Research Topics
Genomes and GenesSpecies | J ImuraSummaryAffiliation: Dokkyo University School of Medicine Country: Japan Publications
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Publications
Localized malignant mesothelioma of the epithelial type occurring as a primary hepatic neoplasm: a case report with review of the literatureJohji Imura
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
APMIS 110:789-94. 2002..To the best of our knowledge, this is the first reported case of localized malignant primary mesothelioma arising in the liver...- Beta-catenin expression as a prognostic indicator in cervical adenocarcinomaJ Imura
Department of Surgical Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Int J Mol Med 8:353-8. 2001.... - Multilocular cystic renal cell carcinoma: a clinicopathological, immuno- and lectin histochemical study of nine casesJohji Imura
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Saitama, Japan
APMIS 112:183-91. 2004..Therefore, MCRCC should be differentiated from other types of renal cell carcinoma on the basis of the histogenesis of the tumour and the clinicopathological findings... - Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesisJohji Imura
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
APMIS 113:140-4. 2005..These findings suggest that the OGCs and MNCs in this patient's tumor originated from monocytes/histiocytes, and most likely developed as part of the stromal reaction to the neoplasm... 
Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancerN Yoshitake
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880, Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321 0293, Japan
Br J Cancer 98:1682-9. 2008..Colorectal cancer patients with nuclear CXCR4 expression in the primary lesion frequently had cytomembrane CXCR4-positive tumours in their LNs. In conclusion, expression of SDF-1 alpha and nuclear CXCR4 predicts LN metastasis in CRCs...- Decreased expression of E-cadherin and Yamamoto-Kohama's mode of invasion highly correlates with lymph node metastasis in esophageal squamous cell carcinomaT Kaihara
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
Pathobiology 69:172-8. 2001..Therefore, examination of the expression of E-cadherin and Y-K's mode of invasion would be helpful in predicting lymph node metastasis in esophageal SCC... - Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndromeT Kimura
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimotsuga, Tochigi, Japan
Clin Exp Immunol 155:16-20. 2009..Moreover, these labelling indices were significantly higher in REG Ialpha-positive than in negative SS patients. REG Ialpha protein may play a role in the regeneration of ductal epithelial cells in the MSGs of patients with SS... - A new in vivo model for studying invasion and metastasis of esophageal squamous cell carcinomaT Furihata
Department of Gastroenterological Surgery, Dokkyo University School of Medicine, Tochigi 321-0293, Japan
Int J Oncol 19:903-7. 2001..This system is an appropriate and a useful model for studying invasion and metastasis of esophageal SCC, and can also be used as a model for developing therapeutic strategies for esophageal cancer in vivo... - Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinomaH Kashida
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
J Gastroenterol 36:809-15. 2001..CONCLUSIONS: These results indicate that an abnormal cytoplasmic staining pattern of cathepsin D may reflect the invasive potential of gastric carcinoma cells... - Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitisS Fujii
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Gut 54:1287-92. 2005..The oestrogen receptor (OR) gene shows age related methylation in the colorectal epithelium and is methylated frequently in sporadic colorectal neoplasia, suggesting that OR methylation may predispose to colorectal neoplasia... - Concurrent occurrence of gastric adenocarcinoma and duodenal neuroendocrine cell carcinoma: a composite tumour or collision tumours ?H Fukui
Department of Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Gut 48:853-6. 2001..One is that both are derived from a common multipotential epithelial stem cell. The second hypothesis is that adenocarcinoma and NEC carcinoma arise from a multipotential epithelial stem cell and a primitive NEC, respectively... - Ectopic hepatocellular carcinoma arising from pancreas: a case report and review of the literatureKeiichi Kubota
Department of Gastroenterological Surgery, Dokkyo University Hospital, 880 Kitakobayashi, Mibu, Tochigi, Japan
World J Gastroenterol 13:4270-3. 2007..The patient is currently doing well without any signs of recurrence in either the remaining pancreas or liver three years after surgery. We report the rare case with ectopic HCC in the pancreas with a review of the literature... - Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line, T.Tn-AT1, by cDNA microarrayHitoshi Kawamata
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo Tsuga, Tochigi 321 0293, Japan
Cancer Sci 94:699-706. 2003..Thus, these genes might regulate the metastasis of esophageal SCC, and could be predictive markers for lymph node metastasis of esophageal SCC... - Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras geneShigeki Tomita
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo Tsuga, Tochigi 321 0293, Japan
Int J Mol Med 9:485-8. 2002..These findings suggest that PPARgamma gene polymorphism may be implicated with the development of colorectal cancers, in which K-ras gene is not mutated... - Molecular and genetic characterization of a non-metastatic human esophageal cancer cell line, T.Tn expressing non-functional mutated p53Taro Sakai
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan
Int J Oncol 21:547-52. 2002..Thus, T.Tn cells are low tumorigenic and weakly invasive but not metastasizing in nude mice, and T.Tn cells are suitable parental cells for establishing a model system to study invasion and metastasis of esophageal SCC... - Clear cell adenocarcinoma of the tongueHiromi Fujita
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:579-82. 2004.... - Dedifferentiation and decreased expression of adhesion molecules, E-cadherin and ZO-1, in colorectal cancer are closely related to liver metastasisT Kaihara
Dept of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
J Exp Clin Cancer Res 22:117-23. 2003..These results indicate that dedifferentiation and a decreased expression of E-cadherin and ZO-1 are closely related to liver metastasis... - Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomasK Ichikawa
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Int J Oncol 20:453-61. 2002..These findings suggest that down-regulated p16 expression is evaluated as a factor of poorer prognosis and also that immunohistochemical pattern of p16 expression becomes a marker reflecting the biological malignancy of EBT patients... - Redifferentiation and ZO-1 reexpression in liver-metastasized colorectal cancer: possible association with epidermal growth factor receptor-induced tyrosine phosphorylation of ZO-1Tsukasa Kaihara
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kita Kobayashi, Mibu, Shimotsuga, Tochigi 321 0293
Cancer Sci 94:166-72. 2003.... - Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinomaMina Hoshino
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
Pathobiology 74:15-21. 2007.... - Cecal adenocarcinoma with prominent rhabdoid feature: report of a case with immunohistochemical, ultrastructural, and molecular analysesTokuyuki Kono
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan
Int J Surg Pathol 15:414-20. 2007..These results suggested that the rhabdoid cells were dedifferentiated adenocarcinoma. Analysis of the rhabdoid cells with molecular techniques is also presented... - Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumorsKenichiroh Mukawa
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
J Gastroenterol Hepatol 20:1584-90. 2005..We therefore classified LSTs as LST-granular (LST-G) or LST-non-granular (LST-NG), according to their macroscopic appearance, and examined the genetic alterations in these two tumor groups compared with those in protruded type tumors... - MEN1 gene mutations in sporadic neuroendocrine tumors of foregut derivationT Fujii
Department of Pathology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
Pathol Int 49:968-73. 1999..Somatic MEN1 gene mutations and deletions may play a crucial role in the tumorigenesis of a subset of foregut-derived NE tumors. Sporadic MEN1 syndrome may occur as a sporadic NE tumor of the pancreas... - Malignant stromal tumor, so called "gastrointestinal stromal tumor", with rhabdomyomatous differentiation occurring in the gallbladderMakoto Furihata
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Pathol Res Pract 201:609-13. 2005..Diffuse positivity for KIT in the cells suggested that the pathogenesis of this tumor may resemble that of GIST. The tumor may have derived from a mesenchymal stem cell that had undergone partial rhabdomyomatous differentiation... - P16-immunostaining pattern as a predictive marker of lymph node metastasis and recurrence in early uterine cervical cancerTatsuo Yamazaki
Department of Obstetrics and Gynecology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Pathobiology 73:176-82. 2006..CONCLUSIONS: The prognosis of patients with early uterine cervical SCC may be predicted by evaluating the P16-immunostaining pattern in the front interface of the infiltrating tumor... 
Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markersHidetsugu Yamagishi
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
Mod Pathol 22:906-13. 2009..Profiling of REG protein expression is useful to for prognostication of patients with gastric cancer...- Tumor cell dissociation score highly correlates with lymph node metastasis in superficial esophageal carcinomaYoko Chibana
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
J Gastroenterol Hepatol 20:1371-8. 2005..Clinical evaluation of TCD scores in endoscopic mucosal resection (EMR) specimens would enable accurate prediction of lymph node metastasis and extend the indication of EMR treatment for SESCC... - REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cellsAkira Sekikawa
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine 880 Kitakobayshi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Carcinogenesis 29:76-83. 2008..The expression of REG Ialpha protein was significantly correlated with that of p-STAT3 in gastric cancer tissues. REG Ialpha protein may play a pivotal role in anti-apoptosis in gastric tumorigenesis under STAT3 activation... - Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: the usefulness of elastic stain for its measurementDaisuke Katsumata
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321 0293, Japan
Surg Today 38:115-22. 2008..As a simple parameter of the local invasion of CRC, we assessed the extent of tumor invasion beyond the outer border of the muscularis propria (MP)... - The CD155/poliovirus receptor enhances the proliferation of ras-mutated cellsTokuyuki Kono
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan
Int J Cancer 122:317-24. 2008..Taken together, our present data suggest that CD155, at least in part, enhances the proliferation of ras-mutated cells... - Involvement of cyclooxygenase-2 and vascular endothelial growth factor in vascularization and lymph node metastasis of colorectal cancers with submucosal invasionAkihito Abe
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
J Gastroenterol Hepatol 22:1071-7. 2007.... - Evaluation of tumor cell dissociation as a predictive marker of lymph node metastasis in submucosal invasive colorectal carcinomaHiroshige Hori
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi 321-0293, Japan
Dis Colon Rectum 48:938-45. 2005..Tumor cell dissociation and decreased membranous expression of E-cadherin would be important predictive markers for lymph node metastasis in submucosal invasive colorectal carcinoma... - Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?Masao Iida
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
Oncol Rep 11:3-7. 2004..This may suggest that aberrant expression of ATBF1 induces the expression of various factors that are otherwise suppressed, and that this somehow determines the biological features of AFP-GC... - Diffuse nodular lymphoid hyperplasia of the large bowel without hypogammaglobulinemia or malabsorption syndrome: a case report and literature reviewShigeki Tomita
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Int J Surg Pathol 10:297-302. 2002..The present case appears to be an essentially benign condition bearing a resemblance, both clinically and histologically, to malignant lymphoma, and from which it can be distinguished by use of immunohistochemical or molecular analysis... - Pathological issues of gastric and lower esophageal cancer: helicobacter pylori infection and its eradicationTakahiro Fujimori
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
J Gastroenterol 37:28-33. 2002..It is also possible that accumulation of genetic abnormalities increases the number of cardiac and lower esophageal cancers. Investigation of cell cycle factors in GERD including ENRD can be expected to reveal the risk of carcinogenesis... - Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancerKeiichi Akasaka
Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
Cancer Chemother Pharmacol 66:691-8. 2010..c.376C > T, resulting in truncated, non-functional ABCG2, was also investigated... - Human papillomavirus infection is involved in the development of colonic squamous cell dysplasia in ulcerative colitis-associated carcinogenesisNaoto Yoshitake
Inflamm Bowel Dis 13:1319-21. 2007 - Long-term survival after repeat resections of metastases in liver, lung, and stomach from sigmoid colon cancer: report of a caseFuyo Yoshimi
Department of Surgery, Ibaraki Prefectural Central Hospital and Cancer Center, 6528 Koibuchi, Kasama, Ibaraki 309 1793, Japan
Surg Today 37:53-60. 2007..As of December 2005, at 7 years 6 months after the first surgery and at 4 years after the last surgery, the patient is still alive with a good quality of life and no sign of recurrence... - Using the supercharge technique to additionally revascularize the gastric tube after a subtotal esophagectomy for esophageal cancerFuyo Yoshimi
Department of Surgery, Ibaraki Prefectural Central Hospital and Cancer Center, 6528 Koibuchi, Tomobe machi, Ibaraki 309 1793, Japan
Am J Surg 191:284-7. 2006..Maintaining sufficient blood flow to the gastric tube after a subtotal esophagectomy for esophageal cancer is crucial for decreasing esophagogastric anastomotic leakage...