Research Topics
Species | Mami YamazakiSummaryAffiliation: Chiba University Country: Japan Publications
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Detail Information
Publications
Molecular genetic study on the anthocyanin chemotypes of Perilla frutescens var. crispaMami Yamazaki
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan 263 8522
Nat Prod Commun 6:423-7. 2011..Furthermore, the candidates of regulatory factors, members of MYB-bHLH-WD complex, of anthocyanin production were characterized in this plant...
Differential gene expression profiles of red and green forms of Perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genesMami Yamazaki
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
FEBS J 275:3494-502. 2008..These results suggest that the genes of the whole anthocyanin biosynthetic pathway are regulated in a coordinated manner in perilla...- Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compoundsYasuyo Yamazaki
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522 Japan
Plant Cell Physiol 44:395-403. 2003..Plant stress compounds like salicylic acid repressed expression of OpSTR and OpTDC, suggesting coordinate regulation of these genes for camptothecin biosynthesis... - A WD-repeat-containing putative regulatory protein in anthocyanin biosynthesis in Perilla frutescensKanokporn Sompornpailin
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Plant Mol Biol 50:485-95. 2002..We propose a model of genetic regulation in which the PFWD protein acts in signal transduction process in a variety of pathways through protein interaction with MYC proteins... - Enhanced radical scavenging activity of genetically modified Arabidopsis seedsTakayuki Tohge
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
Biotechnol Lett 27:297-303. 2005..The present study suggests the feasibility of engineering a transcription factor of flavonoid biosynthesis for health beneficial plant seeds... - Isolation and characterization of anthocyanin 5-O-glucosyltransferase in Perilla frutescens var. crispa by differential displayMami Yamazaki
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Methods Mol Biol 317:255-66. 2006..The biological characters of this enzyme were investigated by using the recombinant protein expressed in yeast. We have shown an example of the application of DD technique to the molecular biology in plant secondary metabolisms... 
Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucoseYasuyo Yamazaki
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Plant Physiol 134:161-70. 2004..This study provides the innovative example for how a computer-aided comprehensive metabolic analysis will refine the experimental design to obtain more precise biological information...- Molecular characterization of a novel quinolizidine alkaloid O-tigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plantsTaketo Okada
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Plant Cell Physiol 46:233-44. 2005..These results indicated that this specialized acyltransferase, isolated for the first time as tigloyltransferase from nature, is committed to control the quinolizidine alkaloid patterns in a tissue-specific manner... - Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factorTakayuki Tohge
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
Plant J 42:218-35. 2005..The functional genomics approach through the integration of metabolomics and transcriptomics presented here provides an innovative means of identifying novel gene functions involved in plant metabolism... - Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza speciesTakashi Asano
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Methods Mol Biol 547:337-45. 2009..The established aseptic plants and hairy roots produced camptothecin, and O. pumila hairy roots accumulated highest amount of camptothecin. Furthermore, we have established methods of plant regeneration from O. pumila hairy roots... - Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plantsSupaart Sirikantaramas
Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
Proc Natl Acad Sci U S A 105:6782-6. 2008..Our results demonstrate the molecular mechanism of self-resistance to endogenously produced toxic compounds and the possibility of adaptive coevolution between the CPT production system and its target Top1 in the producing plants... - Mechanistic study on the oxidation of anthocyanidin synthase by quantum mechanical calculationJun Ichiro Nakajima
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
J Biol Chem 281:21387-98. 2006..Molecular evolutional implications of ANS and related proteins are discussed in terms of reaction dynamics... - Transport of camptothecin in hairy roots of Ophiorrhiza pumilaSupaart Sirikantaramas
Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
Phytochemistry 68:2881-6. 2007..This result indicates that CPT is biosynthesized at the ER and transported to accumulate in the vacuole by the same machinery that is used for vacuolar protein sorting. How O. pumila is insensitive to CPT is discussed... - Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosaeSomnuk Bunsupa
Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
Plant Cell 24:1202-16. 2012..Site-directed mutagenesis and protein modeling studies revealed a structural basis for preferential LDC activity, suggesting an evolutionary implication of L/ODC in the QA-producing plants... - Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thalianaRyo Nakabayashi
Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
Phytochemistry 70:1017-29. 2009.... - A polyhedral approach for understanding flavonoid biosynthesis in ArabidopsisRyo Nakabayashi
Graduate School of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
N Biotechnol 27:829-36. 2010..We focused on natural products chemistry in this polyhedral approach, which proved to be indispensable for elucidating the secondary metabolism in not only Arabidopsis but also other model-like and crop plants... - Metabolomics and differential gene expression in anthocyanin chemo-varietal forms of Perilla frutescensMami Yamazaki
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan
Phytochemistry 62:987-95. 2003..The possible regulatory network leading to differential anthocyanin accumulation in a form-specific manner is discussed... - Camptothecin: therapeutic potential and biotechnologySupaart Sirikantaramas
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho, Inage Ku, Chiba, Japan
Curr Pharm Biotechnol 8:196-202. 2007..In addition, recent advance in the cloning and characterization of biosynthetic enzymes involved in CPT biosynthetic pathway provides valuable information for developing genetically engineered CPT-producing plants... - Recent advances in the biosynthesis and accumulation of anthocyaninsKarin Springob
Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Nat Prod Rep 20:288-303. 2003..The literature from 1997 to the beginning of 2002 is reviewed, and 163 references are cited... - Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plantsYasuyo Yamazaki
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Phytochemistry 62:461-70. 2003..The activity of strictosidine synthase, a key enzyme of camptothecin biosynthesis, was detected in the protein extracts of stems and roots of O. pumila, being correlated with the pattern of strictosidine synthase mRNA expression... - Two flavonoid glucosyltransferases from Petunia hybrida: molecular cloning, biochemical properties and developmentally regulated expressionMami Yamazaki
Laboratory of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Plant Mol Biol 48:401-11. 2002..Southern blotting analysis of genomic DNA indicates that both 3-GT and 5-GT genes exist in two copies in P. hybrida, respectively. The results are discussed in relation to the molecular evolution of flavonoid glycosyltransferases...