J Imura

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi Localized malignant mesothelioma of the epithelial type occurring as a primary hepatic neoplasm: a case report with review of the literature
    Johji Imura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    APMIS 110:789-94. 2002
  2. ncbi Beta-catenin expression as a prognostic indicator in cervical adenocarcinoma
    J Imura
    Department of Surgical Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Int J Mol Med 8:353-8. 2001
  3. ncbi Multilocular cystic renal cell carcinoma: a clinicopathological, immuno- and lectin histochemical study of nine cases
    Johji Imura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Saitama, Japan
    APMIS 112:183-91. 2004
  4. ncbi Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis
    Johji Imura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    APMIS 113:140-4. 2005
  5. pmc Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer
    N Yoshitake
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880, Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321 0293, Japan
    Br J Cancer 98:1682-9. 2008
  6. ncbi Decreased expression of E-cadherin and Yamamoto-Kohama's mode of invasion highly correlates with lymph node metastasis in esophageal squamous cell carcinoma
    T Kaihara
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Pathobiology 69:172-8. 2001
  7. pmc Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndrome
    T Kimura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimotsuga, Tochigi, Japan
    Clin Exp Immunol 155:16-20. 2009
  8. ncbi A new in vivo model for studying invasion and metastasis of esophageal squamous cell carcinoma
    T Furihata
    Department of Gastroenterological Surgery, Dokkyo University School of Medicine, Tochigi 321-0293, Japan
    Int J Oncol 19:903-7. 2001
  9. ncbi Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma
    H Kashida
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    J Gastroenterol 36:809-15. 2001
  10. pmc Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis
    S Fujii
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Gut 54:1287-92. 2005

Collaborators

Detail Information

Publications39

  1. ncbi Localized malignant mesothelioma of the epithelial type occurring as a primary hepatic neoplasm: a case report with review of the literature
    Johji Imura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    APMIS 110:789-94. 2002
    ..To the best of our knowledge, this is the first reported case of localized malignant primary mesothelioma arising in the liver...
  2. ncbi Beta-catenin expression as a prognostic indicator in cervical adenocarcinoma
    J Imura
    Department of Surgical Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Int J Mol Med 8:353-8. 2001
    ....
  3. ncbi Multilocular cystic renal cell carcinoma: a clinicopathological, immuno- and lectin histochemical study of nine cases
    Johji Imura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Saitama, Japan
    APMIS 112:183-91. 2004
    ..Therefore, MCRCC should be differentiated from other types of renal cell carcinoma on the basis of the histogenesis of the tumour and the clinicopathological findings...
  4. ncbi Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis
    Johji Imura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    APMIS 113:140-4. 2005
    ..These findings suggest that the OGCs and MNCs in this patient's tumor originated from monocytes/histiocytes, and most likely developed as part of the stromal reaction to the neoplasm...
  5. pmc Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer
    N Yoshitake
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880, Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321 0293, Japan
    Br J Cancer 98:1682-9. 2008
    ..Colorectal cancer patients with nuclear CXCR4 expression in the primary lesion frequently had cytomembrane CXCR4-positive tumours in their LNs. In conclusion, expression of SDF-1 alpha and nuclear CXCR4 predicts LN metastasis in CRCs...
  6. ncbi Decreased expression of E-cadherin and Yamamoto-Kohama's mode of invasion highly correlates with lymph node metastasis in esophageal squamous cell carcinoma
    T Kaihara
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Pathobiology 69:172-8. 2001
    ..Therefore, examination of the expression of E-cadherin and Y-K's mode of invasion would be helpful in predicting lymph node metastasis in esophageal SCC...
  7. pmc Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndrome
    T Kimura
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimotsuga, Tochigi, Japan
    Clin Exp Immunol 155:16-20. 2009
    ..Moreover, these labelling indices were significantly higher in REG Ialpha-positive than in negative SS patients. REG Ialpha protein may play a role in the regeneration of ductal epithelial cells in the MSGs of patients with SS...
  8. ncbi A new in vivo model for studying invasion and metastasis of esophageal squamous cell carcinoma
    T Furihata
    Department of Gastroenterological Surgery, Dokkyo University School of Medicine, Tochigi 321-0293, Japan
    Int J Oncol 19:903-7. 2001
    ..This system is an appropriate and a useful model for studying invasion and metastasis of esophageal SCC, and can also be used as a model for developing therapeutic strategies for esophageal cancer in vivo...
  9. ncbi Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma
    H Kashida
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    J Gastroenterol 36:809-15. 2001
    ..CONCLUSIONS: These results indicate that an abnormal cytoplasmic staining pattern of cathepsin D may reflect the invasive potential of gastric carcinoma cells...
  10. pmc Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis
    S Fujii
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Gut 54:1287-92. 2005
    ..The oestrogen receptor (OR) gene shows age related methylation in the colorectal epithelium and is methylated frequently in sporadic colorectal neoplasia, suggesting that OR methylation may predispose to colorectal neoplasia...
  11. pmc Concurrent occurrence of gastric adenocarcinoma and duodenal neuroendocrine cell carcinoma: a composite tumour or collision tumours ?
    H Fukui
    Department of Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Gut 48:853-6. 2001
    ..One is that both are derived from a common multipotential epithelial stem cell. The second hypothesis is that adenocarcinoma and NEC carcinoma arise from a multipotential epithelial stem cell and a primitive NEC, respectively...
  12. ncbi Ectopic hepatocellular carcinoma arising from pancreas: a case report and review of the literature
    Keiichi Kubota
    Department of Gastroenterological Surgery, Dokkyo University Hospital, 880 Kitakobayashi, Mibu, Tochigi, Japan
    World J Gastroenterol 13:4270-3. 2007
    ..The patient is currently doing well without any signs of recurrence in either the remaining pancreas or liver three years after surgery. We report the rare case with ectopic HCC in the pancreas with a review of the literature...
  13. ncbi Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line, T.Tn-AT1, by cDNA microarray
    Hitoshi Kawamata
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo Tsuga, Tochigi 321 0293, Japan
    Cancer Sci 94:699-706. 2003
    ..Thus, these genes might regulate the metastasis of esophageal SCC, and could be predictive markers for lymph node metastasis of esophageal SCC...
  14. ncbi Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene
    Shigeki Tomita
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo Tsuga, Tochigi 321 0293, Japan
    Int J Mol Med 9:485-8. 2002
    ..These findings suggest that PPARgamma gene polymorphism may be implicated with the development of colorectal cancers, in which K-ras gene is not mutated...
  15. ncbi Molecular and genetic characterization of a non-metastatic human esophageal cancer cell line, T.Tn expressing non-functional mutated p53
    Taro Sakai
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Int J Oncol 21:547-52. 2002
    ..Thus, T.Tn cells are low tumorigenic and weakly invasive but not metastasizing in nude mice, and T.Tn cells are suitable parental cells for establishing a model system to study invasion and metastasis of esophageal SCC...
  16. ncbi Clear cell adenocarcinoma of the tongue
    Hiromi Fujita
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:579-82. 2004
    ....
  17. ncbi Dedifferentiation and decreased expression of adhesion molecules, E-cadherin and ZO-1, in colorectal cancer are closely related to liver metastasis
    T Kaihara
    Dept of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    J Exp Clin Cancer Res 22:117-23. 2003
    ..These results indicate that dedifferentiation and a decreased expression of E-cadherin and ZO-1 are closely related to liver metastasis...
  18. ncbi Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomas
    K Ichikawa
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Int J Oncol 20:453-61. 2002
    ..These findings suggest that down-regulated p16 expression is evaluated as a factor of poorer prognosis and also that immunohistochemical pattern of p16 expression becomes a marker reflecting the biological malignancy of EBT patients...
  19. ncbi Redifferentiation and ZO-1 reexpression in liver-metastasized colorectal cancer: possible association with epidermal growth factor receptor-induced tyrosine phosphorylation of ZO-1
    Tsukasa Kaihara
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kita Kobayashi, Mibu, Shimotsuga, Tochigi 321 0293
    Cancer Sci 94:166-72. 2003
    ....
  20. ncbi Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma
    Mina Hoshino
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Pathobiology 74:15-21. 2007
    ....
  21. ncbi Cecal adenocarcinoma with prominent rhabdoid feature: report of a case with immunohistochemical, ultrastructural, and molecular analyses
    Tokuyuki Kono
    Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Int J Surg Pathol 15:414-20. 2007
    ..These results suggested that the rhabdoid cells were dedifferentiated adenocarcinoma. Analysis of the rhabdoid cells with molecular techniques is also presented...
  22. ncbi Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors
    Kenichiroh Mukawa
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    J Gastroenterol Hepatol 20:1584-90. 2005
    ..We therefore classified LSTs as LST-granular (LST-G) or LST-non-granular (LST-NG), according to their macroscopic appearance, and examined the genetic alterations in these two tumor groups compared with those in protruded type tumors...
  23. ncbi MEN1 gene mutations in sporadic neuroendocrine tumors of foregut derivation
    T Fujii
    Department of Pathology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    Pathol Int 49:968-73. 1999
    ..Somatic MEN1 gene mutations and deletions may play a crucial role in the tumorigenesis of a subset of foregut-derived NE tumors. Sporadic MEN1 syndrome may occur as a sporadic NE tumor of the pancreas...
  24. ncbi Malignant stromal tumor, so called "gastrointestinal stromal tumor", with rhabdomyomatous differentiation occurring in the gallbladder
    Makoto Furihata
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Pathol Res Pract 201:609-13. 2005
    ..Diffuse positivity for KIT in the cells suggested that the pathogenesis of this tumor may resemble that of GIST. The tumor may have derived from a mesenchymal stem cell that had undergone partial rhabdomyomatous differentiation...
  25. ncbi P16-immunostaining pattern as a predictive marker of lymph node metastasis and recurrence in early uterine cervical cancer
    Tatsuo Yamazaki
    Department of Obstetrics and Gynecology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Pathobiology 73:176-82. 2006
    ....
  26. doi Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers
    Hidetsugu Yamagishi
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Mod Pathol 22:906-13. 2009
    ..Profiling of REG protein expression is useful to for prognostication of patients with gastric cancer...
  27. ncbi Tumor cell dissociation score highly correlates with lymph node metastasis in superficial esophageal carcinoma
    Yoko Chibana
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    J Gastroenterol Hepatol 20:1371-8. 2005
    ..The purpose of the present paper was thus to investigate tumor cell dissociation (TCD) in SESCC as a predictive factor of lymph node metastasis...
  28. ncbi REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells
    Akira Sekikawa
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine 880 Kitakobayshi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Carcinogenesis 29:76-83. 2008
    ..The expression of REG Ialpha protein was significantly correlated with that of p-STAT3 in gastric cancer tissues. REG Ialpha protein may play a pivotal role in anti-apoptosis in gastric tumorigenesis under STAT3 activation...
  29. doi Depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: the usefulness of elastic stain for its measurement
    Daisuke Katsumata
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321 0293, Japan
    Surg Today 38:115-22. 2008
    ..As a simple parameter of the local invasion of CRC, we assessed the extent of tumor invasion beyond the outer border of the muscularis propria (MP)...
  30. ncbi The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells
    Tokuyuki Kono
    Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Int J Cancer 122:317-24. 2008
    ..Taken together, our present data suggest that CD155, at least in part, enhances the proliferation of ras-mutated cells...
  31. ncbi Involvement of cyclooxygenase-2 and vascular endothelial growth factor in vascularization and lymph node metastasis of colorectal cancers with submucosal invasion
    Akihito Abe
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    J Gastroenterol Hepatol 22:1071-7. 2007
    ....
  32. ncbi Evaluation of tumor cell dissociation as a predictive marker of lymph node metastasis in submucosal invasive colorectal carcinoma
    Hiroshige Hori
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi 321 0293, Japan
    Dis Colon Rectum 48:938-45. 2005
    ..We also examined immunohistochemical expression of E-cadherin and beta-catenin in submucosal invasive colorectal carcinoma...
  33. ncbi Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?
    Masao Iida
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    Oncol Rep 11:3-7. 2004
    ..This may suggest that aberrant expression of ATBF1 induces the expression of various factors that are otherwise suppressed, and that this somehow determines the biological features of AFP-GC...
  34. ncbi Diffuse nodular lymphoid hyperplasia of the large bowel without hypogammaglobulinemia or malabsorption syndrome: a case report and literature review
    Shigeki Tomita
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Int J Surg Pathol 10:297-302. 2002
    ..The present case appears to be an essentially benign condition bearing a resemblance, both clinically and histologically, to malignant lymphoma, and from which it can be distinguished by use of immunohistochemical or molecular analysis...
  35. ncbi Pathological issues of gastric and lower esophageal cancer: helicobacter pylori infection and its eradication
    Takahiro Fujimori
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan
    J Gastroenterol 37:28-33. 2002
    ..It is also possible that accumulation of genetic abnormalities increases the number of cardiac and lower esophageal cancers. Investigation of cell cycle factors in GERD including ENRD can be expected to reveal the risk of carcinogenesis...
  36. doi Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer
    Keiichi Akasaka
    Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Cancer Chemother Pharmacol 66:691-8. 2010
    ..c.376C > T, resulting in truncated, non-functional ABCG2, was also investigated...
  37. ncbi Human papillomavirus infection is involved in the development of colonic squamous cell dysplasia in ulcerative colitis-associated carcinogenesis
    Naoto Yoshitake
    Inflamm Bowel Dis 13:1319-21. 2007
  38. ncbi Long-term survival after repeat resections of metastases in liver, lung, and stomach from sigmoid colon cancer: report of a case
    Fuyo Yoshimi
    Department of Surgery, Ibaraki Prefectural Central Hospital and Cancer Center, 6528 Koibuchi, Kasama, Ibaraki 309 1793, Japan
    Surg Today 37:53-60. 2007
    ..As of December 2005, at 7 years 6 months after the first surgery and at 4 years after the last surgery, the patient is still alive with a good quality of life and no sign of recurrence...
  39. ncbi Using the supercharge technique to additionally revascularize the gastric tube after a subtotal esophagectomy for esophageal cancer
    Fuyo Yoshimi
    Department of Surgery, Ibaraki Prefectural Central Hospital and Cancer Center, 6528 Koibuchi, Tomobe machi, Ibaraki 309 1793, Japan
    Am J Surg 191:284-7. 2006
    ..Maintaining sufficient blood flow to the gastric tube after a subtotal esophagectomy for esophageal cancer is crucial for decreasing esophagogastric anastomotic leakage...