Mami Yamazaki

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi request reprint Molecular genetic study on the anthocyanin chemotypes of Perilla frutescens var. crispa
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan 263 8522
    Nat Prod Commun 6:423-7. 2011
  2. doi request reprint Differential gene expression profiles of red and green forms of Perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genes
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    FEBS J 275:3494-502. 2008
  3. ncbi request reprint Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds
    Yasuyo Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba, 263 8522 Japan
    Plant Cell Physiol 44:395-403. 2003
  4. ncbi request reprint A WD-repeat-containing putative regulatory protein in anthocyanin biosynthesis in Perilla frutescens
    Kanokporn Sompornpailin
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Plant Mol Biol 50:485-95. 2002
  5. ncbi request reprint Enhanced radical scavenging activity of genetically modified Arabidopsis seeds
    Takayuki Tohge
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
    Biotechnol Lett 27:297-303. 2005
  6. pmc Coupling deep transcriptome analysis with untargeted metabolic profiling in Ophiorrhiza pumila to further the understanding of the biosynthesis of the anti-cancer alkaloid camptothecin and anthraquinones
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1 8 1, Chiba, 260 8675 Japan
    Plant Cell Physiol 54:686-96. 2013
  7. pmc Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose
    Yasuyo Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Plant Physiol 134:161-70. 2004
  8. ncbi request reprint Isolation and characterization of anthocyanin 5-O-glucosyltransferase in Perilla frutescens var. crispa by differential display
    Mami Yamazaki
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Methods Mol Biol 317:255-66. 2006
  9. ncbi request reprint Molecular characterization of a novel quinolizidine alkaloid O-tigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants
    Taketo Okada
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Plant Cell Physiol 46:233-44. 2005
  10. doi request reprint Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila
    Takashi Asano
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Phytochemistry 91:128-39. 2013

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Molecular genetic study on the anthocyanin chemotypes of Perilla frutescens var. crispa
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan 263 8522
    Nat Prod Commun 6:423-7. 2011
    ..Furthermore, the candidates of regulatory factors, members of MYB-bHLH-WD complex, of anthocyanin production were characterized in this plant...
  2. doi request reprint Differential gene expression profiles of red and green forms of Perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genes
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    FEBS J 275:3494-502. 2008
    ..These results suggest that the genes of the whole anthocyanin biosynthetic pathway are regulated in a coordinated manner in perilla...
  3. ncbi request reprint Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds
    Yasuyo Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba, 263 8522 Japan
    Plant Cell Physiol 44:395-403. 2003
    ..Plant stress compounds like salicylic acid repressed expression of OpSTR and OpTDC, suggesting coordinate regulation of these genes for camptothecin biosynthesis...
  4. ncbi request reprint A WD-repeat-containing putative regulatory protein in anthocyanin biosynthesis in Perilla frutescens
    Kanokporn Sompornpailin
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Plant Mol Biol 50:485-95. 2002
    ..We propose a model of genetic regulation in which the PFWD protein acts in signal transduction process in a variety of pathways through protein interaction with MYC proteins...
  5. ncbi request reprint Enhanced radical scavenging activity of genetically modified Arabidopsis seeds
    Takayuki Tohge
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
    Biotechnol Lett 27:297-303. 2005
    ..The present study suggests the feasibility of engineering a transcription factor of flavonoid biosynthesis for health beneficial plant seeds...
  6. pmc Coupling deep transcriptome analysis with untargeted metabolic profiling in Ophiorrhiza pumila to further the understanding of the biosynthesis of the anti-cancer alkaloid camptothecin and anthraquinones
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1 8 1, Chiba, 260 8675 Japan
    Plant Cell Physiol 54:686-96. 2013
    ..These results suggest that deep transcriptome and metabolome data sets can facilitate the identification of genes and intermediates involved in the biosynthesis of secondary products including camptothecin in O. pumila...
  7. pmc Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose
    Yasuyo Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Plant Physiol 134:161-70. 2004
    ..This study provides the innovative example for how a computer-aided comprehensive metabolic analysis will refine the experimental design to obtain more precise biological information...
  8. ncbi request reprint Isolation and characterization of anthocyanin 5-O-glucosyltransferase in Perilla frutescens var. crispa by differential display
    Mami Yamazaki
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Methods Mol Biol 317:255-66. 2006
    ..The biological characters of this enzyme were investigated by using the recombinant protein expressed in yeast. We have shown an example of the application of DD technique to the molecular biology in plant secondary metabolisms...
  9. ncbi request reprint Molecular characterization of a novel quinolizidine alkaloid O-tigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants
    Taketo Okada
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Plant Cell Physiol 46:233-44. 2005
    ..These results indicated that this specialized acyltransferase, isolated for the first time as tigloyltransferase from nature, is committed to control the quinolizidine alkaloid patterns in a tissue-specific manner...
  10. doi request reprint Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila
    Takashi Asano
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba, Japan
    Phytochemistry 91:128-39. 2013
    ....
  11. ncbi request reprint Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor
    Takayuki Tohge
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    Plant J 42:218-35. 2005
    ..The functional genomics approach through the integration of metabolomics and transcriptomics presented here provides an innovative means of identifying novel gene functions involved in plant metabolism...
  12. pmc Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
    Supaart Sirikantaramas
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Proc Natl Acad Sci U S A 105:6782-6. 2008
    ..Our results demonstrate the molecular mechanism of self-resistance to endogenously produced toxic compounds and the possibility of adaptive coevolution between the CPT production system and its target Top1 in the producing plants...
  13. doi request reprint Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species
    Takashi Asano
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Methods Mol Biol 547:337-45. 2009
    ..The established aseptic plants and hairy roots produced camptothecin, and O. pumila hairy roots accumulated highest amount of camptothecin. Furthermore, we have established methods of plant regeneration from O. pumila hairy roots...
  14. ncbi request reprint Transport of camptothecin in hairy roots of Ophiorrhiza pumila
    Supaart Sirikantaramas
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Phytochemistry 68:2881-6. 2007
    ..This result indicates that CPT is biosynthesized at the ER and transported to accumulate in the vacuole by the same machinery that is used for vacuolar protein sorting. How O. pumila is insensitive to CPT is discussed...
  15. ncbi request reprint Mechanistic study on the oxidation of anthocyanidin synthase by quantum mechanical calculation
    Jun Ichiro Nakajima
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    J Biol Chem 281:21387-98. 2006
    ..Molecular evolutional implications of ANS and related proteins are discussed in terms of reaction dynamics...
  16. pmc Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae
    Somnuk Bunsupa
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
    Plant Cell 24:1202-16. 2012
    ..Site-directed mutagenesis and protein modeling studies revealed a structural basis for preferential LDC activity, suggesting an evolutionary implication of L/ODC in the QA-producing plants...
  17. doi request reprint Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thaliana
    Ryo Nakabayashi
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Phytochemistry 70:1017-29. 2009
    ....
  18. doi request reprint A polyhedral approach for understanding flavonoid biosynthesis in Arabidopsis
    Ryo Nakabayashi
    Graduate School of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
    N Biotechnol 27:829-36. 2010
    ..We focused on natural products chemistry in this polyhedral approach, which proved to be indispensable for elucidating the secondary metabolism in not only Arabidopsis but also other model-like and crop plants...
  19. ncbi request reprint Metabolomics and differential gene expression in anthocyanin chemo-varietal forms of Perilla frutescens
    Mami Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Phytochemistry 62:987-95. 2003
    ..The possible regulatory network leading to differential anthocyanin accumulation in a form-specific manner is discussed...
  20. ncbi request reprint Recent advances in the biosynthesis and accumulation of anthocyanins
    Karin Springob
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Nat Prod Rep 20:288-303. 2003
    ..The literature from 1997 to the beginning of 2002 is reviewed, and 163 references are cited...
  21. ncbi request reprint Camptothecin: therapeutic potential and biotechnology
    Supaart Sirikantaramas
    Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho, Inage Ku, Chiba, Japan
    Curr Pharm Biotechnol 8:196-202. 2007
    ..In addition, recent advance in the cloning and characterization of biosynthetic enzymes involved in CPT biosynthetic pathway provides valuable information for developing genetically engineered CPT-producing plants...
  22. ncbi request reprint Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants
    Yasuyo Yamazaki
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Phytochemistry 62:461-70. 2003
    ..The activity of strictosidine synthase, a key enzyme of camptothecin biosynthesis, was detected in the protein extracts of stems and roots of O. pumila, being correlated with the pattern of strictosidine synthase mRNA expression...
  23. doi request reprint Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids
    Ryo Nakabayashi
    RIKEN Center for Sustainable Resource Science, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045, Japan Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Chuo ku, Chiba, 260 8675, Japan CREST, Japan Science and Technology Agency, 4 1 8 Honcho, Kawaguchi, Saitama, 332 0012, Japan
    Plant J 77:367-79. 2014
    ..These data confirm the usefulness of flavonoids for enhancing both biotic and abiotic stress tolerance in crops. ..
  24. ncbi request reprint Two flavonoid glucosyltransferases from Petunia hybrida: molecular cloning, biochemical properties and developmentally regulated expression
    Mami Yamazaki
    Laboratory of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Plant Mol Biol 48:401-11. 2002
    ..Southern blotting analysis of genomic DNA indicates that both 3-GT and 5-GT genes exist in two copies in P. hybrida, respectively. The results are discussed in relation to the molecular evolution of flavonoid glycosyltransferases...