Kiyohiko Sugano

Summary

Affiliation: Chugai Pharmaceutical Co
Country: Japan

Publications

  1. ncbi request reprint Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test
    Ryusuke Takano
    Pre Clinical Research Department, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka, 412 8513, Japan
    Pharm Res 23:1144-56. 2006
  2. ncbi request reprint Solubility and dissolution profile assessment in drug discovery
    Kiyohiko Sugano
    Global Research and Development, Nagoya Laboratories, Pharmaceutical R and D, Pfizer Inc, Aichi, Japan
    Drug Metab Pharmacokinet 22:225-54. 2007
  3. ncbi request reprint Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor
    K Sugano
    Fuji Gotemba Research Labs, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
    Bioorg Med Chem Lett 10:1939-42. 2000
  4. ncbi request reprint Optimized conditions of bio-mimetic artificial membrane permeation assay
    K Sugano
    Drug Metabolism and Pharmakokinetics Laboratory, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Shizuoka 412 8513, Gotemba, Japan
    Int J Pharm 228:181-8. 2001
  5. ncbi request reprint High throughput prediction of oral absorption: improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay
    K Sugano
    Formulation Technology Laboratory, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka, Japan
    J Biomol Screen 6:189-96. 2001
  6. ncbi request reprint Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model
    Kiyohiko Sugano
    Drug Metabolism and Pharmacokinetics Laboratory, Fuji Gotemba Research Labs, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 241:241-51. 2002
  7. ncbi request reprint Prediction of human intestinal permeability using artificial membrane permeability
    Kiyohiko Sugano
    Pre clinical Research Department I, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 257:245-51. 2003
  8. ncbi request reprint Permeation characteristics of a hydrophilic basic compound across a bio-mimetic artificial membrane
    Kiyohiko Sugano
    Pre clinical Research Department I, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 275:271-8. 2004
  9. ncbi request reprint Prediction of oral drug absorption in humans by theoretical passive absorption model
    Kouki Obata
    Pre clinical Research Department I, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 293:183-92. 2005
  10. ncbi request reprint Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans
    Ryoichi Saitoh
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412 8513, Japan
    Pharm Res 21:749-55. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test
    Ryusuke Takano
    Pre Clinical Research Department, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka, 412 8513, Japan
    Pharm Res 23:1144-56. 2006
    ....
  2. ncbi request reprint Solubility and dissolution profile assessment in drug discovery
    Kiyohiko Sugano
    Global Research and Development, Nagoya Laboratories, Pharmaceutical R and D, Pfizer Inc, Aichi, Japan
    Drug Metab Pharmacokinet 22:225-54. 2007
    ..Recently, these technologies have been improved by the laboratory automation and computational technologies. Finally, the strategies to apply these technologies for a drug discovery project were discussed...
  3. ncbi request reprint Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor
    K Sugano
    Fuji Gotemba Research Labs, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
    Bioorg Med Chem Lett 10:1939-42. 2000
    ..The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity...
  4. ncbi request reprint Optimized conditions of bio-mimetic artificial membrane permeation assay
    K Sugano
    Drug Metabolism and Pharmakokinetics Laboratory, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Shizuoka 412 8513, Gotemba, Japan
    Int J Pharm 228:181-8. 2001
    ..In contrast, EtOH produced an opposite effect on permeability, i.e. an increased P(am) of ketoprofen. Therefore, the high concentration of these co-solvents could lead to the under- or overestimation of drug permeability...
  5. ncbi request reprint High throughput prediction of oral absorption: improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay
    K Sugano
    Formulation Technology Laboratory, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka, Japan
    J Biomol Screen 6:189-96. 2001
    ..The predictability of the PC/PE/PS/PI/CHO/1,7-octadiene membrane was adequate (r = 0.858, n = 31) for use during the early stages of the drug discovery/development process...
  6. ncbi request reprint Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model
    Kiyohiko Sugano
    Drug Metabolism and Pharmacokinetics Laboratory, Fuji Gotemba Research Labs, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 241:241-51. 2002
    ..The mean square root error of the BAMPA-PP-RF model was 13-14%. The BAMPA-PP-RF model was shown to be able to predict the total passive permeability more adequately than BAMPA alone...
  7. ncbi request reprint Prediction of human intestinal permeability using artificial membrane permeability
    Kiyohiko Sugano
    Pre clinical Research Department I, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 257:245-51. 2003
    ..97. Without the correction for the paracellular pathway, P(eff) of small, cationic and hydrophilic compounds were underestimated. Therefore, P(PAMPA-PP-RF) was found to be an adequate in vitro surrogate for P(eff)...
  8. ncbi request reprint Permeation characteristics of a hydrophilic basic compound across a bio-mimetic artificial membrane
    Kiyohiko Sugano
    Pre clinical Research Department I, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 275:271-8. 2004
    ..Ion pair transport was suggested as a possible permeation mechanism of cationic species. However, further investigation is necessary to clarify the reason for the permeation characteristics of HBC...
  9. ncbi request reprint Prediction of oral drug absorption in humans by theoretical passive absorption model
    Kouki Obata
    Pre clinical Research Department I, Chugai Pharmaceutical Co Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Pharm 293:183-92. 2005
    ..67-0.77, as well as the contribution of paracellular permeation. The TPAM was found to predict oral absorption from the chemical structure of drugs with adequate predictability for usage in drug discovery...
  10. ncbi request reprint Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans
    Ryoichi Saitoh
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412 8513, Japan
    Pharm Res 21:749-55. 2004
    ..To improve predictions of fraction dose absorbed (Fa) for hydrophilic drugs, a correction of paracellular permeability using the pore radius of tight junctions (TJs) in Caco-2 monolayers was performed...
  11. ncbi request reprint Biopharmaceutics classification by high throughput solubility assay and PAMPA
    Kouki Obata
    Pre clinical Research Department I, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka, Japan
    Drug Dev Ind Pharm 30:181-5. 2004
    ..Fourteen out of 18 drugs were correctly classified (78% success rate). The result of the present study showed that HTSA could predict BCS class with a high success rate, and PAMPA could also be useful to predict the permeation of drugs...
  12. ncbi request reprint High throughput solubility measurement with automated polarized light microscopy analysis
    Kiyohiko Sugano
    Global Research and Development, Nagoya Laboratories, Pharmaceutical R and D, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Sci 95:2115-22. 2006
    ..These results suggested that the information regarding the solid form of the precipitant is important in interpreting the solubility data. In addition, we developed an automated birefringence diagnose system for drug discovery usage...
  13. ncbi request reprint PAMPA--critical factors for better predictions of absorption
    Alex Avdeef
    pION INC, 5 Constitution Way, Woburn, Massachusetts 01801, USA
    J Pharm Sci 96:2893-909. 2007
    ..The success of using PAMPA in drug discovery depends on careful data interpretation, use of optimal assay conditions, implementation and integration strategies, and education of users...
  14. ncbi request reprint Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential
    Kaori Tomizawa
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories Pfizer Inc, Japan
    J Toxicol Sci 31:315-24. 2006
    ..The ClogP - NC plot differentiated positive and negative compounds with more than 98% accuracy (62/63), indicating its usefulness in drug discovery...
  15. ncbi request reprint Theoretical dissolution model of poly-disperse drug particles in biorelevant media
    Arimichi Okazaki
    Global Research and Development, Nagoya Laboratories, Pharmaceutical R and D, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Sci 97:1843-52. 2008
    ..The results of the present study suggested that the effect of the particle size distribution and the effective diffusion coefficient should be taken into consideration...