J Nezu

Summary

Affiliation: Chugai Pharmaceutical Co
Country: Japan

Publications

  1. ncbi Molecular cloning of a novel vascular endothelial growth factor, VEGF-D
    Y Yamada
    Gene Search Program, Chugai Research Institute for Molecular Medicine, Niihari, Ibaraki, Japan
    Genomics 42:483-8. 1997
  2. ncbi Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase
    J Nezu
    Gene Search Program, Chugai Research Institute for Molecular Medicine, 153 2 Nagai, Niihari, Ibaraki, 300 41, Japan
    Genomics 45:327-31. 1997
  3. ncbi Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients
    J Nezu
    Chugai Research Institute for Molecular Medicine Inc, 153 2 Nagai Niihari, Ibaraki, 300 4101, Japan
    Biochem Biophys Res Commun 261:750-5. 1999
  4. ncbi Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
    J Nezu
    Chugai Research Institute for Molecular Medicine, Ibaraki, Japan
    Nat Genet 21:91-4. 1999
  5. ncbi Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    D E Jenne
    Department of Neuroimmunology, Max Planck Institute of Psychiatry, Martinsried, Germany
    Nat Genet 18:38-43. 1998
  6. ncbi Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    FEBS Lett 419:107-11. 1997
  7. ncbi Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids
    J Nezu
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa
    J Biochem 112:212-9. 1992
  8. ncbi Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, 920 0934, Japan
    Biochem Biophys Res Commun 273:251-60. 2000
  9. ncbi Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations
    H Yabuuchi
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    J Pharmacol Exp Ther 289:768-73. 1999
  10. ncbi Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
    H Mehenni
    Division of Medical Genetics, University of Geneva Medical School, Geneva, Switzerland
    Am J Hum Genet 63:1641-50. 1998

Collaborators

Detail Information

Publications12

  1. ncbi Molecular cloning of a novel vascular endothelial growth factor, VEGF-D
    Y Yamada
    Gene Search Program, Chugai Research Institute for Molecular Medicine, Niihari, Ibaraki, Japan
    Genomics 42:483-8. 1997
    ..The high level of conservation between mouse and human VEGF-D may emphasize the biological importance of this gene. Recently the murine gene, FIGF, which is identical to mouse VEGF-D, was reported...
  2. ncbi Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase
    J Nezu
    Gene Search Program, Chugai Research Institute for Molecular Medicine, 153 2 Nagai, Niihari, Ibaraki, 300 41, Japan
    Genomics 45:327-31. 1997
    ..B1R kinase is reported to be essential for DNA replication of vaccinia virus. The similarity of VRK1 and VRK2 to B1R indicates that these genes may have similar functions...
  3. ncbi Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients
    J Nezu
    Chugai Research Institute for Molecular Medicine Inc, 153 2 Nagai Niihari, Ibaraki, 300 4101, Japan
    Biochem Biophys Res Commun 261:750-5. 1999
    ....
  4. ncbi Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
    J Nezu
    Chugai Research Institute for Molecular Medicine, Ibaraki, Japan
    Nat Genet 21:91-4. 1999
    ..In an affected individual belonging to a third family, we found a homozygous splice-site mutation also resulting in a premature stop codon. These mutations provide the first evidence that loss of OCTN2 function causes SCD...
  5. ncbi Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    D E Jenne
    Department of Neuroimmunology, Max Planck Institute of Psychiatry, Martinsried, Germany
    Nat Genet 18:38-43. 1998
    ..We conclude that germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome...
  6. ncbi Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    FEBS Lett 419:107-11. 1997
    ..It may play a role in the renal excretion of xenobiotics and their metabolites...
  7. ncbi Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids
    J Nezu
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa
    J Biochem 112:212-9. 1992
    ..This suggests the possibility of multiple (at least three) homologous/identical genes encoding 16 kDa proteolipid. The possible presence and significance of isoforms of 16 kDa proteolipid in rats are discussed...
  8. ncbi Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, 920 0934, Japan
    Biochem Biophys Res Commun 273:251-60. 2000
    ..OATP-B, -C, -D and -E exhibited transport activity for [(3)H]estrone-3-sulfate as a common substrate. OATP-C has a high transport activity with broad substrate specificity...
  9. ncbi Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations
    H Yabuuchi
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    J Pharmacol Exp Ther 289:768-73. 1999
    ..Accordingly, OCTN1 was functionally demonstrated to be a multispecific and pH-dependent organic cation transporter, which presumably functions as a proton/organic cation antiporter at the renal apical membrane and other tissues...
  10. ncbi Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
    H Mehenni
    Division of Medical Genetics, University of Geneva Medical School, Geneva, Switzerland
    Am J Hum Genet 63:1641-50. 1998
    ..The elucidation of the molecular etiology of PJS and the positional cloning of the second potential PJS gene will further elucidate the involvement of kinases/phosphatases in the development of cancer-predisposing syndromes...
  11. ncbi Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Biol Chem 273:20378-82. 1998
    ....
  12. ncbi Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier
    Y Kido
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    J Neurochem 79:959-69. 2001
    ..These results suggest that OCTN2 is involved in transport of L-carnitine and acetyl-L-carnitine from the circulating blood to the brain across the BBB...