Fumihiko Horio

Summary

Affiliation: Chubu University
Country: Japan

Publications

  1. ncbi request reprint The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion
    Fumihiko Horio
    Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Matsumoto cho 1200, Kasugai 487 8501, Japan
    Eur J Endocrinol 153:971-9. 2005
  2. ncbi request reprint Ascorbic acid deficiency stimulates hepatic expression of inflammatory chemokine, cytokine-induced neutrophil chemoattractant-1, in scurvy-prone ODS rats
    Fumihiko Horio
    Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Aichi, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:28-32. 2006
  3. doi request reprint Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    Masahito Takikawa
    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487 8501, Japan
    J Nutr 140:527-33. 2010
  4. ncbi request reprint Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice
    Rie Sasaki
    College of Bioscience and Biotechnology, Chubu University, Matsumoto cho, Kasugai, Aichi 487 8501, Japan
    Biochem Pharmacol 74:1619-27. 2007
  5. ncbi request reprint Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase
    Wei Yu
    Department of Anatomy, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Lab Invest 82:1229-39. 2002
  6. ncbi request reprint Suppressive effect of a hot water extract of adzuki beans (Vigna angularis) on hyperglycemia after sucrose loading in mice and diabetic rats
    Tomohiro Itoh
    Imuraya Confectionary Co Ltd, Takachaya 7 1 1, Tsu, Mie 514 8530, Japan
    Biosci Biotechnol Biochem 68:2421-6. 2004
  7. ncbi request reprint Characterization of diabetes-related traits in MSM and JF1 mice on high-fat diet
    Misato Kobayashi
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Nutr Biochem 15:614-21. 2004
  8. ncbi request reprint SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet
    Misato Kobayashi
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
    Biosci Biotechnol Biochem 68:226-30. 2004
  9. ncbi request reprint Characteristics of ascorbic acid metabolism in scurvy-prone spontaneously hypertensive rat, SHR-od
    Kaori Kawai
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:1-6. 2003
  10. ncbi request reprint Dietary sesame seed and its lignan increase both ascorbic acid concentration in some tissues and urinary excretion by stimulating biosynthesis in rats
    Saiko Ikeda
    Department of Nutritional Sciences, Nagoya University of Arts and Sciences, Nissin, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:383-92. 2007

Collaborators

  • Ichiro Niki
  • Takanori Tsuda
  • Shin Nishiumi
  • Itsuko Fukuda
  • Tamio Ohno
  • A Ishikawa
  • Hiroyuki Ito
  • H Ashida
  • K Minakata
  • Nobuyuki Takahashi
  • Saiko Ikeda
  • Misato Kobayashi
  • Masahiko Nishimura
  • Kaori Kawai
  • Masahito Takikawa
  • Natsuko Hada
  • Rie Sasaki
  • Mayumi Kumazawa
  • Takahiro Kawai
  • Fusayo Io
  • Tomohiro Itoh
  • Rea Victoria P Anunciado
  • Yuki Ueno
  • Wei Yu
  • Seiya Inoue
  • Shizufumi Ebihara
  • Masato Fujiyoshi
  • Masako Kuga
  • Akihito Tanaka
  • Natsumi Nishimura
  • Yasuka Isa
  • Hiromi Hoshino
  • Takahito Ichi
  • Maho Kadowaki
  • Yukio Furuichi
  • Nobuyuki Kita
  • Takeshi Tsuchiya
  • Yuko Kurokawa
  • Susumu Makino
  • Shin Tanaka
  • Kumiko Takemori
  • Naoko Nishio
  • Masayuki Mori
  • Takao Namikawa
  • Hiroko Kubota
  • Thomas J Ribar
  • Koji Uchida
  • Toshihiko Osawa
  • Yoshitaka Miura
  • Yoshimi Hasegawa
  • Tae Niwa
  • Michitaka Naito
  • Hideki Nomura
  • Shinya Toyokuni
  • Takao Senda
  • Shin Teradaira
  • Yoji Kato
  • Anthony R Means

Detail Information

Publications20

  1. ncbi request reprint The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion
    Fumihiko Horio
    Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Matsumoto cho 1200, Kasugai 487 8501, Japan
    Eur J Endocrinol 153:971-9. 2005
    ....
  2. ncbi request reprint Ascorbic acid deficiency stimulates hepatic expression of inflammatory chemokine, cytokine-induced neutrophil chemoattractant-1, in scurvy-prone ODS rats
    Fumihiko Horio
    Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Aichi, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:28-32. 2006
    ..These results demonstrate that ascorbic acid deficiency elevates the serum, liver and spleen concentrations of CINC-1 as seen in acute inflammation, and suggest that ascorbic acid deficiency stimulate the hepatic CINC-1 gene expression...
  3. doi request reprint Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    Masahito Takikawa
    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487 8501, Japan
    J Nutr 140:527-33. 2010
    ..These findings provide a biochemical basis for the use of bilberry fruits and have important implications for the prevention and treatment of type 2 diabetes via activation of AMPK...
  4. ncbi request reprint Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice
    Rie Sasaki
    College of Bioscience and Biotechnology, Chubu University, Matsumoto cho, Kasugai, Aichi 487 8501, Japan
    Biochem Pharmacol 74:1619-27. 2007
    ..These findings indicate that C3G has significant potency in an anti-diabetic effect through the regulation of Glut4-RBP4 system and the related inflammatory adipocytokines...
  5. ncbi request reprint Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase
    Wei Yu
    Department of Anatomy, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Lab Invest 82:1229-39. 2002
    ....
  6. ncbi request reprint Suppressive effect of a hot water extract of adzuki beans (Vigna angularis) on hyperglycemia after sucrose loading in mice and diabetic rats
    Tomohiro Itoh
    Imuraya Confectionary Co Ltd, Takachaya 7 1 1, Tsu, Mie 514 8530, Japan
    Biosci Biotechnol Biochem 68:2421-6. 2004
    ....
  7. ncbi request reprint Characterization of diabetes-related traits in MSM and JF1 mice on high-fat diet
    Misato Kobayashi
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Nutr Biochem 15:614-21. 2004
    ..Further investigations using JF1 mice will help to clarify the role of the high-fat diet on human diabetes and obesity...
  8. ncbi request reprint SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet
    Misato Kobayashi
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
    Biosci Biotechnol Biochem 68:226-30. 2004
    ..On the other hand, SM/J showed mildly impaired glucose tolerance, even when fed on a high-fat diet for 10 weeks. These results indicate that SMXA-5 would be available for use as a diabetic model susceptible to a high-fat diet...
  9. ncbi request reprint Characteristics of ascorbic acid metabolism in scurvy-prone spontaneously hypertensive rat, SHR-od
    Kaori Kawai
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:1-6. 2003
    ....
  10. ncbi request reprint Dietary sesame seed and its lignan increase both ascorbic acid concentration in some tissues and urinary excretion by stimulating biosynthesis in rats
    Saiko Ikeda
    Department of Nutritional Sciences, Nagoya University of Arts and Sciences, Nissin, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:383-92. 2007
    ..The data of ODS rat studies also suggest that dietary sesame seed enhances antioxidative activity in the tissues by elevating the levels of two antioxidative vitamins, vitamin C and E...
  11. ncbi request reprint Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid
    Kaori Kawai
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Life Sci 72:1717-32. 2003
    ....
  12. ncbi request reprint Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Imadegawa dori, Kamigyo ku, Kyoto 602 8580, Japan
    J Nutr 133:2125-30. 2003
    ..Our findings provide a biochemical and nutritional basis for the use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of obesity and diabetes...
  13. doi request reprint Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice
    Natsuko Hada
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Physiol Genomics 35:65-74. 2008
    ..A-T2dm2sa mice...
  14. ncbi request reprint Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet
    Mayumi Kumazawa
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Lipid Res 48:2039-46. 2007
    ..This suggests that the SM/J and A/J strains, neither of which develops fatty liver, possess loci causing fatty liver and that the coexistence of these loci causes fatty liver in SMXA-5 mice...
  15. ncbi request reprint Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Kamigyo ku, Kyoto 602 8580, Japan
    Biochem Biophys Res Commun 316:149-57. 2004
    ..These data suggest that anthocyanins have a potency of unique therapeutic advantage and also have important implications for preventing obesity and diabetes...
  16. ncbi request reprint Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice
    Rea Victoria P Anunciado
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Furocho, Chikusa ku, Nagoya 464 8601, Japan
    Exp Anim 52:37-42. 2003
    ..The QTL on Chr 8 affected insulin and phospholipid levels, whereas the Chr 19 QTL was common to the three lipid parameters...
  17. ncbi request reprint Cyanidin 3-O-beta-D-glucoside suppresses nitric oxide production during a zymosan treatment in rats
    Takanori Tsuda
    Junior College Division, Tokai Gakuen University, 2 901 Nakahira, Tenpaku ku, Nagoya 468 8514, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:305-10. 2002
    ..Taken altogether, our findings provide a biochemical basis for the use of C3G as a functional food factor and can also have important implications for the prevention of the NO-mediated inflammatory diseases...
  18. ncbi request reprint Cyanidin 3-O-beta-D-glucoside attenuates the hepatic ischemia-reperfusion injury through a decrease in the neutrophil chemoattractant production in rats
    Takanori Tsuda
    Junior College Division, Tokai Gakuen University, Nagoya, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:134-41. 2002
    ....
  19. ncbi request reprint Increase in oxidative stress in kidneys of diabetic Akita mice
    Yuki Ueno
    Nagoya University Graduate School of Bioagricultural Sciences, Japan
    Biosci Biotechnol Biochem 66:869-72. 2002
    ..These results suggest that hyperglycemia in Akita mice induced oxidative stress and increased these markers in the kidneys...
  20. ncbi request reprint Effects of paraquat on essential antioxidant elements in osteogenic disorder Shionogi rat
    Kayoko Minakata
    Department of Legal Medicine, Hamamatsu University School of Medicine, Japan
    J Toxicol Environ Health A 65:143-7. 2002
    ..PQ produced an increase in kidney Mg and a rise in liver Mg and Zn levels. Cardiac elemental levels were not affected by PQ treatment. PQ, a known oxidant, produced changes in tissue elements involved in antioxidant mechanisms...