Research Topics
Genomes and Genes
| Masashi YamazakiSummaryAffiliation: Chiba University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing
M Yamazaki
Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
J Orthop Res 15:757-64. 1997....Fenestration of vertebral artery at the craniovertebral junction in Down syndrome: a case report
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 29:E551-4. 2004..Case report of a Down syndrome patient with right vertebral artery fenestration and abnormalities of the craniovertebral junction...Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord
Masao Koda
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
Eur Spine J 16:2206-14. 2007..Further investigation is needed to establish an optimal combination of cell therapy and neurotrophin gene transfer for cases of spinal cord injury...Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation
Takeo Furuya
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Brain Res 1295:192-202. 2009..However, the data failed to demonstrate significant synergism from combined therapy compared with the levels of recovery following single-agent treatment...Up-regulation of macrophage migration-inhibitory factor expression after compression-induced spinal cord injury in rats
Masao Koda
Department of Environmental Medical Science, Chiba University Graduate School of Medicine, Japan
Acta Neuropathol 108:31-6. 2004..The MIF may contribute to proliferation of astrocytes around the lesioned site in spinal cord injury because of its cell proliferation-promoting property...Deletion of macrophage migration inhibitory factor attenuates neuronal death and promotes functional recovery after compression-induced spinal cord injury in mice
Yutaka Nishio
Department of Orthopaedic Surgery, Chiba University, Chuo Ku, Japan
Acta Neuropathol 117:321-8. 2009..These results suggest that MIF existence hinders neuronal survival after SCI. Suppression of MIF may attenuate detrimental secondary molecular responses of the injured spinal cord...Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord
Yukio Someya
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
J Neurosurg Spine 9:600-10. 2008..The aim of the present study is to evaluate the efficacy of transplanted BMSC-derived SCs (BMSC-SCs) in a rat model of spinal cord contusion, which is relevant to clinical spinal cord injury...Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice
Masao Koda
Department of Orthopaedic Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Brain Res 1149:223-31. 2007..G-CSF treated mice showed significant recovery of hind limb function compared to that of the control mice. In conclusion, G-CSF showed efficacy for spinal cord injury treatment through mobilization of bone marrow-derived cells...Simulated surgery for a patient with neurofibromatosis type-1 who had severe cervicothoracic kyphoscoliosis and an anomalous vertebral artery
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 35:E368-73. 2010..Case report...Surgical simulation of circumferential osteotomy and correction of cervico-thoracic kyphoscoliosis for an irreducible old C6-C7 fracture dislocation
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Acta Neurochir (Wien) 151:867-72. 2009..However, consistent protocols and procedures have not been fully established for the surgical correction of an irreducible old cervical fracture dislocation associated with spinal deformity...Transplantation of human bone marrow stromal cell-derived Schwann cells reduces cystic cavity and promotes functional recovery after contusion injury of adult rat spinal cord
Takahito Kamada
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Neuropathology 31:48-58. 2011..In conclusion, the functions of hBMSC-SC are comparable to original Schwann cells in rat spinal cord injury models, and are thus potentially useful treatments for patients with spinal cord injury...Surgical management of severe scoliosis with high risk pulmonary dysfunction in Duchenne muscular dystrophy: patient function, quality of life and satisfaction
Masashi Takaso
Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Kitasato 1 15 1, Sagamihara, Kanagawa, Japan
Int Orthop 34:695-702. 2010..6% per year. Most patients and parents believed scoliosis surgery improved their function, sitting balance and quality of life even though patients were at high risk for major complications. Their satisfaction was also high...Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing
Tetsuro Nakazawa
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8677, Japan
Bone 37:711-9. 2005..These results suggest that intermittent treatment with low-dose rhPTH(1-34) induces a larger cartilaginous callus but does not delay chondrocyte differentiation during fracture healing...Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis
Masayuki Hashimoto
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
Acta Neuropathol 109:165-80. 2005..This system is potentially useful for identifying genes that are involved in the response to SCI...Granulocyte colony-stimulating factor (G-CSF) protects oligodendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats
Ryo Kadota
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
PLoS ONE 7:e50391. 2012..The aim of the present study was to elucidate the potential therapeutic effect of G-CSF for SCI in rats...Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model
Koichi Hayashi
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
J Neurosurg Spine 15:582-93. 2011..In the present study, the authors used the neural stem sphere (NSS) method to differentiate iPSCs into astrocytes, which were evaluated after their transplantation into injured rat spinal cords...An analysis of factors causing poor surgical outcome in patients with cervical myelopathy due to ossification of the posterior longitudinal ligament: anterior decompression with spinal fusion versus laminoplasty
Yutaka Masaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
J Spinal Disord Tech 20:7-13. 2007..We compared the surgical outcome of anterior decompression with spinal fusion (ASF) with the surgical outcome of laminoplasty for patients with cervical myelopathy due to ossification of the posterior longitudinal ligament...C5 palsy following anterior decompression and spinal fusion for cervical degenerative diseases
Mitsuhiro Hashimoto
Department of Orthopaedic Surgery, Numazu City Hospital, 550 Harunoki, Higashi shiiji, Numazu, Shizuoka 410 0302, Japan
Eur Spine J 19:1702-10. 2010..Thus, when patients with spinal cord lesions at C3-C4 and C4-C5 levels undergo multilevel ASF, we should be alert to the possible occurrence of postoperative C5 palsy...Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice
Yutaka Nishio
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
J Neuropathol Exp Neurol 66:724-31. 2007..G-CSF is currently used in the clinic for hematopoietic stimulation, and its ongoing clinical trial for brain infarction makes it an appealing molecule that could be rapidly placed into trials for patients with acute SCI...Brain-derived neurotrophic factor suppresses anoikis-induced death of Schwann cells
Masao Koda
Department of Orthopaedic Surgery, Chiba Aoba Municipal Hospital, Chiba, Japan
Neurosci Lett 444:143-7. 2008..Suppression of anoikis may increase survival of grafted cells in case of cell therapy for spinal cord injury...Anomalous vertebral arteries in the extra- and intraosseous regions of the craniovertebral junction visualized by 3-dimensional computed tomographic angiography: analysis of 100 consecutive surgical cases and review of the literature
Masashi Yamazaki
Department of Orthopaedic Surgery, The Spine Section, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 37:E1389-97. 2012..Consecutive case series and literature review...Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of compression myelopathy, Part 1: a phase I and IIa clinical trial
Tsuyoshi Sakuma
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8677, Japan
Eur Spine J 21:482-9. 2012....Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of thoracic myelopathy: a multicenter prospective controlled trial
Tsuyoshi Sakuma
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 37:1475-8. 2012..An open-labeled multicenter prospective controlled clinical trial...Abnormal course of the vertebral artery at the craniovertebral junction in patients with Down syndrome visualized by three-dimensional CT angiography
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Neuroradiology 50:485-90. 2008..We determined the incidence of vertebral artery (VA) anomalies at the craniovertebral junction (CVJ) in patients with Down syndrome, and characterized the VA anomalies...Autogenous iliac crest bone graft versus banked allograft bone in scoliosis surgery in patients with Duchenne muscular dystrophy
Toshiyuki Nakazawa
Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Sagamihara City, Kanagawa, Japan
Int Orthop 34:855-61. 2010....Regulation of semaphorin 3A expression in neurons of the rat spinal cord and cerebral cortex after transection injury
Masayuki Hashimoto
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677 Chiba, Japan
Acta Neuropathol 107:250-6. 2004..It is likely that the up-regulation occurred in neurons whose descending fibers were transected. These results suggest that Sema3A is regulated differently in spinal motoneurons and brain neurons following axonal injury...Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord
Takahito Kamada
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
J Neuropathol Exp Neurol 64:37-45. 2005..Transplantation of BMSC-SCs is a potentially useful treatment for spinal cord injury...The use of hemopoietic stem cells derived from human umbilical cord blood to promote restoration of spinal cord tissue and recovery of hindlimb function in adult rats
Yutaka Nishio
Department of Orthopaedic Surgery, Chiba University Graduate School of dicine, Tougane Chiba Prefecture Hospital, Chiba, Japan
J Neurosurg Spine 5:424-33. 2006..The authors investigated the effects of hemopoietic stem cells that were derived from HUCB and transplanted into the injured spinal cords of rats...Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice
Masao Koda
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
Neuroreport 16:1763-7. 2005..No significant difference was observed in the recovery between both groups. Both hematopoietic stem cells and marrow stromal cells have the potential to restore the injured spinal cord and to promote functional recovery...Less invasive and less technically demanding decompressive procedure for lumbar spinal stenosis--appropriate for general orthopaedic surgeons?
Masashi Takaso
Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato1 15 1, Sagamihara, Kanagawa, Japan
Int Orthop 35:67-73. 2011..The described technique of MSPO yielded promising results with few complications. The authors believe MSPO is less technically demanding and appropriate for general orthopaedic surgeons, occasional spine surgeons and chief residents...Surgical correction of spinal deformity in patients with congenital muscular dystrophy
Masashi Takaso
Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato 1 15 1, Minami Sagamihara, Kanagawa 252 0375, Japan
J Orthop Sci 15:493-501. 2010..The purpose of this study was to review the clinical and radiological results of spinal deformity surgery in this group of patients with CMD...Association between serum leptin and bone metabolic markers, and the development of heterotopic ossification of the spinal ligament in female patients with ossification of the posterior longitudinal ligament
Yoshikazu Ikeda
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Eur Spine J 20:1450-8. 2011..Our results suggest that hyperleptinemia, in combination with hyperinsulinemia, may contribute to the development of heterotopic ossification of the spinal ligament in female patients with OPLL...Static versus dynamic factors for the development of myelopathy in patients with cervical ossification of the posterior longitudinal ligament
Takayuki Fujiyoshi
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
J Clin Neurosci 17:320-4. 2010..Thus, by controlling the dynamic factors (hypermobility), we might be able to reduce neurological deterioration in patients with cervical OPLL...Anomalous vertebral artery at the extraosseous and intraosseous regions of the craniovertebral junction: analysis by three-dimensional computed tomography angiography
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 30:2452-7. 2005..This study examined the extraosseous and intraosseous anomalies of vertebral arteries in patients who underwent surgery of the craniovertebral junction...Neuroprotective therapy using granulocyte colony-stimulating factor for acute spinal cord injury: a phase I/IIa clinical trial
Hiroshi Takahashi
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Eur Spine J 21:2580-7. 2012..To confirm the safety and feasibility of G-CSF administration for acute spinal cord injury (SCI), we have initiated a phase I/IIa clinical trial of neuroprotective therapy using G-CSF...Neuroprotective effects of granulocyte colony-stimulating factor and relationship to promotion of angiogenesis after spinal cord injury in rats: laboratory investigation
Junko Kawabe
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Japan
J Neurosurg Spine 15:414-21. 2011..The aim of this study was to assess the effects of G-CSF on the vascular system after SCI...Two-year results for scoliosis secondary to Duchenne muscular dystrophy fused to lumbar 5 with segmental pedicle screw instrumentation
Masashi Takaso
Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
J Orthop Sci 15:171-7. 2010..This study was performed to determine the efficacy and safety of stopping segmental pedicle screw constructs at L5 during surgical treatment of scoliosis associated with Duchenne muscular dystrophy (DMD)...Can the caudal extent of fusion in the surgical treatment of scoliosis in Duchenne muscular dystrophy be stopped at lumbar 5?
Masashi Takaso
Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
Eur Spine J 19:787-96. 2010..This method in appropriate patients can be a viable alternative to instrumentation and fusion to the sacrum/pelvis in the surgical treatment of DMD scoliosis...Interferon-γ decreases chondroitin sulfate proteoglycan expression and enhances hindlimb function after spinal cord injury in mice
Takayuki Fujiyoshi
Department of Neurobiology, Chiba University, Chiba, Japan
J Neurotrauma 27:2283-94. 2010..Our results indicate that IFN-γ exhibits therapeutic effects in mouse contusive SCI, presumably by reducing CSPG expression from reactive astrocytes and increasing the expression of neurotrophic factors...Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord
Masao Koda
Division of Rehabilitation Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
J Neurotrauma 21:329-37. 2004..These results indicate that the recovery was caused by regeneration of rubrospinal axons, not by simple enhancement of the central pattern generator...Treatment with basic fibroblast growth factor-incorporated gelatin hydrogel does not exacerbate mechanical allodynia after spinal cord contusion injury in rats
Takeo Furuya
Chiba University Graduate School of Medicine, Chiba, Japan
J Spinal Cord Med 36:134-9. 2013..Besides stimulating angiogenesis or cell survival, basic fibroblast growth factor (bFGF) has the potential for protecting neurons in the injured spinal cord...Postoperative paralysis following posterior decompression with instrumented fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
J Clin Neurosci 18:294-6. 2011....Brain-derived neurotrophic factor suppresses delayed apoptosis of oligodendrocytes after spinal cord injury in rats
Masao Koda
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
J Neurotrauma 19:777-85. 2002..BDNF administration may therefore be useful for the clinical treatment of spinal cord injury through the suppression of secondary events...Posterior decompression with instrumented fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8677, Japan
Eur Spine J 19:691-8. 2010..Since neurological recovery progresses slowly after PDF, we suggest that additional anterior decompression surgery is not desirable during the early stage of recovery...Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury
Tomohiro Miyashita
Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
J Neurotrauma 26:955-64. 2009..Thus, reexpression of the embryonic repulsive cues in adult tissues contributes to the failure of axon regeneration in the central nervous system...Evidence of enhanced expression of osteopontin in spinal hyperostosis of the twy mouse
Atsuomi Aiba
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 34:1644-9. 2009..Gene expression and protein localization of osteopontin (OPN) in spinal hyperostosis of the twy mouse by means of in situ hybridization, immunohistochemistry, and Northern blot analysis...Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice
Shuhei Koshizuka
Department of Orthopaedic Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
J Neuropathol Exp Neurol 63:64-72. 2004..These results suggest that transplantation of HSCs from bone marrow is an effective strategy for the treatment of spinal cord injury...Clinical results of surgery for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: operative indication of posterior decompression with instrumented fusion
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 31:1452-60. 2006..This retrospective study was conducted to investigate the clinical outcomes of several surgical procedures for thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL)...C1 dome-like laminotomy and posterior C1-C2 polyaxial screw-rod fixation for a patient with cervical myelopathy due to a retro-odontoid pseudotumor
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8677, Japan
J Clin Neurosci 16:99-103. 2009..Successful C1-C2 fusion, adequate decompression of the spinal cord, and spontaneous regression of the retro-odontoid mass were achieved by this procedure without any apparent restriction in neck movement...Comparison of clinical outcomes between laminoplasty, posterior decompression with instrumented fusion, and anterior decompression with fusion for K-line (-) cervical ossification of the posterior longitudinal ligament
Masao Koda
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 2608670, Japan
Eur Spine J 25:2294-301. 2016..The aim of the present study was to compare the clinical outcome of LMP, posterior decompression with instrumented fusion (PDF) and anterior decompression and fusion (ADF) for patients with K-line (-) OPLL...Postoperative Increase in Occiput-C2 Angle Negatively Impacts Subaxial Lordosis after Occipito-Upper Cervical Posterior Fusion Surgery
Taigo Inada
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Asian Spine J 10:744-7. 2016..Retrospective case series...Granulocyte colony-stimulating factor attenuates spinal cord injury-induced mechanical allodynia in adult rats
Kei Kato
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Japan
J Neurol Sci 355:79-83. 2015..The present results demonstrate a therapeutic effect of G-CSF treatment for SCI-induced NeP, possibly through the inhibition of microglial activation and the suppression of p38MAPK phosphorylation and the upregulation of interleukin-1β...Resolution of low back symptoms after corrective surgery for dropped-head syndrome: a report of two cases
Masao Koda
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
BMC Res Notes 8:545. 2015..Cervical deformity can influence global sagittal balance. We report two cases of severe low back pain and lower extremity radicular pain associated with dropped-head syndrome. Symptoms were relieved by cervical corrective surgery...Mid- to long-term outcomes of posterior decompression with instrumented fusion for thoracic ossification of the posterior longitudinal ligament
Masao Koda
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 2608670, Japan Electronic address
J Clin Neurosci 27:87-90. 2016..PDF surgery for thoracic OPLL is thus considered a relatively safe and stable surgical procedure considering the mid- to long-term outcomes...Transplanted Peripheral Blood Stem Cells Mobilized by Granulocyte Colony-Stimulating Factor Promoted Hindlimb Functional Recovery After Spinal Cord Injury in Mice
Hiroshi Takahashi
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Cell Transplant 25:283-92. 2016..Transplantation of G-CSF-mobilized PBSCs has advantages for treatment of spinal cord injury in the ethical and immunological viewpoints, although further exploration is needed to move forward to clinical application. ..Neurological deterioration induced by sitting in patients after cervicothoracic posterior decompression with instrumented fusion surgery for ossification of the longitudinal ligament: two cases reports
Masao Koda
Departments of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuo K, Chiba, 260 8670, Japan
BMC Res Notes 8:133. 2015..We report on Japanese patients who showed neurological deterioration induced by sitting after cervicothoracic posterior decompression with instrumented fusion, but showed immediate neurological recovery after bed rest...Bone union and remodelling of the non-ossified segment in thoracic ossification of the posterior longitudinal ligament after posterior decompression and fusion surgery
Masao Koda
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuo Ku, Chiba, 260 8670, Japan
Eur Spine J 24:2555-9. 2015..The purpose of the present study was to elucidate the course of bone union and remodelling of the non-ossified segment of thoracic OPLL (T-OPLL) after PDF surgery...Neuroprotective therapy with granulocyte colony-stimulating factor in acute spinal cord injury: a comparison with high-dose methylprednisolone as a historical control
Koshiro Kamiya
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 2608670, Japan
Eur Spine J 24:963-7. 2015..In this study, we retrospectively analyzed the clinical outcome in SCI patients treated with G-CSF and compared these results to a historical cohort of SCI patients treated with high-dose methylprednisolone sodium succinate (MPSS)...Multicenter prospective nonrandomized controlled clinical trial to prove neurotherapeutic effects of granulocyte colony-stimulating factor for acute spinal cord injury: analyses of follow-up cases after at least 1 year
Taigo Inada
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan Spinal Cord Injury Center, Hokkaido Chuo Rosai Hospital, Hokkaido, Japan Department of Orthopaedic Surgery, Kobe Red Cross Hospital, Kobe, Japan Department of Orthopaedic Surgery, Japan LHWO Spinal Injuries Center, Iizuka, Japan and Department of Clinical Research, Chiba University Hospital, Chiba, Japan
Spine (Phila Pa 1976) 39:213-9. 2014..An open-labeled multicenter prospective nonrandomized controlled clinical trial...Cervical myelopathy in patients with athetoid cerebral palsy
Takeo Furuya
Spine Division, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 38:E151-7. 2013..Retrospective clinical study...Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis
Tetsuro Nakazawa
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
J Orthop Res 22:520-5. 2004..These findings suggest that periostin is a specific marker for preosteoblasts and may play an important role in periosteal callus formation during the early stage of fracture healing...Upregulation of osteopontin expression in rat spinal cord microglia after traumatic injury
Masayuki Hashimoto
The Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
J Neurotrauma 20:287-96. 2003..Osteopontin protein was found in the cytoplasm at 3 days and secreted into the extracellular matrix at 7 days. Triple immunolabeling showed that osteopontin was localized in activated microglia surrounded by astrocytes...Adenoviral gene transfer in the peripheral nervous system
Tomoko Saito Watanabe
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
J Orthop Sci 11:64-9. 2006..There are no data showing efficiency of protein transduction in the PNS, which consists of a variety of cell types, many of which are postmitotic...Cervical myelopathy in patients with ossification of the posterior longitudinal ligament
Macondo Mochizuki
Department of Orthopaedic Surgery, Numazu City Hospital, Shizuoka, Japan
J Neurosurg Spine 10:122-8. 2009..Additionally, the authors analyzed the factors contributing to the development and aggravation of myelopathy in patients with OPLLinduced spinal canal stenosis...Gene expression for type-specific collagens in osteogenic protein-1 (rhBMP-7)-induced lumbar intertransverse process fusion in rabbits
Junshiro Hisamitsu
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Connect Tissue Res 47:256-63. 2006..In OP-1-induced PLF, therefore, osteogenic action of OP-1 seems to be quite intensive in the early phase but not in the late phase...Occipitocervical fusion has potential to improve sleep apnea in patients with rheumatoid arthritis and upper cervical lesions
Hiromi Ataka
Department of Orthopaedic Surgery, Matsudo City Hospital, Department of Anesthesiology, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 35:E971-5. 2010..Case series...Intraoperative spinal subarachnoid hematoma in a patient with cervical ossification of the posterior longitudinal ligament
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 35:E359-62. 2010..Case report...Identification of Pip4k2beta as a mechanical stimulus responsive gene and its expression during musculoskeletal tissue healing
Sakae Sano
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Cell Tissue Res 323:245-52. 2006..In the Achilles tendon, however, expression remained decreased until 4 weeks after transection. We suggest that the expression of Pip4k2beta can be used as a marker for cells receiving a suitable mechanical stimulus...Traumatic C6-7 subluxation with anomalous course of vertebral arteries treated with pedicle screw/rod fixation. Case report
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Japan
J Neurosurg Spine 7:65-70. 2007..Preoperative detection of anomalous VAs will affect decisions on the appropriate corrective surgery option in cases of cervical spine injuries...Effects of a single percutaneous injection of basic fibroblast growth factor on the healing of a closed femoral shaft fracture in the rat
Fumitake Nakajima
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8677, Japan
Calcif Tissue Int 81:132-8. 2007..We conclude that, in the healing of closed fractures of long bones, administration of bFGF forms a larger callus but does not necessarily accelerate the healing process...Image fusion for preoperative evaluation of vertebral artery in a patient with atlantoaxial vertical subluxation and chronic renal failure
Ryo Kadota
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Eur Spine J 19:S96-9. 2010....Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol
Koji Yamazaki
Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Mol Reprod Dev 72:291-8. 2005..These results suggest that the increased type I collagen expression is associated with the relative stromal overgrowth in the epididymis of DES-treated mice...Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat
Akira Ogasawara
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Bone 43:832-9. 2008..These results show the molecular basis for diminished cartilage formation and delayed union in fracture healing of the STZ-induced diabetic rats...Paraparesis caused by rib exostosis in a child with Down syndrome: a case report
Chikato Mannoji
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 33:E911-3. 2008..Case report...Surgical simulation of instrumented posterior occipitocervical fusion in a child with congenital skeletal anomaly: case report
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 31:E590-4. 2006..Case report of a child with a congenital skeletal anomaly who underwent instrumented surgery at the craniovertebral junction (CVJ)...Usefulness of 3-dimensional full-scale modeling for preoperative simulation of surgery in a patient with old unilateral cervical fracture-dislocation
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 32:E532-6. 2007..Case report...Efficacy and reliability of highly functional open source DICOM software (OsiriX) in spine surgery
Tomonori Yamauchi
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
J Clin Neurosci 17:756-9. 2010..In addition, any clinician, can obtain information using OsiriX at any time. Thus, OsiriX is a helpful tool in preoperative planning for spine surgery...Anomalous vertebral artery at the craniovertebral junction in a patient with Down syndrome. Case report
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
J Neurosurg Spine 1:338-41. 2004..With preoperative 3D CT angiography, the anomalous VA can be identified precisely and the possible risk of intraoperative VA injury predetermined...Transient paraparesis after laminectomy for thoracic myelopathy due to ossification of the posterior longitudinal ligament: a case report
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Spine (Phila Pa 1976) 30:E343-6. 2005..Case report...Postmortem findings in a woman with history of laminoplasty for severe cervical spondylotic myelopathy
Yukio Someya
Graduate School of Medicine, Chiba University, Chiba, Japan
J Spinal Cord Med 34:523-6. 2011..Her sensory disturbance, spasticity, and vesicorectal disturbance, which corresponded to long tract sign, had improved after surgery...[Updates of ossification of posterior longitudinal ligament. Clinical results and complication of surgery for thoracic myelopathy due to ossification of posterior longitudinal ligament]
Masashi Yamazaki
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine
Clin Calcium 19:1499-504. 2009..We recommend that one stage posterior decompression with instrumented fusion be selected for cases in whom the spinal cord is severely damaged pre-operatively...Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repa
Arata Nakajima
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Endocrinology 144:4659-68. 2003..These results indicate a differential role of FGFR3 in skeletal development and fracture repair...Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34)
Arata Nakajima
Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Japan
J Bone Miner Res 17:2038-47. 2002..The resultant effect to increase callus mechanical strength supports the concept that clinical investigations on the ability of injectable low-dose PTH(1-34) to enhance fracture healing are indicated...Increased expression of macrophage migration inhibitory factor during fracture healing in rats
Shin Onodera
Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, 060 8638 Sapporo, Japan
Histochem Cell Biol 121:209-17. 2004..These results suggest the possibility that MIF plays an important role in fracture healing in association with proliferation of stromal cells, and the induction of MMP-13 in osteoblasts or chondrocytes...Surgical management of severe scoliosis with high-risk pulmonary dysfunction in Duchenne muscular dystrophy
Masashi Takaso
Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Kitasato1 15 1, Sagamihara City, Kanagawa, Japan
Int Orthop 34:401-6. 2010..DMD patients with severe scoliosis and FVC considered too low to permit reasonable surgical risk could undergo surgery and could benefit from surgery...Infection-related atlantoaxial subluxation (Grisel syndrome) in an adult with Down syndrome
Masashi Yamazaki
Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
Spine (Phila Pa 1976) 33:E156-60. 2008..Case report...Posterior instrumented fusion without neural decompression for incomplete neurological deficits following vertebral collapse in the osteoporotic thoracolumbar spine
Hiromi Ataka
Department of Orthopaedic Surgery, Matsudo City Hospital, Matsudo, Chiba, Japan
Eur Spine J 18:69-76. 2009..We suggest that neural decompression is not essential for the treatment of neurological impairment due to osteoporotic vertebral collapse with dynamic mobility...Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats
Kenji Takahashi
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
Calcif Tissue Int 74:187-93. 2004..Shockwaves can yield dramatic activation of cells in normal long bones, and drive the cells to express genes for osteogenesis...