive therapy for patients with chronic kidney disease
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Clin Exp Hypertens 33:366-72. 2011
    ..5 mg in terms of blood control. The former combination is considered advantageous for maintaining renal function and artery wall elasticity without influencing uric acid or lipid metabolism...
  8. ncbi request reprint Urinary excretion of liver fatty acid-binding protein in health-check participants
    Toshihiko Ishimitsu
    Department of Cardiovascular Medicine, Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Clin Exp Nephrol 9:34-9. 2005
    ..We analyzed factors relating to the urinary L-FABP excretion in health-check participants...
  9. ncbi request reprint Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene
    T Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 321 0293, Mibu, Tochigi, Japan
    Peptides 22:1739-44. 2001
    ..8%; 13 repeats, 33.1%; 14 repeats, 35.0% and 19 repeats, 3.1%. This DNA variation does not seem to affect the transcription of the AM gene, because plasma concentrations of AM were not significantly different between the genotypes...
  10. ncbi request reprint Variations of human adrenomedullin gene and its relation to cardiovascular diseases
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hypertens Res 26:S129-34. 2003
    ..It is suggested that existence of the 19-repeat allele is associated with genetic predispositions to develop essential hypertension and diabetic nephropathy...
  11. ncbi request reprint Protective effects of an angiotensin II receptor blocker and a long-acting calcium channel blocker against cardiovascular organ injuries in hypertensive patients
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    Hypertens Res 28:351-9. 2005
    ....
  12. ncbi request reprint Increased cardiovascular risk in long-term hemodialysis patients carrying deletion allele of ACE gene polymorphism
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Kidney Dis 44:466-75. 2004
    ....
  13. ncbi request reprint Effects of valsartan on the progression of chronic renal insufficiency in patients with nondiabetic renal diseases
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertens Res 28:865-70. 2005
    ....
  14. ncbi request reprint Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Kidney Int 63:2230-5. 2003
    ..In this study, we investigated the association between DNA variations in AM gene and the predisposition to develop nephropathy in type 2 diabetes mellitus...
  15. ncbi request reprint Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats
    Toshihiko Ishimitsu
    Department of Hypetension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Am J Hypertens 19:1233-40. 2006
    ..The objective of this study was to evaluate the effect of year-long antihypertensive therapy with a calcium channel blocker and an angiotensin-converting enzyme (ACE) inhibitor on cardiac and renal injury...
  16. ncbi request reprint Benazepril slows progression of renal dysfunction in patients with non-diabetic renal disease
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Nephrology (Carlton) 12:294-8. 2007
    ..The present study examined the effects of benazepril, an angiotensin-converting enzyme inhibitor, on the progression of renal insufficiency in patients with non-diabetic renal disease...
  17. ncbi request reprint Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 30:621-6. 2007
    ..A further large-scale clinical trial will be needed in order to apply the findings of this study to the treatment of patients with renal disease...
  18. doi request reprint Predictive significance of blood pressure values for the incidence of cardiovascular events in chronic hemodialysis patients
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 31:1703-9. 2008
    ..In conclusion, PP is a better predictor of death and cardiovascular events than other blood pressure values in chronic hemodialysis patients...
  19. doi request reprint Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension
    Toshihiko Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 32:962-8. 2009
    ..These properties may provide cardiovascular protection in addition to the hypotensive effect...
  20. ncbi request reprint Microsatellite DNA polymorphism of human adrenomedullin gene in normotensive subjects and patients with essential hypertension
    T Ishimitsu
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertension 38:9-12. 2001
    ..In conclusion, microsatellite DNA polymorphism of AM gene may be associated with the genetic predisposition to EH, although the gene expression is not likely to be affected by the genotypes...
  21. ncbi request reprint Effect of a hypocaloric diet on adrenomedullin and natriuretic peptides in obese patients with essential hypertension
    J Minami
    Department of Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    J Cardiovasc Pharmacol 36:S83-6. 2000
    ..These vasodilator peptides may act against further elevation in blood pressure in obese patients with essential hypertension...
  22. ncbi request reprint Two molecular forms of plasma adrenomedullin during tilt test in healthy subjects
    T Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 321 0293, Mibu, Tochigi, Japan
    Peptides 22:1867-72. 2001
    ..These findings may support the hypothesis that plasma AM is secreted in a constitutive manner from the vascular wall...
  23. ncbi request reprint Production and clearance sites of two molecular forms of adrenomedullin in human plasma
    T Nishikimi
    Research Institute, National Cardiovascular Center, Fujishirodai, Suita, Osaka
    Am J Hypertens 13:1032-4. 2000
    ..Considering that AM preferentially dilates pulmonary vessels rather than systemic vessels, a possible role of this peptide is suggested in the regulation of pulmonary vascular tonus...
  24. ncbi request reprint Role of increased circulating and renal adrenomedullin in rats with malignant hypertension
    T Nishikimi
    Research Institute, Fujishirodai, Suita, Osaka 565, Japan
    Am J Physiol Regul Integr Comp Physiol 281:R2079-87. 2001
    ....
  25. ncbi request reprint Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure
    T Nishikimi
    Research Institute, National Cardiovascular Centre, Osaka, Japan
    J Hypertens 19:765-73. 2001
    ....
  26. ncbi request reprint The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension
    T Nishikimi
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Sci (Lond) 100:61-6. 2001
    ....
  27. ncbi request reprint Glucocorticoid regulation of adrenomedullin in a rat model of endotoxic shock
    Y Hattori
    Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Life Sci 62:PL181-9. 1998
    ..Our studies demonstrate that glucocorticoid upregulates the expression and secretion of AM in vivo, and endogenous glucocorticoid is required for increased AM secretion under certain conditions such as endotoxic shock...
  28. ncbi request reprint Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene
    T Shindo
    Department of Cardiovascular Medicine, University of Tokyo, and Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan
    Circulation 104:1964-71. 2001
    ..Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice...
  29. ncbi request reprint Elevation of two molecular forms of adrenomedullin in plasma and urine in patients with acute myocardial infarction treated with early coronary angioplasty
    H Asakawa
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan
    Clin Sci (Lond) 100:117-26. 2001
    ....
  30. ncbi request reprint Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 194:720-5. 1993
    ..By RNA blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues including adrenal medulla, ventricle, lung and kidney as well as pheochromocytoma...
  31. ncbi request reprint Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro
    Y Tomoda
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, 565 8565, Osaka, Japan
    Cardiovasc Res 49:721-30. 2001
    ..These facts suggest that cardiac cells possess an autocrine/paracrine capability mediated by AM...
  32. ncbi request reprint Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    K Toshinai
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 281:1220-5. 2001
    ..Conversely, db/db mice, which are deficient in the leptin receptor, had lower ghrelin mRNA levels than control mice. These findings suggest that this novel gastrointestinal hormone plays a role in the regulation of energy balance...
  33. ncbi request reprint Hemodynamic and hormonal effects of human ghrelin in healthy volunteers
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka 565 - 8565, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1483-7. 2001
    ..In summary, human ghrelin elicited a potent, long-lasting GH release and had beneficial hemodynamic effects via reducing cardiac afterload and increasing cardiac output without an increase in heart rate...
  34. ncbi request reprint Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells
    I Makino
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, 814 0180, Japan
    Biochem Biophys Res Commun 288:515-20. 2001
    ..The results suggest that the increase in functional AM receptor during phenotypic change may in part contribute to the development of vascular lesions, such as in atherosclerosis...
  35. ncbi request reprint Cerebral endothelial cells are a major source of adrenomedullin
    B Kis
    Department of Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neuroendocrinol 14:283-93. 2002
    ..Cerebral endothelial cells are a potential source of adrenomedullin in the central nervous system, where adrenomedullin can also be involved in the regulation of neuroendocrine functions...
  36. ncbi request reprint Secretion of proadrenomedullin N-terminal 20 peptide from cultured neonatal rat cardiac cells
    T Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College Kihara, Kiyotake, Japan
    Life Sci 69:239-45. 2001
    ..These results suggest that PAMP is secreted along with AM from rat cardiac myocytes and fibroblasts, and the secretion is augmented by the growth-promoting stimuli of Ang II and FBS for these cells...
  37. ncbi request reprint Two molecular forms of adrenomedullin in congenital heart disease
    K Watanabe
    Department of Pediatrics, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Pediatr Cardiol 24:559-65. 2003
    ..These results suggest that plasma AM-m and AM-Gly are similarly regulated and the main clearance site of AM-m is the lung in patients with congenital heart disease...
  38. ncbi request reprint Receptors for adrenomedullin in human vascular endothelial cells
    J Kato
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Eur J Pharmacol 289:383-5. 1995
    ..These findings indicate that the cultured endothelial cells of human umbilical vein possess specific adrenomedullin receptors coupled with the adenylate cyclase activity that may have little affinity with CGRP...
  39. ncbi request reprint Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide
    J Sakata
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 195:921-7. 1993
    ..Synthetic rat adrenomedullin elicits a potent and long-lasting hypotensive activity in anesthetized rats...
  40. ncbi request reprint Genomic structure of human adrenomedullin gene
    T Ishimitsu
    Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 203:631-9. 1994
    ..These indicate that the human AM gene has components for its functional expression and that the expression may be subject to the activity of protein kinase C and the feedback from cAMP level...
  41. ncbi request reprint Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP)
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    FEBS Lett 351:35-7. 1994
    ..The present data indicate that PAMP is an endogenous biologically active peptide which is processed from adrenomedullin precursor...
  42. ncbi request reprint Immunoreactive adrenomedullin in human plasma
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    FEBS Lett 341:288-90. 1994
    ..Plasma immunoreactive adrenomedullin significantly increased in patients with hypertension, with a progressive rise proportionate to disease severity...
  43. ncbi request reprint Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma
    K Kitamura
    Department of First Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 192:553-60. 1993
    ..These data suggest that adrenomedullin is a new hormone participating in blood pressure control. Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control...
  44. ncbi request reprint Uroguanylin gene expression in the alimentary tract and extra-gastrointestinal tissues
    M Miyazato
    National Cardiovascular Center Research Institute, Osaka, Japan
    FEBS Lett 398:170-4. 1996
    ..Evidence for uroguanylin expression in extra-gastrointestinal tissues indicates the possible existence of a novel system for water and electrolyte homeostasis, and a more global effect of uroguanylin on epithelial cell function...
  45. ncbi request reprint Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase
    Y Nagatomo
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 223:539-43. 1996
    ..The present data suggest that NEP may be involved in the circulation control by degrading PAMP as well as ANP...
  46. ncbi request reprint Comparison of intravenous adrenomedullin with atrial natriuretic peptide in patients with congestive heart failure
    H Oya
    Department of Internal Medicine, Research Institute, Osaka, Japan
    Am J Cardiol 86:94-8. 2000
  47. ncbi request reprint Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion
    C B Djurhuus
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, University of Aarhus, Denmark
    Horm Metab Res 34:411-3. 2002
  48. ncbi request reprint Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure
    T Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Kyoto University Hospital, Japan
    J Endocrinol 188:333-44. 2006
    ..These observational associations warrant further experimental studies to clarify the physiologic significance of these effects...
  49. ncbi request reprint Identification of rat gamma atrial natriuretic polypeptide and characterization of the cDNA encoding its precursor
    K Kangawa
    Nature 312:152-5. 1984
    ..Differences in the rat and human precursor nucleotide sequences around the termination codons lead to a difference in processing pattern...
  50. ncbi request reprint Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats
    N Murakami
    Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889 2155, Japan
    J Endocrinol 174:283-8. 2002
    ....
  51. ncbi request reprint Effects of ghrelin on food intake and neuroendocrine function in sheep
    T Sugino
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima Shi, Hiroshima 739 8528, Japan
    Anim Reprod Sci 82:183-94. 2004
    ..This mini review describes mechanisms regulating ghrelin secretion at feeding time, and also focuses on the neuroendocrine functions of ghrelin...
  52. ncbi request reprint Adrenomedullin contributes to vascular hyporeactivity in cirrhotic rats with ascites via a release of nitric oxide
    H Kojima
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Scand J Gastroenterol 39:686-93. 2004
    ..Plasma levels of adrenomedullin, a potent vasodilator peptide, are increased in cirrhotic patients, whereas its role in vascular hyporeactivity in cirrhosis has not been clarified...
  53. ncbi request reprint A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep
    T Sugino
    High tech Research Center and Laboratory of Animal Nutrition, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada shi, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 295:255-60. 2002
    ....
  54. ncbi request reprint Adrenomedullin regulates blood-brain barrier functions in vitro
    B Kis
    Department of Physiology, University of Occupational and Environmental Health, Iseigaoka 1-1 Yahatanishi-ku, Kitakyushu 807-8555, Japan
    Neuroreport 12:4139-42. 2001
    ..AM treatment resulted in functional activation of P-glycoprotein efflux pump in vitro. Our results indicate that AM as an autocrine mediator plays an important role in the regulation of BBB properties of the cerebral endothelial cells...
  55. ncbi request reprint Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension
    Y Makino
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, 45 1, 7 chome Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Clin Endocrinol Metab 86:5079-82. 2001
    ..These findings suggested that the reduced expression of adrenomedullin receptor component in umbilical artery and uterus may have some role in PIH...
  56. ncbi request reprint Identification of amyloid prealbumin variant in familial amyloidotic polyneuropathy (Japanese type)
    S Tawara
    Biochem Biophys Res Commun 116:880-8. 1983
    ....
  57. ncbi request reprint Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)
    K Kangawa
    Biochem Biophys Res Commun 118:131-9. 1984
    ..Accordingly, we proposed a name "alpha-human atrial natriuretic polypeptide (alpha-hANP)" for the peptide. The complete amino acid sequence of the peptide has been established by microsequencing as well as synthesis...
  58. ncbi request reprint Catalytic site of rat liver and bovine heart fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase. Identification of fructose 6-phosphate binding site
    K Kitamura
    Research Service of the Veterans Administration Medical Center, Dallas, Texas 75216
    J Biol Chem 264:6344-8. 1989
    ....
  59. ncbi request reprint Cloning and sequence analysis of cDNA encoding a precursor for rat brain natriuretic peptide
    M Kojima
    Department of Biochemistry, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 159:1420-6. 1989
    ..Comparing sequences of precursors of ANP and BNP thus far identified, structural and processing features characteristic of the BNP family were discussed...
  60. ncbi request reprint Isolation and identification of human brain natriuretic peptides in cardiac atrium
    J Hino
    Department of Biochemistry, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 167:693-700. 1990
    ....
  61. ncbi request reprint Cloning and sequence analysis of complementary DNA encoding a precursor for chicken natriuretic peptide
    N Akizuki
    Department of Biochemistry, Miyazaki Medical College, Japan
    FEBS Lett 280:357-62. 1991
    ..However, a characteristic AT-rich nucleotide sequence commonly found in mammalian BNPs was also present in the 3'-untranslated region. Thus, chNP is concluded to be classified into the BNP-type...
  62. ncbi request reprint Purification, cDNA cloning, and expression of UDP-N-acetylglucosamine: beta-D-mannoside beta-1,4N-acetylglucosaminyltransferase III from rat kidney
    A Nishikawa
    Department of Biochemistry, Osaka University Medical School, Japan
    J Biol Chem 267:18199-204. 1992
    ..The GnT-III activity in transiently transfected COS-1 cells was found to be about 500-3600-fold as compared to that in non- or mock-transfected cells...
  63. ncbi request reprint A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 217:993-1000. 1995
    ..The ksGC contains in its N-terminal region a protein kinase-like domain, which is usually a characteristic feature only of particulate type guanylyl cyclases. This unique feature of ksGC suggests a novel pathway of cGMP synthesis...
  64. ncbi request reprint Plasma adrenomedullin in patients with primary aldosteronism
    K Kato
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Am J Hypertens 8:997-1000. 1995
    ..Judging from the potent hypotensive activity of AM, the present findings suggest that AM participates in defense mechanisms acting against the elevation of blood pressure in the patients with PA...
  65. ncbi request reprint cDNA cloning of canine adrenomedullin and its gene expression in the heart and blood vessels in endotoxin shock
    Y Ono
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Shock 10:243-7. 1998
    ..In addition, the plasma concentrations of the AM were high enough to allow for AM to act as a vasodilating hormone. Consequently, AM may be one of the factors facilitating severe hypotension complicated with endotoxin shock...
  66. ncbi request reprint Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    H Ariyasu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    J Clin Endocrinol Metab 86:4753-8. 2001
    ..We conclude that the stomach is a major source of circulating ghrelin and that plasma ghrelin-like immunoreactivity levels reflect acute and chronic feeding states in humans...
  67. ncbi request reprint Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression
    T Sekiguchi
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, 910-1193, Fukui, Japan
    Gene 273:251-7. 2001
    ..This clearly indicates that the bullfrog receptor is a counterpart of mammalian NPR-A, and is specific for ANP or BNP but not for CNP...
  68. ncbi request reprint Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides
    M Matsumoto
    Suntory Institute for Medicinal Research and Development, Kurakake 2716 1, Akaiwa, Chiyoda Machi, Ohra Gun, Gunma 370 0503, Japan
    Biochem Biophys Res Commun 287:142-6. 2001
    ..In addition, more stable ether or thioether bonds are capable of replacing the octanoyl ester bond in ghrelin, advantageous for the generation of pharmaceuticals with longer stability...
  69. ncbi request reprint Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta
    H Nishimatsu
    Department of Urology, Faculty of Medicine, University of Tokyo, Japan
    Circ Res 89:63-70. 2001
    ....
  70. ncbi request reprint Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes
    T Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, Kihara, Kiyotake, Japan
    J Hypertens 19:757-63. 2001
    ..CONCLUSIONS: These results suggest that PKC and the Ca2+/calmodulin signaling systems are involved in angiotensin II-induced adrenomedullin secretion from rat cardiac myocytes...
  71. ncbi request reprint Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats
    F Yoshihara
    Research Institute, National Cardiovascular Center, Osaka, Japan
    Hypertension 37:216-22. 2001
    ..The present findings suggest that increased renal AM levels in decompensated heart failure, presumably due to increased AM production in renal tubules, in part, are involved in the regulation of sodium excretion...
  72. ncbi request reprint A role for ghrelin in the central regulation of feeding
    M Nakazato
    Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    Nature 409:194-8. 2001
    ..We conclude that ghrelin is a physiological mediator of feeding, and probably has a function in growth regulation by stimulating feeding and release of growth hormone...
  73. ncbi request reprint Expression of adrenomedullin in the endometrium of the human uterus
    M Michishita
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan
    Obstet Gynecol 93:66-70. 1999
    ..Our purpose was to determine whether adrenomedullin is present in the human uterus...
  74. ncbi request reprint Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 185:134-41. 1992
    ..VIP and CGRP-I significantly increased platelet cAMP levels 15- and 6-fold, respectively. These results suggest that VIP and CGRP-I and -II act upon platelets as well as upon vascular tissue...