Masashi Yamazaki

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing
    M Yamazaki
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
    J Orthop Res 15:757-64. 1997
  2. ncbi Fenestration of vertebral artery at the craniovertebral junction in Down syndrome: a case report
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 29:E551-4. 2004
  3. pmc Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Eur Spine J 16:2206-14. 2007
  4. doi Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation
    Takeo Furuya
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Brain Res 1295:192-202. 2009
  5. ncbi Up-regulation of macrophage migration-inhibitory factor expression after compression-induced spinal cord injury in rats
    Masao Koda
    Department of Environmental Medical Science, Chiba University Graduate School of Medicine, Japan
    Acta Neuropathol 108:31-6. 2004
  6. doi Deletion of macrophage migration inhibitory factor attenuates neuronal death and promotes functional recovery after compression-induced spinal cord injury in mice
    Yutaka Nishio
    Department of Orthopaedic Surgery, Chiba University, Chuo Ku, Japan
    Acta Neuropathol 117:321-8. 2009
  7. doi Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord
    Yukio Someya
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Neurosurg Spine 9:600-10. 2008
  8. ncbi Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Brain Res 1149:223-31. 2007
  9. doi Simulated surgery for a patient with neurofibromatosis type-1 who had severe cervicothoracic kyphoscoliosis and an anomalous vertebral artery
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 35:E368-73. 2010
  10. doi Surgical simulation of circumferential osteotomy and correction of cervico-thoracic kyphoscoliosis for an irreducible old C6-C7 fracture dislocation
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Acta Neurochir (Wien) 151:867-72. 2009

Collaborators

Detail Information

Publications88

  1. ncbi Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing
    M Yamazaki
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
    J Orthop Res 15:757-64. 1997
    ....
  2. ncbi Fenestration of vertebral artery at the craniovertebral junction in Down syndrome: a case report
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 29:E551-4. 2004
    ..Case report of a Down syndrome patient with right vertebral artery fenestration and abnormalities of the craniovertebral junction...
  3. pmc Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Eur Spine J 16:2206-14. 2007
    ..Further investigation is needed to establish an optimal combination of cell therapy and neurotrophin gene transfer for cases of spinal cord injury...
  4. doi Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation
    Takeo Furuya
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Brain Res 1295:192-202. 2009
    ..However, the data failed to demonstrate significant synergism from combined therapy compared with the levels of recovery following single-agent treatment...
  5. ncbi Up-regulation of macrophage migration-inhibitory factor expression after compression-induced spinal cord injury in rats
    Masao Koda
    Department of Environmental Medical Science, Chiba University Graduate School of Medicine, Japan
    Acta Neuropathol 108:31-6. 2004
    ..The MIF may contribute to proliferation of astrocytes around the lesioned site in spinal cord injury because of its cell proliferation-promoting property...
  6. doi Deletion of macrophage migration inhibitory factor attenuates neuronal death and promotes functional recovery after compression-induced spinal cord injury in mice
    Yutaka Nishio
    Department of Orthopaedic Surgery, Chiba University, Chuo Ku, Japan
    Acta Neuropathol 117:321-8. 2009
    ..These results suggest that MIF existence hinders neuronal survival after SCI. Suppression of MIF may attenuate detrimental secondary molecular responses of the injured spinal cord...
  7. doi Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord
    Yukio Someya
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Neurosurg Spine 9:600-10. 2008
    ..The aim of the present study is to evaluate the efficacy of transplanted BMSC-derived SCs (BMSC-SCs) in a rat model of spinal cord contusion, which is relevant to clinical spinal cord injury...
  8. ncbi Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Brain Res 1149:223-31. 2007
    ..G-CSF treated mice showed significant recovery of hind limb function compared to that of the control mice. In conclusion, G-CSF showed efficacy for spinal cord injury treatment through mobilization of bone marrow-derived cells...
  9. doi Simulated surgery for a patient with neurofibromatosis type-1 who had severe cervicothoracic kyphoscoliosis and an anomalous vertebral artery
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 35:E368-73. 2010
    ..Case report...
  10. doi Surgical simulation of circumferential osteotomy and correction of cervico-thoracic kyphoscoliosis for an irreducible old C6-C7 fracture dislocation
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Acta Neurochir (Wien) 151:867-72. 2009
    ..However, consistent protocols and procedures have not been fully established for the surgical correction of an irreducible old cervical fracture dislocation associated with spinal deformity...
  11. doi Transplantation of human bone marrow stromal cell-derived Schwann cells reduces cystic cavity and promotes functional recovery after contusion injury of adult rat spinal cord
    Takahito Kamada
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuropathology 31:48-58. 2011
    ..In conclusion, the functions of hBMSC-SC are comparable to original Schwann cells in rat spinal cord injury models, and are thus potentially useful treatments for patients with spinal cord injury...
  12. pmc Surgical management of severe scoliosis with high risk pulmonary dysfunction in Duchenne muscular dystrophy: patient function, quality of life and satisfaction
    Masashi Takaso
    Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Kitasato 1 15 1, Sagamihara, Kanagawa, Japan
    Int Orthop 34:695-702. 2010
    ..6% per year. Most patients and parents believed scoliosis surgery improved their function, sitting balance and quality of life even though patients were at high risk for major complications. Their satisfaction was also high...
  13. ncbi Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing
    Tetsuro Nakazawa
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8677, Japan
    Bone 37:711-9. 2005
    ..These results suggest that intermittent treatment with low-dose rhPTH(1-34) induces a larger cartilaginous callus but does not delay chondrocyte differentiation during fracture healing...
  14. ncbi Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis
    Masayuki Hashimoto
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
    Acta Neuropathol 109:165-80. 2005
    ..This system is potentially useful for identifying genes that are involved in the response to SCI...
  15. pmc Granulocyte colony-stimulating factor (G-CSF) protects oligodendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats
    Ryo Kadota
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    PLoS ONE 7:e50391. 2012
    ..The aim of the present study was to elucidate the potential therapeutic effect of G-CSF for SCI in rats...
  16. doi Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model
    Koichi Hayashi
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    J Neurosurg Spine 15:582-93. 2011
    ..In the present study, the authors used the neural stem sphere (NSS) method to differentiate iPSCs into astrocytes, which were evaluated after their transplantation into injured rat spinal cords...
  17. ncbi An analysis of factors causing poor surgical outcome in patients with cervical myelopathy due to ossification of the posterior longitudinal ligament: anterior decompression with spinal fusion versus laminoplasty
    Yutaka Masaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Spinal Disord Tech 20:7-13. 2007
    ..We compared the surgical outcome of anterior decompression with spinal fusion (ASF) with the surgical outcome of laminoplasty for patients with cervical myelopathy due to ossification of the posterior longitudinal ligament...
  18. pmc C5 palsy following anterior decompression and spinal fusion for cervical degenerative diseases
    Mitsuhiro Hashimoto
    Department of Orthopaedic Surgery, Numazu City Hospital, 550 Harunoki, Higashi shiiji, Numazu, Shizuoka 410 0302, Japan
    Eur Spine J 19:1702-10. 2010
    ..Thus, when patients with spinal cord lesions at C3-C4 and C4-C5 levels undergo multilevel ASF, we should be alert to the possible occurrence of postoperative C5 palsy...
  19. ncbi Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice
    Yutaka Nishio
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neuropathol Exp Neurol 66:724-31. 2007
    ..G-CSF is currently used in the clinic for hematopoietic stimulation, and its ongoing clinical trial for brain infarction makes it an appealing molecule that could be rapidly placed into trials for patients with acute SCI...
  20. doi Brain-derived neurotrophic factor suppresses anoikis-induced death of Schwann cells
    Masao Koda
    Department of Orthopaedic Surgery, Chiba Aoba Municipal Hospital, Chiba, Japan
    Neurosci Lett 444:143-7. 2008
    ..Suppression of anoikis may increase survival of grafted cells in case of cell therapy for spinal cord injury...
  21. doi Anomalous vertebral arteries in the extra- and intraosseous regions of the craniovertebral junction visualized by 3-dimensional computed tomographic angiography: analysis of 100 consecutive surgical cases and review of the literature
    Masashi Yamazaki
    Department of Orthopaedic Surgery, The Spine Section, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 37:E1389-97. 2012
    ..Consecutive case series and literature review...
  22. pmc Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of compression myelopathy, Part 1: a phase I and IIa clinical trial
    Tsuyoshi Sakuma
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8677, Japan
    Eur Spine J 21:482-9. 2012
    ....
  23. ncbi Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of thoracic myelopathy: a multicenter prospective controlled trial
    Tsuyoshi Sakuma
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 37:1475-8. 2012
    ..An open-labeled multicenter prospective controlled clinical trial...
  24. doi Abnormal course of the vertebral artery at the craniovertebral junction in patients with Down syndrome visualized by three-dimensional CT angiography
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Neuroradiology 50:485-90. 2008
    ..We determined the incidence of vertebral artery (VA) anomalies at the craniovertebral junction (CVJ) in patients with Down syndrome, and characterized the VA anomalies...
  25. pmc Autogenous iliac crest bone graft versus banked allograft bone in scoliosis surgery in patients with Duchenne muscular dystrophy
    Toshiyuki Nakazawa
    Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Sagamihara City, Kanagawa, Japan
    Int Orthop 34:855-61. 2010
    ....
  26. ncbi Regulation of semaphorin 3A expression in neurons of the rat spinal cord and cerebral cortex after transection injury
    Masayuki Hashimoto
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677 Chiba, Japan
    Acta Neuropathol 107:250-6. 2004
    ..It is likely that the up-regulation occurred in neurons whose descending fibers were transected. These results suggest that Sema3A is regulated differently in spinal motoneurons and brain neurons following axonal injury...
  27. ncbi Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord
    Takahito Kamada
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Neuropathol Exp Neurol 64:37-45. 2005
    ..Transplantation of BMSC-SCs is a potentially useful treatment for spinal cord injury...
  28. ncbi The use of hemopoietic stem cells derived from human umbilical cord blood to promote restoration of spinal cord tissue and recovery of hindlimb function in adult rats
    Yutaka Nishio
    Department of Orthopaedic Surgery, Chiba University Graduate School of dicine, Tougane Chiba Prefecture Hospital, Chiba, Japan
    J Neurosurg Spine 5:424-33. 2006
    ..The authors investigated the effects of hemopoietic stem cells that were derived from HUCB and transplanted into the injured spinal cords of rats...
  29. ncbi Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Neuroreport 16:1763-7. 2005
    ..No significant difference was observed in the recovery between both groups. Both hematopoietic stem cells and marrow stromal cells have the potential to restore the injured spinal cord and to promote functional recovery...
  30. pmc Less invasive and less technically demanding decompressive procedure for lumbar spinal stenosis--appropriate for general orthopaedic surgeons?
    Masashi Takaso
    Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato1 15 1, Sagamihara, Kanagawa, Japan
    Int Orthop 35:67-73. 2011
    ..The described technique of MSPO yielded promising results with few complications. The authors believe MSPO is less technically demanding and appropriate for general orthopaedic surgeons, occasional spine surgeons and chief residents...
  31. doi Surgical correction of spinal deformity in patients with congenital muscular dystrophy
    Masashi Takaso
    Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato 1 15 1, Minami Sagamihara, Kanagawa 252 0375, Japan
    J Orthop Sci 15:493-501. 2010
    ..The purpose of this study was to review the clinical and radiological results of spinal deformity surgery in this group of patients with CMD...
  32. pmc Association between serum leptin and bone metabolic markers, and the development of heterotopic ossification of the spinal ligament in female patients with ossification of the posterior longitudinal ligament
    Yoshikazu Ikeda
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 20:1450-8. 2011
    ..Our results suggest that hyperleptinemia, in combination with hyperinsulinemia, may contribute to the development of heterotopic ossification of the spinal ligament in female patients with OPLL...
  33. doi Static versus dynamic factors for the development of myelopathy in patients with cervical ossification of the posterior longitudinal ligament
    Takayuki Fujiyoshi
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Clin Neurosci 17:320-4. 2010
    ..Thus, by controlling the dynamic factors (hypermobility), we might be able to reduce neurological deterioration in patients with cervical OPLL...
  34. ncbi Anomalous vertebral artery at the extraosseous and intraosseous regions of the craniovertebral junction: analysis by three-dimensional computed tomography angiography
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 30:2452-7. 2005
    ..This study examined the extraosseous and intraosseous anomalies of vertebral arteries in patients who underwent surgery of the craniovertebral junction...
  35. pmc Neuroprotective therapy using granulocyte colony-stimulating factor for acute spinal cord injury: a phase I/IIa clinical trial
    Hiroshi Takahashi
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Eur Spine J 21:2580-7. 2012
    ..To confirm the safety and feasibility of G-CSF administration for acute spinal cord injury (SCI), we have initiated a phase I/IIa clinical trial of neuroprotective therapy using G-CSF...
  36. doi Neuroprotective effects of granulocyte colony-stimulating factor and relationship to promotion of angiogenesis after spinal cord injury in rats: laboratory investigation
    Junko Kawabe
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Japan
    J Neurosurg Spine 15:414-21. 2011
    ..The aim of this study was to assess the effects of G-CSF on the vascular system after SCI...
  37. doi Two-year results for scoliosis secondary to Duchenne muscular dystrophy fused to lumbar 5 with segmental pedicle screw instrumentation
    Masashi Takaso
    Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    J Orthop Sci 15:171-7. 2010
    ..This study was performed to determine the efficacy and safety of stopping segmental pedicle screw constructs at L5 during surgical treatment of scoliosis associated with Duchenne muscular dystrophy (DMD)...
  38. pmc Can the caudal extent of fusion in the surgical treatment of scoliosis in Duchenne muscular dystrophy be stopped at lumbar 5?
    Masashi Takaso
    Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Kitasato1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    Eur Spine J 19:787-96. 2010
    ..This method in appropriate patients can be a viable alternative to instrumentation and fusion to the sacrum/pelvis in the surgical treatment of DMD scoliosis...
  39. doi Interferon-γ decreases chondroitin sulfate proteoglycan expression and enhances hindlimb function after spinal cord injury in mice
    Takayuki Fujiyoshi
    Department of Neurobiology, Chiba University, Chiba, Japan
    J Neurotrauma 27:2283-94. 2010
    ..Our results indicate that IFN-γ exhibits therapeutic effects in mouse contusive SCI, presumably by reducing CSPG expression from reactive astrocytes and increasing the expression of neurotrophic factors...
  40. ncbi Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord
    Masao Koda
    Division of Rehabilitation Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    J Neurotrauma 21:329-37. 2004
    ..These results indicate that the recovery was caused by regeneration of rubrospinal axons, not by simple enhancement of the central pattern generator...
  41. pmc Treatment with basic fibroblast growth factor-incorporated gelatin hydrogel does not exacerbate mechanical allodynia after spinal cord contusion injury in rats
    Takeo Furuya
    Chiba University Graduate School of Medicine, Chiba, Japan
    J Spinal Cord Med 36:134-9. 2013
    ..Besides stimulating angiogenesis or cell survival, basic fibroblast growth factor (bFGF) has the potential for protecting neurons in the injured spinal cord...
  42. doi Postoperative paralysis following posterior decompression with instrumented fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Clin Neurosci 18:294-6. 2011
    ....
  43. ncbi Brain-derived neurotrophic factor suppresses delayed apoptosis of oligodendrocytes after spinal cord injury in rats
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Neurotrauma 19:777-85. 2002
    ..BDNF administration may therefore be useful for the clinical treatment of spinal cord injury through the suppression of secondary events...
  44. pmc Posterior decompression with instrumented fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8677, Japan
    Eur Spine J 19:691-8. 2010
    ..Since neurological recovery progresses slowly after PDF, we suggest that additional anterior decompression surgery is not desirable during the early stage of recovery...
  45. doi Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury
    Tomohiro Miyashita
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurotrauma 26:955-64. 2009
    ..Thus, reexpression of the embryonic repulsive cues in adult tissues contributes to the failure of axon regeneration in the central nervous system...
  46. doi Evidence of enhanced expression of osteopontin in spinal hyperostosis of the twy mouse
    Atsuomi Aiba
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 34:1644-9. 2009
    ..Gene expression and protein localization of osteopontin (OPN) in spinal hyperostosis of the twy mouse by means of in situ hybridization, immunohistochemistry, and Northern blot analysis...
  47. ncbi Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice
    Shuhei Koshizuka
    Department of Orthopaedic Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
    J Neuropathol Exp Neurol 63:64-72. 2004
    ..These results suggest that transplantation of HSCs from bone marrow is an effective strategy for the treatment of spinal cord injury...
  48. ncbi Clinical results of surgery for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: operative indication of posterior decompression with instrumented fusion
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 31:1452-60. 2006
    ..This retrospective study was conducted to investigate the clinical outcomes of several surgical procedures for thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL)...
  49. doi C1 dome-like laminotomy and posterior C1-C2 polyaxial screw-rod fixation for a patient with cervical myelopathy due to a retro-odontoid pseudotumor
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8677, Japan
    J Clin Neurosci 16:99-103. 2009
    ..Successful C1-C2 fusion, adequate decompression of the spinal cord, and spontaneous regression of the retro-odontoid mass were achieved by this procedure without any apparent restriction in neck movement...
  50. doi Comparison of clinical outcomes between laminoplasty, posterior decompression with instrumented fusion, and anterior decompression with fusion for K-line (-) cervical ossification of the posterior longitudinal ligament
    Masao Koda
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 2608670, Japan
    Eur Spine J 25:2294-301. 2016
    ..The aim of the present study was to compare the clinical outcome of LMP, posterior decompression with instrumented fusion (PDF) and anterior decompression and fusion (ADF) for patients with K-line (-) OPLL...
  51. pmc Postoperative Increase in Occiput-C2 Angle Negatively Impacts Subaxial Lordosis after Occipito-Upper Cervical Posterior Fusion Surgery
    Taigo Inada
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Asian Spine J 10:744-7. 2016
    ..Retrospective case series...
  52. doi Granulocyte colony-stimulating factor attenuates spinal cord injury-induced mechanical allodynia in adult rats
    Kei Kato
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Japan
    J Neurol Sci 355:79-83. 2015
    ..The present results demonstrate a therapeutic effect of G-CSF treatment for SCI-induced NeP, possibly through the inhibition of microglial activation and the suppression of p38MAPK phosphorylation and the upregulation of interleukin-1β...
  53. pmc Resolution of low back symptoms after corrective surgery for dropped-head syndrome: a report of two cases
    Masao Koda
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    BMC Res Notes 8:545. 2015
    ..Cervical deformity can influence global sagittal balance. We report two cases of severe low back pain and lower extremity radicular pain associated with dropped-head syndrome. Symptoms were relieved by cervical corrective surgery...
  54. doi Mid- to long-term outcomes of posterior decompression with instrumented fusion for thoracic ossification of the posterior longitudinal ligament
    Masao Koda
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 2608670, Japan Electronic address
    J Clin Neurosci 27:87-90. 2016
    ..PDF surgery for thoracic OPLL is thus considered a relatively safe and stable surgical procedure considering the mid- to long-term outcomes...
  55. doi Transplanted Peripheral Blood Stem Cells Mobilized by Granulocyte Colony-Stimulating Factor Promoted Hindlimb Functional Recovery After Spinal Cord Injury in Mice
    Hiroshi Takahashi
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Cell Transplant 25:283-92. 2016
    ..Transplantation of G-CSF-mobilized PBSCs has advantages for treatment of spinal cord injury in the ethical and immunological viewpoints, although further exploration is needed to move forward to clinical application. ..
  56. pmc Neurological deterioration induced by sitting in patients after cervicothoracic posterior decompression with instrumented fusion surgery for ossification of the longitudinal ligament: two cases reports
    Masao Koda
    Departments of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuo K, Chiba, 260 8670, Japan
    BMC Res Notes 8:133. 2015
    ..We report on Japanese patients who showed neurological deterioration induced by sitting after cervicothoracic posterior decompression with instrumented fusion, but showed immediate neurological recovery after bed rest...
  57. doi Bone union and remodelling of the non-ossified segment in thoracic ossification of the posterior longitudinal ligament after posterior decompression and fusion surgery
    Masao Koda
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1, Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Eur Spine J 24:2555-9. 2015
    ..The purpose of the present study was to elucidate the course of bone union and remodelling of the non-ossified segment of thoracic OPLL (T-OPLL) after PDF surgery...
  58. doi Neuroprotective therapy with granulocyte colony-stimulating factor in acute spinal cord injury: a comparison with high-dose methylprednisolone as a historical control
    Koshiro Kamiya
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 2608670, Japan
    Eur Spine J 24:963-7. 2015
    ..In this study, we retrospectively analyzed the clinical outcome in SCI patients treated with G-CSF and compared these results to a historical cohort of SCI patients treated with high-dose methylprednisolone sodium succinate (MPSS)...
  59. doi Multicenter prospective nonrandomized controlled clinical trial to prove neurotherapeutic effects of granulocyte colony-stimulating factor for acute spinal cord injury: analyses of follow-up cases after at least 1 year
    Taigo Inada
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan Spinal Cord Injury Center, Hokkaido Chuo Rosai Hospital, Hokkaido, Japan Department of Orthopaedic Surgery, Kobe Red Cross Hospital, Kobe, Japan Department of Orthopaedic Surgery, Japan LHWO Spinal Injuries Center, Iizuka, Japan and Department of Clinical Research, Chiba University Hospital, Chiba, Japan
    Spine (Phila Pa 1976) 39:213-9. 2014
    ..An open-labeled multicenter prospective nonrandomized controlled clinical trial...
  60. doi Cervical myelopathy in patients with athetoid cerebral palsy
    Takeo Furuya
    Spine Division, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 38:E151-7. 2013
    ..Retrospective clinical study...
  61. ncbi Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis
    Tetsuro Nakazawa
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Orthop Res 22:520-5. 2004
    ..These findings suggest that periostin is a specific marker for preosteoblasts and may play an important role in periosteal callus formation during the early stage of fracture healing...
  62. ncbi Upregulation of osteopontin expression in rat spinal cord microglia after traumatic injury
    Masayuki Hashimoto
    The Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Neurotrauma 20:287-96. 2003
    ..Osteopontin protein was found in the cytoplasm at 3 days and secreted into the extracellular matrix at 7 days. Triple immunolabeling showed that osteopontin was localized in activated microglia surrounded by astrocytes...
  63. ncbi Adenoviral gene transfer in the peripheral nervous system
    Tomoko Saito Watanabe
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Orthop Sci 11:64-9. 2006
    ..There are no data showing efficiency of protein transduction in the PNS, which consists of a variety of cell types, many of which are postmitotic...
  64. doi Cervical myelopathy in patients with ossification of the posterior longitudinal ligament
    Macondo Mochizuki
    Department of Orthopaedic Surgery, Numazu City Hospital, Shizuoka, Japan
    J Neurosurg Spine 10:122-8. 2009
    ..Additionally, the authors analyzed the factors contributing to the development and aggravation of myelopathy in patients with OPLLinduced spinal canal stenosis...
  65. ncbi Gene expression for type-specific collagens in osteogenic protein-1 (rhBMP-7)-induced lumbar intertransverse process fusion in rabbits
    Junshiro Hisamitsu
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Connect Tissue Res 47:256-63. 2006
    ..In OP-1-induced PLF, therefore, osteogenic action of OP-1 seems to be quite intensive in the early phase but not in the late phase...
  66. doi Occipitocervical fusion has potential to improve sleep apnea in patients with rheumatoid arthritis and upper cervical lesions
    Hiromi Ataka
    Department of Orthopaedic Surgery, Matsudo City Hospital, Department of Anesthesiology, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 35:E971-5. 2010
    ..Case series...
  67. doi Intraoperative spinal subarachnoid hematoma in a patient with cervical ossification of the posterior longitudinal ligament
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 35:E359-62. 2010
    ..Case report...
  68. ncbi Identification of Pip4k2beta as a mechanical stimulus responsive gene and its expression during musculoskeletal tissue healing
    Sakae Sano
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Cell Tissue Res 323:245-52. 2006
    ..In the Achilles tendon, however, expression remained decreased until 4 weeks after transection. We suggest that the expression of Pip4k2beta can be used as a marker for cells receiving a suitable mechanical stimulus...
  69. ncbi Traumatic C6-7 subluxation with anomalous course of vertebral arteries treated with pedicle screw/rod fixation. Case report
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Japan
    J Neurosurg Spine 7:65-70. 2007
    ..Preoperative detection of anomalous VAs will affect decisions on the appropriate corrective surgery option in cases of cervical spine injuries...
  70. ncbi Effects of a single percutaneous injection of basic fibroblast growth factor on the healing of a closed femoral shaft fracture in the rat
    Fumitake Nakajima
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8677, Japan
    Calcif Tissue Int 81:132-8. 2007
    ..We conclude that, in the healing of closed fractures of long bones, administration of bFGF forms a larger callus but does not necessarily accelerate the healing process...
  71. pmc Image fusion for preoperative evaluation of vertebral artery in a patient with atlantoaxial vertical subluxation and chronic renal failure
    Ryo Kadota
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Eur Spine J 19:S96-9. 2010
    ....
  72. ncbi Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol
    Koji Yamazaki
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mol Reprod Dev 72:291-8. 2005
    ..These results suggest that the increased type I collagen expression is associated with the relative stromal overgrowth in the epididymis of DES-treated mice...
  73. doi Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat
    Akira Ogasawara
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Bone 43:832-9. 2008
    ..These results show the molecular basis for diminished cartilage formation and delayed union in fracture healing of the STZ-induced diabetic rats...
  74. doi Paraparesis caused by rib exostosis in a child with Down syndrome: a case report
    Chikato Mannoji
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 33:E911-3. 2008
    ..Case report...
  75. ncbi Surgical simulation of instrumented posterior occipitocervical fusion in a child with congenital skeletal anomaly: case report
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 31:E590-4. 2006
    ..Case report of a child with a congenital skeletal anomaly who underwent instrumented surgery at the craniovertebral junction (CVJ)...
  76. ncbi Usefulness of 3-dimensional full-scale modeling for preoperative simulation of surgery in a patient with old unilateral cervical fracture-dislocation
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 32:E532-6. 2007
    ..Case report...
  77. doi Efficacy and reliability of highly functional open source DICOM software (OsiriX) in spine surgery
    Tomonori Yamauchi
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Clin Neurosci 17:756-9. 2010
    ..In addition, any clinician, can obtain information using OsiriX at any time. Thus, OsiriX is a helpful tool in preoperative planning for spine surgery...
  78. ncbi Anomalous vertebral artery at the craniovertebral junction in a patient with Down syndrome. Case report
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Neurosurg Spine 1:338-41. 2004
    ..With preoperative 3D CT angiography, the anomalous VA can be identified precisely and the possible risk of intraoperative VA injury predetermined...
  79. ncbi Transient paraparesis after laminectomy for thoracic myelopathy due to ossification of the posterior longitudinal ligament: a case report
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Spine (Phila Pa 1976) 30:E343-6. 2005
    ..Case report...
  80. pmc Postmortem findings in a woman with history of laminoplasty for severe cervical spondylotic myelopathy
    Yukio Someya
    Graduate School of Medicine, Chiba University, Chiba, Japan
    J Spinal Cord Med 34:523-6. 2011
    ..Her sensory disturbance, spasticity, and vesicorectal disturbance, which corresponded to long tract sign, had improved after surgery...
  81. doi [Updates of ossification of posterior longitudinal ligament. Clinical results and complication of surgery for thoracic myelopathy due to ossification of posterior longitudinal ligament]
    Masashi Yamazaki
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine
    Clin Calcium 19:1499-504. 2009
    ..We recommend that one stage posterior decompression with instrumented fusion be selected for cases in whom the spinal cord is severely damaged pre-operatively...
  82. ncbi Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repa
    Arata Nakajima
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Endocrinology 144:4659-68. 2003
    ..These results indicate a differential role of FGFR3 in skeletal development and fracture repair...
  83. ncbi Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34)
    Arata Nakajima
    Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Japan
    J Bone Miner Res 17:2038-47. 2002
    ..The resultant effect to increase callus mechanical strength supports the concept that clinical investigations on the ability of injectable low-dose PTH(1-34) to enhance fracture healing are indicated...
  84. ncbi Increased expression of macrophage migration inhibitory factor during fracture healing in rats
    Shin Onodera
    Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, 060 8638 Sapporo, Japan
    Histochem Cell Biol 121:209-17. 2004
    ..These results suggest the possibility that MIF plays an important role in fracture healing in association with proliferation of stromal cells, and the induction of MMP-13 in osteoblasts or chondrocytes...
  85. pmc Surgical management of severe scoliosis with high-risk pulmonary dysfunction in Duchenne muscular dystrophy
    Masashi Takaso
    Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Kitasato1 15 1, Sagamihara City, Kanagawa, Japan
    Int Orthop 34:401-6. 2010
    ..DMD patients with severe scoliosis and FVC considered too low to permit reasonable surgical risk could undergo surgery and could benefit from surgery...
  86. doi Infection-related atlantoaxial subluxation (Grisel syndrome) in an adult with Down syndrome
    Masashi Yamazaki
    Spine Section, Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 33:E156-60. 2008
    ..Case report...
  87. pmc Posterior instrumented fusion without neural decompression for incomplete neurological deficits following vertebral collapse in the osteoporotic thoracolumbar spine
    Hiromi Ataka
    Department of Orthopaedic Surgery, Matsudo City Hospital, Matsudo, Chiba, Japan
    Eur Spine J 18:69-76. 2009
    ..We suggest that neural decompression is not essential for the treatment of neurological impairment due to osteoporotic vertebral collapse with dynamic mobility...
  88. ncbi Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats
    Kenji Takahashi
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Calcif Tissue Int 74:187-93. 2004
    ..Shockwaves can yield dramatic activation of cells in normal long bones, and drive the cells to express genes for osteogenesis...